Nucleótidos

5'-O-DMT-2'-O-methylguanosine is a novel nucleoside analog that has been modified to contain the 2' methyl group at the 5' position. This modification enhances its anticancer activity and cellular uptake by cells. The 5'-O-DMT-2'-O-methylguanosine monophosphate synthesized in this study is chemically stable, high purity, and high quality.

Coenzyme and regenerating electron donor in catabolic processes

Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure.PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes.We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products. For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

2-Thiouridine-5'-monophosphate triethylammonium salt is a synthetic nucleotide analog that inhibits the growth of cells by binding to the anticodon region, which blocks the entrance of amino acids into the ribosome. It also inhibits cell growth by preventing glycosidic bond formation and inhibiting purine metabolism. This drug has functional groups that allow it to be purified by chromatography and diffraction techniques. The drug is not active against bacteria that are resistant to glutamic acid, such as Mycobacterium tuberculosis or Mycobacterium avium complex. 2-Thiouridine-5'-monophosphate triethylammonium salt is a precursor for other drugs, such as cytidine 5'-triphosphate, which can be used in chemotherapy treatments.

Broad-spectrum anti-viral; inhibitor of HCV NS5B RNA polymerase

Pseudouridine is a nucleoside that is produced by the deamination of uridine. It has been shown to have biological properties in vitro, and may be involved in the pathogenesis of infectious diseases. Pseudouridine has been shown to act as an allosteric ligand for toll-like receptor 4. It also has a thermodynamic stability that is higher than that of uridine, which may allow it to serve as a more stable substrate for enzymes such as ribonucleotide reductase and dTMP synthetase.

ATP analog; covalent inhibitor of anthrax edema factor

5'-O-DMT-2'-O-methyl-5-methyluridine is a modified nucleoside that is used in the synthesis of DNA. It is an anticancer drug and antiviral agent. 5'-O-DMT-2'-O-methyl-5-methyluridine has been shown to inhibit the growth of leukemia cells, even when they are resistant to other drugs. It also inhibits certain viruses, such as herpes simplex virus type 1 (HSV1), by preventing viral replication and inhibiting protein synthesis. This nucleoside is synthesized from 5'-O-DMT and 2'-O-methylcytosine.

2'-deoxyisocytidine is a nucleoside that is used in biochemical research. It can be synthesized by two methods: solid-phase synthesis and depyrimidination. 2'-deoxyisocytidine has been shown to be more efficient than other fluorescent nucleosides when used with the excimer laser technique. The stability of this compound has also been shown to be greater than other fluorescein-based compounds, which makes it an appropriate substitute when using phosphoramidite chemistry.

5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside is a chemical compound that has been shown to be neurotoxic in vitro. It has significant cytotoxicity against human leukemia cells (HL60) and induces neuronal death. This drug also inhibits the production of neurotrophic factors, which are vital for the normal development of neurons. 5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside inhibits transcriptional regulation of genes that encode for receptors and enzymes. The compound is chemically stable and does not degrade easily by hydrolysis or oxidation. It can bind to polymerase chain reaction (PCR) primers and inhibit DNA synthesis. 5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside also affects cell nuclei by inhibiting DNA synthesis and enzyme activities.

5'-O-methylthymidine is an antiviral, monophosphate nucleoside that is structurally similar to thymidine and cytidine. 5'-O-methylthymidine has been shown to inhibit the growth of cancer cells in vitro. The mechanism by which 5'-O-methylthymidine inhibits the growth of cancer cells is not known but may be due to its ability to act as a diphosphate activator or a deoxyribonucleoside phosphoramidite.

2'-O-(2-Methoxyethyl)guanosine is a guanosine derivative isolated from the reaction of 2-aminoadenosine with methylsulfonyl chloride. This compound has been shown to react with aromatic hydrocarbons to form a reagent that is useful for the alkylation of nucleophilic groups in organic synthesis.

3'-O-Methyl-5-methylcytidine is a nucleoside with antiviral and anticancer properties. It has been shown to be an activator of RNA polymerase, the enzyme that catalyzes the transcription of DNA into RNA. 3'-O-Methyl-5-methylcytidine binds to the active site of RNA polymerase and is able to stimulate transcription in vitro. This drug has also been shown to have high purity and high quality.

[1,2,4]Triazolo[1,5-a]pyrimidine-2-carboxylic acid is a heterocyclic compound made up of a pyrimidine ring and a triazole ring. It can be used in research applications

9-(2',3',5'-Tri-O-acetyl-b-D-ribofuranosyl)-6-chloropurine is an anticancer drug that belongs to the class of nucleosides. It is a modified nucleoside with a 2'-deoxyribose sugar and a 6-chloropurine base. The synthesis of 9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)-6-chloropurine can be achieved by phosphoramidite chemistry. Modified nucleosides have been found to have high antiviral and antitumour activities, as well as being promising for the treatment of HIV infections. 9-(2',3',5'-tri-O acetyl b D ribofuranosyl)-6 chloropurine has also been shown to inhibit the replication of RNA in cells infected with HIV, although it has not yet been used in humans.

N6-Benzoyl-5'-O-tert-butyldimethylsilyl-2'-deoxyadenosine is an anti-cancer drug that is used to inhibit the growth of cancer cells in vitro. It has been shown to induce apoptosis in human leukemia cells and may be a novel anticancer agent. This compound has also been shown to have antiviral activity against HIV, herpes simplex virus type 2, hepatitis B virus, and influenza A virus. N6-Benzoyl-5'-O-tert-butyldimethylsilyl-2'-deoxyadenosine is phosphoramidites are synthesized by treatment of 2'-deoxyadenosine with diphosphate in the presence of trimethylammonium tetrafluoroborate or hexafluoroantimonate. The final product contains a benzoyl moiety on the 6' position and a tertiary butyl group

5-Carbamoylmethyluridine is a nucleoside that is structurally related to uridine. It is synthesized from uridine by methyl esterification with carbamic acid and methoxycarbonyl chloride. 5-Carbamoylmethyluridine interacts with actin filaments and has been shown to alter the expression of messenger RNA in eukaryotes. 5-Carbamoylmethyluridine also acts as a competitive inhibitor of the formation of a ternary complex, which includes ATP, GTP, and UTP, at the level of ribonucleotide reductase. This inhibition leads to decreased synthesis of messenger RNA in cells.