Compuestos deuterados

<p>Stability Hygroscopic<br>Applications Lauroyl-L-carnitine-d3 Hydrochloride is labelled Lauroyl-L-carnitine (L178680) which is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Lauroyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Stability Hygroscopic<br>Applications d4-Succinic Acid is a useful reagent as an internal standard for GC/MS analysis.<br>References Schummer, C., et al.: Talanta, 77, 1473 (2009);<br></p>

<p>Applications n-Hexadecane-d34 is the labeled compound of Hexadecane(H293630). Hexadecane has been used to prepare emulsions in water. It is also used as a substrate for the bacterial production of biosurfactants.<br>References Rang, M., et al.: J. Colloid Interface Sci., 209, 179 (1999); Hills, B., et al.: Magn. Reson. Imaging, 18, 319 (2000); Noordman, W., et al.: Appl. Environ. Microbiol., 68, 4502 (2002)<br></p>

<p>Applications Dodecylbenzene-d5 is an intermediate used in the synthesis of PHT-427-d4 (Major) (P399157), which is a deuterated version of PHT-427 (P399158), a pleckstrin homology domain inhibitor to Akt and PKB Kinase (PDPK1).<br>References Lucero-Acuna, A., et al.: Int J Pharm, 494, 249 (2015)<br></p>

<p>Applications Cyclohexanol-d12 (CAS# 66522-78-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Glyburide-d3 (methoxy-d3) (CAS# 1219803-02-7) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications Labelled nucleotide.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010), Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010),<br></p>

<p>Applications Labelled Fumaric Acid (F500380). Occurs in many plants. Essential to vegetable and tissue respiration. Used as an antioxidant.<br>References Jelitto, T., et al.: Planta, 188, 238 (1992), Son, H., et al.: J. Agric. Food Chem., 56, 8007 ( 2008),<br></p>

<p>Applications Compound forms a complex with Mefenamic acid increasing its transdermal permeation properties<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fang, L., et al.: J. Pharm. Sci., 93, 144 (2004), Gibellini, F., et al.: Biochem. J., 415, 135 (2008),<br></p>

<p>Applications 5-Fluorouridine-13C,15N2 is a compound useful in organic synthesis.<br></p>

<p>Applications n-Tetracosane-d50 is the labeled compound of n-Tetracosane(T291458). n-Tetracosane is GC-MS component analysis and antibacterial activities of the supercritical extracts from Carthamus tinctorius L.n-Tetracosane is an energy storage compound. it is also used to analyze different voltage components.<br>References Ma, Jia-lin, et al.: Anhui Nongye Kexue, 44, 172-174 (2016); Liu, H., et al., Faming Zhuanli Shenqing, (2019); Zhang, Wen-juan, et al.; 37, 4-9 (2016);<br></p>

<p>Applications Labelled Glycerol (G598400). Glycerol is used both in sample preparation and gel formation for polyacrylamide gel electrophoresis. Glycerol (5-10%) increases the density of a sample so that the sample will layer at the bottom of a gel’s sample well. Glycerol is also used to aid in casting gradient gels and as a protein stabilizer and storage buffer component.<br>References Bartsch, W., et al.: Arzeim.-Forsch., 26, 1581 (1976),<br></p>

<p>Applications Labelled Aldicarb (A514650). Aldicar is used as an insecticide. Used in Pesticide detection.<br>References Ashby, J., et al.: Environ. Mutagen., 7, 919 (1985), Ashby, J., et al.: Mutat. Res., 257, 229 (1991), Kazius, J., et al.: J. Med. Chem., 48, 312 (2005), Benigni, R., et al.: Mutagenesis, 25, 335 (2010),<br></p>

<p>Applications L-Valine (1-13c, 99%) (cas# 81201-85-6) is a useful research chemical.<br></p>

<p>Applications Isotope labelled Epoxiconazole is a fungicide used to inhibit the metabolism and growth of mycelia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gromadzka, K., et al.: Cereal. Res. Commun., 40, 518 (2012); Chen, Yu,, Plant. Disease., 96, 1495 (2012); Echeverria-Saenz, S., et al.: Sci. Total. Environ., 440, 106 (2012);<br></p>

<p>Applications Triclabendazole Sulfone-D3 is a stable isotopically labelled metabolite of Triclabendazole (T774175), an anthelmintic.<br>References Wolff, K., et al.: Vet. Parasitol., 13, 145 (1983)<br></p>

<p>Applications Used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smyth, H.F., et al.: J. Ind. Hyg. Toxicol., 30, 63 (1948),<br></p>

<p>Applications A labelled metabolite of Amodiaquine (A634200), an antimalarial.<br>References Bayliss, M., et al.: Xenobiotica, 29, 253 (1999), Projean, D., et al.: Drug Metab. Dispos., 31, 748 (2003), Bray, P., et al.: Mol. Microbiol., 56, 323 (2005), Xiang, H., et al.: J. Pharm. Sci., 95, 2657 (2006),<br></p>

<p>Applications Bis(4-hydroxyphenyl) Sulfone is commonly used as a reactant in epoxy reactions and is also used as a latent thermal catalyst for epoxy resin.<br>References Fu, J.W., et al.: Adv. Mat. Rsch., 266, 1022 (2011); Li, J.X., et al.: Polymers. Adv. Tech., 23, 803 (2012);<br></p>

<p>Applications 1,4-Butane-1,1,2,2,3,3,4,4-d8-diamine (D416027) is a labelled isotope of 1,4-Diaminobutane (D416025). It is an amino acid degradation product. Used in the preparation of hexahydropyrimidines as novel hepatitis C virus inhibitors. Also a reagent in the synthesis of antibacterial castor oil-based polyurethane membranes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hwang, J. et al.: Eur. J. Med. Chem., 70, 315 (2013); Yari, A. et al.: J. Biomed. Mat. Res., 102A, 84 (2014);<br></p>

<p>Applications n-Docosane-d46 (CAS# 260411-88-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethanolamine-d7 (CAS# 1219802-89-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Betaine-d3 Hydrochloride is a useful gastric acidifier.<br>References Wilcken, D.E., et al.: N. Engl. J. Med., 309, 448 (1983),<br></p>

<p>Applications Suberyl glycine-d4 is deuterium labelled Suberylglycine (S688755), which is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).<br>References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000); Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009); Scalbert, A., et al.: Metabolomics, 5, 435 (2009)<br></p>

<p>Applications The precursor of the ubiquitous natural compound malondialdehyde.<br>References Basu, A.K., et al.: J. of Labelled Compounds &amp; Radiopharmaceuticals, XX11, 11, 1175 (1985)<br></p>

<p>Stability Very Hygroscopic<br>Applications Metolachlor ESA-d6 Sodium Salt is deuterium labelled salt form of Metolachlor ESA (M338860) which is a synthetic herbicide.<br>References Mai, H., et al.: Aquat. Toxicol. 147, 48 (2014); McCarty, G. W., et al.: Sci Total Environ 473-474, 473 (2014);<br></p>

<p>Applications N-Methyl-d3-formamide (CAS# 87955-92-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications N1-Acetylspermidine-d3 Dihydrochloride is the isotope labelled analog of N1-Acetylspermidine Dihydrochloride (A187845); an analog of Spermidine (S680400) which is an antineoplastic.<br>References Bergeron, R. et al.: J. Med. Chem, 40, 1475 (1997)<br></p>

<p>Applications 2,5-Furandicarboxylic Acid-13C6 is isotopically labelled analogue of 2,5-Furandicarboxylic Acid (F863750), which is Furan (F863650) derivative that can be produced from biomass derived sugars using catalytic processes.<br>References Tong, X., et al.: Appl. Catal., A, 385, 1 (2010);<br></p>

<p>Applications Medetomidine-d5 (d5-Major) is an intermediate in the synthesis of Dexmedetomidine-d4 L-Tartrate (d4-Major) (D299006). Dexmedetomidine-d4 L-Tartrate is the labeled salt analogue of Dexmedetomidine (D299000), an α2-Adrenergic agonist; (+)-isomer of Medetomidine; sedative; analgesic.<br>References Rajala, R., et al.: Eur. J. Pharm. Sci., 1, 219 (1994); Jalonen, J., et al.: Anesthesiology, 86, 331 (1997); Talke, P., et al.: Anesth. Analg., 85, 1136 (1997); Bhana, N., et al.: Drugs, 59, 263 (2000)<br></p>

<p>Applications 4-Hydroxychlorpropham-d7 is an intermediate in the synthesis of 4-Hydroxychlorpropham-d7 Sulfate Sodium Salt (H825077). 4-Hydroxychlorpropham-d7 Sulfate Sodium Salt is derived from Isopropanol-d7 (I822752), which is a deuterated alcohol used in the study of lignite liquefaction. 4-Hydroxychlorpropham-d7 is also the labelled analogue of 4-Hydroxychlorpropham (H825078). 4-Hydroxychlorpropham is an intermediate in synthesizing 4-Hydroxychlorpropham Sulfate Sodium Salt (H825075), which is a chemical herbicide used in the protection of crops. It also maintains the ability to induce mitochondrial dysfunction in rat hepatocytes.<br>References Kuznetov, P.N. et al.: Fuel, 70, 559 (1991); EPA.: Fed. Reg., 72, 37646 (2007); Nakagawa, Y. et al.: Toxicol., 200, 123 (2004)<br></p>

<p>Stability Volatile<br>Applications Assignments of far-IR (FIR) laser lines have been found for optically pumped Methanol-13C.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moraes, J.C.S., et. al.: J. Mol. Spec., 177, 302 (1996)<br></p>

<p>Applications 4-Nitrophenol-13C6 is an intermediate in the synthesis of labelled 4-Aminophenol (A618920). It is also a nephrotoxic metabolite of Acetaminophen (A161220) and Phenacetin (P294580) (1,2).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Watanabe, et al.: Drug Metab. Dispos., 38, 1532 (2010)(2) Batuta, S. and Begum, N. A. Synth. Commun. 47, 137-147 (2017)<br></p>

<p>Applications The compund has cytotoxic effects. Labelled Norharmane.<br>References Elfarra, A., et al.: Drug Metab. Dispos., 26, 779 (1998), Da Costa, A., et al.: Biocell, 23, 65 (1999), Janetzky, B., et al.: Drug Dev. Res., 46, 51 (1999), Kutty, R., et al.: Toxicol. Appl. Pharmacol., 107, 377 (1991), Riederer, F., et al.: J. Neurochem., 81, 814 (2002), Schott, Y., et al.: Bioorg. Med. Chem. Lett., 16, 5840 (2006),<br></p>

<p>Applications Glutaric Acid (2,2,4,4-D4, 98%) (cas# 19136-99-3) is a useful research chemical.<br></p>

<p>Applications An adenosine receptor ligand and a major metabolite of caffeine.<br>References Proc. Natl. Acad. Sci. USA 78, 3260 (1981); Cell Mol. Neurobiol., 3, 69 (1983); Eur. J. Pharmacol., 179, 295 (1990)<br></p>

<p>Applications 16alpha-Hydroxy-17beta-estradiol-2,4-d2 (CAS# 53866-32-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications The microwace spectra of Dichloroacetic Acid-d1 consists of many weak absorption lines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Van Zoeren, E., et al.: J. Mol. Struct., 97, 315-322 (1983);<br></p>

<p>Applications Bis(4-hydroxyphenyl) Sulfone-d4 is the isotope labelled compound commonly used as a reactant in epoxy reactions and is also used as a latent thermal catalyst for epoxy resin.<br>References Fu, J.W., et al.: Adv. Mat. Rsch., 266, 1022 (2011); Li, J.X., et al.: Polymers. Adv. Tech., 23, 803 (2012);<br></p>

<p>Applications Hydantoin-5-13C,1-15N (cas# 1189697-61-7) is a compound useful in organic synthesis.<br></p>

<p>Applications L-Methionine Sulfoxide 13C1 is a labelled analogue of L-Methionine Sulfoxide ( M260450). L-Methionine Sulfoxide ( M260450) an intermediate in the synthesis of the acyclic amino carboxylic acid L-Methionine sulfoximine.<br>References Lee, B., et al.: J. Biol. Chem., 283, 28361 (2008), Nordqvist, A., et al.: Bioorg. Med. Chem., 16, 5501 (2008);Balog, E., et al.: Biochem., 48, 3005 (2009);<br></p>

<p>Applications (±)-Mianserin-d3 HCl (methyl-d3) (CAS# 1219804-97-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Acetamide (A133060) which is often used as plasticizer and as industrial solvent (1). It can also be used for the transamidation of carboxamides in 1,4-dioxane in the absence of a catalyst (2) . Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Ma, X. et al.: Carb. Polym. 2004 Aug:57(2):197-2032. Vanjari, R. et al.: Tetrahedron. Lett. 2013 MayL54(20):2553-5<br></p>

<p>Applications Ademethionine-d3 1,4-Butanedisulfonate, is a labeled analogue of Ademethionine 1,4-Butanedisulfonate (A280355), used in the synthesis of sulfonio-adenosyl-L-methionine (SAMe) salts.<br></p>

<p>Applications Labelled Tetraglyme. It is used as a solvent.<br></p>

<p>Applications Isotope labelled Resiquimod (R144680) is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.<br>References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);<br></p>

<p>Applications Octadecanoic-17,17,18,18,18-d5 Acid (CAS# 211443-83-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Urethane (U82500), which is a naturally occurring contaminant in fermented foods, particularly wine, stone-fruit brandies, and bread. This substance is reasonably anticipated to be a human carcinogen (1) despite being an additive in some alcoholic beverages and foods (2). It binds covalently with DNA however due to its low unavoidable daily intake, it is considered of negligible concern (3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Mirvish, S. et al.: Adv. Cancer Res. 1968;11:1-42.2. Battaglia R. et al.: Food Addit Contam. 1990 Jul-Aug;7(4):477-96.3. Zimmerli B. et al.: Mutat Res. 1991 Mar-Apr;259(3-4):325-50.<br></p>

<p>Applications Labelled Monobutyl Phosphate (M525050). Mono and dibasic phosphate esters are anionic surfactants which have the main feature of the stability in alkaline conditions over other surfactants. They have a wide range of properties including outstanding wetting, emulsification, lubrication, coupling activity and detergency.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ramirez, F., et al.: Tetrahedron, 35, 1581 (1979);<br></p>

<p>Applications One of the vitamins of the B6 complex; present in many foodstuffs (yeast, liver and cereals). It has a role in transporting protein Bsu1, contributes to thiamine uptake; characterization of thiamine (vitamin B1) transporter Thi9 from Schizosaccharomyces pombe.<br>References Williams, R., et al.: J. Biol. Chem., 87, 581 (1930), Rodionov, D., et al.: J. Biol. Chem., 277, 48949 (2002),Nosaka, K., et al.: Mol. Microbiol., 58, 467 (2005),<br></p>

<p>Applications Isotope Labelled 2,4,6-Trichloroanisole (T774085), which is considered the main compound responsible for the cork taint, a wine flavor defect usually perceived as a moldy off-flavor. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Chatonnet P. et al.: J Agric Food Chem. 2004 Mar 10;52(5):1255-62. 2. Cserjesi, A. et al.: Can J Microbiol. 1972 Jan;18(1):45-9.<br></p>

<p>Applications Isosilybin A+B mixture - d3 is the isotope labelled mixture of Isosilybin A and Isosilybin B. Isosilybin (I901000) is useful in the treatment of liver disease.<br>References Parthasarathy, M.R., et al.: Phytochemistry, 18, 506 (1979),<br></p>

<p>Applications Benzene-13C6 ,is isotopically labelled benzene, an organic compound that is a natural constituent of crude oil and one of the most basic petrochemicals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Feng, Z.X.. et al.: J. Phys. Chem. Lett. 4, 285 (2013); Pilling. M., et al.: Chem. Eng. Prog., 108, 32 (2012);<br></p>

<p>Applications Labelled glycerol kinase substrate specificity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Castro, C., et al.: Biochemistry, 7, 3213 (1968), Janssen, D., et al.: Eur. J. Biochem., 171, 67 (1988), Kurihara, T., et al.: J. Biochem., 117, 1317 (1995),<br></p>

<p>Applications Labelled Morpholine. Morpholines compounds used as selective inhibitors of cytochrome p450 2a13 in treatment of cancer. Salicylate as analgesic; antipyretic; anti-inflammatory.<br> E0<br>References Paladini, D., et al.: Biochem., 48, 5760 (2009), Bard, B., et al.: J. Med. Chem., 52, 3416 (2009),<br></p>

<p>Applications 4-Ethylphenyl-d4 Sulfate Potassium Salt is the isotope labelled analog of 4-Ethylphenyl Sulfate Potassium Salt (E925865); a newly identified uremic substance.<br>References Kaori, K., et al.: J. Chromatogr. B, 878, 2997 (2010)<br></p>

<p>Applications o-Anisidine is a highly toxic environmental pollutant and digestive system carcinogen. It is also a toxin that has been identified to be present in cigarettes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Coggins, C.R.E. et al.: Inhal. Toxicol., 23, 41 (2011); Dracinska, H. et al.: Neuroendorinol. Lett., 27, 9 (2006); Naiman, K. et al.: Neuroendocrinol. Lett., 31, 36 (2010);<br></p>

<p>Applications Cyclohexanone-d10 is the isotope labelled analog of Cyclohexanone (C987980). Cyclohexanone, is an intermediate in the synthesis of CCNU, an effective antitumor agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Farmer, P.B., et al.: J. Med. Chem., 21, 514 (1978);<br></p>

<p>Applications Labelled Hydroxyurea. An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.<br>References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),<br></p>

<p>Applications Labelled 1,2-Bis(2,4,6-tribromophenoxy)ethane (B585425). One of the major "novel" brominated flame retardants (NBFRs) from varous polymer materials. An environmental pollutant.<br>References Zhu, L., et al.: Environ. Sci. Technol., 40, 3711 (2006), Qui, X., et al.: Environ. Sci. Technol., 42, 31 (2008), Stone, R., et al.: Science, 325, 1055 (2009),<br></p>

<p>Applications Flutolanil-d7 is a labeled analogue of Flutolanil (F599430), a fungicide that has been used for controlling brown patch on creeping bentgrass fairways.<br>References Daniels, J.P., Latin, R.: Plant Disease, 97, 1620 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications 4,4'-Dipyridyl-d8 as a solid-solution approach to control the dynamics of molecular rotors in crystal solids.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Inukai, M., et al.: J. Amer. Chem. Soc., 137, 12183-12186 (2015)<br></p>

<p>Applications N-(2-Hydroxyethyl)nitotinamide-d4 is labelled N-(2-Hydroxyethyl)nitotinamide (H942365), an intermediate used to prepare oxadiazole oxide derivatives as vasodilators. It is also a derivative of Nicorandil (N398500) which is an antiaginal.<br>References Boschi, D., et al.: Bioorg. Med. Chem., 8, 1727 (2000); Nagai, H., et al.: Chem. Pharm. Bull., 32, 1063 (1984); Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008)<br></p>

<p>Stability Hygroscopic<br>Applications Benzyl Alcohol (D7, 98%) (cas# 71258-23-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications A labelled isomer of dichloropropanol; shows metabolite toxicity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Omura, M., et al.: Bull. Environ. Contam. Toxicol., 55, 1 (1995),<br></p>

<p>Applications Labelled analogue of 2-Bromopropane, a short chain alkyl halide used in organic synthesis primarily as an alkylating agent for introducing the isopropyl functional groups.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mayants, A.G. et al.: Zhur. Org. Khim., 25, 419 (1989); Miller, B. et al.: J. Org Chem., 30, 3895 (1965);<br></p>

<p>Applications Isotope labelled 5,6-Dihydrothymine is a derivative of Thymine, a nucleobase in the nucleic acid of DNA. 5,6-Dihydrothymine is a radiolysis product of DNA.<br>References Hubbard, K. et al.: Biochemistry, 28, 4382 (1989); Cadet, J. et al.: Int. J. Rad. Biol. Rel. Stud. Phys. Chem. Med., 39, 119 (1981);<br></p>

<p>Applications (±)-3-Amino-iso-butyric-2,3,3-d3 Acid is the labeled version of DL-3-Aminoisobutyric Acid (A603043(P)), which is a useful compound for suppressing atherosclerosis in apolipoprotein E-knockout mouse.<br>References Shimba, Y., et al.: Bio. Pharma. Bull., 43, 1016 (2020)<br></p>

<p>Applications Labelled analogue of Diphenyl Phosphate, an organophosphate diester and metabolite of the flame retardant Triphenyl phosphate (T808990) and also a metabolite of 2-Ethylhexyl diphenyl phosphate.<br>References Cooper, E.M. et al.: Anal. Bioanal. Chem., 401, 2123 (2011); Nishimaki-Mogami, T. et al.: Arch. Toxicol., 61, 259 (1988);<br></p>

<p>Applications n-Hexyl 4-Hydroxybenzoate-2,3,5,6-d4 (CAS# 2241800-08-6) is a useful isotopically labeled research compound. This compound has been found to be an endocrine disruptor that was found in a study involving pantyhose.<br>References Li, A.,et.al., Environ.Sci.Technol., 52,10812-10819,(2018);<br></p>

<p>Applications Cyanamide-​15N2 is an intermediate in the synthesis of 5-Azacytidine-15N4 (A796002), which is a labelled Azacytidine (A796000), a potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>

<p>Applications 1,10-Decanedioic-2,2,9,9-d4 Acid (CAS# 339080-77-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Pentacosane-d52 (CAS# 121578-13-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Stearic-D35 Acid is used for preparation of deuterated octadecanethiols. Stearic-D35 Acid is an isotope labeled analog of Stearic Acid (S686495), which is used in the synthesis of surfactants and detergents due to the fatty acid component of its structure.<br>References Badia, A., et al.: J. Am. Chem. Soc., 119, 2682 (1997); Dax, D. et al.: BioRes., 8, 3771 (2013); Ghumare, A. et al.: J. Surf. Deter., 26, 85 (2013);<br></p>

<p>Applications Ethylbenzene-d10 (cas# 25837-05-2) is a useful research chemical.<br></p>

<p>Stability Volatile<br>Applications 2-Pentylfuran-d11 is the labeled analogue of 2-Pentylfuran (P284953), a volatile compound that is detected in meat smoke aerosol, rice aroma and tomato paste volatiles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rogge, W., et al.: Environ. Sci. Technol., 25, 1112 (1991); Buttery, R., et al.: J. Agric. Food Chem., 36, 1006 (1988); Buttery, R., et al.: J. Agric. Food Chem., 38, 336 (1990);<br></p>

<p>Applications Phenoxy-d5-acetic Acid (cas# 154492-74-7) is a compound useful in organic synthesis.<br></p>

<p>Applications L-Serine (15n, 98%) (cas# 59935-32-9) is a useful research chemical.<br></p>

<p>Applications Acetaminophen-13C2, 15N1 is doubly labeled Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>

<p>Applications Suberic Acid-d4, is a labeled analogue of Suberic Acid (S688670), which is used in the preparation of reduction-sensitive micelles affecting their cellular uptake. This has potential application in delivery of anticancer drugs. It is also used in the fluorescent detection of amidinium-carboxylate and amidinium formation.<br>References Cui, C. et al.: Biomat., 34, 3858 (2013); Kusukawa, T. et al.: Tetra., 68, 9973 (2012);<br></p>

<p>Applications Thiamine hydrochloride phosphate-d3 was used as a reagent in the redn. of cytochrome c in its reaction with thiamine and its structural analogs.<br>References Vovk, A. I, et al.: Russian J. of Gen. Chem. 72(11), 1808-1812. (2002)<br></p>

<p>Applications Ethyl 2-Oxo-4-phenylbutyrate-d5 (cas# 1189911-53-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Metabolite of Salicylic Acid (S088125).<br>References Jurkowski, W., et al.: Current Drug Metab., 10, 448 (2009), Appeldoorn, M., et al.: J. Agric. Food Chem., 57, 7693 (2009), van Oijen, M., et al.: Pharmacol., 83, 237 (2009),<br></p>

<p>Applications Biochemical tool for selective reduction of disulfide bridges at low pH; reductant for redox assay.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Neuburger, M., et al.: Eur. J. Biochem., 267, 2882 (2000), Krijt, J., et al.: Clin. Chem., 47, 1821 (2001), Yen, T.-Y., et al.: J. Mass Spectrom., 37, 15 (2002),<br></p>

<p>Applications Labelled selective herbicide. Potential symptoms of overexposure are irritation of eyes and skin<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dalgaard-Mikkelsen, S., et al.: Pharmacol. Rev., 14, 225 (1962), Muller, K., et al.: J. Environ. Qual., 31, 309<br></p>

<p>Applications Labelled Sodium Cyanoborohydride is a commonly used as a reagent in the reductive amination of aldehydes and ketones and in the reductive alkylation of amines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hsu, J. et al.: J. Am. Soc. Mass Spec., 17, 194 (2006); Ducrocq, C. et al.: J. Label. Comp. Radiopharm., 22, 61 (1985);<br></p>

<p>Applications Dihexylphthalate-d4 is an labeled analog of Dihexylphthalate (B185430), which is a phthalic ester, which is used as a plasticizers for vinyl plastics. Phthalates may be associated with reproductive toxicity in humans and animals.<br>References Saido, K., et al.: ?J. Am. Oil Chem. Soc 61, 945 (1984); Foghmoes, S., et al.: J. Eur. Ceram. Soc. 36, 3441 (2016); Przybyli?ska, P. A. and Wyszkowski, M.: Ecol. Chem. Eng., S 23,347 (2016)<br></p>

<p>Applications Linagliptin-d3 is the isotope labelled analogue of a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.<br>References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011);<br></p>

<p>Applications 1-Bromobutane-2,2-d2 (CAS# 55724-40-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethanolamine-13C2 is the labeled analogue of Ethanolamine (E676500), which is used in the preparation of various pharmaceutical compounds and inhibitors. Ethanolamine-13C2, is also a 13C-labeled lipid precursor, used for the detection of phospholipid metabolism and the synthesis of phosphatidylethanolamine in T47D human breast cancer cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ronen, S. M., et al.: Magnetic Resonance Med., 25, 384 (1992); Lombardo, L. et al.: J. Med. Chem., 47, 6658 (2004); Egan, T.: J. Med. Chem., 43, 283 (2000);<br></p>

<p>Applications Succinic Acid-1,4-13C2 (cas# 79864-95-2) is a compound useful in organic synthesis.<br></p>