Toxicología

<p>Applications 11-Desmethyl Rifaximin is a compound useful in organic synthesis.<br></p>

<p>Applications Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters. Has little effect on the dopamine transporter.<br>References Wood, M.D., et al.: Neuropharmacology, 26, 1081 (1987), Casis, O., et al.: J. Cardiovasc. Pharmacol., 32, 521 (1998), Linner, L., et al.: Biol. Psychiatry, 46, 766 (1999), Teschemacher, et al.: Br. J. Pharmacol., 128, 479 (1999),<br></p>

<p>Applications A labelled inhibitor of glucose synthesis.<br>References Garcia-Salguero, L. et al.: Arch. Int. Physiol., Biochim. Biophys., 99, 237, (1991); Martirosyan, A., et al.: Biochem. Pharmacol., 68, 1729 (2004);<br></p>

<p>Applications Labelled Cefixime (C242800). Orally active, third generation cephalosporin antibiotic.<br>References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984),Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985), Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986),<br></p>

<p>Applications Anastrozole Acid Amide is a derivative of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic.<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>

<p>Applications Harpagoside is an iridoid glycoside along with with Harpagide (H105270), the potential to be strong anti-inflammatory agents providing the bulk of the observed effects from their plant origins.<br>References Zhang, L. et al.: Bioorg Med. Chem., 19, 4882 (2011); Wen, B. et al.: J. Ethnopharm., 147, 503 (2013);<br></p>

<p>Applications A fluorimetric substrate for cytochrome P450 IAI. Inhibits vasorelaxant responses to acetylcholine.<br>References Donato, M.T., et al.: Anal. Biochem., 213, 29 (1993), Oyekan, A.O., et al.: J. Pharmacol. Exp. Ther., 268, 262 (1994)<br></p>

<p>Applications Crospovidone is a drug excipient or inactive ingredient in drug formulations, specifically used as a pelletization agent in order to facilitate drug absorption.<br>References Verheyen, P. et al.: Drug. Dev. Ind. Pharm., 35, 1325 (2009); Liew, C. et al.: Pharm. Res., 22, 1387 (2005);<br></p>

<p>Applications N-Octanoyl-d15-glycine is labelled N-Octanoylglycine (O239735) which is a derivative of Glycine (G615990) and is an amphiphilic lipoamino acid commonly used in cosmetics for its antibacterial properties. N-Octanoylglycine is the active ingredient in products designed to treat seborrheic dermatitis on the scalp and acne prone skin.<br>References Georgalas, A.: Cosmet. Toiletries, 127, 96 (2012); Nakamura, S.: Frag. J., 39, 36 (2011)<br></p>

<p>Applications Diuretic and antihypertensive.<br>References Fuster, D., et al.: Endocrinol., 139, 3849 (1998), Selvaag, E., et al.: Photodermatol., Photoimmunol., Photomed., 18, 90 (2002), Beyer, J., et al.: Ther. Drug Monitor., 27, 509 (2005),<br></p>

<p>Applications 2-Hydroxyisoquinoline-1,3(2H,4H)-dione was recently discovered as a scaffold for the inhibition of HIV-1 integrase and the RNase H function of HIV-1 reverse transcriptase. Its interaction with Mg2+ and Mn2+ was investigated using different spectroscopic techniques and it was reported that 2-hydroxyisoquinoline-1,3(2H,4H)-dione forms a 1:1 complex with Mg2+ but a 1:2 complex with Mn2+. Antiviral agent.<br>References Greenwald, J., et al.: Biochemistry, 38, 8892 (1999), Tramontano, E., et al.: Antiviral Res., 65, 117 (2005), Schultz, S., et al.: Virus Res., 134, 86 (2008), Williams, P., et al.: Bioorg. Med. Chem. Lett., 22, 6754 (2010),<br></p>

<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>

<p>Applications (+)-trans-Allethrin is a synthetic pyrethroid derivative used as an insecticide. Allethrin is commonly used in many household insecticide products due to its low toxicity towards humans. Pesticide component.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br>References Chatterjee, N. et al.: Food. Chem., 196, 1 (2016);<br></p>

<p>Applications An acylamino acid fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ravelo-Perez, L., et al.: Food Chem., 111, 764 (2008), Wong, J., et al.: J. Agric. Food Chem., 58, 5897 (2010),<br></p>

<p>Applications Fluoroacetamide (cas# 640-19-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive<br>Applications Metoxadiazone is used as an insecticide used to control rice hoppers, cockroaches and ants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ambrosi, D., et al.: BCPC Symp. Ser., 2, 533 (1979);<br></p>

<p>Applications A metabolite of Aniline. Arylamines are predominantly conjugated by constitutive enzyme forms in the liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Axelrod, J., et al.: J. Biol. Chem., 232 835 (1958), Lilienblum, W., et al.: Biochem. Pharmacol., 33, 2041 (1984),<br></p>

<p>Stability Hygroscopic<br>Applications Dioxybenzone-d3 is an isotopic analog of Dioxybenzone (D486365), a compound used in sunscreen formulations to block out UVB and UVA harmful rays.<br>References Baumgartner, V. et al.: J. Planar. Chrom. Modern. TLC., 22, 19 (2009); Kunisue, T. et al.: Anal. Meth., 2, 707 (2010);<br></p>

<p>Applications Cacodylic acid is used for dermatologic treatment in cronic eczema, anemia and as a tonic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mandal, B., et al.: Talanta, 58, 201 (2002), Naranmandura, H., et al.: Chem. Res. Toxicol., 20, 616 (2007), Naranmandura, H., et al.: Toxicol. Appl. Pharmacol., 227, 390 (2008), Violin, J., et al.: J. Biol. Chem., 283, 2949 (2008),<br></p>

<p>Applications Apremilast is an oral phosphodiesterase 4 inhibitor used in the treatment of psoriatic arthritis.<br>References Gan, E., et al.: BioDrugs, 27, 359 (2013); Pathan, E., et al.: Annal. Rheum. DIs., 72, 1475 (2013);<br></p>

<p>Applications A metabolite of Drotaverine (D689700).<br>References Lalla, J.K., et al.: J. Pharma. Biomed. Anal., 11, 385 (1993),<br></p>

<p>Applications Acid Red 114 is an azo dye used in diagnostics and textiles industry. It is also present in wastewater and textile effluents contributing to environmental hazards.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br>References Yang, S. et al.: J. Env. Sci. Health., 52, 682 (2017); Ring, M. et al.: PLoS One., 10, e0116488 ((2015);<br></p>

<p>Applications Cholinesterase inhibitor. Ectoparasiticide. This compound is a contaminant of emerging concern (CECs) and used in Pesticide detection.Useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chauzat, M., et al.: Env. Entomol., 38, 514 (2009), Raut, P., et al.: Pestol., 33, 21 (2009), Henseler, R., et al.: Toxicol., 261, 9 (2009), Banerjee, K., et al.: J. Agric. Food Chem., 57, 4068 (2009),<br></p>

<p>Applications Dinosam is used in preparation of Chitosan gel and application thereof in shampoo for preventing alopecia.Also, used in methods and formulations for preventing downward migration of agricultural materials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Qiu, Y., et al.: Faming Zhuanli Shenqing, (2020); Shieh, A., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications Prometryn is a methylthiotriazine herbicide used for the control of several annual grasses and broadleaf weeds. Prometryn works by inhibiting the electron transport in target broadleaves and grasses.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Qu, J.R.,et al.: Food. Chem., 135, 1148 (2012); Fenoll, J., et al.: J. Photochem. Photobiol., 238, 81 (2012);<br></p>

<p>Applications tert-Butyl Pitavastatin is used to prepare hemicalcium salt.<br>References Van Der Schaaf, P., et al.: PCT Int. Appl. (2004), WO 2004072040 A1 20040826.<br></p>

<p>Applications A metabolite of Quinidine.<br>References Small, D.L., et al.: J. Chem. Med., 22, 1014 (1979), Guentert, T.W., et al.: Eur. J. Drug Metab. Pharmacokinet., 7, 31 (1982), Rakhir, A., et al.: J. Pharmacokinet. Biopharm., 12, 1 (1984), Christie, D.J., et al.: J. Lab. Clin. Med., 112, 92 (1988),<br></p>

<p>Applications Lofentanil is a very potent and long-acting opiate agonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lembeck, F., Donnerer, J.: Eur. J. Pharmacol., 114, 241 (1985)<br></p>

<p>Applications 1,2,4-Triazolo[3,4-b]benzothiazole-5-methanol is the major alcohol metabolite of tricyclazole (T291465) which is an common active ingredient in several commercial fungicide products used to control rice blast fungus, in transplanted and direct-seeded rice.<br>References Koons, J., et al.: J. Agri. Food Chem., 33, 552 (1985)<br></p>

<p>Applications CP 1282 is the tautomer of the antibiotic Cefotetan (C242970) with similar degradation rates.<br>References Koshiro, A. et al.: Chem. Pharm. Bull., 37, 1864 (1989); Naber, K. et al.: Zeitsch. Antmickrob. Antineoplast. Chemother., 2, 161 (1984);<br></p>

<p>Applications A metabolite of Mirtazapine (M365000). This compounds contains some of the alpha anomer.<br>References Sandker, G., et al.: Xenobiotica, 24, 143 (1994), Dahl, M., et al.: Clin. Drug Invest., 13, 37 (1997),<br></p>

<p>Applications Abiraterone is a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.<br>References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389 (2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005);<br></p>

<p>Applications A labelled metabolite of Prochlorperazine.<br>References Finn, A., et al.: J. Clin. Pharmacol., 45, 1383 (2005),<br></p>

<p>Applications Zolmitriptan is a serotonin 5HTID-receptor agonist and used to treat migraine (1,2,3).<br>References (1) Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995)(2) Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996)(3) Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>

<p>Applications 4-(4-(4-(4H-1,2,4-Triazol-4-yl)phenyl)piperazin-1-yl)phenyl Acetate is an intermediate in the synthesis of Deoxo Anhydro Itraconazole Bromide (D231675). Deoxo Anhydro Itraconazole Bromide is an impurity of Itraconazole (I937500), which is orally active antimycotic drug structurally related to Ketoconazole (K186000). Antifungal.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984); Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989); Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993)<br></p>

<p>Applications Antilipemic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Metz, G., et al.: Arzneim.-Forsch., 27, 1173 (1977), Hassan, A.M., et al.: Anal. Profiles Drug Subs., 11, 197 (1982),<br></p>

<p>Impurity Calcium Folinate Hydrate EP Impurity E<br>Stability Unstable in Basic Solution<br>Applications 5-Formyltetrahydropteroic Acid is an impurity of Folic Acid (F680300); a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA. It also acts as a cofactor in biological reactions involving folate.<br>References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010); Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010); Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010); McKay, D., et al.: Nut. J., 9 (2010)<br></p>

<p>Applications Phentermine is an appeitie suppressant used in the treatment of obesity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ryan D.H., et. al.: Obesity Research, 7, 313 (1999); Wadden, T.A., et. al.: Oesity Research, 5, 218 (1997)<br></p>