mTOR
Los inhibidores de mTOR son compuestos que inhiben la actividad de la Proteína diana de la rapamicina en mamíferos (mTOR), un regulador central del crecimiento celular, la proliferación, el metabolismo y la supervivencia. La vía de mTOR se altera con frecuencia en el cáncer y otras enfermedades, lo que convierte a mTOR en un objetivo crítico para la intervención terapéutica. Los inhibidores de mTOR se utilizan ampliamente en la investigación relacionada con el cáncer, el envejecimiento y los trastornos metabólicos. En CymitQuimica, ofrecemos una variedad de inhibidores de mTOR para apoyar su investigación en transducción de señales, oncología y desarrollo terapéutico.
Se han encontrado 163 productos de "mTOR"
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Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Fórmula:C13H14N6OPureza:98.21% - 99.69%Forma y color:SolidPeso molecular:270.29Ref: TM-T7014
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)74,00€10mg117,00€25mg226,00€50mg364,00€100mg532,00€PP121
CAS:PP-121 inhibits PDGFR, Hck, mTOR, VEGFR2, Src, Abl, and DNA-PK with IC50 values ranging from 2 to 60 nM.Fórmula:C17H17N7Pureza:98.45% - 99.93%Forma y color:SolidPeso molecular:319.36Polyphyllin I
CAS:Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Fórmula:C44H70O16Pureza:98% - 99.5%Forma y color:SolidPeso molecular:855.02Torin 1
CAS:Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.Fórmula:C35H28F3N5O2Pureza:98.3% - 99.33%Forma y color:SolidPeso molecular:607.62G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Fórmula:C22H19F2NO3Pureza:97.3%Forma y color:SolidPeso molecular:383.39Ref: TM-T8742
1mg35,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg96,00€25mg172,00€50mg248,00€100mg348,00€200mg470,00€Apitolisib
CAS:Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).Fórmula:C23H30N8O3SPureza:98.28% - 99.64%Forma y color:SolidPeso molecular:498.6Torkinib
CAS:Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).Fórmula:C16H16N6OPureza:99.11%Forma y color:SolidPeso molecular:308.34Ref: TM-T2414
5mg54,00€1mL*10mM (DMSO)59,00€10mg71,00€25mg90,00€50mg129,00€100mg215,00€200mg319,00€500mg530,00€DIM-C-pPhOH
CAS:CDIM8 (DIM-C-pPhOH) opposes NR4A1, halts TGF-β breast cancer migration, induces ROS/ER stress, and mimics Nur77 RNAi in pancreatic cancer.Fórmula:C23H18N2OPureza:98.61% - 99.93%Forma y color:SolidPeso molecular:338.4Ref: TM-T4400
2mg42,00€1mL*10mM (DMSO)56,00€5mg62,00€10mg79,00€25mg144,00€50mg215,00€100mg356,00€200mg469,00€Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),
Fórmula:C9H6O4Pureza:97.47% - 99.8%Forma y color:SolidPeso molecular:178.14D-α-Hydroxyglutaric acid disodium
CAS:D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.Fórmula:C5H6Na2O5Pureza:97.16%Forma y color:SolidPeso molecular:192.08GSK1059615
CAS:GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.Fórmula:C18H11N3O2SPureza:99.3% - ≥95%Forma y color:SolidPeso molecular:333.36TMBIM6 antagonist-1
CAS:TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitorFórmula:C15H12N2O3Pureza:99.26%Forma y color:SolidPeso molecular:268.27Ref: TM-T8649
1mg88,00€2mg114,00€5mg177,00€1mL*10mM (DMSO)190,00€10mg299,00€25mg537,00€50mg767,00€100mg1.054,00€500mg2.115,00€Zotarolimus
CAS:Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).Fórmula:C52H79N5O12Pureza:95% - 98.01%Forma y color:SolidPeso molecular:966.21(+)-Usnic acid
CAS:(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.Fórmula:C18H16O7Pureza:98.22%Forma y color:SolidPeso molecular:344.32CZ415
CAS:CZ415 is a potent and highly selective mTOR inhibitor.Fórmula:C22H29N5O4SPureza:97.54% - 98.36%Forma y color:SolidPeso molecular:459.56Ref: TM-T3514
1mg39,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)72,00€10mg104,00€25mg212,00€50mg319,00€100mg447,00€200mg618,00€VS-5584
CAS:VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Fórmula:C17H22N8OPureza:97.82% - 99.54%Forma y color:SolidPeso molecular:354.41Dihydromyricetin
CAS:Dihydromyricetin, a flavonoid from Ampelopsis, is an antioxidant that blocks dihydropyrimidinase (IC50: 48 μM) and activates autophagy via mTOR inhibition.Fórmula:C15H12O8Pureza:96.68% - 98.229%Forma y color:SolidPeso molecular:320.25MHY1485
CAS:MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.Fórmula:C17H21N7O4Pureza:97.74% - >99.99%Forma y color:SolidPeso molecular:387.39DMH-25
CAS:DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.
Fórmula:C15H8Br3NO3Pureza:99.26%Forma y color:SolidPeso molecular:489.94ETP-45658
CAS:ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).Fórmula:C16H17N5O2Pureza:99.14%Forma y color:SolidPeso molecular:311.34Ref: TM-T25399
1mg50,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg172,00€25mg299,00€50mg485,00€100mg708,00€
