mTOR
Los inhibidores de mTOR son compuestos que inhiben la actividad de la Proteína diana de la rapamicina en mamíferos (mTOR), un regulador central del crecimiento celular, la proliferación, el metabolismo y la supervivencia. La vía de mTOR se altera con frecuencia en el cáncer y otras enfermedades, lo que convierte a mTOR en un objetivo crítico para la intervención terapéutica. Los inhibidores de mTOR se utilizan ampliamente en la investigación relacionada con el cáncer, el envejecimiento y los trastornos metabólicos. En CymitQuimica, ofrecemos una variedad de inhibidores de mTOR para apoyar su investigación en transducción de señales, oncología y desarrollo terapéutico.
Se han encontrado 163 productos de "mTOR"
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NSC781406
CAS:NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).Fórmula:C29H27F2N5O5S2Pureza:99.58%Forma y color:SolidPeso molecular:627.68Ref: TM-T16355
2mg39,00€5mg60,00€1mL*10mM (DMSO)84,00€10mg87,00€25mg159,00€50mg231,00€100mg355,00€200mg505,00€Thioridazine hydrochloride
CAS:Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4Fórmula:C21H27ClN2S2Pureza:99.55% - 99.957%Forma y color:White To Off-White SolidPeso molecular:407.04SN32976
CAS:SN32976 is a pan PI3K inhibitor. SN32976 potently inhibited PI3K isoforms and mTOR, displaying preferential activity for PI3Kα and sparing of PI3Kδ.Fórmula:C24H33F2N9O4SPureza:98.06%Forma y color:SolidPeso molecular:581.64Rapamycin
CAS:Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with immunosuppressive effects.Fórmula:C51H79NO13Pureza:97.08% - 99.90%Forma y color:Yellow SolidPeso molecular:914.17Ref: TM-T1537
10mg34,00€25mg46,00€1mL*10mM (DMSO)48,00€50mg50,00€100mg65,00€200mg101,00€500mg178,00€1g268,00€MT 63-78
CAS:MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM).
Fórmula:C21H14N2O2Pureza:97.11%Forma y color:SolidPeso molecular:326.35NV-5138
CAS:NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.Cost-effective and quality-assured.Fórmula:C7H13F2NO2Pureza:98% - ≥98%Forma y color:SolidPeso molecular:181.18Ref: TM-T12270
1mg94,00€1mL*10mM (DMSO)166,00€5mg203,00€10mg326,00€25mg698,00€50mg1.108,00€100mg1.603,00€DEPTOR-IN-1
CAS:DEPTOR-IN-1 is an inhibitor of DEPTOR with a Kd of 9.3 μM.Fórmula:C24H16Cl2FNO4Pureza:97.84%Forma y color:SolidPeso molecular:472.29PI3K-IN-22
CAS:PI3K-IN-22 is a dual kinase inhibitor of PI3Kα and mTOR, with IC50s of 0.9 and 0.6 nM respectively. PI3K-IN-22 could be used in cancer.Fórmula:C31H35F3N8O3Forma y color:SolidPeso molecular:624.66PF-06465603
CAS:PF-06465603 is a metabolite of PF-04691502, a highly potent and selective ATP competitive kinase inhibitor of class 1 PI3Ks and mTOR.Fórmula:C22H25N5O5Forma y color:SolidPeso molecular:439.46MKC-1
CAS:MKC-1 (Ro-31-7453) is an oral bisindolylmaleimide inhibitor that disrupts tubulin polymerization, potentially halting cancer cell division.Fórmula:C22H16N4O4Pureza:99.63% - 99.85%Forma y color:SolidPeso molecular:400.39Ref: TM-T9831
500mgA consultar1mg54,00€5mg118,00€1mL*10mM (DMSO)127,00€10mg168,00€25mg293,00€50mg423,00€100mg588,00€mTOR inhibitor-12
mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to centralFórmula:C19H24N6O2SPureza:98%Forma y color:SolidPeso molecular:400.5RMC-4529
CAS:RMC-4529 is a chemical compound that demonstrates potent inhibition, with an IC50 value of 1.0 nM, against p-4E-BP1-(T37/46) in mTOR kinase cellular assays.Fórmula:C90H139N13O23Forma y color:SolidPeso molecular:1771.17RMC-6272
CAS:RMC-6272 (RM-006) is a bi-steric mTORC1 inhibitor with selective potency over mTORC2 and shows greater effects than Rapamycin on TSC2-deficient tumors.Fórmula:C95H141FN6O27SForma y color:SolidPeso molecular:1850.25PI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withForma y color:Odour SolidRef: TM-L1300
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarYB-3-17
CAS:YB-3-17 is a bifunctional molecule that can inhibit mTOR with an IC50 of 0.22 nM or degrade the G1 to S phase transition 1 gene (GSPT1) through the PROTAC mechanism, with a DC50 of 5 nM. It exhibits antiproliferative activity at nanomolar concentrations in various glioblastoma cell lines. Additionally, YB-3-17 shows antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon)Fórmula:C38H39N11O6Forma y color:SolidPeso molecular:745.786FD274
CAS:FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM,Fórmula:C22H14ClFN6O2SPureza:98%Forma y color:SoildPeso molecular:480.9FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Forma y color:LiquidmTOR inhibitor 13
CAS:Urea derivative; selective mTOR blocker; IC50: 0.29nM (mTOR), 119nM (PI3Kα).Fórmula:C24H22N6O2SPureza:99.75%Forma y color:SolidPeso molecular:458.54RMC-4627
CAS:RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.Fórmula:C93H141N11O23Forma y color:SolidPeso molecular:1781.17Thioether-cyclized helix B peptide, CHBP TFA
Thioether-cyclized helix B peptide, CHBP (TFA), is the trifluoroacetic (TFA) salt of CHBP.Fórmula:C56H93N19O22S·xC2HF3O2Pureza:98%Forma y color:SolidPeso molecular:1416.52 (free base)mTOR inhibitor 9c
CAS:mTOR inhibitor 9c is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively.Fórmula:C21H22FN5O2SPureza:99.23%Forma y color:SoildPeso molecular:427.5(32-Carbonyl)-RMC-5552
CAS:(32-Carbonyl)-RMC-5552, a potent mTOR inhibitor, blocks mTORC1/C2, with pIC50 values >9 for p-P70S6K and p-4E-BP1, and 8~9 for p-AKT1/2/3.Fórmula:C93H134N10O24Forma y color:SolidPeso molecular:1776.141Thioether-cyclized helix B peptide, CHBP
CAS:Thioether-cyclized helix B peptide (CHBP) enhances metabolic stability and exerts renoprotective effects by promoting autophagy through the inhibition of mTORFórmula:C56H93N19O22SPureza:98%Forma y color:SolidPeso molecular:1416.52mTOR inhibitor-14
mTOR Inhibitor-14 (compound 14c) is a potent inhibitor of mTOR with minimal inhibition of CYP2C8 and has demonstrated the capability to inhibit tumor growth [1Pureza:98%Forma y color:Odour SolidmTOR inhibitor WYE-28
CAS:mTOR inhibitor WYE-28, Potent mTOR (IC50=0.08 nM) and PI3Kα (IC50=6 nM) inhibitor, short half-life in mouse microsomes.Fórmula:C30H34N8O5Pureza:98.13%Forma y color:SolidPeso molecular:586.65AJ2-30
CAS:AJ2-30: Inhibits SLCl5A4, TLR9-B cell activation, MDP transport, NOD signaling; for inflammation study.Fórmula:C23H22N4Pureza:>99.99%Forma y color:SoildPeso molecular:354.45Ref: TM-T77644
1mg48,00€5mg101,00€1mL*10mM (DMSO)114,00€10mg167,00€25mg334,00€50mg537,00€100mg762,00€200mg1.018,00€QL-IX-55
CAS:QL-IX-55 has a wide range of applications in life science related research.Fórmula:C24H14F4N4OForma y color:SolidPeso molecular:450.39mTOR inhibitor 9e
CAS:mTOR inhibitor 9e is a selective mTOR inhibitor with IC50 of 0.68nM and 1359nM for mTOR and PI3Kα, respectively.Fórmula:C22H23N5O2SPureza:98.84%Forma y color:SoildPeso molecular:421.52WYE-687
CAS:WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Fórmula:C28H32N8O3Pureza:99.93%Forma y color:SolidPeso molecular:528.61DA-143
DA-143 is a selective inhibitor of DNA-PKcs (IC50: 2.5 nM), demonstrating disparate inhibitory effects on mTOR, PI3KΔ, and ATM, with IC50 values of 280 nM, 106 nM, and 6,594 nM, respectively. This compound effectively blocks the phosphorylation of DNA-PKcs substrates and enhances the sensitivity of cancer cells to doxorubicin.Forma y color:Odour SolidKinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Forma y color:Odour SolidRef: TM-L1600
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarAschantin
CAS:Aschantin is a useful organic compound for research related to life sciences. The catalog number is T126072 and the CAS number is 13060-15-6.Fórmula:C22H24O7Forma y color:SolidPeso molecular:400.427MCX 28
CAS:MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity.Fórmula:C25H19N5O4S3Forma y color:SolidPeso molecular:549.642DII
2DII is a potent and selective mTORC2 inhibitor. It specifically binds to the mSin1 PH domain, resulting in a decreased phosphorylation of AKT1.Fórmula:C54H76ClN7O11SForma y color:SolidPeso molecular:1066.74mTOR inhibitor 9f
CAS:mTOR inhibitor 9f is a selective mTOR inhibitor with IC50 of 1.25nM and 82nM for mTOR and PI3Kα, respectively.Fórmula:C25H23N5O2SPureza:99.18%Forma y color:SoildPeso molecular:457.55RMC-5552
CAS:RMC-5552 selectively inhibits mTORC1 with ~40-fold selectivity over mTORC2, demonstrating anticancer activity and research utility.Fórmula:C93H136N10O24Forma y color:SolidPeso molecular:1778.16Cbz-B3A
CAS:Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.Fórmula:C35H58N6O9Pureza:98.59%Forma y color:SolidPeso molecular:706.87Anti-Phospho-MTOR (Ser2448) Antibody (2K503)
Anti-Phospho-MTOR (Ser2448) Antibody (2K503) is an antibody targeting Phospho-MTOR (Ser2448). Anti-Phospho-MTOR (Ser2448) Antibody (2K503) can be used in ELISA, WB, IHC, IF.Forma y color:Odour LiquidAnti-Phospho-mTOR (Ser2481) Antibody (4R8)
Anti-Phospho-MTOR (Ser2481) Antibody (4R8) is an antibody targeting Phospho-MTOR (Ser2481). Anti-Phospho-MTOR (Ser2481) Antibody (4R8) can be used in ELISA, WB, IF.Forma y color:Odour LiquidS6K1-IN-DG2
CAS:S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.Fórmula:C16H17BrN6OPureza:99.99%Forma y color:SolidPeso molecular:389.25Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Fórmula:C25H17F2N5O3SPureza:98% - 99.8%Forma y color:SolidPeso molecular:505.5Lupiwighteone
CAS:Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.Fórmula:C20H18O5Pureza:98.92%Forma y color:SolidPeso molecular:338.35Samotolisib
CAS:Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.Fórmula:C23H26N4O3Pureza:98.41% - 99.69%Forma y color:SolidPeso molecular:406.48mTOR inhibitor-1
CAS:C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.Fórmula:C16H15BrN2O3Pureza:99.43%Forma y color:SolidPeso molecular:363.21Mito-LND
CAS:Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.Fórmula:C43H45BrCl2N3OPPureza:97.25% - 98.34%Forma y color:SolidPeso molecular:801.62PF-04691502
CAS:PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.Fórmula:C22H27N5O4Pureza:96.27% - ≥95%Forma y color:SolidPeso molecular:425.48Ref: TM-T6251
1mg34,00€2mg43,00€5mg63,00€1mL*10mM (DMSO)65,00€10mg88,00€25mg117,00€50mg187,00€100mg333,00€Corynoxine
CAS:Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.Fórmula:C22H28N2O4Pureza:96.83% - 99.93%Forma y color:SolidPeso molecular:384.47Salidroside
CAS:Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor.Cost-effective and quality-assured.Fórmula:C14H20O7Pureza:97.81%Forma y color:Red-Brown Fine PowderPeso molecular:300.30Ref: TM-T2717
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg81,00€25mg130,00€50mg178,00€100mg268,00€200mg408,00€OSI-027
CAS:OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.Fórmula:C21H22N6O3Pureza:97.42%Forma y color:SolidPeso molecular:406.44Ref: TM-T6319
1mg39,00€2mg50,00€5mg81,00€1mL*10mM (DMSO)84,00€10mg131,00€25mg235,00€50mg369,00€100mg537,00€
