Antimicrobianos

<p>A broad-spectrum antibiotic of cephalosporin class, which inhibits bacterial cell wall synthesis by targeting the penicillin-binding protein, involved in peptidoglycan synthesis. This third-generation cephalosporin is very active against Pseudomonas species and can also be used to treat bacterial meningitis as it penetrates in the cerebrospinal fluid.</p>

<p>b-Apo-oxytetracycline is a tetracycline antibiotic and is used for the treatment of bacterial infections. It binds to the 30S ribosomal subunit, inhibiting protein synthesis.</p>

<p>Neospiramycin I is a macrolide antibiotic with action on bacterial ribosomes to inhibit protein synthesis and is used for treating bacterial infections in research applications.</p>

<p>Ceftazidime is a broad-spectrum beta-lactam antibiotic that inhibits bacterial growth by inhibiting penicillin-binding proteins (PBPs). It is used to treat many bacteria infections including pneumonia and septicaemia. It has shown to be effective against some treatment-resistant bacteria such as Pseudomonas aeruginosa.</p>

<p>Flucloxacillin sodium is a beta-lactam antibiotic with action on bacterial cell wall synthesis and is used for treating skin, bone, and respiratory infections.</p>

Capastat sulfate is an antibiotic with action against Mycobacterium tuberculosis by inhibiting protein synthesis and is used for treating tuberculosis.

<p>Anti-viral; inhibits Hepatitis C virus NS3/4a protease</p>

<p>Lamivudine (commonly called 3TC) is a potent nucleoside analogue reverse transcriptase inhibitor. It is one of the front line treatments for HIV.  It is an analogue of cytidine, and can inhibit both types (1 and 2) of HIV reverse transcriptase as well as the reverse transcriptase of hepatitis B. It needs to be phosphorylated to its triphosphate form before it is active.</p>

<p>Lomefloxacin is a fluoroquinolone antibiotic with a mode of action that inhibits bacterial DNA gyrase and topoisomerase IV. It is used for treating bacterial infections like bronchitis and urinary tract infections.</p>

Fosmidomycin sodium hydrate is an antibiotic, which is a natural product derived from Streptomyces lavendulae. This compound specifically inhibits the non-mevalonate pathway of isoprenoid biosynthesis by targeting 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), an essential enzyme in the pathway. By disrupting this process, fosmidomycin effectively impedes the synthesis of essential isoprenoid precursors, which are crucial for the survival and proliferation of certain bacteria and parasites.

<p>Inhibitor of protein synthesis; glycylcycline class</p>

<p>Tilmicosin is a macrolide antibiotic that is used in veterinary medicine. It is used to treat bovine respiratory disease and inhibits bacterial growth by binding to the 50S ribosomal subunit of the bacteria resulting in reduced protein synthesis.</p>

<p>Saquinavir is a HIV protease inhibitor drug that is used with other antiretroviral drugs for the treatment of HIV-1. As this drug prevents HIV protease activity, it prevents the proteolysis of the Gag polyprotein and thus results in non-infectious virus particles.</p>

Amicoumacin B is a bacterial metabolite, which is derived from *Bacillus subtilis*. This compound exhibits a strong antibacterial function by targeting bacterial ribosomes, thereby inhibiting protein synthesis. As a result, it disrupts the growth and proliferation of bacterial cells, making it effective against a broad spectrum of Gram-positive bacteria.

<p>Geneticin is very efficient against gram-negative bacteria, however it is not applied for treating infections due to high renal toxicity. Geneticin and its resistance genes found application in the selection of transgenic cell lines including yeasts such as P. pastoris and S. serevisiae, other eukaryotic cell lines such as CHO or HEK293, but also plant cells and bacterial cells.</p>

<p>Anti-viral; non-nucleoside reverse transcriptase inhibitor</p>

Antibiotic of anthracycline class; DNA synthesis inhibitor

<p>Exalamide is an arenecarboxamide antifungal agent with action on fungal growth inhibition and is used for research on fungal infections.</p>

Butoconazole nitrate is an antifungal agent and is used for the treatment of vaginal yeast infections. It inhibits the synthesis of ergosterol, disrupting the fungal cell membrane.

<p>Closantel sodium dihydrate is a salicylanilide antiparasitic agent with action on flukes, nematodes, and arthropods and is used for veterinary treatment of parasitic infections.</p>

<p>Dihydrostreptomycin B is an aminoglycoside antibiotic, which is derived from the bacterium Streptomyces griseus. This antibiotic operates by binding to the 30S subunit of the bacterial ribosome, leading to the inhibition of protein synthesis. The binding disrupts the decoding site, causing misreading of mRNA and ultimately resulting in bactericidal activity.</p>

Oritavancin diphosphate is a lipoglycopeptide antibiotic with action on bacterial cell wall synthesis and is used for treating acute bacterial skin and skin structure infections.

<p>Inhibitor of protein synthesis; streptogramin</p>

Triclabendazole is a benzimidazole anthelmintic with action on liver flukes by disrupting their microtubule formation and is used for treating fascioliasis in humans and animals.

Raltegravir is an antiretroviral agent that is used for the treatment of HIV infections. It inhibits HIV integrase in order to prevent viral genome from being inserted into the human genome. It binds to the active site of the enzyme and prevents it from binding to a target sequence on the viral DNA. This drug is metabolized by glucuronidation.

<p>N-Boc-protected -Guanidino Oseltamivir is a fine chemical that belongs to the group of versatile building blocks. It is a complex compound that has been used in research as a reagent and speciality chemical. N-Boc-protected -Guanidino Oseltamivir is an important intermediate for the synthesis of a variety of useful compounds, such as pharmaceuticals and natural products. This compound is also used as a reaction component in organic syntheses, especially for the preparation of high quality and useful scaffolds.</p>

<p>Tylosin tartrate is a macrolide antibiotic with action on bacterial protein synthesis inhibition and is used for treating bacterial infections in livestock and poultry.</p>

<p>Clofazimine is a phenazine dye antibiotic with action on bacterial DNA interference and is used for treating leprosy and erythema nodosum leprosum.</p>

<p>Inhibitor of protein synthesis; macrolide class</p>

<p>Inhibitor of hepatitis C viral enzyme NS3-4A serine protease</p>

<p>N-Demethyl roxithromycin is a metabolite of roxithromycin with action on bacterial protein synthesis inhibition and is used for research on macrolide antibiotics.</p>

Fenbendazole is a benzimidazole anthelmintic with action on microtubule formation in parasites and is used for treating gastrointestinal parasites in animals.

<p>Anti-retroviral; HIV protease inhibitor</p>

Piperaquine tetraphosphate tetrahydrate is an antimalarial compound with action on Plasmodium parasites by disrupting DNA synthesis and is used for treating malaria in combination therapies.

<p>Anti-fungal; glucan synthase inhibitor</p>

Fenticonazole nitrate is an imidazole antifungal agent with action on fungal cell membrane disruption and is used for treating fungal infections like vaginal thrush and athlete's foot.

<p>Inhibits chaperone protein HSP90; anti-proliferative; antineoplastic</p>

<p>Doxorubicin (DOX) is an antineoplastic chemotherapy drug used to treat breast, ovarian and pancreatic cancers. It is an antitumor antibiotic that inhibits DNA topoisomerase II. DOX interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. It also leads to the generation of reactive oxygen species (ROS), which further damage DNA as well as proteins and membranes. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance. Pegylated liposomal doxorubicin has also been developed to treat breast and ovarian cancers, myeloma, and HIV-related Kaposi’s sarcoma.</p>

<p>Temocillin disodium is a beta-lactamase-resistant penicillin antibiotic with action on bacterial cell wall synthesis and is used for treating infections caused by multidrug-resistant gram-negative bacteria.</p>

<p>Pimodivir is a non-nucleoside-derived inhibitor of the polymerase basic protein 2 (PB2) subunit found in the polymerase complex of the influenza A virus. In general, pimodivir is indicated for the treatment of patients with severe influenza although knowledge about possible rise of resistance is not available.</p>

<p>Dihydrostreptomycin sesquisulfate, EP is an aminoglycoside antibiotic, structurally derived from Streptomyces griseus. This compound originates from microbial biosynthesis, a method which harnesses the natural antibiotic-producing capabilities of microbial cultures. The mode of action of dihydrostreptomycin sesquisulfate involves binding to the 30S subunit of bacterial ribosomes, which interrupts the process of protein synthesis, ultimately leading to bacterial cell death.</p>

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<p>BIOSAFE® RTU Antimicrobial, 1% aqueous solution<br>BIOSAFE® Antimicrobial is a non-leaching silicon-based antimicrobial that imparts bacteriostatic, fungistatic, and algistatic properties<br>to coatings and resins for manufactured goods.<br>3-(Trihydroxysilyl)propyldimethyloctadecyl ammoniumchloride, 1% aqueous solution; 3-(Trihydroxysilyl)propyldimethyloctadecyl ammonium chloride; Octadecyldimethyl(3-trihydroxysilylpropyl)ammonium chloride, 84% active condensed; Silsesquioxanes, 3-(dimethyloctadecylammonio)propyl, hydroxy-terminated, chlorides<br>EPA Registration Number: 83019-21% of HM4100 in waterUsed in water based surface treatments and coatingsMicrobiostatic agent that protects articles from deterioration and discolorationLeach resistantActive against forms of fungi, algae, and bacteriaHigh antimicrobial performance in ISO and ASTM testingDoes not promote development of resistant microorganismsIncompatible with anionic detergentsTypical use concentrations of 0.25-0.5 wt% active relative to the substrate being treated<br>Water Based Surface Treatments<br>CarpetNon-wovensRoll goodsBuilding materialsShoesIndoor environment surfaces<br></p>

<p>BIOSAFE® Quaternary Siloxane Powder<br>BIOSAFE® Antimicrobial is a non-leaching silicon-based antimicrobial that imparts bacteriostatic, fungistatic, and algistatic properties<br>to coatings and resins for manufactured goods.<br>3-(Trihydroxysilyl)propyldimethyloctadecyl ammonium chloride; Octadecyldimethyl(3-trihydroxysilylpropyl)ammonium chloride, 84% active condensed; Silsesquioxanes, 3-(dimethyloctadecylammonio)propyl, hydroxy-terminated, chlorides<br>EPA Registration Number: 83019-1FDA Approved for Food ContactNSF 51 approvedNo VOCsUsed in resin blending, compounding, and coatingsMicrobiostatic agent that protects articles from deterioration and discolorationLeach resistantActive against forms of fungi, algae, and bacteriaHigh antimicrobial performance in ISO and ASTM testingDoes not promote development of resistant microorganismsRecommended process temperature: &lt;170 °CTypical use concentrations of 0.25-0.5 wt% active relative to the substrate being treatedIncompatible with anionic surfactantsAvailable in aqueous solutions HM4005 and HM4001<br>Resin Compatibility<br>TPU - Thermoplastic PolyurethaneUrethane FoamPolyether bock amide (PEBAX®)Silicone (not post-cured)Polyamide 6 (PA6 or nylon 6)Acrylic (cast and thermoplastic)Acrylic AdhesivesSpun FiberFiberglass Gel Coat<br>Used in Certainty® SmartBoost™ Laundry Additive<br>For more information on BIOSAFE® products, please contact Customer Service at 888.734.8344.<br></p>

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<p>Applications 2,2'-Methylenebis(4-bromophenol) can be derived from bromophenols from the red alga Odonthalia corymbifera and display potential antimicrobial activity. It is used as an intermediate in the synthesis of Albuterol Dimer (A514515) which is an impurity of the drug Albuterol used to treat asthma.<br>References Oh, K., et al.: Bioorg. Med. Chem. Lett., 18, 104 (2008); Haddad, N., et al.: Tetrahedron Lett., 43, 1135 (2002);<br></p>

<p>Applications Benzyltriphenylphosphonium Chloride was used as a reagent in the organic synthesis of several compounds including that of stabilised phosphonium ylides containing saturated oxygen heterocycles. Also used in the synthesis of novel substituted cis-stilbene derivatives which display antimicrobial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Aitken, R., et al.: Org. Biomol. Chem., 14, 1794 (2016); Jain, D., et al.: World J. Pharm. Sci., 4, 1473 (2015);<br></p>