Antibióticos

Applications n-Pentyl 4-Hydroxybenzoate-2,3,5,6-d4 (CAS# 1219798-66-9) is a useful isotopically labeled research compound.

Applications Telocinobufagin is isolated as a major component from skin secretion of the toad Bufo rubescens. Telocinobufogenin is a novel antibiotic cardiotonic.
References Akizawa, T., et al.: Chem. Pharm. Bull., 42, 754 (1994); Hancock, R., et al.: Antimicrob. Agents Chemother., 43, 1317 (1999); Jing, Y., et al.: J. Cancer Res., 85, 645 (1994); Kamano, Y., et al.: J. Med. Chem., 45, 5440 (2002); Schoner, W., et al.: Eur. J. Biochem., 269, 2440 (2002); Cunha Filho, G., et al.: Toxicon, 45, 777 (2005)

Impurity Piperacillin EP Impurity B
Stability Hygroscopic, Temperature Sensitive
Applications Piperacilloic Acid (Piperacillin EP Impurity B) is a degradation product of Piperacillin (P479950), a new β-lactam antibiotic.
References Waxman, D.J., et al.: J. Biol. Chem., 255, 3964 (1980), Waley, S.G., et al.: Biochem. J., et al.: 205, 631 (1982),

Applications Surfactin is a lipopeptide antibiotic and biosurfactant.

Herbicidin C is an antibiotic, which is derived from a microbial source, specifically from certain strains of actinobacteria. This compound functions as an inhibitor, interfering with specific metabolic pathways within target organisms. Its mode of action involves disrupting the synthesis of critical proteins, which are essential for cell survival and growth.

Penicillin G sodium is a natural penicillin antibiotic with action on bacterial cell wall synthesis and is used for treating bacterial infections such as pneumonia, gonorrhea, and anthrax.

Aminoglycoside antibiotic; inhibits protein synthesis by inducing miscoding

Nalidixic acid sodium salt is a sodium salt form of nalidixic acid with similar action and applications as nalidixic acid.

Cephradine is a first-generation cephalosporin antibiotic with action on bacterial cell wall synthesis and is used for treating bacterial infections like urinary tract infections, respiratory infections, and skin infections.

Membrane-disrupting agent

5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate is an antibacterial compound with a broad spectrum of activity against Gram-positive and Gram-negative bacteria. It is active against strains resistant to other antibiotics, such as, tetracycline and penicillin. 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate has been shown to be effective in vitro against Campylobacter jejuni - the most common cause of bacterial gastroenteritis in humans. The compound also inhibits the growth cycle of Campylobacter jejuni by arresting the cells at the G1 phase. The molecule has been shown to inhibit DNA synthesis in E. coli and S. typhimurium with IC50 values of 1 ÎŒM and 0.8 ÎŒM respectively. This molecule has been tested for its surface active properties and it can be used as an additive in personal care products for improved wetting and spreading on surfaces. The compound is also researched for its antifungal efficacy against Candida albicans by inhibiting the growth cycle of the fungus.

Inhibitor of cell-wall synthesis; carbapenem class

Epioxytetracycline is a degradation product of the antibiotic oxytetracycline. It has been found in wastewater.

Inhibitor of protein synthesis; aminoglycoside

Inhibitor of isoleucyl-tRNA synthetase; inhibitor of protein synthesis

Inhibitor of RNA synthesis

Antibiotic of tetracycline class; protein synthesis inhibitor

Inhibitor of cell-wall synthesis; carbapenem class

Tobramycin used to treat severe infections with gram-negative bacteria and it is often applied in combination with beta-lactams. It has similar antimicrobial effects to gentamicin and is effective against all Enterobacteriacae, but more effective than gentamicin against P. aeruginosa, which is why it is often used for gentamicin-resistant strains, especially in the case of cystic fibrosis.

Inhibitor of protein synthesis; aminoglycoside

Second-generation lipoglycopeptide antibiotic

Cephalosporin antibiotic; interferes with cell wall biosynthesis

Puromycin is active against both prokaryotic and eukaryotic cells. Puromycin resistance gene (pac) is a common choice for the selection of mammalian cells since its first application in 1988, especially for therapeutic proteins in mammalian cells where it was used to produce high levels of protein of interest. Puromycin can also be used as a selection marker for Archea.

Amicetin is a type of antibiotic, which is derived from bacterial sources, specifically from Streptomyces species. It functions primarily by inhibiting protein synthesis in susceptible bacteria, achieved through interfering with the aminoacyl-tRNA binding process on the ribosome. This mechanism disrupts the translation process, thereby preventing bacterial growth and replication.

Fluoroquinolone; inhibits bacterial DNA gyrase

Inhibitor of cell-wall synthesis; carbapenem class

9-Erythromycin 9-oxime is an activty inpurity, binding to the 50S ribosomal subunit of bacteria.

Nadifloxacin is a fluoroquinolone antibiotic with action on bacterial DNA gyrase to inhibit DNA synthesis and is used for treating acne vulgaris and bacterial skin infections.

Cinoxacin is a quinolone antibiotic with action on bacterial DNA synthesis inhibition and is used for treating urinary tract infections.

Inhibitor of protein synthesis; aminoglycoside