PI3K
Los inhibidores de PI3K son compuestos que bloquean la actividad de las fosfoinosítido 3-quinasas (PI3Ks), una familia de enzimas involucradas en una amplia gama de procesos celulares, incluidos el crecimiento, la proliferación, la supervivencia y el metabolismo. La vía PI3K/Akt/mTOR a menudo está desregulada en el cáncer, lo que convierte a PI3K en un objetivo clave para la terapia contra el cáncer. Los inhibidores de PI3K son herramientas fundamentales para estudiar la transducción de señales, la biología del cáncer y el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos una variedad de inhibidores de PI3K para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 231 productos de "PI3K"
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NIH-12848
CAS:NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.Fórmula:C20H14F3N3SPureza:99.84% - 99.9%Forma y color:SolidPeso molecular:385.41Ref: TM-T3556
2mg35,00€5mg51,00€10mg75,00€25mg133,00€50mg225,00€100mg323,00€200mg447,00€1mL*10mM (DMSO)55,00€BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Fórmula:C28H25F3N6O2Pureza:95.74% - 99.78%Forma y color:SolidPeso molecular:534.53Ref: TM-T6072L
1mg47,00€2mg62,00€5mg92,00€10mg147,00€25mg295,00€50mg485,00€100mg737,00€1mL*10mM (DMSO)107,00€Fimepinostat
CAS:Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both PI3K class I and pan-HDAC enzymes, with potential antineoplastic activity.Fórmula:C23H24N8O4SPureza:98.27% - 99.87%Forma y color:SolidPeso molecular:508.55Ref: TM-T2078
2mg47,00€5mg70,00€10mg97,00€25mg175,00€50mg311,00€100mg512,00€500mg1.093,00€1mL*10mM (DMSO)79,00€Rigosertib sodium
CAS:Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.Fórmula:C21H24NNaO8SPureza:98% - 99.37%Forma y color:SolidPeso molecular:473.47TASP0415914
CAS:TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). TFórmula:C13H17N5O3SPureza:98.14%Forma y color:SolidPeso molecular:323.37Ref: TM-T7879
1mg52,00€5mg111,00€10mg177,00€25mg299,00€50mg424,00€100mg587,00€200mg792,00€1mL*10mM (DMSO)127,00€Wortmannin
CAS:Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.Fórmula:C23H24O8Pureza:95.84% - 99.77%Forma y color:White SolidPeso molecular:428.43Ref: TM-T6283
1mg38,00€2mg49,00€5mg80,00€10mg119,00€25mg235,00€50mg406,00€100mg602,00€1mL*10mM (DMSO)88,00€Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Fórmula:C17H20F3N7O2Pureza:97.58% - 98.92%Forma y color:SolidPeso molecular:411.38PI3K-IN-1
CAS:PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.Fórmula:C31H29N5O6SPureza:97.03% - 98%Forma y color:SolidPeso molecular:599.66PI-3065
CAS:PI-3065 is a novel potent and selective PI3K p110δ inhibitor.Fórmula:C27H31FN6OSPureza:99.84% - ≥95%Forma y color:SolidPeso molecular:506.64AS-252424
CAS:AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.Fórmula:C14H8FNO4SPureza:99.06% - 99.09%Forma y color:SolidPeso molecular:305.28Ref: TM-T6208
1mg37,00€2mg52,00€5mg77,00€10mg128,00€25mg205,00€50mg309,00€100mg447,00€500mg973,00€1mL*10mM (DMSO)84,00€Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Fórmula:C19H24O5Pureza:96.66% - 99.93%Forma y color:SolidPeso molecular:332.39PF-04691502
CAS:PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.Fórmula:C22H27N5O4Pureza:96.27% - ≥95%Forma y color:SolidPeso molecular:425.48Ref: TM-T6251
1mg34,00€2mg43,00€5mg63,00€10mg88,00€25mg117,00€50mg187,00€100mg333,00€1mL*10mM (DMSO)65,00€Oroxin B
CAS:Oroxin B (Hypocretin-2) has antioxidant activity.Fórmula:C27H30O15Pureza:98.22% - 99.87%Forma y color:SolidPeso molecular:594.52GDC0084
CAS:GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.
Fórmula:C18H22N8O2Pureza:99.72% - 99.87%Forma y color:SolidPeso molecular:382.42Copanlisib
CAS:Copanlisib (BAY 80-6946), a PI3K inhibitor, may block tumor growth and improve cancer treatment efficacy.Fórmula:C23H28N8O4Pureza:99% - 99.88%Forma y color:SolidPeso molecular:480.52PF-4989216
CAS:PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.Fórmula:C18H13FN6OSPureza:99.85%Forma y color:SolidPeso molecular:380.4Ref: TM-T6938
2mg39,00€5mg65,00€10mg101,00€25mg187,00€50mg329,00€100mg398,00€200mg565,00€1mL*10mM (DMSO)67,00€GNE-477
CAS:GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.Fórmula:C21H28N8O3S2Pureza:98.88% - 99.55%Forma y color:SolidPeso molecular:504.63Ref: TM-T3692
1mg44,00€2mg57,00€5mg93,00€10mg138,00€25mg286,00€50mg447,00€100mg677,00€1mL*10mM (DMSO)92,00€Leniolisib
CAS:Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
Fórmula:C21H25F3N6O2Pureza:99.88%Forma y color:SolidPeso molecular:450.461-Deoxynojirimycin
CAS:1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.Fórmula:C6H13NO4Pureza:99.65% - 99.98%Forma y color:White-Beige Solid CrystallinePeso molecular:163.17Ref: TM-T3675
2mg46,00€5mg62,00€10mg79,00€25mg147,00€50mg261,00€100mg339,00€500mg817,00€1mL*10mM (DMSO)60,00€Dihydrocapsaicin
CAS:Dihydrocapsaicin, similar to capsaicin, is an irritant found in Capsicum, used in "pure" capsaicin products at about 10%, activates VR1, and is an antioxidant.Fórmula:C18H29NO3Pureza:99.8% - ≥95%Forma y color:White CrystalPeso molecular:307.43
