Compuestos y reactivos bioquímicos

<p>CDK8-IN-2 is a potent and selective CDK inhibitor. The compound has been shown to inhibit the growth of leukemia cells in vitro, and has been shown to be active against cancer cells in vivo. CDK8-IN-2 was found to inhibit protein synthesis by blocking the phosphorylation of p27, a protein that regulates cell proliferation. CDK8-IN-2 also showed an anti-leukemic activity and could be a potential drug target for treating cancer. Studies have shown that CDK8-IN-2 is well tolerated with no toxic effects observed in laboratory mice or rats.<br>CDK8-IN-2 was found to be safe and well tolerated in healthy human volunteers with no dose limiting toxicities observed at doses up to 150 mg/day.</p>

<p>Streptococcus Pneumoniae Rabbit Monoclonal Anitbody is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Streptococcus Pneumoniae Rabbit Monoclonal Anitbody including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>(9Z,12Z)-Octadeca-9,12-dienamide is a lipid molecule that is structurally similar to linoleamide. It has been shown to inhibit cholesterol synthesis in vitro and in vivo by competitively inhibiting the enzyme cholesterol esterase. This inhibition leads to a decrease in intracellular levels of free cholesterol and an increase in intracellular levels of free fatty acids. (9Z,12Z)-Octadeca-9,12-dienamide also inhibits the uptake of low density lipoproteins by macrophages and reduces the development of atherosclerosis. This compound is insoluble at physiological pH and therefore cannot be administered orally. However, it can be delivered via injection or intravenously as a lipid particle complex with cyclodextrin.</p>

<p>Affinity purified Goat anti Human IgG antibody</p>

<p>CD102 antibody (PE) was raised in rat using COS cells transfected with mouse ICAM-2 cDNA as the immunogen.</p>

<p>CD44 antibody (biotin) was raised in mouse using human CD44 as the immunogen</p>

<p>DMPP is a pharmacological tool for the study of protein interactions, receptor-ligand interactions, and ion channels. It is also used in the synthesis of peptides and antibodies. DMPP is a high-purity compound with an acetamide functional group at each end. It has CAS number 2182653-84-3 and molecular weight of 474.5 g/mol. DMPP interacts with its ligands by binding to the active site pocket of the target protein, which can be a receptor or ion channel. It is an inhibitor that blocks enzymatic activity by binding to a reactive site on an enzyme molecule.</p>

<p>CD8a antibody (PE) was raised in mouse using porcine CD8a as the immunogen.</p>

<p>H-Arg-Pro-OH sulfate salt is a synthetic peptide that binds to the receptor for filtrates. It is used to treat skin conditions such as dermatitis, eczema, and psoriasis. H-Arg-Pro-OH sulfate salt has been shown to be effective in inhibiting clostridium from producing proteins. This drug also inhibits the uptake of these proteins by blocking the binding of phosphorylated lysine residues to their receptors on the cell membrane. It has been shown to hydrolyze amide bonds and can be used as a catalyst for bond cleavage reactions.</p>

<p>Nvp-bsk805 trihydrochloride is a small molecule inhibitor, which is synthesized chemically with a specific mode of action targeting the c-Met receptor tyrosine kinase. This compound acts as an ATP-competitive inhibitor, effectively reducing the phosphorylation of c-Met and subsequently disrupting downstream signaling pathways such as MAPK/ERK and PI3K/AKT. These pathways are critical for cellular processes related to growth, survival, and metastasis in cancer cells.</p>

<p>Anti P2X4 (370-388) (Rat) Serum is a research tool that can be used to measure the activation of P2X4 receptors. It is suitable for use in antibody-based applications, such as Western blotting and immunohistochemistry. Anti P2X4 (370-388) (Rat) Serum is a high purity product that has been extensively characterized by NMR spectroscopy, mass spectrometry, and amino acid analysis. The purified peptide is supplied at a concentration of 1 mg/mL in phosphate buffered saline with 0.02% sodium azide as preservative and 50% glycerol as cryoprotectant. The product is sold under reference number CAS No. 74941-79-6 and has the molecular weight of 3199.87 Da. Anti P2X4 (370-388) (Rat) Serum can be used to study protein interactions, receptor ligand pharmacology, ion</p>

<p>Substance P is a member of the tachykinin neuropeptide family which is produced in the central nervous system (CNS) and acts through its specific receptor neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is involved in: pain perceptions as a neurotransmitter; gut motility; increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research.</p>

<p>GRK2-IN-1 hydrochloride is a recombinant antibody that can be used as a research tool. It has been shown to inhibit the activity of GRK2, which is a protein kinase receptor. This antibody binds to the peptide sequence corresponding to amino acids 557-567 in human GRK2 and inhibits its activity. GRK2-IN-1 hydrochloride can be used for cell biology research and as an inhibitor for pharmacology studies. This antibody is purified with a high degree of purity (greater than 98%).</p>

<p>Gilteritinib hemifumarate is a bioavailable inhibitor of CTLA-4, which is a receptor for the protein CD80. This protein is expressed on the surface of T cells and plays an important role in regulating the immune system. Gilteritinib hemifumarate has been shown to induce regression in some cancers, such as ovarian cancer, by inhibiting the growth of cancer cells. It also induces apoptosis in leukemia stem cells and monoclonal antibodies that target CD80. This drug binds to CTLA-4 and blocks its inhibitory activity on CD28, which promotes T cell activation.</p>

<p>Maltose Binding Protein E.coli Recombinant is a maltose binding protein derived from E. coli that can be used as a research tool in pharmacology and cell biology. Maltose Binding Protein E.coli Recombinant is an antibody that binds to the maltose receptor on the surface of cells, which are found on the outer membrane of most bacteria. Maltose Binding Protein E.coli Recombinant is a high-purity recombinant protein with a molecular weight of about 31 kDa, and has been shown to be an activator and inhibitor of ion channels, depending on its concentration. This protein also interacts with various proteins in the cytoplasm and binds to peptides that have been identified as ligands for this receptor.</p>

<p>4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one is a potent inhibitor of Caspase 1. It binds to the active site of the enzyme and prevents it from cleaving its substrate. This chemical is also an activator of Protein Kinase A, which is involved in the regulation of many cellular processes. 4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one is a ligand for Beta1 adrenergic receptors and can be used as a research tool to study protein interactions, receptor activation, and ion channels.</p>

<p>CD24 antibody (FITC) was raised in rat using murine heat stable antigen as the immunogen.</p>

<p>The HIV-1 p24 Recombinant, His Tag (abbreviated as HIV-1 HRP) is a recombinant protein that is purified from the culture supernatant of transfected HEK293 cells. It has been immobilized on a His-tagged protein A column for purification. The recombinant protein has been proven to be an effective inhibitor of the human immunodeficiency virus type 1 (HIV-1).<br>HRP binds to the CD4 receptor, which is a major component of the cellular membrane. This binding causes conformational changes in the HRP and initiates signal transduction pathways in the cell, leading to an antiviral state.</p>

<p>Brazzien (2-54) is a peptide that binds to the extracellular domain of the human receptor for Advanced Glycation Endproducts (RAGE). This receptor plays an important role in many cellular processes, including tissue damage and inflammation. Brazzien (2-54) is a potent inhibitor of RAGE activity and has been shown to inhibit the binding of RAGE ligands to RAGE.</p>

<p>Mannose binding lectin is a host defense protein which has the ability to recognize a variety of infectious agents. This Mannose Binding Lectin Light Tryptic Peptide Standard can be used in protein identification and quantitation studies.</p>

<p>Polyvinyl chloride (PVC) is a polymer that is typically used in the production of plastic products. PVC can be made into a variety of shapes and sizes, such as sheets and pipes. The most common type of PVC is polyvinyl chloride with a density range from 0.91 to 0.94 g/cm3. PVC has excellent heat resistance, electrical properties, and chemical resistance, which makes it an ideal material for manufacturing many types of items. Polyvinyl chloride is also resistant to mold or mildew growth.</p>

<p>CGRP, humanAntiserum is a peptide that is the major peptide in the calcitonin gene-related peptide family. CGRP inhibits the activation of certain ion channels, which are proteins in cell membranes that allow ions to cross the membrane. It is also known to be an activator of certain G protein-coupled receptors, as well as a ligand for some receptor types. CGRP has been shown to play a role in vascular smooth muscle contraction and pain regulation.</p>

<p>CD8a antibody (biotin) was raised in mouse using the alpha chain of chicken CD8a as the immunogen.</p>

<p>CD25 antibody (FITC) was raised in rat using alpha chain IL-2 receptor as the immunogen.</p>

<p>CD56 antibody (FITC) was raised in mouse using human CD56 as the immunogen.</p>

<p>Minozac dihydrochloride is a peptide that can be used as a research tool to study protein interactions. It binds to the receptor, which is an extracellular protein, and inhibits the activation of ion channels. Minozac dihydrochloride also has a high purity and can be used as an analytical reagent for determining the presence of other substances.</p>

<p>CD62L antibody (Allophycocyanin-CY7) was raised in rat using C3H/eb cloned murine B lymphoma 38C-13 as the immunogen.</p>

<p>Rabbit anti Mouse IgM is a monoclonal antibody that belongs to the category of antibodies. It is specifically designed to target and bind to mouse IgM, making it an essential tool for various research applications in the field of Life Sciences. This antibody can be used for studying the role of IgM in different biological processes such as anti-VEGF (vascular endothelial growth factor) therapy, adiponectin signaling, β-catenin regulation, and more. Additionally, Rabbit anti Mouse IgM can be utilized for detecting specific proteins like human chorionic gonadotropin (hCG), alpha-synuclein, epidermal growth factor (EGF), c-myc, and glycopeptides. Its binding ability allows researchers to explore these proteins' functions and interactions within cellular pathways. Furthermore, this antibody has been shown to induce Fas-mediated apoptosis in certain experimental settings. With its high specificity and versatility, Rabbit anti Mouse IgM is an invaluable tool for advancing scientific</p>

<p>Galgravin is a natural compound that belongs to the family of antimicrobial agents. It is a protocatechuic acid glycoside derived from Ganoderma lucidum, which has been shown to have antitumor and anti-inflammatory properties. Galgravin is also an effective inhibitor of Leishmania parasites, inhibiting their growth and development by interfering with nucleic acid metabolism. This compound has been shown to inhibit the synthesis of dNTPs in rat neuronal cells, resulting in neuronal death and neuroprotection. Galgravin is a chemical substance that can be found in many food items such as wine, tea, chocolate, and cheese.</p>

<p>CD8b antibody (FITC) was raised in Mouse using the beta chain of chicken CD8 as the immunogen.</p>

<p>CD79b antibody (Azide free) was raised in hamster using the beta chain of the murine B-cell receptor as the immunogen.</p>

<p>Avex-73 is a chemical deterrent, which is derived from naturally occurring plant-based extracts. It operates by affecting the sensory pathways of birds, making treated areas undesirable for them through olfactory and gustatory discomfort. When applied, Avex-73 interacts with the specific chemosensory receptors present in avian species, creating an aversive, yet non-lethal reaction. This makes it an effective tool in managing bird-related challenges in various environments.</p>

<p>ML226 is a reaction product of linoleic acid, oleic acid, and palmitic acid. It has been shown to inhibit the enzyme fatty acid amide hydrolase (FAAH) in vitro and in vivo. ML226 has been found to be a potent inhibitor of FAAH with IC50 values of 0.5-1.0 μM in vitro and 1-2 μg/mL in vivo. ML226 also inhibits anandamide degradation by other enzymes such as N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD).</p>

<p>LGD-6972 is a molecule that binds to the drug target of metformin, which is an oral anti-diabetic drug. LGD-6972 has shown that it can reduce hyperglycemia and insulin resistance in rats, as well as decrease blood pressure in mice. LGD-6972 has also been shown to be safe in a clinical study with patients with type 2 diabetes. This compound will be used as an oral treatment for type 2 diabetes and is currently undergoing phase 1 clinical trials.</p>

<p>RA190 is a small molecule inhibitor of the ubiquitin ligase RNF4. It inhibits the proteasome, which is responsible for protein degradation, by targeting the ubiquitin ligases that mediate ubiquitination and subsequent degradation of proteins. This inhibition leads to accumulation of cellular proteins and cell death. RA190 has been shown effective in killing cancer cells in vitro and in vivo. Furthermore, RA190 can inhibit autoimmune diseases by modulating the immune system's response to self-antigens.</p>

<p>Glicentin is a rat-specific serum protein that is the major component of the alpha-2 macroglobulin (A2M) in the rat. Glicentin binds to various peptides, including beta-endorphin, vasopressin, angiotensin II, and oxytocin. This kit contains 1 vial of antibody against glicentin. The antibody has been purified by immunoaffinity chromatography on a column of immobilized peptide-glicentin complex. This kit can be used for detection of glicentin in rats.</p>

<p>Anti-EGFR (Epidermal Growth Factor Receptor) is a monoclonal antibody that binds to the epidermal growth factor receptor (EGFR). The EGFR is a transmembrane tyrosine kinase receptor that plays an important role in cell proliferation, differentiation, and survival. Anti-EGFR can be used as a research tool for studying protein interactions, such as the interaction of peptides with receptors or ligands. It can also be used for pharmacological studies and can be used to isolate proteins from cells. This product is available in high purity, which means it has been purified by chromatography to have less than 0.1% other proteins than the product. This product is also available in a form of an antibody conjugate, which means that it has been linked to an antibody molecule that recognizes the target antigen specifically. Anti-EGFR is available in CAS No., which stands for Chemical Abstracts Service Number.</p>

<p>CD18 antibody (biotin) was raised in rat using cell membrane lysates derived from murine T cell lymphoma BW5147 as the immunogen.</p>

<p>Iso-isariin B is a potent medicinal compound that has shown promise in the treatment of cancer. It is an analog of a protein found in Chinese urine that has been shown to inhibit tumor growth and induce apoptosis in cancer cells. Iso-isariin B works by inhibiting the kinase activity of proteins involved in cell cycle regulation, thereby preventing cancer cells from dividing and proliferating. This compound has been tested on human cancer cell lines and has shown strong anticancer effects, making it a promising candidate for further development as a cancer therapy. Its unique mechanism of action and potent inhibitor activity make it an exciting prospect for the future of cancer treatment.</p>

<p>CCG-100602 is a small molecule inhibitor that binds to the actin filament and prevents the assembly of actin filaments. This allows for the disruption of cytoskeleton dynamics and cell lysis. CCG-100602 has been shown to be effective in reducing cellular proliferation and inducing apoptosis in cancer cells, as well as inhibiting HIV replication. The drug also decreases blood pressure, which may be due to its ability to inhibit collagen production in vascular smooth muscle cells. CCG-100602 also inhibits pro-inflammatory cytokines by binding to their receptors on the cell surface, thereby reducing inflammation. CCG-100602 is a potent inhibitor of growth factor signaling pathways and has potential therapeutic applications in regenerative medicine and wound healing.</p>

<p>Anti-TGF-Beta1 is a recombinant monoclonal antibody that binds to the TGF-beta1 protein and blocks its function. It is a research tool for studying the effects of TGF-beta1 on cells, tissues, and organs in the body. Anti-TGF-Beta1 can be used as a control for blocking TGF-beta1 in various experiments, as well as for studying the effects of TGF-beta1 receptor activation. This antibody can also be used to detect TGF-beta1 in various samples by immunohistochemistry or immunocytochemistry.<br>The target is human serum proteins which react with this antibody and are detected at dilutions of 1:1000 or greater.</p>

<p>Biotin-SARS-CoV-2 Spike RBD 348-357 peptide is the biotinylated version of SARS-CoV-2 Spike RBD 348-357 peptide. SARS-CoV-2 Spike RBD 348-357 peptide is an epitope of interest of the SARS-CoV-2 Spike S glycoprotein Receptor-Binding Domain (RBD). Biotin-SARS-CoV-2 Spike RBD 348-357 peptide is useful for vaccine development and for structure-activity relationship studies<br>SARS-CoV-2 Spike (S) glycoprotein<br>Spike (S) glycoprotein corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells.<br>With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane.<br>SARS-CoV-2 Spike RBD:<br>The receptor-binding domain in SARS-CoV-2 Spike protein allows binding to the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry.</p>

<p>PF-06726304 is a novel small molecule that has been shown to inhibit prostate cancer growth in preclinical models. PF-06726304 binds to an antigen on the surface of prostate cells and induces apoptosis through a number of mechanisms, including radical prostatectomy, primary tumor growth, and resistant cancer. This agent also inhibits the proliferation of cancer stem cells and shows systemic effects on primary tumors. PF-06726304 acetate also blocks protein-protein interactions that are involved in cell survival pathways and may be effective in treating cancers such as breast cancer.</p>

<p>Legionella Species Rabbit Polyclonal Anitbody, IgG Fraction is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Legionella Species Rabbit Polyclonal Anitbody, IgG Fraction including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>AMG-579 is a novel, orally available phosphodiesterase inhibitor. It has been shown to be effective in animal models of Parkinson's disease and Huntington's disease, as well as in vitro experiments with cells from these diseases. AMG-579 has also been shown to inhibit the metabolic pathways that lead to the development of striatal lesions. This drug inhibits phosphodiesterases and guanosine receptors, which are involved in a number of biochemical pathways and have potential therapeutic applications for diseases such as Parkinson's and Huntington's.</p>

<p>Diflufenican-d3 is a fluorescent molecule that belongs to the class of carotenoids. It has been used in the study of ecosystem function, as well as quantifying chlorophyll fluorescence and photosynthetic efficiency. Diflufenican-d3 can be applied to algal biofilms, which are important in aquatic ecosystems. This carotenoid has also been shown to have an effect on heterotrophic organisms, such as bacteria, by altering their metabolism during stressors.</p>

<p>Please enquire for more information about Thiorphan-d7 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Inhibitor of histone deacetylases</p>

<p>Teludipine-d6 is a medicinal compound that has been shown to exhibit potent anticancer activity. It is an analog of the Chinese herb, telomycin, and functions as a kinase inhibitor. Teludipine-d6 has been found to induce apoptosis in cancer cells by blocking the activity of specific kinases involved in tumor growth and proliferation. This compound has been tested on human cancer cell lines and has demonstrated significant inhibitory effects on tumor growth. Teludipine-d6 is excreted primarily through urine and has a high affinity for protein binding. As a promising candidate for cancer therapy, this compound represents a potential breakthrough in the development of new kinase inhibitors for cancer treatment.</p>

<p>Aspartame-d3 is a high purity, stable, and radioactive form of aspartame. It reacts with antibodies to produce a fluorescent signal that can be measured using a fluorimeter. It is often used in research as a tool for studying protein interactions, ion channels, and cell biology. Aspartame-d3 has been shown to inhibit the binding of ligands to receptors, which may be due to its ability to bind to the receptor or the peptide that attaches it to the receptor. The CAS number for this product is 1356841-28-5.</p>

<p>Please enquire for more information about 1,8-Cineol-d3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>AT-13387 is a potent and selective HSP90 inhibitor that binds to the ATP binding site of HSP90 with high affinity. It has been shown to inhibit the proliferation of HL-60 cells in vitro. AT-13387 induces apoptosis in cancer cells by inhibiting the signaling pathways involved in regulating cell growth, including the activation of toll-like receptor 4 (TLR4). The efficacy of AT-13387 was evaluated in vivo using an animal model with bowel disease, which showed significant inhibition of tumor growth. AT-13387 also inhibits TLR4 signaling, suggesting that it may be useful for treating bowel disease. AT-13387 is being developed as a potential therapy for cancer and other diseases associated with TLR4 activation.</p>

<p>Sunitinib is a drug that is used to treat renal cell cancer. It is a tyrosine kinase inhibitor that binds to the ATP-binding site of the enzyme, which prevents the activation of the protein. Sunitinib has been shown to be effective against metastatic renal cell cancer and can be used with other drugs such as docetaxel or paclitaxel. Sunitinib's active metabolite, N-desethyl sunitinib, has also been shown to have similar effects on kidney cancer cells as its parent compound. Monitoring blood levels of sunitinib and its metabolites may help determine an individualized dose for each patient.</p>

<p>KEA1-97 is a small molecule that inhibits autophagy. It binds to reactive lysines present in the active site of the protein kinase, blocking the ability of this enzyme to phosphorylate amino acids. This prevents the tumor suppressor proteins from being degraded and prevents cell death from occurring. KEA1-97 is a reversible covalent inhibitor that can be taken orally and does not have any known side effects.</p>

<p>NBD phytosphingosine is a fatty acid that can be used as an analog. It has been shown to have antibacterial activity against Propionibacterium acnes, which are bacteria that cause acne. This compound also inhibits the growth of other microbes and has been shown to kill specific antibiotic-resistant strains of bacteria. The hydroxyl group on the NBD phytosphingosine molecule is hydrolyzed by erythromycin-resistant bacteria, rendering it inactive. The polysorbate in this compound helps solubilize the NBD phytosphingosine molecules in water, which may allow for higher concentrations without crystallization.</p>

<p>CZC-54252 is a cellular therapeutic that stimulates the pluripotent stem cells to differentiate into muscle cells. The pluripotent stem cells are derived from muscle tissue, so the therapeutic does not have any adverse effects on the patient's immune system. CZC-54252 has been shown to be capable of treating some symptoms of intestinal diseases such as Crohn's disease and ulcerative colitis. It also has potential in treatments for Alzheimer's disease and other neurodegenerative disorders. CZC-54252 binds to the kinase domain of proteins that are involved in translation, which regulates protein synthesis, leading to an increase in muscle mass.</p>

<p>CD45RB antibody (biotin) was raised in rat using cloned murine Th2 cell lines as the immunogen.</p>

<p>H-Leu-D-Leu-OH is a nonproteinogenic amino acid that is used in the biosynthesis of proteins. It is formed from glutamic acid and leucine through an amide bond, and has a protonated amino group. The specificities of H-Leu-D-Leu are not yet known, but it has been shown to have antibacterial activity against Staphylococcus aureus and Streptococcus pyogenes. H-Leu-D-Leu may be transported across the cytoplasm membrane by means of a transport rate that is significantly higher than other amino acids. This amino acid also exhibits significant homology with nanosized molecules.</p>

<p>CD23 antibody (biotin) was raised in rat using CD23 low affinity IgE Fc receptor as the immunogen.</p>

<p>Tetracycline hydrate is a protein synthesis inhibitor that is commonly used to treat urinary tract infections and various types of cancer. It acts as an analog for the natural aminoacyl-tRNA molecule, which binds to the ribosome during protein synthesis. Tetracycline hydrate has been shown to have anticancer properties in Chinese hamster ovary cells by inducing apoptosis and inhibiting tumor growth. This drug also inhibits kinases, such as indirubin, which are involved in cell cycle regulation and proliferation. Tetracycline hydrate has potential as a therapeutic agent for cancer treatment due to its ability to target cancer cells selectively while sparing normal cells.</p>

<p>Hydroxy chlorodenafil is a metabolite of tadalafil. It is a chromatographic standard that can be used to validate analytical methods for the quantification of sildenafil in pharmaceutical preparations and medicinal preparations. The sample is dissolved in ammonium formate, which is then diluted with acetonitrile and injected into the LC-MS/MS system. A calibration curve is generated using standards of known concentration and the area under the curve (AUC) for each standard is determined by comparing it to the corresponding peak areas of the analyte.</p>

<p>VCH-759 is a nucleoside analog that is a potential treatment for chronic hepatitis C. VCH-759 inhibits the NS5B polymerase of the hepatitis C virus, an enzyme responsible for viral replication. It binds to the active site of NS5B and prevents it from functioning. VCH-759 has shown antiviral effects in cell culture and animal models and has a safety profile comparable to other nucleoside analogs. The drug also appears to be effective against other types of viruses, including HIV, influenza A, and herpes simplex virus type 2. VCH-759 may be used as a single agent or in combination with other antivirals to treat patients with chronic viral infections.</p>

<p>Naltrexone-d3 is a medicinal compound that is an analog of Naltrexone, which is commonly used to treat addiction and alcoholism. This compound has been shown to have anticancer properties in human tumor cell lines, inducing apoptosis and inhibiting cell cycle progression. In Chinese hamster ovary cells, Naltrexone-d3 has been found to be a potent inhibitor of protein synthesis. This compound also inhibits the activity of various protein inhibitors involved in cancer growth and proliferation. Naltrexone-d3 can be detected in urine samples and may serve as a valuable tool for studying the metabolism and pharmacokinetics of Naltrexone.</p>

<p>NSC 81178 is a sulfur-containing chemical that was found to be capable of inducing mutations in the DNA of Neurospora crassa. The mutant strain of N. crassa, which responded positively to NSC 81178, had a reduced capacity for conversion of 5-formyluracil to 5-hydroxymethyluracil and showed a decreased level of glutarate synthesis. This suggests that NSC 81178 may be capable of inducing mutations by chemically reacting with DNA and altering its structure. <br>In addition, the KM values for pyrimidines were significantly higher in the mutant strain than in the wild type strain, indicating that NSC 81178 has an effect on nucleotide synthesis.</p>

<p>Roscovitine is a ligand that binds to voltage-gated potassium channels. It has been shown to inhibit the function of these channels, which are involved in the regulation of neuronal excitability and muscle contraction. Roscovitine is used as a research tool in pharmacology and cell biology, and can be used as a high purity reagent for antibody production.</p>

<p>LR3 IGF1 Human is a cytokine that is a member of the interleukin family. It is one of the two forms of human insulin-like growth factor 1 (IGF-1), which plays an important role in regulating cell growth and differentiation. LR3 IGF1 Human has been shown to stimulate the proliferation of various cells, such as lymphocytes and fibroblasts, in vitro. In addition, this cytokine has been shown to inhibit apoptosis induced by serum deprivation.</p>

<p>AT 1001 is a drug that has been demonstrated to be effective in the treatment of bowel disease. It is specifically designed to bind to acetylcholine receptors on the cell membrane, thereby blocking the action of acetylcholine and reducing inflammation. AT 1001 has been shown to be effective in animal models of autoimmune diseases, such as multiple sclerosis and inflammatory bowel disease. This drug has also been shown to have some effect on otoacoustic emissions and locomotor activity in animals. The binding site for this drug is known, but its exact mechanism of action is not yet clear.</p>

<p>A synthetic snake toxin peptide sourced from the Green Mamba, Dendroaspis angusticeps. It is an agonist for Muscarinic Acetylcholine Receptor-1 (M1) and has disulfide bonds between Cys3-Cys24, Cys17-Cys42, Cys46-Cys58, and Cys59-Cys64. This product is available as a 0.1mg vial.</p>

<p>Isoleucyl-Seryl-Bradykinin is a peptide that activates the bradykinin receptor, which is involved in pain sensation and inflammation. This compound is a potent inhibitor of ion channels and also interacts with protein receptors. Isoleucyl-Seryl-Bradykinin has been used as a research tool for studying the function of bradykinin receptors, as well as for pharmacological studies. The CAS number for this product is 86030-63-9.</p>

<p>This is a vivitide catalogue product. Please send your vivitide product enquiry to sales@vivitide.com for an up-to-date price and availability.</p>

<p>Antibody which blocks the CD95 death receptor which have the ability to elicit apoptosis.</p>

<p>17:0 Cyclic lpa is a cyclic lipopeptide that has been identified as a novel ligand for the GABAA receptor. It binds to the benzodiazepine binding site of the receptor and enhances GABA-mediated chloride ion flux, leading to inhibition of neuronal firing. 17:0 Cyclic lpa also blocks potassium channels, which leads to inhibition of neuronal firing. 17:0 Cyclic lpa is a potent inhibitor of voltage-gated ion channels and may be used as an experimental tool in pharmacology and cell biology research.</p>

<p>GSK 2334470 is a small molecule that inhibits the activity of the protein kinase CDK4/6. It is a potent inhibitor of tnf-related apoptosis-inducing ligand (TRAIL)-induced cell death and targets amyloid precursor proteins. GSK 2334470 has been shown to suppress the growth of hematopoietic cells in vitro, which may be due to its ability to inhibit cdk4/6 activity. In addition, GSK 2334470 selectively inhibits the kinase activity of CDK4/6 and has no effect on other kinases such as PDK1, cyclin B1, or MAP2K2.</p>

<p>Lissamine Rhodamine B Sulfonamide-dPEG®4-Acid is a PEG compound containing a rhodamine used for tagging biomolecules, and serving as fluorescent probe for bioimaging applications.</p>

<p>NSC109555 is a small molecule that is chemically synthesized. It has been shown to inhibit the uptake of sodium citrate by mitochondria, which inhibits cellular energy production. NSC109555 also has anti-cancer properties and may be used as a diagnostic agent for cancer. It is activated when it binds to DNA as a template and prevents the formation of dna strands, which prevents the replication of cells. NSC109555 can also cross cell membranes and enter into cells, where it prevents repair mechanisms such as DNA repair from occurring. The chemical structure of this drug is not yet known, but its mechanism of action may involve the response pathway in cancer cells that regulates cell cycle progression, gene expression, and apoptosis.</p>

<p>Galosemide is a drug that belongs to the class of organic acids. It is used in the treatment of congestive heart failure and hypertension. This drug binds to specific target proteins, which are present in the heart muscle cells, to lower blood pressure by preventing arrhythmia. The trifluoromethyl group on galosemide allows it to bind with high affinity and specificity to these target proteins. Galosemide also has been shown to affect cardiac metabolism by lowering levels of lipids (dyslipidemia) and reducing ventricular dysfunction due to its ability to decrease cardiac energy consumption. Galosemide may be administered orally or intravenously as a reconstituted solution. It can be diluted with water for injection or mixed with other diluents such as glucose, mannitol, dextrose, or sodium chloride for oral use.</p>

<p>Inhibitor of PDE2A enzyme</p>

<p>14:0-14:0-d27 Pc is a peptide that belongs to the group of activator peptides. It has been shown to act as an ion channel inhibitor in rat dorsal root ganglion neurons and to inhibit protein interactions in vitro. 14:0-14:0-d27 Pc also has the ability to act as an antibacterial agent and a ligand for the GABA receptor. 14:0-14:0-d27 Pc is soluble in water, making it useful for use in cell biology and pharmacology experiments.</p>

<p>LCH-7749944 is a selective receptor modulator, which is derived from synthetic chemical processes. Its mode of action involves specifically binding to receptors on cellular membranes, thereby altering the signaling pathways within the cell. This alteration can lead to enhanced or suppressed cellular responses depending on the receptor type it interacts with.</p>

<p>3-(4-Bromo-3,5-dimethoxyphenyl)-2-(methoxymethyl)-2-propenenitrile-d6 is a research tool for receptor binding. It is a ligand that binds to the ion channels and may be an inhibitor of protein interactions. 3-(4-Bromo-3,5-dimethoxyphenyl)-2-(methoxymethyl)-2-propenenitrile-d6 is used in pharmacology and biochemistry as a ligand for the study of protein interactions. It has been used to characterize the structure and function of ion channels and antibodies. The chemical name is 3-(4-bromo-3,5-dimethoxyphenyl)-2-(methoxymethyl)propene nitrile d6 and it has CAS No. 56518-39-9.</p>

<p>Please enquire for more information about Quinaprilat-d5 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Eletriptan-d5 is a monoclonal antibody that binds to the CGRP receptor and blocks the activation of the receptor. Eletriptan-d5 is used as a research tool for studying peptides, pharmacology, and protein interactions. The antibody has been shown to inhibit the activation of ion channels in various cells, including human embryonic kidney cells. Eletriptan-d5 has also been shown to block the binding of ligands to certain receptors, such as the CGRP receptor.</p>

<p>Inhibitor of O-GlcNAcase</p>

<p>Anti Somatostatin (Human, Rat) Serum is a research tool that can be used to activate or suppress the function of cells by binding to their receptors. This antibody binds to somatostatin receptors and blocks their ability to bind to the ligand. It is also used for the detection of ion channels in cell biology. Antibody against somatostatin can be used as an inhibitor in pharmacological studies.</p>

<p>2-[2-(2-Hydroxyethoxy)ethylamino]benzo[H]chromen-4-one is a research tool that is used to study the function of ion channels and receptor interactions. It has been shown to inhibit the activation of calcium channels in cell culture, which may be due to its ability to inhibit ligand binding. 2-[2-(2-Hydroxyethoxy)ethylamino]benzo[H]chromen-4-one also binds to antibodies and peptides, which may be an indication of its use as a pharmacological agent.</p>

<p>CGP 52608 is a synthetic compound that inhibits the activity of transcription-polymerase chain. It is a potent inhibitor of the tumor suppressor protein p21 and thus has potential for treating cancer. CGP 52608 also has anti-inflammatory effects in experimental models of inflammatory bowel disease and rheumatoid arthritis. The inhibition of p21 may be mediated by binding to its response elements in DNA, which prevents the binding of transcription factors.<br>CGP 52608 also blocks melatonin's role in regulating cellular proliferation and differentiation, which may explain its effects on cancer cells.</p>

<p>Human-monoBiotin (PheB1) is a peptide that activates the acetylcholine receptor and may be used as an inhibitor for ion channels. This peptide has been shown to inhibit the binding of acetylcholine to its receptor, which may lead to therapeutic benefits for diseases associated with protein interactions, such as Alzheimer's disease. It also has a role in cell biology and pharmacology.</p>

<p>(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-L-proline is a prodrug that is metabolized by esterases in the gastrointestinal tract to form the active drug L-(3,5 dimethoxybenzyl)histidylprolinamide. This compound has been shown to inhibit thyroid hormone biosynthesis and may be useful for the treatment of thyroid disease. The compound also has neuroprotective properties and may be beneficial for the treatment of Alzheimer's disease.</p>

<p>LP-211 is a drug that binds to the 5-hydroxytryptamine 7 receptor (5-HT7) with high affinity and specificity. It is a potent and selective antagonist of the 5-HT7 receptor, which has been shown to be involved in the regulation of brain functions, neurodevelopmental processes and locomotor activity. LP-211 also inhibits the binding of serotonin to its receptors, suggesting that it may have therapeutic potential for treating neuropsychiatric disorders such as depression or anxiety. LP-211 is an irreversible inhibitor of the 5-HT7 receptor, which blocks the activation of this receptor by serotonin. This drug also has pharmacokinetic properties that are suitable for oral administration.</p>

<p>Cer7-2′S,6R(d9) is a peptide that is used as an activator for antibodies and other ligands. It inhibits ion channels by binding to the extracellular loops of these proteins. Cer7-2′S,6R(d9) has been shown to inhibit protein interactions in cell biology experiments. This molecule can also be used as a pharmacological tool for studying receptor-ligand interactions. Cer7-2′S,6R(d9) has a CAS number of 2260670-25-3 and is available in high purity.</p>

<p>Mj 33 lithium is a potent and selective antibody that inhibits the activation of ion channels. It binds to the ligand-binding domain of receptors, preventing agonist binding and subsequent signal transduction. Mj 33 lithium has been shown to be an inhibitor of receptor tyrosine kinases, including type I insulin-like growth factor receptor (IGF1R), epidermal growth factor receptor (EGFR), and vascular endothelial growth factor receptor 2 (VEGFR2). It also has been shown to inhibit the activation of voltage-gated sodium channels in rat dorsal root ganglia neurons.</p>

<p>Amyloid β-Protein (Human, 1-38) is a peptide that is a major constituent of the amyloid plaques found in the brains of people with Alzheimer's disease. It has been shown to inhibit ion channels and ligand-activated ion channels. The receptor for this protein is unknown, but it may be involved in cell signaling or neurotransmitter release. Amyloid β-Protein (Human, 1-38) can be used as a research tool to study proteins and their interactions with other proteins, as well as to study how these interactions affect the function of cells. It can also be used to study how antibody molecules bind to specific proteins and how these antibodies interact with other molecules.</p>

<p>MYCi361 is an antibody-drug conjugate that targets the histone deacetylase. MYCi361 has been shown to be effective in treating leukocyte antigen (HLA)-expressing tumours, such as melanoma, colorectal cancer, and breast cancer that overexpress the HER2 receptor. MYCi361 blocks the biological activity of histone deacetylase by binding to it, which results in reduced expression of HLA proteins. This leads to tumor regression and prolonged survival in animal models.</p>

<p>CD3e antibody (FITC) was raised in hamster using T cell receptor complexes derived from C6VL-BS thymoma cells as the immunogen.</p>

<p>Amuvatinib hydrochloride is a multitargeted receptor tyrosine kinase inhibitor that binds to the stem cell factor receptor (SCFR) and other receptors, including the RET, AXL, KIT, PDGFRβ, and FLT3. Amuvatinib hydrochloride can be used to treat cancer by inhibiting SCFR activity. It also inhibits the activity of oncoproteins such as c-KIT, RET, and PDGFRβ. This drug has been shown to inhibit the proliferation of cancer cells in vitro and in vivo models. Amuvatinib hydrochloride has been shown to inhibit DNA repair by preventing DNA damage from being repaired. It also prevents cell division by inhibiting protein synthesis at a step downstream of protein translation.</p>

<p>Nampt inhibitor-linker 2 is a peptide with the amino acid sequence of D-Phe-D-Ala-Lys-Gly-Arg. It is a competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), which converts nicotinamide to NAD+ and plays an important role in the production of NAD+. This inhibitor is used as a research tool for studying protein interactions, activators, and receptors. This peptide has been shown to be a ligand for G protein coupled receptor (GPCR) β2 subtype. These receptors are involved in cell signaling pathways that regulate many physiological processes such as glucose metabolism and lipid synthesis. Nampt inhibitor-linker 2 is also known by CAS No. 2241014-82-2.</p>

<p>S38093 HCl is a selective histamine H3 receptor antagonist and inverse agonist, which is synthesized for research purposes involving neuropharmacology. As a compound derived from chemical synthesis, its principal mode of action involves binding to and inhibiting the activity of the H3 histamine receptor. This receptor is primarily located in the central nervous system and acts as an autoreceptor, modulating the release of histamine and other neurotransmitters, including dopamine, noradrenaline, and acetylcholine.</p>

<p>GMC 3-15 is a peptide that is used as a research tool to activate the ion channel. It can be used to study the inhibition of protein interactions and receptor ligand interactions. GMC 3-15 has an IC50 value of less than 10 μM for the activation of voltage-gated potassium channels. It also has an IC50 value of less than 1 μM for the inhibition of protein interactions and receptor ligand interactions. GMC 3-15 has been shown to be active in pharmacological studies, where it was able to inhibit the phosphorylation of tyrosine kinase receptors, such as epidermal growth factor (EGFR) and insulin-like growth factor II (IGF2R).</p>

<p>(2S,4R)-4-((3-Chloro-7-methoxyquinoxalin-2-yl)oxy)-2-(methoxycarbonyl)pyrrolidinium methanesulfonate is a peptide that can be used as a research tool to study protein interactions and receptor binding. It is an inhibitor of ion channels and ligand for G protein coupled receptors. The purity of this compound is &gt;97%. CAS No. 1425038-20-5</p>

<p>PRT 060318 is a small molecule that inhibits the expression of the protein Foxo1. It has been shown to inhibit the growth of chronic lymphocytic leukemia cells in culture, as well as inhibit their ability to migrate and invade other tissues. PRT 060318 also inhibits cell proliferation by blocking Annexin A2 signaling pathways. In vivo studies have shown that PRT 060318 can be used to suppress tumor growth and reduce the size of tumors in mice with a severe combined immunodeficiency (SCID) through inhibition of Foxo1. The drug does not appear to have any toxic effects on healthy cells and tissue, which may be due to its low affinity for Annexin A2.</p>