mTOR
Los inhibidores de mTOR son compuestos que inhiben la actividad de la Proteína diana de la rapamicina en mamíferos (mTOR), un regulador central del crecimiento celular, la proliferación, el metabolismo y la supervivencia. La vía de mTOR se altera con frecuencia en el cáncer y otras enfermedades, lo que convierte a mTOR en un objetivo crítico para la intervención terapéutica. Los inhibidores de mTOR se utilizan ampliamente en la investigación relacionada con el cáncer, el envejecimiento y los trastornos metabólicos. En CymitQuimica, ofrecemos una variedad de inhibidores de mTOR para apoyar su investigación en transducción de señales, oncología y desarrollo terapéutico.
Se han encontrado 163 productos de "mTOR"
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NV-5138 hydrochloride
NV-5138 hydrochloride: a leucine analog, oral brain mTORC1 activator via Sestrin2, for antidepressant research.Fórmula:C7H14ClF2NO2Forma y color:SolidPeso molecular:217.64Gedatolisib
CAS:Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signalingFórmula:C32H41N9O4Pureza:98% - 99.36%Forma y color:SolidPeso molecular:615.73XL388
CAS:XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.Fórmula:C23H22FN3O4SPureza:99.39% - 99.53%Forma y color:SolidPeso molecular:455.5DS-7423
CAS:DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.Fórmula:C22H27F3N10O2Pureza:99.98%Forma y color:SolidPeso molecular:520.51Ref: TM-T36083
1mg110,00€5mg268,00€1mL*10mM (DMSO)304,00€10mg409,00€25mg670,00€50mg888,00€100mg1.305,00€Palomid 529
CAS:Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration.Fórmula:C24H22O6Pureza:98.40% - 98.59%Forma y color:SolidPeso molecular:406.43Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Fórmula:C19H24O5Pureza:96.66% - 99.93%Forma y color:SolidPeso molecular:332.39mTOR inhibitor-1
CAS:C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.Fórmula:C16H15BrN2O3Pureza:99.43%Forma y color:SolidPeso molecular:363.21GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFórmula:C17H20N6O2SPureza:98%Forma y color:SolidPeso molecular:372.44KU-0063794
CAS:KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.Fórmula:C25H31N5O4Pureza:98.21% - >99.99%Forma y color:SolidPeso molecular:465.54Cyclovirobuxine D
CAS:Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.Fórmula:C26H46N2OPureza:97.78% - 98%Forma y color:SolidPeso molecular:402.66OSI-027
CAS:OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.Fórmula:C21H22N6O3Pureza:97.42%Forma y color:SolidPeso molecular:406.44Ref: TM-T6319
1mg39,00€2mg50,00€5mg81,00€1mL*10mM (DMSO)84,00€10mg131,00€25mg235,00€50mg369,00€100mg537,00€PF-04691502
CAS:PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.Fórmula:C22H27N5O4Pureza:96.27% - ≥95%Forma y color:SolidPeso molecular:425.48Ref: TM-T6251
1mg34,00€2mg43,00€5mg63,00€1mL*10mM (DMSO)65,00€10mg88,00€25mg117,00€50mg187,00€100mg333,00€WYE-687 dihydrochloride
CAS:WYE-687 dihydrochloride is an mTOR inhibitor with IC50 of 7 nM, also targeting PI3Kα (81 nM) and PI3Kγ (3.11 μM).Fórmula:C28H34Cl2N8O3Forma y color:SolidPeso molecular:601.53MHY-1685
CAS:MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.Fórmula:C11H8N2O4Pureza:99.76%Forma y color:SolidPeso molecular:232.19Desmethyl-VS-5584
CAS:Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.Fórmula:C16H20N8OPureza:>99.99%Forma y color:SolidPeso molecular:340.38Samotolisib
CAS:Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.Fórmula:C23H26N4O3Pureza:98.41% - 99.69%Forma y color:SolidPeso molecular:406.48KU-0060648
CAS:KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.Fórmula:C33H34N4O4SPureza:98.75%Forma y color:SolidPeso molecular:582.71PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Fórmula:C19H16N4O3Pureza:97.79% - 99.3%Forma y color:SolidPeso molecular:348.36LY-2584702 free base
CAS:LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).Fórmula:C21H19F4N7Pureza:98.72% - 99.51%Forma y color:SolidPeso molecular:445.42Ref: TM-T6159
1mg44,00€2mg56,00€5mg108,00€10mg140,00€25mg299,00€50mg404,00€100mg592,00€500mg1.243,00€WYE-354
CAS:WYE-354 is a selective mTOR inhibitor (IC50=5 nM), targeting mTORC1/C2 over PI3Kα (>100x) and PI3Kγ (>500x), sparing P-AKT(T308).Fórmula:C24H29N7O5Pureza:97.86% - 99.61%Forma y color:SolidPeso molecular:495.53Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Fórmula:C17H20F3N7O2Pureza:97.58% - 98.92%Forma y color:SolidPeso molecular:411.38Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Fórmula:C25H17F2N5O3SPureza:98% - 99.8%Forma y color:SolidPeso molecular:505.5Sapanisertib
CAS:Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.Fórmula:C15H15N7OPureza:99.19% - >99.99%Forma y color:SolidPeso molecular:309.33Ref: TM-T1838
1mg40,00€2mg51,00€5mg85,00€1mL*10mM (DMSO)88,00€10mg96,00€25mg160,00€50mg235,00€100mg350,00€500mg838,00€Everolimus
CAS:Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.
Fórmula:C53H83NO14Pureza:97.76% - 99.78%Forma y color:Off-White To Light Yellow PowdPeso molecular:958.22SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Fórmula:C15H8Cl2FN3OPureza:99.56%Forma y color:SolidPeso molecular:336.15Ref: TM-T8719
1mg43,00€5mg87,00€1mL*10mM (DMSO)94,00€10mg133,00€25mg227,00€50mg344,00€100mg429,00€200mg597,00€L-Leucine
CAS:L-Leucine is an essential amino acid vital for protein synthesis, metabolism, muscle and bone repair, blood sugar control, and wound healing.Fórmula:C6H13NO2Pureza:99.83%Forma y color:White Solid CrystallinePeso molecular:131.17Torin 2
CAS:Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.Fórmula:C24H15F3N4OPureza:98.31% - 99.32%Forma y color:SolidPeso molecular:432.4Vistusertib
CAS:Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.Fórmula:C25H30N6O3Pureza:97.08% - 99.06%Forma y color:SolidPeso molecular:462.54Ref: TM-T1961
1mg34,00€5mg71,00€1mL*10mM (DMSO)79,00€10mg111,00€25mg170,00€50mg225,00€100mg358,00€200mg530,00€PKCβ inhibitor 1
CAS:PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,Fórmula:C24H21N5O2Pureza:99.33%Forma y color:SolidPeso molecular:411.46Ref: TM-T8376
500µg37,00€1mg52,00€5mg101,00€1mL*10mM (DMSO)110,00€10mg177,00€25mg391,00€50mg692,00€100mg945,00€Onatasertib
CAS:Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity.Fórmula:C21H27N5O3Pureza:99.14% - 99.93%Forma y color:SolidPeso molecular:397.47Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Fórmula:C13H14N6OPureza:98.21% - 99.69%Forma y color:SolidPeso molecular:270.29Ref: TM-T7014
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)74,00€10mg117,00€25mg226,00€50mg364,00€100mg532,00€PP121
CAS:PP-121 inhibits PDGFR, Hck, mTOR, VEGFR2, Src, Abl, and DNA-PK with IC50 values ranging from 2 to 60 nM.Fórmula:C17H17N7Pureza:98.45% - 99.93%Forma y color:SolidPeso molecular:319.36Polyphyllin I
CAS:Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Fórmula:C44H70O16Pureza:98% - 99.5%Forma y color:SolidPeso molecular:855.02Torin 1
CAS:Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.Fórmula:C35H28F3N5O2Pureza:98.3% - 99.33%Forma y color:SolidPeso molecular:607.62G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Fórmula:C22H19F2NO3Pureza:97.3%Forma y color:SolidPeso molecular:383.39Ref: TM-T8742
1mg35,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg96,00€25mg172,00€50mg248,00€100mg348,00€200mg470,00€Apitolisib
CAS:Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).Fórmula:C23H30N8O3SPureza:98.28% - 99.64%Forma y color:SolidPeso molecular:498.6Torkinib
CAS:Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).Fórmula:C16H16N6OPureza:99.11%Forma y color:SolidPeso molecular:308.34Ref: TM-T2414
5mg54,00€1mL*10mM (DMSO)59,00€10mg71,00€25mg90,00€50mg129,00€100mg215,00€200mg319,00€500mg530,00€DIM-C-pPhOH
CAS:CDIM8 (DIM-C-pPhOH) opposes NR4A1, halts TGF-β breast cancer migration, induces ROS/ER stress, and mimics Nur77 RNAi in pancreatic cancer.Fórmula:C23H18N2OPureza:98.61% - 99.93%Forma y color:SolidPeso molecular:338.4Ref: TM-T4400
2mg42,00€1mL*10mM (DMSO)56,00€5mg62,00€10mg79,00€25mg144,00€50mg215,00€100mg356,00€200mg469,00€Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),
Fórmula:C9H6O4Pureza:97.47% - 99.8%Forma y color:SolidPeso molecular:178.14D-α-Hydroxyglutaric acid disodium
CAS:D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.Fórmula:C5H6Na2O5Pureza:97.16%Forma y color:SolidPeso molecular:192.08GSK1059615
CAS:GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.Fórmula:C18H11N3O2SPureza:99.3% - ≥95%Forma y color:SolidPeso molecular:333.36TMBIM6 antagonist-1
CAS:TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitorFórmula:C15H12N2O3Pureza:99.26%Forma y color:SolidPeso molecular:268.27Ref: TM-T8649
1mg88,00€2mg114,00€5mg177,00€1mL*10mM (DMSO)190,00€10mg299,00€25mg537,00€50mg767,00€100mg1.054,00€500mg2.115,00€Zotarolimus
CAS:Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).Fórmula:C52H79N5O12Pureza:95% - 98.01%Forma y color:SolidPeso molecular:966.21(+)-Usnic acid
CAS:(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.Fórmula:C18H16O7Pureza:98.22%Forma y color:SolidPeso molecular:344.32CZ415
CAS:CZ415 is a potent and highly selective mTOR inhibitor.Fórmula:C22H29N5O4SPureza:97.54% - 98.36%Forma y color:SolidPeso molecular:459.56Ref: TM-T3514
1mg39,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)72,00€10mg104,00€25mg212,00€50mg319,00€100mg447,00€200mg618,00€VS-5584
CAS:VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Fórmula:C17H22N8OPureza:97.82% - 99.54%Forma y color:SolidPeso molecular:354.41Dihydromyricetin
CAS:Dihydromyricetin, a flavonoid from Ampelopsis, is an antioxidant that blocks dihydropyrimidinase (IC50: 48 μM) and activates autophagy via mTOR inhibition.Fórmula:C15H12O8Pureza:96.68% - 98.229%Forma y color:SolidPeso molecular:320.25MHY1485
CAS:MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.Fórmula:C17H21N7O4Pureza:97.74% - >99.99%Forma y color:SolidPeso molecular:387.39DMH-25
CAS:DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.
Fórmula:C15H8Br3NO3Pureza:99.26%Forma y color:SolidPeso molecular:489.94ETP-45658
CAS:ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).Fórmula:C16H17N5O2Pureza:99.14%Forma y color:SolidPeso molecular:311.34Ref: TM-T25399
1mg50,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg172,00€25mg299,00€50mg485,00€100mg708,00€
