Ácidos y reactivos sintéticos

<p>Applications Epacadostat is a potent and novel indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. It has high selectivity over IDO2 and tryptophan 2,3-dioxygenase (TDO).<br>References Yue, Eddy W., et al.: ACS Med. Chem. Lett., 8, 486 (2017);<br></p>

<p>Applications KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. By blocking Akt signaling, KP372-1 has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells.<br>References Zeng, Z., et al.: Cancer Res, 66, 3737-3746 (2006); Mandal, M., et al.: Br. J. Cancer, BJC, 92, 1899-1905 (2005)<br></p>

<p>Applications Gefarnate is a synthetic isoprenoid that is used to treat chronic gastric and duodenic ulcers. Gerfarnate is also used for gastric ulcer prophylaxis.<br>References Barbara, L., et al.: Curr. Med. Res. Opin., 2, 399 (1974); Kobayashi, K., et al.: Toko. J. Exp. Med., 140, 181 (1983); Newman, C. &amp; Montgomery, D.: Brit. J. Clin. Pract., 27, 85 (1973); Smith, P., et al.: Scand. J. Gastroenterol., 10, 753 (1975)<br></p>

<p>Applications An organophosphorous compound that is a widely used mono-pyridylphosphine ligand in transition metal complexes for catalysis.<br>References Xue, Z. et al.: Macromol. Res., 15, 302 (2007); Gladiali, S. et al.: J. Mol. Catal., 66, 183 (1991);<br></p>

<p>Applications A reagent used in the synthesis of glycidol, a stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.<br>References Palomo, J.M. et al.: Tetrahedron Asymm., 16, 869 (2005); Hiles, R.A., et al.: Food Cosmet. Toxicol., 19, 347 (1981); Thompson, E.D., et al.: Food Chem. Toxicol., 22, 665 (1984);<br></p>

<p>Applications NE-100 is a potent and selective σ1 receptor antagonist.<br>References Sabino, V., et al.: Psychopharmacology, 205, 327 (2009); Kunitachi, S., et al.: Brain Res., 1279, 189 (2009)<br></p>

<p>Applications Tetramethylammonium Bromide (cas# 64-20-0) is a useful research chemical.<br></p>

<p>Applications 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase.<br>References Lee, H.G., et al.: J. Neurosci. Res., 87 269 (2009),<br></p>

<p>Applications Tideglusib is used in the treatment of brain atrophy, and movement disorder issues.<br>References Hoeglinger, G. et al.: Movement DIs., 29, 579 (2014); Tolosa, E. et al.: Movement Dis., 29, 570 (2014);<br></p>

<p>Applications 2,3-Dichloropyrazine is a substrate used for an efficient synthesis of aloisine (A575450), a potent cyclin-dependent kinase.<br>References Chekmarev, D.S., et al.: Tetrahedron., 62, 9919 (2006);<br></p>

<p>Applications The (R)-enantiomer intermediate in the preparation of Oxiracetam (O846905).<br>References Kondepudi, D., et al.: Science, 250 975 (1990), Di Silvestro, G., et al.: J. Pharm. Sci., 82, 758 (1993),<br></p>

<p>Applications An intermediate for polycyclic indazole derivatives that are ERK inhibitors.<br>References Orjales, A., et al.: J. Med. Chem., 46, 5512 (2003), Mariappan, P., et al.: J. Eur. Urology., 51, 67 (2007), Hughes, J., et al.: Bioorg. Med. Chem. Lett., 18, 4872 (2008), Kielbasa, W., et al.: Drug Metab. Dispos., 37, 137 (2009),<br></p>

<p>Applications 2,4-Dichloro-5-trifluoromethylpyrimidine is a reactant in the preparation of pyrimidine derivatives as inhibitors of gene ALK protein Kinase phosphorylating kinase and as cell proliferation inhibitors.<br>References Yang, E.H., et. al.: Bull. Korean Chem. Soc., 34, 3129 (2013)<br></p>

<p>Applications An optically active resolving agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Helv. Chim. Acta, 61, 2773 (1978)<br></p>

<p>Stability Unstable in solution. Small amounts of precipitate should have no effect on use.<br>Applications 1-Chloro-N,N-2-trimethylpropenylamine acts as a reagent in the synthesis and antitumor activity of (-)-bassianolide in human cancer cells through cell cycle arrest. Enantioselective total synthesis of nannocystins A and A0 as elongation factor 1 inhibitors. Total synthesis of (-)-caprazamycin A with antibacterial activity against Mycobacterium tuberculosis (TB) via diastereoselective aldol reaction.<br>References Mun, B., et al.: Bioorg. Chem., 69, 64 (2016); Huang, J., et al.: Org. Lett., 18, 4702 (2016); Nakamura, H., et al.: Angew. Chem., Int. Ed., 54, 3136 (2015)<br></p>

<p>Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);<br></p>

<p>Applications (S)​-​(+)​-​Pantolactone is a versatile cyclic ester reactant used in the preparation of tunable ligands carbohydrate-derived diarylphosphinites for asymetric catalysis hydrovinylation of styrene derivatives.<br>References Park, H., RajanBabu, T.: J. Am. Chem. Soc., 124, 734 (2002);<br></p>

<p>Applications 1-Carboxy-1-methylethoxyammonium Hydrochloride is used as a reactant in the synthesis of carbon-11 labeled celecoxib derivatives as new candidate PET radioligands for imaging of inflammation.<br>References Gao, M., et al.: Appl. Radiat. Isot., 67, 2019 (2009);<br></p>

<p>Impurity Abacavir - In House Impurity<br>Applications (1R)-(-)-2-Azabicyclo[2.2.1]hept-5-en-3-one (Abacavir - In House Impurity) is an Abacavir (A105000) intermediate (1). It is also an intermediate in the synthesis of carbocyclic sugar amines, carbanucleosides, and carbocyclic dinucleotide analogues (2).<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Slama, J.T., et al.: Biochemistry, 27, 183 (1988)<br></p>

<p>Stability Moisture, Temperature Sensitive<br>Applications An inhibitor of yeast a-glucosidase. Used in the synthesis of 1-deoxynojirimycin (DNJ), an important glycosidase inhibitor.<br>References Legler, G., et al.: Carbohydr. Res., 155, 119 (1986), Mitrakou, A., et al.: Diabetic Med., 15, 657 (1998), Fan, J., et al.: Nat. Med., 5, 112 (1999), Cox, T., et al.: Lancet, 355, 1481 (2000),<br></p>

<p>Applications 1-Bromopentadecane is a building block that has been used in the preparation of 1-alkyl-4-(1-alkyl-4-oxo-1,4-dihydroquinolin-2-yl)pyridinium bromide as antibacterial and antioxidant agents.<br>References Kahriman, N., et. al.: Eur. J. Med. Chem., 69, 348 (2013)<br></p>

<p>Applications Intermediate in the preparation of Histamine antagonists and Omeprazole metabolites<br>References Nishikawa, Y., et al.: J. Med. Chem., 32, 583 (1989),<br></p>

<p>Applications A reagent used in the synthesis of Pitavastatin.<br>References Mukaiyama, H., et al.: Chem. Pharm. Bull., 55, 881 (2007), Paruch, K., et al.: Bioorg. Med. Chem. Lett., 17, 6220 (2007),<br></p>

<p>Applications 5-Bromopentyltrimethylammonium Bromide (cas# 15008-33-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Copper (I) bromide is used as a reagent to brominate electron-rich aromatic compounds (e.g. Phenol: P318000). Copper (I) bromide is also used to brominate aliphatic ketones (e.g. Acetone: A163800).<br>References Bhatt, S. &amp; Nayak, S.: Synth. Comm., 37, 1381 (2007); Kojima, Y. &amp; Kawaguchi, S.: Bull. Chem. Soc. Jpn., 45, 1293 (1972)<br></p>

<p>Applications Benzyltributylammonium Chloride (cas# 23616-79-7) is a useful research chemical.<br></p>

<p>Applications Extremely valuable and versatile alcohol used as a chiral building block in organic synthesis, used in the preparation of chiral 2-amino-1-phenylethanols as pharmaceutical intermediates.<br>References Bagnoli, L., et al.: Chem. Eur. J., 17, 993 (2011)<br></p>

<p>Applications 7-Amino-alpha-tetralone<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Sumanirole is a high affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Sumanirole displays &gt;200-fold selectivity for the D2 receptor against other dopamine receptor subtypes (Ki values are 9.0, 1940, &gt;2190 and &gt;7140 for D2, D3, D4 and D1 receptors respectively). Sumanirole exhibits antiParkinsonian activity similar to Ropinirole (R641000).<br>References McCall, et al.: J. Pharmacol. Exp. Ther., 314 1248 (2005), Stephenson, et al.: J. Pharmacol. Exp. Ther., 314 1257 (2005),<br></p>

<p>Stability Volatile<br>Applications Allyltrimethylsilane is used in the allylation of aldehydes, imines, allylic and benzylic alcohols, and chiral α-keto-amides that are derived from (S)-proline esters.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yadav, J.S., et al.: Tetrahedron Lett., 43, 3783 (2002); Aggarwal, V.K., et al.: Tetrahedron Lett., 37, 3745 (1996); Wang, D.K., et al.: J. Org. Chem., 64, 4233 (1999); Kaur, G., et al.: Tetrahedron Lett., 38, 2521 (1997); Soai, K., et al.: J. Chem. Soc., Chem. Commun., 15, 1016 (1984)<br></p>

<p>Applications Lanthanum(III) Trifluoromethanesulfonate is a catalyst that is used for the trans-esterification of Jatropha curcas L. oil with methanol and higher alcohols. Studies on rats and mice showed that Lanthanum(III) Trifluoromethanesulfonate is a moderately hazardous substance causing slight irritation of the skin and that the maximum permitted concentration in the workplace is 2.0 mg/m3.<br>References Daniel, L., et al.: J. Am. Oil Chem. Soc., 91, 325 (2014); Zhurba, O.M., et al.: Toksikologicheskii Vestnik, no vol., 20 (2005)<br></p>

<p>Applications (3R,5R)-Atorvastatin Sodium Salt is an Atorvastatin impurity in bulk drug and tablets.<br>References Posvar, E., et al.: J. Clin. Pharmacol., 36, 728 (1996), Lea, A., et al.: Drugs, 53, 828 (1997), Miao, X., et al.: J. Chromatogr., 998, 133 (2003),<br></p>

<p>Applications 4-(4-Boc-piperazine-1-carbonyl)phenylboronic acid pinacol ester<br></p>

<p>Applications 4-(Bromomethyl)benzoic Acid Methyl Ester is an ester derivative of a bromoalkylated benzoic acid. 4-(Bromomethyl)benzoic Acid Methyl Ester is used in the preparation of potential anti-HIV agents. It is also used as a catalyst for rearrangement of benzylthiothiazoline derivatives in the preparation aldose reductase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cushman, M. et al.: Bioorg. Med. Chem. Lett., 8, 833 (1998); Nagao, Y. et al.: Chem. Pharmac. Bull., 36, 509 (1988);<br></p>

<p>Applications Intermediate for the synthesis of enantiopure substituted 1,4-Dioxanes. Extremely valuable and versatile alcohol used as a chiral building block in organic synthesis.<br>References Bagnoli, L., et al.: Chem. Eur. J., 17, 993 (2011)<br></p>

<p>Applications VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by Scopolamine (S200000) in a preclinical rodent model.<br>References Bridges, et al.: Bioorg. Med. Chem. Lett., 20, 1972 (2010); Lebois, et al.: ACS Chem. Neurosci., 1, 104 (2010),<br></p>

<p>Applications Benzyl Isocyanate is a general reagent used in the synthesis of complex bisindolylmethanes. Also used in the preparation of urea derivatives of thiazol-2-ethylamines for their anti-trypanosomal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Patrick, D. et al.: Bioorg. Med. Chem., 24, 2451 (2016);<br></p>

<p>Applications Niobium Pentachloride is a reagent used in the synthesis of mixed chloro-aryloxide compounds and dyes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ilin, A. et al.: J. Alloy. Comp., 748, 543 (2018); Yuan, L. et al.: Inorg. Chem., 57, 4226 (2018);<br></p>

<p>Applications 5-Methoxy-2-formylphenylboronic acid is a reagent used in the total synthesis of laetevirenol A via intramolecular Friedel-Crafts alkylation.<br>References Choi, Y. L., et al.: J. Org. Chem., 77, 8762 (2012)<br></p>

<p>Applications Ammonium Bicarbonate is a useful reagent in the synthesis of double-shelled CoMn2O5 hollow microcubes used as anode material for lithium-ion batteries.<br>References Zhou, L., et al.: Adv. Mater., 24, 745 (2012);<br></p>

<p>Applications LY2157299 is a TGF-β type I receptor kinase inhibitor. LY2157299 has been used to inhance chemotherapy action against triple negative breast cancer (TNBC).<br>References Bhola, N.E., et. al.: J. Clin. Invest., 123, 1348 (2013)<br></p>

<p>Applications Mirin is an MRN-ATM pathway inhibitor blocking 3’ and 5’ exonuclease activity associated with Mre11, inducing G2 cell cycle arrest.<br>References Shibata, A. et al.: Mol Cell., 53, 7 (2014);<br></p>

<p>Applications Sodium Cyanide is used in the synthesis of antihypertensive agents, such as 2-amino-4-aryl-2-imidazolines. Also used in the synthesis of nonpeptidic cyanamides as potent reversible inhibitors of human cathespins K and L.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matier, W. et al.: J. Med. Chem., 16, 901 (1974); Falgueyret, J. et al.: J. Med. Chem., 44, 94 (2001);<br></p>

<p>Applications SCH772984 is a novel and selective inhibitor of ERK1/2 that displays behaviors of both type I and type II kinase inhibitors and has nanomolar cellular potency in tumor cells with mutations in BRAF, NRA5, or KRAS and induces tumor regressions in xenograft models.<br>References Morris, E. J., et. al.: Cancer Discovery, 3, 742 (2013)<br></p>

<p>Applications 1,2-Diformylhydrazine as a bidentate ligand forms 1:1 metal to ligand complexes with transition metals Mn, Zn and Ni. It combines with iron (II) and iron(III) in alkaline conditions to a complex of an intense red-purple color making it a useful reagent in spectrophotometric analysis of iron(II) and iron(III). It was observed that mice were more likely to develop lung tumor when administered 1,2-Diformylhydrazine as a 2% solution.<br>References Nagabhushana, B., et al.: Anal. Bioanal. Chem., 373, 299 (2002); Bhargavi, G., et al.: P. Indian As-chem. Sci., 115, 23 (2003); Toth, B., Z. Krebsforsch. Klin. O., 92, 11 (1978);<br></p>

<p>Applications Diethylenetriamine-pentaacetic acid calcium trisodium salt<br></p>

<p>Applications L-(-)-Lactide is a cyclic lactic acid derivative used in the ring-opening polymerization of Poly-L-lactic acid (PLLA), which is commonly found in biodegradable plastics. Polymers derived from L-(-)-Lactide also provide a therapeutic use in the field of prosthetics as they do not have any adverse effects on proliferation and differentiation of bone cells.<br>References Nakamura, T. et al.: J. Biomed. Mat. Res., 23, 1115 (1999); Otto, T.E. et al.: J. Biomed. Mat. Res., 32, 513 (1996); Kale, G. et al.: Pach. Technol. Sci., 20, 49 (2007);<br></p>

<p>Applications L-AP3 is a selective antagonist of the PI-linked metabotropic glutamate response.<br></p>

<p>Applications Triethyl Orthoacetate is used in the preparation of potent and selective human A3 adenosine receptor antagonists. Also used in the preparation of 1,3,4-oxadiazoles for potential antimicrobial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Squarcialupi, L. et al.: J. Med. Chem., 56, 2256 (2013); Vodela, S. et al.: Chin. Chem. Lett., 24, 625 (2013);<br></p>

<p>Applications (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic Acid Methyl Ester is a dioxolane derivative used in the preparation of matrix metalloproteinases (MMP) inhibitors.<br>References Wada, C.K. et al.: J. Med. Chem., 45, 219 (2002); Chang, S.-J. et al.: Org. Proc. Res. Dev., 6, 329 (2002);<br></p>

<p>Applications LY 2874455 is a pan-FGFR inhibitor which remain the focus of research for use in lung and bladder cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gozgit, J. et al.: Mol. Cancer Ther., 11, 690 (2012); Zhao, G. et al.: Mol. Cancer Ther., 10, 2200 (2011);<br></p>

<p>Applications Tetrapropylammonium bromide (cas# 1941-30-6) is a useful research chemical.<br></p>

<p>Applications 2-Chlorobenzaldehyde Oxime is a chemical reagent used in the synthesis of antimicrobial hydroxamates which are potential inhibitors of deoxy-D-xylulose 5-phosphate synthase inhibiting growth of influenzae. Also used in the preparation ofsubstituted oxazole based firefly luciferase inhibitors.<br>References Poutiainen, P. et al.: J. Med. Chem., 56, 1064 (2013); Hayashi, D. et al.: Chem. Comm., 49, 5535 (2013);<br></p>

<p>Applications 4-Methylphenethylamine is the monomethylated derivative of phenethylamine (P321335) and can readily cross the blood-brain barrier in rats showing a brain-uptake index of 98%.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mosnaim, A. D., et al.: Neurochem. Res., 38, 842 (2013)<br></p>

<p>Applications Bis(triphenylphosphoranylidene)ammonium chloride is a catalyst that is used in the preparation of 5-Hydroxy-clethodim Sulfoxide (H918380). 5-Hydroxy-clethodim Sulfoxide is an impurity of Clethodim (C573250), a post-emergent herbicide. Bis(triphenylphosphoranylidene)ammonium chloride is also a useful new reagent for the synthesis of nucleoside-5’-di and triphosphates.<br>References Falb, L.N., J. Agric. Food Chem., 38, 875 (1990); Hunter., J.H., et al.: Weed Technol., 9, 432 (1995); Beistein J. of Org. Chem. 11: 469 (2015)<br></p>

<p>Applications A Nicotinic acid (N429250) analogue used as a growth factor in Erwinia amylovora growth (pear and apple blossoms).<br>References Davis, A., et al.: Planta, 205, 305 (1998), Valls, F., et al.: J. Agric. Food Chem., 48, 3392 (2000), Gardener, M., et al.: J. Chem. Ecol., 2001, 27, 2545 (2001),<br></p>

<p>Applications 2,3-Pyrazinedicarboxylic Acid has been found to exhibit antifungal and antibacterial acitivity. It has also been used as a reagent in the preparation of transition metal pyrazinedicarboxylate complexes.<br>References Beaula, T.J., et al.: Spectrochim. Acta A, 138, 723 (2015); Premkumar, T., et al.: World J. Microb. Biot., 21, 479 (2005); Gunay, G., et al.: Inorg. Chim. Acta, 399, 19 (2013)<br></p>

<p>Stability Air Sensitive<br>Applications A multifunctional compound which shows antioxidant activity in a skin cell model of UVA-induced stress.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sies, H., et al.: Eur. J. Biochem., 215, 213 (1993), Meotti, F., et al.: Environ. Res., 94, 276 (2004),<br></p>

<p>Applications Sodium diformamide, 98% (cas# 18197-26-7) is a useful research chemical.<br></p>