Nucleósidos

<p>Adenosine-2-carboxamide (ACA) is a potent and selective adenosine A2A receptor ligand with high affinity and selectivity. This drug has been shown to be a competitive antagonist of the adenosine A2A receptor with an IC50 of 0.8 nM and was highly selective for this receptor over the other adenosine receptors. ACA has also been shown to inhibit binding of radioligands to the adenosine A2A receptor in functional assays, as well as improve binding activity in cell-based assays. These results were confirmed by in silico studies that showed ACA to have high binding affinity, low off-target activity, and good pharmacokinetic properties.</p>

<p>8-Aminoadenosine can be used to study the mitochondrial membrane potential, a critical cellular function in which ATP levels are maintained by oxidative phosphorylation. 8-Aminoadenosine is one of the few drugs that have been shown to increase ATP levels in cells. It does this by increasing the permeability of mitochondria membranes and the rate of electron transport from complex I to complex II. The reaction mechanism is thought to involve an intramolecular hydrogen transfer from NADH to 8-aminoadenosine, forming an unstable intermediate that undergoes a conformational change that enables it to react with oxygen. 8-Aminoadenosine has been shown as an effective treatment for certain autoimmune diseases and resistant breast cancer. It also has anti-inflammatory effects, as well as receptor activity against HIV infection and Toll-like receptors.</p>

<p>2’-Deoxy-2’-fluoroguanosine 5’-monophosphate triethyl ammonium is a modified nucleotide that inhibits the replication of DNA by blocking the activity of the enzyme ribonuclease (RNase). It has been shown to inhibit the growth of cancer cells and is currently being studied as an anticancer agent. 2'-Deoxy-2'-fluoroguanosine 5'-monophosphate triethyl ammonium has also been shown to have antiviral properties against herpes simplex virus type 1. The compound is a synthetic nucleoside phosphoramidite with high purity and quality, which can be used for synthesis of oligonucleotides and ribonucleosides.</p>

<p>3'-Deoxycytidine is a nucleoside analog used to treat hepatitis. It is an inhibitor of the viral enzyme reverse transcriptase and prevents the synthesis of viral DNA by blocking the formation of low-energy hydrogen bonds between the 3'-hydroxyl group and the 5'-phosphate group of deoxyribonucleotide triphosphates. 3'-Deoxycytidine can be synthesized using solid-phase methods, and has been shown to inhibit human immunodeficiency virus (HIV) in control experiments. This drug also has been shown to have anti-inflammatory effects in experimental bladder inflammation models.</p>

<p>5'-O-Benzoylthymidine is an oxidative, single-stranded DNA (ssDNA) stabilizing agent. It has been shown to stabilize ssDNA by preventing the formation of intrastrand and interstrand disulfide bonds. This agent also destabilizes ssDNA by forming covalent adducts with the 5' ends of oligodeoxyribonucleotides. The stability and destabilization of ssDNA can be used in research on nucleic acid sequences, such as antigene sequences or oligonucleotide sequences.</p>

<p>o-Topolin riboside is a hydroxy derivative that can be found in Helleborus niger. It has been shown to have hormone-like effects on the body, and is an endogenous compound that can be found in human blood plasma. The dry weight of H. niger leaves was increased by o-topolin riboside, and it also increased the photosynthetic activity of isolated chloroplasts from wheat leaves. The enzyme immunoassays showed that o-topolin riboside binds to both apical and basal surfaces of excised chloroplasts. This binding inhibits the decomposition of pyridine nucleotides, which are necessary for photosynthesis. The binding also inhibits the degradation of starch and glycogen, leading to an increase in carbon dioxide fixation rates.</p>

<p>6-Thioguanosine is a purine analog that is used in the treatment of skin cancer and bowel disease. It has been shown to be an inhibitor of leukemia cells and also inhibits the growth of colon cancer cells. 6-Thioguanosine binds to the rate constant for uridine phosphorylation, which prevents the production of DNA. This drug also has an anti-inflammatory effect on bowel disease, which may be due to its ability to inhibit bcl-2 protein expression.<br>6-Thioguanosine is a fluorescent derivative that can be used as a substrate for x-ray diffraction data or as a biological sample in biological studies.</p>

<p>5,6-Dihydro-2'-deoxyuridine (dUrd) is a pyrimidine nucleoside that is an important component of DNA. It is phosphorylated by deoxyribonucleoside kinase to form dUrd monophosphate. This compound has been shown to inhibit the activity of catalase and other enzymes that hydrolyze hydrogen peroxide, indicating it may have antiviral properties. The enzyme activities of 5,6-dihydro-2'-deoxyuridine on simplex virus type 1 have been studied in vitro using lymphoblastoid cells. In these studies, the compounds was found to inhibit viral growth and terminate replication. 5,6-Dihydro-2'-deoxyuridine also inhibits the synthesis of DNA by inhibiting oxidative deamination reactions and termini formation in herpes simplex virus type 1. This drug has also been shown to inhibit amine oxidases in hep</p>

<p>7-Deaza-2',3'-dideoxyguanosine is a nucleoside analogue that is silylated on the 2' and 3' hydroxyl groups. It is also substituted with a deoxygenated 7-deaza-2',3'-dideoxyribose moiety. The substitution of the ribose sugar with deoxygenated 7-deaza-2',3'-dideoxyribose prevents the formation of hydrogen bonds between the sugar and phosphate backbones, which inhibits the enzyme ribonucleotide reductase from catalyzing the conversion of ribonucleotides to deoxynucleotides. This in turn blocks DNA synthesis, leading to cell death.br&gt;<br>7-Deaza-2',3'-dideoxyguanosine has been shown to be effective against Mycobacterium tuberculosis and Mycobacterium avium complex.</p>

<p>2'-Deoxy-5-ethynylcytidine is a cytosine analog that inhibits the synthesis of viral DNA and the production of new virus particles. It has been shown to inhibit herpes simplex virus type-1 (HSV-1) in cell cultures, as well as other viruses such as vaccinia and adenovirus. 2'-Deoxy-5-ethynylcytidine has also been shown to have anti-cancer properties in animal studies. This drug binds to the cellular nucleic acid, preventing transcription of viral genes into messenger RNA and preventing protein synthesis, thereby inhibiting replication of the virus. 2'-Deoxy-5-ethynylcytidine also inhibits the synthesis of cellular DNA by binding to nuclear DNA.<br>2'-Deoxy-5-ethynylcytidine is an analog of cytosine that binds to dna polymerase and prevents it from adding on new nucleotides, which blocks viral reproduction.</p>

<p>3'-Amino-2',3'-dideoxyadenosine's lack of a 3'-hydroxyl group makes it a chain terminator for DNA polymerase, a key application in Sanger sequencing. Additionally, the 3'-amino group serves as a functional handle for modifying the 3' end of oligonucleotides with various labels or conjugates, expanding their utility in research and diagnostics.</p>

<p>3’-Deoxy-5-methoxyuridine is a modified nucleoside that has antiviral and anticancer properties. It is an activator of DNA synthesis, which is the first step in the process of DNA replication. It also inhibits DNA gyrase and topoisomerase II, enzymes that maintain the integrity of bacterial DNA. 3’-Deoxy-5-methoxyuridine phosphoramidites are used in anticancer drugs.</p>

<p>2'-Deoxy-5-formyluridine (2DFO) is a nucleobase analogue that inhibits the enzymatic activity of DNA glycosylases, which are enzymes that remove sugar residues from damaged DNA. 2DFO has been shown to induce apoptosis in cancer cells by inhibiting DNA synthesis and promoting oxidative damage to the cell's DNA. 2DFO has also been shown to inhibit the growth of DU-145 cells in vitro and in vivo models. This drug was found to be more effective at preventing metastasis of colorectal cancer when it was administered with a platinum-based chemotherapy drug.</p>

<p>2'-Bromo-2'-deoxyuridine is a synthetic nucleoside analog of deoxyuridine, in which the 2'-hydroxyl group of the ribose sugar is replaced with a bromine atom (Br) at the 2' position. This modification allows it to be incorporated into DNA during DNA synthesis, where it can replace the normal thymidine. This molecule can potentially be used in molecular biology and cell biology as a thymidine analog to study DNA replication, cell proliferation, and DNA repair.</p>

<p>5'-O-Acetyl-2',3'-dideoxy-3'-fluoro-cytidine is an anticancer agent that has been shown to cause DNA chain termination. This drug is a modified nucleoside with the 3' hydroxyl group replaced by a 2',3'-dideoxy group. It inhibits cell division, and is active against various types of cancer cells. 5'-O-Acetyl-2',3'-dideoxy-3'-fluoro-cytidine may be used as a radiosensitizer for cancer therapy, in addition to its use as an antiviral agent.</p>

<p>The 4-Amino-6-hydroxy-2-mercapto-5-nitrosopyrimidine ammonium salt is a solvent that has been used in the synthesis of various organic and inorganic compounds. It is a five membered ring compound with solvents, such as chlorides, and it can be found in diffraction patterns. 4-Amino-6-hydroxy-2-mercapto-5 nitrosopyrimidine ammonium salt can also act as a ligand in metal complexes. The molecule has carbonyl groups which chelate to the metal atom and form a ring with chlorine atoms.</p>

<p>N2-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-guanosine 3'-CE phosphoramidite is a novel, modified ribonucleoside that is used for the synthesis of oligodeoxyribonucleotides. It has been shown to have antiviral and anticancer properties. N2-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-guanosine 3'-CE phosphoramidite is an analog of guanosine and has been shown to be an activator of RNA polymerase II. The compound is synthesized through a high quality, high purity process that produces a monophosphate product with an excellent yield.</p>

<p>2'-Deoxy-8-oxo-adenosine is a nucleoside that is a hydrogen bond donor. It is an analogue of adenosine, and has been shown to inhibit the growth of breast cancer cells. 2'-Deoxy-8-oxo-adenosine reacts with the enzyme dATP pyrophosphohydrolase to form 8-oxo-2'-deoxyadenosine, which inhibits mitochondrial DNA synthesis by preventing the incorporation of inorganic phosphate into mitochondrial DNA. This process leads to reduced ATP production, leading to cell death. The reactive properties of 2'-Deoxy-8-oxo-adenosine make it suitable for use as a probe molecule in chemical biology, as well as in biochemical studies on human serum.</p>

<p>Also known as AMT, this is a catabolite of the nucleoside analog zidovudine (AZT), a drug used to treat HIV infection.</p>

<p>2'-Amino-2'-deoxyinosine is a modified nucleoside, based on inosine. This compound has a 2'-amino substitution instead of a 2'-hydroxyl group, which has the potential to make the nucleoside more resistant to enzymatic degradation and<br> enhance or alter base-pairing properties.</p>

<p>2'-O-tert-Butyldimethylsilyl-N2-DMF-5'-O-tritylguanosine 3'-CE phosphoramidite (BTS) is a novel, modified nucleoside that has been synthesized to be used in the synthesis of DNA and RNA. This compound is an activator of ribonucleotide reductase and can be used to produce deoxyribonucleosides. BTS has shown anticancer activity in some studies and can also be used as antiviral agents. BTS also has high purity and quality, which makes it suitable for use in pharmaceuticals.</p>

<p>N2-Isobutyryl-7’-HO-N-trityl-morpholino guanosine is a novel nucleoside analog that has been synthesized to have an improved pharmacological profile.</p>

<p>Glycosylated pyrimidine analog; RNA component</p>

<p>1-(5'-O-DMT-b-D-xylofuranosyl)thymine is a nucleoside that is used as an activator for phosphoramidites. It has antiviral and anticancer activity. 1-(5'-O-DMT-b-D-xylofuranosyl)thymine is also a component of DNA and RNA, and has been found to have antitumour properties.</p>

<p>Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure.PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes.We can supply PolyI:C to all stages of your project - from R&amp;D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.<br>For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'</p>

<p>N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite is an activator for the synthesis of DNA and RNA. It is a novel nucleoside analog that inhibits the growth of cancer cells by blocking the synthesis of DNA and RNA. N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite also has antiviral properties, which may be due to its ability to inhibit viral protein synthesis. This compound has been shown to be effective against herpes simplex type 1 and 2 viruses (HSV1 and HSV2).</p>

<p>5-Azido-2'-deoxyuridine is a diazonium salt that inhibits the replication of DNA. This compound is synthesized using natural compounds, including 5-azidouracil and formamide. The structure of this compound has been shown to be chromatographically similar to uridine and binds to DNA in vitro. It also has been shown to have biological properties that inhibit the growth of trichomonas vaginalis and dna replication. 5-Azido-2'-deoxyuridine is not very stable in dimethylformamide but can be stored at −20°C for up to two years.</p>

<p>2’,3’,5’-Tri-O-benzoyl-2’C-methyl-5-trifluoromethyluridine is a nucleoside that has been synthesized from uridine. It is used in the synthesis of deoxyribonucleosides and ribonucleosides. This product can be used for the treatment of cancer and antiviral purposes.</p>

<p>3'-O-Methyluridine is a nucleoside that is used in the preparation of oligonucleotides and as a substrate for uridine phosphorylase. It is used to study the termination of RNA synthesis, which occurs when there are no more ribose residues in the RNA template strand. When this happens, an adenosine residue is added by polyphosphate kinase to the 3' end of the RNA strand. This addition causes a release of pyrophosphate and leads to end of DNA synthesis. The acid hydrolysis technique can be used to separate 3'-O-methyluridine from other nucleotides. This reaction produces guanosine, which can be detected using polymerase chain reaction (PCR) techniques such as polyacrylamide gel electrophoresis (PAGE).</p>

<p>5’-[Biotin TEG] (CUG)28-3’ RNA is a novel synthetic biotin-labeled RNA. It is phosphoramidites and ribonucleosides. 5’-[Biotin TEG] (CUG)28-3’ RNA is used as an antiviral agent.</p>

<p>2’,3’,5’-Tri-O-benzoyl-2’C-methyl-3-deazauridine is a novel modified nucleoside. It has been shown to be an active DNA activator and to inhibit the replication of RNA and DNA. 2’,3’,5’-Tri-O-benzoyl-2’C-methyl-3-deazauridine has also been shown to have antiviral activity against HIV by inhibiting reverse transcriptase. In addition, it has anticancer effects in experimental models of cancer. 2'',3''',5'''-Tri-'O'-benzoyl-'2'''C-'methyl-'3'''Deazauridine is available as a high purity phosphoramidite.</p>

<p>3'-Azido-5'-O-benzyl-3'-deoxy-D3-thymidine is a novel, activator ribonucleoside that has been synthesized to be used in the treatment of cancer and other diseases. It is an analog of thymidine and is phosphorylated by cellular enzymes to form 3'-azido-5'-O-benzyl-3'-deoxyuridine monophosphate (ABPMP) which inhibits viral DNA synthesis. This compound also shows antiviral effects against influenza A virus in vitro and can inhibit the replication of human immunodeficiency virus type 1 (HIV-1).</p>

<p>8-Aza-7-deaza-2'-C-methyladenosine is a DNA nucleoside that can be used as an antiviral and anticancer agent. It is synthesized by reacting 8-aza-7-deazaguanosine monophosphate with 2'-C-methyladenosine. The compound has been shown to have antiviral activity against HIV, HSV, and HCV in vitro. In addition, this compound has been shown to inhibit the growth of human ovarian cancer cells. 8-Aza-7-deaza-2'-C-methyladenosine has also been shown to inhibit the growth of leukemia cells in vitro, which may be due to its ability to activate the p53 tumor suppressor gene.</p>

<p>8-Aza-7-deaza-2'-deoxyadenosine is a single-stranded DNA analogue that is used as a conjugate to deliver drugs to cells. It has been shown to be effective in the treatment of HIV by suppressing viral replication and the production of infectious virions. The drug is photolabile, which means it can be activated with light and then delivered to cells. 8-Aza-7-deaza-2'-deoxyadenosine has also been shown to inhibit the growth of human immunodeficiency virus (HIV) in vitro, but does not inhibit the growth of other viruses such as herpes simplex virus type 1 or adenovirus.</p>

<p>1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-methyluracil is a nucleoside analog for research applications. It contains a β-D-arabinofuranose sugar and the fluorine (F) substitution at the 2'-position enhances stability and improves resistance to enzymatic degradation. The 5-methyluracil base makes it structurally similar to thymidine, allowing it to be recognized by DNA polymerases and kinases.</p>

<p>Ribavirin is a synthetic nucleoside analog that is used as an antiviral agent. Ribavirin 5'-monophosphate dilithium (RPM) is a high-quality, novel phosphoramidite monophosphate of ribavirin. It has antiviral activity against herpesviruses, adenoviruses, and poxviruses. The antiviral properties of RPM are due to its ability to inhibit viral RNA synthesis through inhibition of the viral enzyme ribonucleotide reductase. RPM is also active against DNA viruses such as human papilloma virus and Epstein-Barr virus.</p>

<p>N6-Acetyl-2',3',5'-tri-O-acetyl-8-hydroxyadenosine is a modified nucleoside that is used in the synthesis of oligonucleotides. It is an activator with antiviral and anticancer properties, as well as various other biological activities. The CAS number for this product is 91359-02-2. The purity of this product ranges from 99% to 100%. This chemical has not been previously synthesized and has not been modified by any substituents or moieties.</p>

<p>2,4-Diamino-6,7-dimethylpteridine is a ligand that can bind to an orphan cytosine opposite an abasic site in RNA duplexes</p>

<p>2'-O-Allyladenosine is a synthetic nucleoside analog that has been shown to be a competitive inhibitor of the enzyme guanosine kinase. It has a high yield and can be used as a synthon for the preparation of 2'-deoxyribose nucleosides. The alkylation of allyl groups onto adenosines provides an efficient method for synthesizing allylated purines, which are analogs with increased stability and affinity for DNA sequences. 2'-O-Allyladenosine has been shown to bind to DNA, RNA, and proteins. Its interaction with DNA is stronger than that of unmodified adenosine, due to the presence of two allyl groups that can form hydrogen bonds with the phosphate backbone. This interaction may also lead to increased affinity for sequences containing G-C base pairs.</p>

<p>2',3'-Dideoxy-3'-fluoroguanosine is a synthetic nucleoside analog based on guanosine. It is structurally altered to interfere with DNA or RNA synthesis, making it potentially useful as an antiviral or anticancer agent.</p>

<p>1-(3`,5`-Di-O-benzoyl-2`-deoxy-2`-fluoro-beta-L-arabinofuranosyl)thymine is a nucleoside analog with modifications that influence its biological activity. It contains a thymine base and 3',5'-Di-O-benzoyl groups that protect hydroxyl functionalities during chemical synthesis. This molecule also has the sugar 2'-Deoxy-2'-fluoro-β-L-arabinofuranose made up of an L-arabinose configuration and a 2'-Fluoro substitution, the latter of which enhances stability and resistance to enzymatic degradation.</p>

<p>N4-Acetyl-5'-O-Tritylcytidine is a novel nucleoside that is a phosphoramidite. It is used in the synthesis of ribonucleosides, deoxyribonucleosides, and DNA. N4-Acetyl-5'-O-Tritylcytidine has antiviral activities.</p>

<p>Acetyl coenzyme A lithium salt is a drug that inhibits the production of acetyl-CoA, which is an important molecule in the metabolism of fatty acids. This drug has been shown to be effective against cancerous cells by inhibiting the synthesis of lysine residues and carnitine. Acetyl coenzyme A lithium salt has also been shown to inhibit the growth of typhimurium, which may be due to its ability to inhibit NADPH-cytochrome p450 reductase. Acetyl coenzyme A lithium salt has not been shown to have any carcinogenic potential in humans, but it has been shown to have carcinogenic potential in animal models.</p>

<p>N6-Benzoyl-2'-deoxy-8-oxoadenosine is a base modified deoxy nucleoside</p>

<p>2'-Deoxy-N4-methylcytidine is a modified nucleoside that is used to inhibit the activity of protein kinases. It has been shown to inhibit the function of two different types of enzymes, eukaryotic protein kinase and bacterial RNA polymerase. 2'-Deoxy-N4-methylcytidine inhibits the activity of these enzymes by modifying their structure, which in turn prevents them from carrying out their normal functions. This modification can be achieved through deamination or protonation reactions with this drug. The effects of this drug are nonparametric and are observed at transcript levels.</p>

<p>3',5'-Di-O-acetyl-2'-deoxy-5-formyluridine is a novel antiviral agent that is active against viruses of the herpes family. It also has anticancer properties, and may be used to treat leukemia. 3',5'-Di-O-acetyl-2'-deoxy-5-formyluridine inhibits viral DNA synthesis by binding to the ribonucleoside triphosphate at the 5' position of the growing chain, preventing further elongation. This compound also inhibits bacterial growth by inhibiting DNA synthesis and protein synthesis. 3',5'-Di-O-acetyl-2'-deoxy-5-formyluridine can be activated by diphosphorylation to form a nucleoside phosphoramidite that can be used for chemical syntheses of oligonucleotides and other nucleic acids.<br>3',5'-Di-O-acetyl-2'-deoxy</p>

<p>5,6-Dinitro-1-(b-D-ribofuranosyl)benzamidazole is a novel and synthetic nucleoside analog that is being studied as an anticancer drug. It has been shown to have high antiviral activity against HIV, herpes simplex virus type 1, and herpes simplex virus type 2. 5,6-Dinitro-1-(b-D-ribofuranosyl)benzamidazole is a phosphoramidate prodrug of the natural compound 6-nitrobenzoxazole. This drug is activated by deoxyribonucleosides in vivo to form the monophosphate which inhibits viral DNA synthesis. The phosphoramidate prodrug form of 5,6-dinitrobenzoxazole has been shown to be more potent than the parent compound in inhibiting replication of HIV and herpes simplex virus types 1 and 2. Modified forms of this</p>

<p>N6-Benzyladenosine is a nucleoside that is synthesized from adenosine and benzylamine. It is a component of the nutrient solution for cell culture studies, which has been shown to have an effect on the hydrophobic effect in cells. This compound also acts as a co-factor for epidermal growth factor and enzyme activities. N6-Benzyladenosine has been used in the development of monoclonal antibodies with covalent linkages. It is also being studied as a potential biomarker for various cancers, including prostate cancer and other solid tumors. In addition, this compound has been shown to be a sesquiterpene lactone with structural analysis and pharmacokinetic properties. N6-Benzyladenosine can be found in plants such as tomato and ginger at physiological levels.</p>

<p>2'-Deoxy-3'-O-DMT-N2-Isobutyrylguanosine is a synthetic nucleoside that has the ability to activate and inhibit the growth of cancer cells. This compound is a phosphoramidite, and it has been modified by the addition of an isobutyrate group at the 2' position. The structure of this nucleoside is similar to that of natural guanosine, but with an additional 2' oxygen atom. This modification can be used for inhibition of DNA synthesis in cells and may have antiviral effects.</p>

<p>3'-Deoxyadenosine is a nucleoside that is an inhibitor of adenylate cyclase. It has been shown to inhibit the growth of mouse tumor cells and induce apoptosis in HL-60 cells. 3'-Deoxyadenosine inhibits the production of pro-apoptotic protein, which may be due to its ability to activate toll-like receptor 4. 3'-Deoxyadenosine also has strong anti-inflammatory properties and can be used for the treatment of infectious diseases caused by bacteria, such as Mycobacterium tuberculosis or Streptococcus pyogenes. 3'-Deoxyadenosine binds to DNA polymerases and inhibits the replication of DNA by blocking the incorporation of deoxynucleotides into DNA. This compound has been shown to have thermodynamic data consistent with a stable secondary structure at high temperatures.br&gt;</p>