Estándares farmacéuticos

Applications A compund from thermal decomposition of Capsaicin, as a possible carcinogen. E/Z = 4.4/1 (by NMR).
References Fusco, B., et al.: Drugs, 53, 909 (1997), Buisman, G., et al.: Biotechnol. Lett., 20, 131 (1998), Kobata, K., et al.: Bios. Biotechnol. Biochem., 66, 319 (2002), Aluru, M., et al.: J. Exp. Bot., 54, 1655 (2003),

Applications An intermediate used in the preparation of Zanamivir derivatives.
References Andrews, D., et al.: Eur. J. Med. Chem., 34, 563 (1999), Altamore, T., et al.: Bioorg. Med. Chem., 14, 1126 (2006),

Applications 1-Acetyl-N-(5,6,7,8-tetrahydronaphthalen-1-yl)-4,5-dihydro-1h-imidazol-2-amine is a useful synthesis intermediate.

Applications 6-Methoxy-m-cresol is a useful chemical reagent. It has been found as one of the chemical constituent of phytoncides and has antioxidative activity.
References Abe T., et al., Aroma Res., 7, 56-62 (2006)

Applications Diethyl 2,2'-((((6-chloroquinoxaline-2,3-diyl)bis(oxy))bis(4,1-phenylene))bis(oxy))dipropanoate is an intermediate used in the preparation of ethyl 2-[4-(3-fluoro-2-quinoxalinyloxy)phenoxy]propanoate, a new fluoro analog of the herbicide quizalofopethyl.
References Makino, K., et al.: J. Fluorine Chem., 37, 119 (1987)

Applications Cresyl Diphenyl Phosphate-d7 Isomer 2 is the deuterated form of Cresyl Diphenyl Phosphate (C783015), which is a phosphorus flame retardant additive.
References van der Veen., et al.: Chemosphere, 88, 1119 (2012);

Applications trans-2-Chloro-3-((1r,4r)-4-phenylcyclohexyl)naphthalene-1,4-dione is an intermediate in the synthesis of Atovaquone derivatives (A793500).

Applications 1-(4-Nitrophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Applications An intermediate of Rosuvastatin (R700500).
References Laufer, S., et al.: J. Med. Chem., 45, 2733 (2002), Palani, A., et al.: Bioorg. Med. Chem. Lett., 13, 709 (2003),

Applications 6-Chloro-2,3-dihydro-1-oxo-1H-isoindole-5-carboxylic Acid Methyl Ester is a useful synthetic intermediate.

Stability Hygroscopic
Applications A main Levomepromazine metabolite
References Hals, P., et al.: Human Toxicol., 3, 497 (1984), Cutroneo, P., et al.: J. Pharm. Biomed. Anal., 41, 333 (2006),

Applications N-Guanyl-S-Methyl-Isothiourea Hydroiodide is a reactant used in the synthesis of novel compounds that may be used as HIV entry inhibitors.
References Wilkinson, R. et al.: Antimicrob. Agents Chemother., 55, 255 (2011);

Applications 2-[(naphthalen-2-yloxy)methyl]oxirane is a monoesters of ibuprofen where are used as prodrugs with analgesic activity
References Soltani Rad. et al., Bioorg. Chem. 107, 104570(2021)

Applications A metabolite of Eplerenone. Used in combination therapy for treatment of cardiovascular disorders.
References Staessen, J., et al.: J. Endocrinol., 91, 457 (1981), de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), MacFadyen, R., et al.: Cardiovasc. Res., 35, 30 (1997),

Stability Hygroscopic
Applications Intermediate in the synthesis of luminescent agents.

Applications 3,5-Dibromosalicylic Acid

Applications [N,N 0-Disalicylidene-1,2-ethanediaminato-(2-)]manganese(III) Chloride (cas# 53177-12-1) is a useful research chemical.

Applications 1,1'-((3,3',5,5'-Tetramethyl-[1,1'-biphenyl]-4,4'-diyl)bis(oxy))bis(propan-2-one) is an intermediate in the synthesis of Mexiletine Dimer (M340805), which is an impurity compound of Mexiletine (M340800), an antiarrhythmic (class IB).
References Singh, E.M., et al.: Br. J. Pharmacol., 44, 1 (1972); Scott, K.N., et al.: Drug Metab. Dispos., 1, 506 (1973); Chew, C.Y.C., et al.: Drugs, 17, 161 (1979); Abounassif, M.A., et al.: Anal. Profiles Drug Subs., 20, 433 (1991);

Applications Prostanozol (P838700) derivative.

Applications Olopatadine Isopropyl Ester-d6 is labelled Olopatadine Isopropyl Ester (O575025), an intermediate used to prepare Olopatadine (O575000, HCl salt) via Wittig reaction. Olopatadine is a dual acting histamine H1-receptor antagonist and mast cell stabilizer.
References Kamei, C., et al.: Arzneim.-Forsch., 45, 1005 (1995); Sharif, N.A., et al.: J. Pharmacol. Exp. Ther., 278, 1252 (1996); Abelson, M.B., et al.: Am. J. Ophthalmol., 125, 797 (1998); Silva, G., et al.: Eur. Pat. Appl., EP 2145882 A1 20100120 (2010)

Applications Benzoic-3,5-d2 Acid (CAS# 37960-84-2) is a useful isotopically labeled research compound.

Stability Hygroscopic
Applications 3,​3',​3''-​(2,​4,​6-​boroxintriyl)​tris-Pyridine Hydrochloride is a compound useful in organic synthesis.

Applications Phosphoric Acid Tris(3-​methylphenyl) Esteris a human urinary organophosphate flame retardant metabolite. It is also used to study properties of supercooled liquids.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Schindler, B., et al.: J. Chromat. B, 877, 375 (2009); Heuberger, G., et al.: J. Phys. Chem., 100, 15255 (1996); Blochowicz, T., et al.: J. Chem. Phys., 118, 7544 (2003)

Applications Metabolite from phenanthrene degradation.
References Pinyakong, O. et al.: FEMS Microbiol. Lett. 191, 115 (2000)

Impurity Irbesartan Bromo N2-Trityl Impurity
Stability Moisture Sensitive
Applications An intermediate in the synthesis of Losartan and Valsartan.

Stability Hygroscopic
Applications 4-Amino-4'-nitrostilbene-2,2'-disulfonic Acid Disodium Salt (cas# 6634-82-8) is a compound useful in organic synthesis.
References Taylor, A., et al.: Biochem., 38, 11172 (1999),

Applications 5,6,7,8-Tetrahydronaphthalene-1-carbonyl Chloride is used in the synthesis of a sweetening agent, N-5,6,7,8-Tetrahydro-1-naphthoyl-α-L-glutamyl-5-amino-2-pyridine carbonitrile.
References Nofre, C., et al.: Eur. Pat. Appl. (1992), EP 511087 A1

Applications 1-(2’,5’-Dimethoxyphenyl)-2-azidoethanone (cas# 329039-62-5) is a compound useful in organic synthesis.

Applications 4,4'-Bi(1,2-naphthoquinone) is a reagent used in the preparation of antimalarial agents.
References Archer, S., et al.: Journal of Medicinal Chemistry, 23, 516 (1980);

Applications N-(1-Ethylpropyl)-N-methyl-β-alanine is a compound useful in organic synthesis.

Applications Cholesterol-d6 has been used in safe procedures to measure the percentage of cholesterol absorption, based on that of D. B. Zilversmit (1972), by using Cholesterol-d6 as a stable nonradioactive isotopic tracer of cholesterol that was administered orally into normal individuals to facilitate clinical investigation.
References Bosner, Matthew S., Journal of Lipid Research, 34, 1047-53, (1993)

Stability Hygroscopic
Applications Guanosine 3',5'-cyclic monophosphate is an intracellular second messenger which are involved in the transduction of a diverse array of stimuli, mediating metabolic and growth regulation.
References Aladelokun, O., et al.: Curr. Drug Metab., 18, 1132-1135 (2017)

Applications 1-Acetyl-2-[1-(2-naphthyl)ethyl]benzene (cas# 1246820-30-3) is a compound useful in organic synthesis.

Applications 4,4'-Diamino-2,2'-bipyridine is a bidendate chelator.

Applications 2'-O-Methyl-d3 Paclitaxel is a labeled analogue of 2'-O-Methyl Paclitaxel (M326135), a potential cytotoxic agent.
References Kant, J., et. al.: Bioorg. med. Chem. Lett., 3, 2471 (1993)

Applications 2-Cyano-2-(hydroxyimino)acetic Acid is a degradation product of Cymoxanil (C988995), which is a fungicide applied as a seed treatment or as a foliar application to the plants to control late blight. It is an effective ligand for Cu2+ and Ni2+ ions over a broad pH range and useful reagent for synthesizing chelating agents.
References Morrica, P., et al.: J. Agric. Food Chem. 52, 99 (2004); Dhingani, J. C., et al.: J. Pure. App. Microbiol., 6, 1683 (2012); Bakirici, G.T., et al.: Food. Chem., 135, 1901 (2012); Sliva, T. Y., et al.: Dalton Trans. 11, 1863 (1998)

Applications 2-(3-Nitrophenyl)ethanamine (cas# 83304-13-6) is a useful research chemical.

Applications Labelled analogue of Fenthion Sulfoxide, the sulfoxide anlogue and metabolite of the organothiophosphate insecticide Fenthion (F278000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wallnoefer, P. et al.: Pflanzensch.-Nach., 29, 236 (1976); Minelli, E.V. et al.: J. Agric. Food. Chem., 44, 936 (1996);

Applications (3R,3'R)-N,N'-(ethane-1,2-diyl)bis(3-amino-4-(2,4,5-trifluorophenyl)butanamide) is a useful chemical reagent.

Applications Didemethyl Curcumin-d6 is an isotope labelled form of Didemethyl Curcumin(D439500); a metabolite of Curcumin (C838500) with potent activity against Trypanosoma and Leishmania species.
References Asai, A., et al.: Life Sci., 67, 2785 (2000), Sharma, R., et al.: Eur. J. Cancer, 41, 1955 (2005), King, R., et al.: Curr. Drug Metab., 7, 541 (2006),

Applications 2-Nitromorphine is an intermediate in the synthesis of 3-O-(Codein-2-yl)morphine (C634500), an impurity of Codeine (C634075).
References Chatterjie, N., et al.: Syn. Commun., 9, 647 (1979);

Applications (2,6-difluorobenzoyl)urea (cas# 1342075-20-0) is a useful research chemical.

Stability Hygroscopic
Applications Nicotine-N-(4-deoxy-4,5-didehydro)-β-D-glucuronide is a possible metabolite of Nicotine (N412420).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Hydrazinecarboximidothioic Acid Methyl Ester Hydroiodide

Applications O-Methyl Oxazepam Acetate is an impurity of Oxazepam (O845700), which is an anxiolytic; muscle relaxant (skeletal); anticonvulsant; ligand for the GABAA receptor benzodiazepine modulatory site. Controlled substance (depressant).
References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Sisenwine, et al.: Arzneim. Forsch., 22, 682 (1972), Shearer, C.M., et al.: Anal. Profiles Drug Subs., 3, 441 (1974), Greenblatt, D.J., et al.: Clin. Pharmacokinet., 6, 89 (1981),

Stability Temperature Sensitive
Applications It is used in efficient synthesis of 1β-O-acyl glucuronides via regioselective acylation of allyl or benzyl D-glucuronate.Αcyl glucuronides are known metabolites of important drugs.
References Kaspersen, F., et al.: Xenobiotica, 17, 1451 (1987), Ebner, T., et al.: Drug Metab. Dispos., 27, 1143 (1999), Shipkova, M., et al.: Ther. Drug Monit., 25, 1 (2003), Stachulski, A., et al.: J. Med. Chem., 49, 6931 (2006),

Stability Moisture Sensitive
Applications Pentathiodiphosphorus(V) Acid P,P′-Bis(pyridinium betaine) is an thionating agent used in synthetic chemistry.
References Bergman, J., et al.: J. Org. Chem., 76, 1546 (2011);

Applications A prototypical BCRP inhibitor. Inhibits the Bcrp1-mediated transport.
References Neville, K., et al.: Clin. Cancer Res., 10, 2525 (2004), Reardon, D., et al.: J. Clin. Oncol. 23, 9359 (2005), Pan, G., et al.: Drug Metab. Dispos., 35, 1165 (2007),

Applications Artemether Succinate Dimer is a derivative compound of Artemisinin (A777500), an antimalarial.
References Klayman, D.L., et al.: Science, 228, 1049 (1985); Price, R.N., et al.: Expert Opin. Invest. Drugs, 9, 1815 (2000); Meshnick, S.R., et al.: Int. J., Parasitol., 32, 1655 (2002);

Applications (±)-Napropamide-d10 (N,N-diethyl-d10) is a useful isotopically labeled compound of Napropamid (N378700)

Applications 3-Chloro-5-fluoro Clodinafop Propargyl is an impurity of Clodinafop Propargyl (C584515), which is a herbicide that is used for weed control in wheat.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Aliverdi, A., et al.: Weed Biol. Management, 9, 292 (2009), Hochberg, O., et al.: Weed Res., 49, 37 (2009), Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010),

Applications b-Phenylethyl Furoate (cas# 7149-32-8) is a useful research chemical.

Applications A thienopyrimidine derivative as herbicides.
References Kourounakis, A., et al.: Drug Dev. Res., 2000, 49(4), 227 (2000),

Applications 4’-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-[1,1’-biphenyl]-4-carboxylic Acid is a building block for the preparation of vitronectin receptor antagonists.
References Neustadt, B.R., et. al.: Bioorg. Med. Chem. Lett., 8, 2395 (1998)

Stability Hygroscopic
Applications 3,3',5-triiodo-β-hydroxy-D/L-thyronine is an impurity or analog of 3,3’,5-Triiodo-D-thyronine (T795375), which is a structural analogue of the thyroid hormone Thyroxine (T425600). 3,3’,5-Triiodo-D-thyronine has been shown to reduce cholesterol in blood serum.
References Mintz, D.O., et. al.: New Engl. J. Med., 266, 808 (1962)

Applications Valeryl Chloride is used in the preparation of potent inhibitors of secretory phospholipase A2. Also used in the synthesis of small-molecule inhibitors of protein geranylgeranyltransferase Type I.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Castellano, S. et al.: J. Am. Chem. Soc., 129, 5843 (2007); Hagishita, S et al.: J. Med. Chem., 39, 3636 (1996);

Applications 2,4,5-Trichlorophenoxyacetic Acid Isobutyl Ester is a component in herbicide formulation used in the protection of crops.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Noble, A. et al.: Pest. Sci., 28, 203 (1990);

Applications 2'-O-Butyryladenosine 3',5'-cyclic phosphate DMAP is an intermediate in the synthesis of 2'-O-Monobutyryladenosine-3', 5'-cyclic Monophosphate (M525120), which is an impurity of Bucladesine Sodium Salt (B689320), a cell-permeable cAMP analogue that activates cAMP dependent protein kinase (PKA) or the cAMP/PKA signaling pathway.
References Yamauchi, J., et al.: J. Neurosci., 31, 12579 (2011); Ma, D., et al.: Mol. Pharmacol., 55, 50 (1999)

Applications N-Methyl(p-tosyl)carbamic Acid Methyl Ester is a methyl ester derivative of N-[(arylsulfonyl)methyl]carbamates that display intramolecular shielding.
References Van der Werf, S. et al.: Rec. Trav. Chim. Pays-Bas, 89, 423 (1970);

Applications Intermediate in the synthesis of an impurity of Mesna (M225750).

Applications Bis(2-ethylhexyl) Azelate-d34 is the isotope labelled analog of Bis(2-ethylhexyl) Azelate (B433820); a compound used in the preparation of plasticizers.
References Nakajima, N., et al.: J. App. Polym. Sci., 95, 448 (2005); van Oosterhout, J., et al.: Polym., 44, 8081 (2003)

Applications Methyl(4-methylnaphthalen-1-ylmethyl)amine is a reagent in the preparation of heterocyclic compounds as enoyl-acyl carrier protein reductase FabI inhibitors and antibacterial agents.
References Stuetz, A., et al.: J. Med. Chem., 29, 112 (1986); Berman, J., et al.: PCT Int. Appl., 2004:515512 (2004)

Applications rac cis-Paroxetine N-Methyl is an impurity formed in the synthesis Paroxetine (P205750) related compounds.
References Gangula, S., et al.: Syn. Commun., 42, 3344 (2012);

Stability Light Sensitive
Applications (1R,​3S)​-3-​(2,​2-​Dichloroethenyl)​-​2,​2-​dimethylcyclopropanecarboxam​ide is a useful research chemical.

Applications 8-Fluoro-5-isoquinolinecarboxylic Acid Methyl Ester is a useful synthetic compound.

Applications p-Nitrophenyl Acetate-13C,d3 (cas# 1794766-80-5) is a compound useful in organic synthesis.

Applications Fluorescent Brightener KSN (cas# 5242-49-9) is a useful research chemical.

Applications Filipin III is a cholesterol-binding, fluorescing antibiotic. Also, it is a pentaene macrolide produced by Streptomyces filipinensis, widely used for the detection and quantitation of cholesterol in biological membranes and as a tool for the diagnosis of Niemann-Pick type C disease;Polyene antibiotic, most extensively used tool for the specific detection of fluorescently labeled 3-β-hydroxysterols.
References Payero, T. D., et al.: Microb. Cell Fact., 14, 1-14 (2015); Stanislas, T., et al.: Methods Mol. Biol., 1209, 13-29 (2014)

Applications 6-Chloro-2-cyclohexyl-2,3-dihydro-1,3-dioxo-1H-isoindole-5-sulfonamide is an intermediate in the synthesis of Chlorexolone (C327080), a sulfonamide based antibiotic.

Applications An intermediate for the prepararion of 1-Hydroxypyrene β-D-Glucuronide, a metabolite of 1-Hydroxypyrene.