Estándares farmacéuticos

Applications 7-Methoxy-1-naphthalenol is used in the synthesis of Agomelatine (A430000).

Applications 6,9,12,15,18-Heneicosapentaynoic Acid Methyl Ester is a methyl analog of 6,9,12,15,18-Heneicosapentaynoic Acid.

Applications Intermediate for the synthesis of 2-Hydroxymethyl Loratadine.
References Cerrada, V., et al.: ARKIVOC, 9, 200 (2005).

Applications 2'-​Amino-​5'-​(4-​carboxyphenyl)​-[1,​1':3',​1''-​terphenyl]​-​4,​4''-​dicarboxylic Acid is used in the synthesis of Zinc Imidazolate Tris(carboxyphenyl)aniline Metal Organic Frameworks (MOFs).
References Fu, H., et al.: Inorg. Chem., 55, 3928 (2016)

Applications 2-Hydroxybutanoic-d3 Acid Sodium Salt is the labeled analogue of a degredation product of isotactic P[(R)-2-hydroxybutyrate] and Its copolymer with (R)-Lactate.
References Matsumoto, K., et. al.: Biomacromolecules, 14, 1913 (2013)

Stability Moisture Sensitive
Applications 1-Naphthyl Isocyanate was used in the preparation of cationic aromatic urethane.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References McEntyre, C.J., et al.: Anal. Chim. Acta, 644, 90-94 (2009)

Applications Bromo-2’-nitroacetophenone is used in the novel synthesis of 5-pyridylindolizine derivatives.
References Georgescu, E. et al.: J. Hetero. Chem., 50, 78 (2013);

Applications 4-Hydroxymethylbicyclo[2.2.2]octane-1-carboxylic Acid Methylamide-d3 is the isotope labelled analog of 4-Hydroxymethylbicyclo[2.2.2]octane-1-carboxylic Acid Methylamide (H946935); a useful synthetic intermediate.

Applications 2,2',4,4'-Tetranitro-1,1'-biphenyl is an intermediate used in the synthesis of substituted dibenzophospholes.
References Cornforth, J., et al.: J. Chem. Soc. Perkin Transactions 1:  Organic and Bio-Organic Chemistry, 10, 2299 (1982)

Applications Testosterone-16,16,17-d3 Hexanoate is a useful isotopically labeled compound of Testosterone Hexanoate (T155125)

Applications 3-(Triisopropylsilyl)oxy-isourolithin A is an intermediate for the synthesis of Isourolithin A 9-Glucuronide (I917525), which is a metabolite of ellagitannins and ellagic acid in different mammals.
References Gonzalez-Barrio, R., et al.: J. Agric. Food Chem., 59, 1152 (2011)

Applications (3,4-Dinitrophenyl)(phenyl-d5)methanone is an intermediate for the synthesis of Mebendazole-d8 (M200502), which is labelled Mebendazole (M200500). Anthelmintic (Nematodes).
References Al-Badr, A.A., et al.: Anal. Profiles Drug Subs., 16, 291 (1987)

Applications Lactosyl-C18-sphingosine has been found to have a strong interaction with HIV-1 Gp120.
References McReynolds, K.D., et. al.: Bioconjugate Chem., 10, 1021 (1999)

Applications 2-Amino-3-chlorobenzoic Acid is a plant growth regulator.
References James, C. S., et a.: Ann. Appl. Biol., 61, 295 (1968)

Applications 1-(2-Nitroethyl)-2-naphthol is an aromatic alcohol that is used in photoacid for extremely long lived and reversible pH jumps.
References Nunes, R.M.D., et al.: J. Am. Chem. Soc., 131, 26 (2009);

Applications 3'-O-Levulinoyl-N-benzoyl-2'-deoxycytidine is a protected nucleotide derivative/building block.
References Kiuru, E., et al.: Helvetica Chimica Acta, 96, 1997-2008 (2013);

Applications (±)-Zopiclone-d3 (N-methyl-d3) (CAS# 1398066-10-8) is a useful isotopically labeled research compound.

Applications 4-Chlorosulfonylcinnamic Acid (cas# 17641-30-4) is a compound useful in organic synthesis.

Applications (+)-Carotol is an essential oil extracted from Seseli libanotis plant. A natural product.
References Chizzola, R.: Chem. Biodivers., 16, 6 (2019), El O., et al.: Res. J. Pharm. Biol. Chem. Sci., 9, 1524 (2018)

Applications 2-[2-(4’-Chloro-biphenyl-4-yl)-2-oxo-ethyl]acrylic Acid (cas# 58211-82-8) is a compound useful in organic synthesis.

Applications 1-(3-Bromophenyl)thiourea
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications METHYL 2-METHYL-1-OXO-1,2,3,4-TETRAHYDRONAPHTHALENE-2-CARBOXYLATE (cas# 54125-61-0) is a useful research chemical.

Applications A 9-substituted derivative of the polycyclic aromatic hydrocarbon (PAH) Anthracene (A678400).

Applications 1,2,3,4-Tetrahydro-1,2,8-naphthalenetriol is a reagent is used in the preparation of pharmaceuticals and in organic synthesis.

Applications Benzyl 4-Nitrophenyl Carbonate is used as a reagent in the synthesis of Janus PEG-based dendrimers for use in combination therapy by controlled multi-drug loading and sequential release. Benzyl 4-Nitrophenyl Carbonate is also used as a reagent in the synthesis of Norfloxacin analogs which can exhibit antibacterial and antifungal activities under visible and UV light.
References Acton, A.L., et al.: Biomacromolecules, 14, 564 (2013); Bakhotmah, D.A., et al.: ISRN Org. Chem., 184754, 11 (2011)

Applications BIS(4-NITROPHENYL) SULFONE (cas# 1156-50-9) is a useful research chemical.

Applications Isotope labelled δ-Valerolactone used in the synthesis of various antibiotics including the ionophore antibiotic X-14547A. Also used in the preparation of polyesters via copolymerization.
References Nicolaou, K. et al.: J. Org. Chem., 50, 1440 (1985); Parrish, B. et al.: J. Polym. Sci. Polym, Chem., 40, 1983 (2002);

Applications 2-Bromoethyl-4-nitrophenyl Ether (cas# 13288-06-7) is a compound useful in organic synthesis.

Applications 5’-Cholesteryl-TEG Phosphoramidite is used in the synthesis of immunostimulatory oligonucleotides for in vivo cell modification for immunotherapy.
References Liu, H. et al.: Angew. Chem. Int. Ed., 50, 7052 (2011);

Applications α-(Bromomethyl)-α-butyl-4-chlorobenzeneacetonitrile-d9 is an intermediate used in the synthesis of Myclobutanil-d9 (M831402), which is the labeled analogue of Myclobutanil (M831400), an fungicide used on a wide range of food crops. Myclobutanil inhibits the biosynthesis of ergosterol, a critical component of fungal membranes.
References Kumar, A., et al.: J. Mycol. Plant. Pathnol., 42, 443 (2012); An, Y.R., et al.: Toxicol., 303, 94 (2013); Keinath, A.P., et al.: Crop. Protect., 42, 338 (2012);

Applications Bis(carboxyethylgerm​anium) Sesquioxide is a reagent used in the synthesis of carbon nanotubes.
References She, X. et al.: ACS App. Mat. Inter., 8, 10383 (2016);

Applications (4-Chloro-3-nitrophenyl)-(2-thienyl)methanone (cas# 31431-18-2) is a compound useful in organic synthesis.

Applications 4-tert-Butyldimethylsiloxyacetophenone is an intermediate in the synthesis of 1-(4-(2-Cyclobutoxyethyl)phenoxy)-3-(isopropylamino)propan-2-ol (C988245), which is a derivative of Betaxolol (B328000).
References Philippe, M.M., et. al.: Am. Chem. Soc., 30, 1003 (1987)

Applications 3,4-Dihydro-1H-indolo[2,3-b][1,8]naphthyridin-2(10H)-one, is a derivative of 6,7,8,9-Tetrahydro-7-hydroxy-5-methyl-3-phenyl-pyrido[3’,2’:4,5]imidazo[1,2-a]pyrimidinium Chloride (H957770), a carcinogen used in the study of intestinal bacteria metaboism. Created through the heat processing of food.
References Vanhaecke, L.. et al.: Food Chem. Toxicol., 46, 140 (2008);

Applications Methyl trans-Cinnamate is one of the odour active compounds of Tahitian vanilla flavour and basil oil. Methyl trans-Cinnamate is naturally found in Magnolia liliflora oil, which is used to create a variety of nematicides. Methyl trans-Cinnamate also inhibits mushroom tyrosinase and has antimicrobial effects against Escherechia coli in food.
References Adams, A., et al.: J. Am. Oil Chem. Soc., 88, 201 (2011); Blank, A., et al.: Ind. Crop. Prod., 38, 93 (2012); Brunschwig, C., et al.: Food Res. Int., 46, 148 (2012); Huang, Q., et al.: J. Agr. Food Chem., 57, 2565 (2009)

Applications 3',5'-Dihydroxyacetophenone is a dihydroxy derivative of acetophenone. 3',5'-Dihydroxyacetophenone shows inhibitory activity towards plant germination and growth as well as some antitumor activity.
References Lohaus, E. et al.: Zeitsch. Naturforsch. C J. Biosci., 37C, 802 (1982); Nakamura, E.S. et al.: Cancer Lett., 177, 119 (2002);

Applications N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N,4-dimethyl-1-naphthalenemethanamine-d3 is an isotope labelled impurity of Terbinafine (T107500), an orally active, antimycotic allylamine and a specific inhibitor of squalene epoxidase.
References Petranyi, G., et al.: Science, 224, 1239 (1984); Ryder, N.S., et al.: Antimicrob. Agents Chemother., 27, 252 (1985); Evans, E.G.V., et al.: Br. Med. J., 318, 1031 (1999);

Applications 2-Hydroxy-3-(carboxymethylamino)-hydrocinnamic Acid, Dipotassium Salt (cas# 100750-38-7 ) is a compound useful in organic synthesis.

Applications 3-(4-Hydroxyphenyl)propionic Acid-d4 is the deuterated isotope of 3-(4-Hydroxyphenyl)propionic Acid (H9508200). Antioxidant
References Arnous, A., et al.: J. Agr. Food Chem., 49, 5736 (2001)

Applications Testosterone-2,2,4,6,6-d5 Benzoate is a useful isotopically labeled compound of Testosterone Benzoate (T155015)

Applications 5-Chloronaphthalen-1-amine

Applications N,N’-Bis(3-pyridyl)urea (cas# 39642-60-9) is a compound useful in organic synthesis.

Applications 1-[(2-Nitrophenyl)sulfonyl]-1H-pyrrole is used in the preparation of various 2-​substituted N-​nosylpyrroles.
References Shibata, M. et al. Tetrahedron. 71, 4495 (2015);

Applications Methyl Cyano(2-nitrophenyl)acetate (cas# 113772-13-7) is a compound useful in organic synthesis.

Applications Pimelic Acid-d4 is the labelled form of Pimelic Acid (P445040). Pimelic Acid is a metabolite found in four biofluids from dairy cows that may be used as biomarkers of milk.
References Sun, H., et. al.: J. Proteome Res., 14, 1287 (2015)

Applications Methyl trans-Cinnamate-d5 (phenyl-d5) (CAS# 61764-82-7) is a useful isotopically labeled research compound.

Applications Intermediate for the synthesis of O-desmethylvenlafaxine.

Applications N-Fmoc-(13C9,15N)-L-Tyrosine O-Tertbutyl Ether is the isotope labelled protected form of L-Tyrosine (T899975), an essential amino acid that exhibits in vitro antioxidant and antiradical activities. L-Tyrosine is used as a precursor to synthesize catecholamines (e.g. Norepinephrine HCl [N674500]) in human keratinocytes, and also for the synthesis of proteins and thyroid hormones.
References Gülçin, ?.: Amino Acids, 32, 431 (2007); Langen, K., et al.: Nuc. Med. Biol., 29, 625 (2002); Schallreuter, K., et al.: J. Invest. Derm., 104, 953 (1995); Zhang, W., et al.: Neuropharmacology, 47, 438 (2004)

Stability Hygroscopic
Applications 2’-Deoxyisoguanosine is a nucleoside which is used to synthesize Duplex DNA and DNA/RNA hybrids and DNA mismatch pairs for analysis of helix stability.
References Ingale, S. et al.: J. Org. Chem., 80, 3124 (2015); Seela, F. et al.: ChemBioChem., 11, 1443 (2010);

Applications N-(2,2-Diethoxyethyl)-1,2,3,4-tetrahydronaphthalene-1-carboximidamide Hydrochloride is an intermediate in the synthesis of 2-(1,2,3,4-Tetrahydronaphthalen-1-yl)-1H-imidazole (T294110), which is a novel 2-imidazole derivative with potent and selective α1A adrenoceptor partial agonists.
References Whitlock, G.A., et al.: Bioorg. Med. Chem. Lett., 18, 2930 (2008);

Applications N-[2-[[(1,2,3,4-tetrahydro-1-naphthalenyl)carbonyl]amino]ethyl]-carbamic Acid 1,1-Dimethylethyl Ester is an intermediate used in the synthesis of N-(2-Aminoethyl)-1,2,3,4-tetrahydro-1-naphthalenecarboxamide Hydrochloride (A608010), which is an acidic salt of N-(2-Aminoethyl)-1,2,3,4-tetrahydro-1-naphthalenecarboxamide (A607980), a degradation product of tetrahydrozoline.
References Andermann, G., et al.: J. Pharm. Belg., 37, 309 (1982); Nicolas, A., et al.: Talanta, 31, 229 (1984); Andermann, G., et al.: J. Chromatogr., 298, 189 (1984)

Applications 7-(Hydroxymethyl)-1,8-naphthyridin-2(1H)-one is used as a reactant in the synthesis of photoswitchable unsymetrical ligands possessing pairs of different base recognition elements for DNA hetero-mismatches.
References Dohno, C., et al.: Eur. J. Org. Chem., 1, 4051 (2009);

Applications 1,3-Dihydro-N-nitro-1,3-dioxo-2H-isoindole-2-carboximidothioic acid Methyl Ester is an intermediate in the synthesis of Dinoteturan (D482100), a neonicotinoid insecticide.
References Wakita, T., et al.: J. Pesticide. Sci., 29, 348 (2004);

Applications Methyl(4-methylnaphthalen-1-ylmethyl)amine-d3 is the isotope analog of Methyl(4-methylnaphthalen-1-ylmethyl)amine. Methyl(4-methylnaphthalen-1-ylmethyl)amine is a reagent in the preparation of heterocyclic compounds as enoyl-acyl carrier protein reductase FabI inhibitors and antibacterial agents.
References Stuetz, A., et al.: J. Med. Chem., 29, 112 (1986); Berman, J., et al.: PCT Int. Appl., 2004:515512 (2004)

Applications 9-Chlorophenanthrene is a monochlorinated phenanthracene with mutagenic activity. Studies suggest that its carcinogenicity might be associated with aryl hydrocarbon receptor signaling.
References LaVoie, E.J. et al.: Mut. Res. Gen. Toxicol. Test., 116, 91 (1983); Ohura, T. et al.: Environ. Toxicol., 24, 180 (2010);

Applications Intermediate in the preparation of Azasetron.
References Kawakita, T., et al.: Chem. Pharm. Bull., 40, 624 (1992),

Applications 2-Bromo-4-nitrophenol

Applications 2-Butoxynaphthalene (cas# 10484-56-7) is a useful research chemical.

Applications naphthalene-2-sulfonohydrazide (cas# 10151-46-9) is a useful research chemical.

Applications 1,3-Di(methyl-d3)-naphthalene is the labeled analogue of 1,3-Dimethylnaphthalene (D476385), a polycyclic aromatic hydrocarbon (PAH) that has been shown to have cytochrome P 450 2A6 and 2A5 inhibitory activities.
References Wammer, K.H., Peters, C.A.: Environ. Sci. Technol., 39, 2571 (2005); Roy, K., Roy, P.P.: Eur. J. Med. Chem., 44, 1941 (2009)

Stability Hygroscopic
Applications 3,3'-Diaminobenzidine