mTOR
Los inhibidores de mTOR son compuestos que inhiben la actividad de la Proteína diana de la rapamicina en mamíferos (mTOR), un regulador central del crecimiento celular, la proliferación, el metabolismo y la supervivencia. La vía de mTOR se altera con frecuencia en el cáncer y otras enfermedades, lo que convierte a mTOR en un objetivo crítico para la intervención terapéutica. Los inhibidores de mTOR se utilizan ampliamente en la investigación relacionada con el cáncer, el envejecimiento y los trastornos metabólicos. En CymitQuimica, ofrecemos una variedad de inhibidores de mTOR para apoyar su investigación en transducción de señales, oncología y desarrollo terapéutico.
Se han encontrado 163 productos de "mTOR"
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Cyclovirobuxine D
CAS:Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.Fórmula:C26H46N2OPureza:97.78% - 98%Forma y color:SolidPeso molecular:402.66Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Fórmula:C19H24O5Pureza:96.66% - 99.93%Forma y color:SolidPeso molecular:332.39GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFórmula:C17H20N6O2SPureza:98%Forma y color:SolidPeso molecular:372.44Hederacolchiside A1
CAS:Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.Fórmula:C47H76O16Pureza:98.76% - 99.92%Forma y color:SolidPeso molecular:897.1Ref: TM-T2P2806
1mg46,00€5mg114,00€1mL*10mM (DMSO)161,00€10mg167,00€25mg268,00€50mg408,00€100mg587,00€200mg825,00€Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Fórmula:C13H14N6OPureza:98.21% - 99.69%Forma y color:SolidPeso molecular:270.29Ref: TM-T7014
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)74,00€10mg117,00€25mg226,00€50mg364,00€100mg532,00€WYE-354
CAS:WYE-354 is a selective mTOR inhibitor (IC50=5 nM), targeting mTORC1/C2 over PI3Kα (>100x) and PI3Kγ (>500x), sparing P-AKT(T308).Fórmula:C24H29N7O5Pureza:97.86% - 99.61%Forma y color:SolidPeso molecular:495.53CDC25B-IN-2
CAS:BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.Fórmula:C15H12N2O3Pureza:99.12%Forma y color:SolidPeso molecular:268.27Torin 1
CAS:Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.Fórmula:C35H28F3N5O2Pureza:98.3% - 99.33%Forma y color:SolidPeso molecular:607.62Vistusertib
CAS:Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.Fórmula:C25H30N6O3Pureza:97.08% - 99.06%Forma y color:SolidPeso molecular:462.54Ref: TM-T1961
1mg34,00€5mg71,00€1mL*10mM (DMSO)79,00€10mg111,00€25mg170,00€50mg225,00€100mg358,00€200mg530,00€Sapanisertib
CAS:Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.Fórmula:C15H15N7OPureza:99.19% - >99.99%Forma y color:SolidPeso molecular:309.33Ref: TM-T1838
1mg40,00€2mg51,00€5mg85,00€1mL*10mM (DMSO)88,00€10mg96,00€25mg160,00€50mg235,00€100mg350,00€500mg838,00€L-Leucine
CAS:L-Leucine is an essential amino acid vital for protein synthesis, metabolism, muscle and bone repair, blood sugar control, and wound healing.Fórmula:C6H13NO2Pureza:99.83%Forma y color:White Solid CrystallinePeso molecular:131.17SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Fórmula:C15H8Cl2FN3OPureza:99.56%Forma y color:SolidPeso molecular:336.15Ref: TM-T8719
1mg43,00€5mg87,00€1mL*10mM (DMSO)94,00€10mg133,00€25mg227,00€50mg344,00€100mg429,00€200mg597,00€Everolimus
CAS:Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.
Fórmula:C53H83NO14Pureza:97.76% - 99.78%Forma y color:Off-White To Light Yellow PowdPeso molecular:958.22XL388
CAS:XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.Fórmula:C23H22FN3O4SPureza:99.39% - 99.53%Forma y color:SolidPeso molecular:455.53BDO
CAS:3BDO is a new mTOR activator. 3BDO inhibits autophagy.Fórmula:C18H17NO5Pureza:97.76%Forma y color:SolidPeso molecular:327.33Ref: TM-T14033
1mg34,00€2mg44,00€5mg64,00€1mL*10mM (DMSO)71,00€10mg92,00€25mg195,00€50mg313,00€100mg467,00€Torin 2
CAS:Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.Fórmula:C24H15F3N4OPureza:98.31% - 99.32%Forma y color:SolidPeso molecular:432.4G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Fórmula:C22H19F2NO3Pureza:97.3%Forma y color:SolidPeso molecular:383.39Ref: TM-T8742
1mg35,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg96,00€25mg172,00€50mg248,00€100mg348,00€200mg470,00€Onatasertib
CAS:Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity.Fórmula:C21H27N5O3Pureza:99.14% - 99.93%Forma y color:SolidPeso molecular:397.47LY-2584702 free base
CAS:LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).Fórmula:C21H19F4N7Pureza:98.72% - 99.51%Forma y color:SolidPeso molecular:445.42Ref: TM-T6159
1mg44,00€2mg56,00€5mg108,00€10mg140,00€25mg299,00€50mg404,00€100mg592,00€500mg1.243,00€Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),
Fórmula:C9H6O4Pureza:97.47% - 99.8%Forma y color:SolidPeso molecular:178.14
