ATM / ATR
Los inhibidores de ATM (Ataxia Telangiectasia Mutada) y ATR (ATM y Rad3-relacionada) se dirigen a quinasas clave involucradas en la respuesta al daño del ADN (DDR) que se activan en respuesta a rupturas de doble hebra de ADN y estrés replicativo. Estos inhibidores interrumpen la capacidad de estas quinasas para detectar y reparar el daño del ADN, lo que puede llevar a una mayor inestabilidad genómica y muerte celular, particularmente en células cancerosas que dependen de mecanismos robustos de reparación del ADN para sobrevivir. Los inhibidores de ATM/ATR son herramientas cruciales en la investigación y terapia contra el cáncer, especialmente en combinación con agentes que dañan el ADN. En CymitQuimica, ofrecemos una amplia gama de inhibidores de ATM/ATR de alta calidad para apoyar su investigación en la respuesta al daño del ADN, biología del cáncer y desarrollo terapéutico.
Se han encontrado 72 productos de "ATM / ATR"
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Elimusertib hydrochloride(1876467-74-1 free base)
Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumorFórmula:C20H22ClN7OPureza:98.8% - 99.03%Forma y color:SolidPeso molecular:411.89Ref: TM-T10468
1mg34,00€5mg84,00€10mg114,00€25mg224,00€50mg331,00€100mg470,00€200mg647,00€1mL*10mM (DMSO)92,00€Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Fórmula:C23H26O7Pureza:99.13% - 99.92%Forma y color:SolidPeso molecular:414.45FEN1-IN-1
CAS:FEN1-IN-1 (LNT-1), a FEN1 active site inhibitor, partly works by coordinating Mg2+ ions.Fórmula:C15H12N2O5SPureza:99.65% - 99.80%Forma y color:SolidPeso molecular:332.33Abd110
CAS:Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].Fórmula:C41H42N8O7SForma y color:SolidPeso molecular:790.89GJ071 oxalate
CAS:GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.Fórmula:C20H29N3O7SPureza:99.97%Forma y color:SolidPeso molecular:455.53Ref: TM-T31932
1mg73,00€5mg149,00€10mg213,00€25mg319,00€50mg450,00€100mg605,00€200mg802,00€1mL*10mM (DMSO)166,00€Antitumor agent-28
CAS:Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.Fórmula:C25H32N6O4SForma y color:SolidPeso molecular:512.63Hexapeptide-11
CAS:Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.Fórmula:C36H48N6O7Pureza:98%Forma y color:SolidPeso molecular:676.8ATM Inhibitor-8
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value ofFórmula:C26H34N6O2Pureza:98%Forma y color:SolidPeso molecular:462.59Berzosertib
CAS:Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.Fórmula:C24H25N5O3SPureza:97.34% - >99.99%Forma y color:SolidPeso molecular:463.55Ref: TM-T2669
1mg35,00€5mg74,00€10mg92,00€25mg155,00€50mg225,00€100mg359,00€200mg525,00€500mg833,00€1mL*10mM (DMSO)77,00€ATR-IN-9
CAS:ATR-IN-9 from patent WO2020087170A1 is a potent ATR kinase inhibitor with an IC50 of 10 nM.Fórmula:C22H27N7O2Forma y color:SolidPeso molecular:421.505CA-M11
CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.Fórmula:C34H46N2O6SForma y color:SolidPeso molecular:610.80ATM Inhibitor-9
ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].Fórmula:C25H32N6O2Pureza:98%Forma y color:SolidPeso molecular:448.56Ceralasertib
CAS:Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.Fórmula:C20H24N6O2SPureza:98% - 99.99%Forma y color:SolidPeso molecular:412.51AZD0156
CAS:AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.
Fórmula:C26H31N5O3Pureza:99.13% - 99.87%Forma y color:SolidPeso molecular:461.56PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Fórmula:C14H16ClN3O4S2Pureza:97.72%Forma y color:SolidPeso molecular:389.88Ref: TM-T2616
1mg42,00€5mg85,00€10mg105,00€25mg200,00€50mg305,00€100mg427,00€200mg613,00€1mL*10mM (DMSO)94,00€KU60019
CAS:Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.Fórmula:C30H33N3O5SPureza:95.9% - 99.7%Forma y color:SolidPeso molecular:547.67GJ103 sodium salt
CAS:GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.Fórmula:C16H13N4NaO3SPureza:99.70% - 99.91%Forma y color:SolidPeso molecular:364.36NU6027
CAS:NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-Fórmula:C11H17N5O2Pureza:98.36%Forma y color:SolidPeso molecular:251.29KU-55933
CAS:KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.
Fórmula:C21H17NO3S2Pureza:97.21% - >99.99%Forma y color:SolidPeso molecular:395.49AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Fórmula:C18H20N8O2Pureza:99.03% - 99.85%Forma y color:SolidPeso molecular:380.4Ref: TM-T7122
1mg38,00€5mg84,00€10mg113,00€25mg177,00€50mg295,00€100mg447,00€200mg650,00€1mL*10mM (DMSO)93,00€
