Aminoácidos y derivados

<p>M04060 - Coriphosphine O</p>

<p>Stability Hygroscopic<br>Applications Spermidine is a biogenic polyamine formed from putrescine. Spermidine is a precursor of Spermine. Spermidine is essential for both normal and neoplastic tissue growth.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abraham, A.K., et al.: Eur. J. Biochem., 106, 257 (1980), Mach, M., et al.: Biochem. J., 202, 153 (1982), Thyss, A., et al.: Eur. J. Cancer Clin. Oncol., 18, 611 (1982),<br></p>

<p>Stability Hygroscopic<br>Applications L-Glutamic Acid, Magnesium Salt Hydrobromide is an metabolite of L-Glutamic acid, a non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. It is also a key molecule in cellular metabolism. L-Glutamic Acid, Magnesium Salt Hydrobromide has also been investigated for sedative properties as a tranquilizer.<br>References McEntee, W., et al.: Psychopharmacology, 111, 391 (1993), Manev, H., et al.: Mol. Pharmacol., 36, 106 (1989), Hamanaka, T., et al.: Toho. Igakkai. Zasshi., 20, 663 (1973);<br></p>

<p>Applications L-Glutamine-2,3,3,4,4-d5 is the isotope labelled analog of L-Glutamine (G597000); an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.<br>References Rivett, A., et al.: J. Biol. Chem., 260, 300 (1985); Watford, M., et al.: Metabolism, 49, 141 (2000); Wilmore, D., et al.: J. Nutr., 131, 2543S (2001)<br></p>

<p>Applications (S)-Carbidopa Methyl Ester N-cyclohexylideneis an impurity of Carbidopa (C175915), a prodrug inhibitor of aromatic amino acid decarboxylase.<br>References Sletzinger, M., et al.: J. Med. Chem., 6, 101 (1963)<br></p>

<p>Applications Benzyl Acetate, is found naturally in many flowers, It has pleasant sweet aroma reminiscent of jasmine, and thus is used widely in perfumery industry, and also as a flavouring agent. It is also used as a solvent.<br>References Schiestl, F. P., et al.: J. Chem. Ecology, 29 (2004); Qian-qian, M., et al.: Jingxi Huagong, 30, 442 (2013);<br></p>

<p>Applications Tyramine Hydrochloride is a naturally occurring monoamine derived from tyrosine. Neurotransmitter.<br>References Roy, K., et al.: J. Mol. Liq., 230, 104-112 (2017); Roy, M. N., et al.: Chem. Phys. Lett., 655-656, 43-50 (2016)<br></p>

<p>Applications L-Histidine is an essential amino acid for human development which the body cannot produce on its own. L-Histidine is one of the 22 proteinogenic amino acids. L-Histidine precursor to histamine (H436500) and a component of carnosine.<br>References Kopple, J.D. et al.: J. Clin. Invest., 55, 881 (1975); Sachs, D.H., et al.: J. Biol. Chem., 246, 6576 (1971); Mercer, L.P., et al.: Nutrition, 6, 273 (1990); Morgan, W.T., et al.: J. Biol. Chem., 268, 6256 (1993);<br></p>

<p>Stability Very Hygroscopic, Moisture Sensitive<br>Applications 3,4-Dihydroxyphenylglycolaldehyde (Dopegal) is the monoamine oxidase metabolite of dopamine which is toxic of in a concentrated amount and may be a target for Alzheimer or Parkinson’s therapy.<br>References Burke, W. et al.: Neurotoxical., 25, 101 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications Indole-3-carboxaldehyde- 13C8 is the labelled Indole-3-carboxaldehyde (I615020) which is a tryptophan (T947200) metabolite from Streptomyces staurosporeus and it is chemical constituent from Inula wissmanniana. Indole-3-carboxaldehyde and other tryptophan metabolites play an important role in mammalian gut immune homeostasis.<br>References Yang, S., et al.: J. Nat. Prod., 60, 44 (1997); Cheng, X. et al.: Chem. Nat. Compd., 49, 815 (2013); Zelante, T., et al,: Immunity, 39, 372 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications 4-Ethylcatechol is one of the main phenolic off-flavour markers in French ciders.<br>References Alonso-Salces, R., et al.: Anal. Bioanal. Chem., 379, 464 (2004), Xu, Y., et al.: J. Agr. Food Chemi., 55, 3051 (2007),<br></p>

<p>Applications 2,5-Piperazinedione, can be used as an intermediate in the preparation of various pharmaceutical and biologically active compounds. It can be used in the synthesis of dipeptide isosteres by cross-metathesis.<br>References Enholm, J.E. et al.: Tetrahedron, 68, 6920 (2012);<br></p>

<p>Applications Iminodiacetic Acid is used as a reagent in the synthesis of poly(N-isopropylacrylamide) (PNIPAM) microgel particles for metal affinity binding of peptides.<br>References Tsai, H., et al.: Colloids Surf. B, 114, 104 (2014)<br></p>

<p>Applications A labelled, essential amino acid.<br>References Liu, F., et al.: Bioorg. Med. Chem., 18, 4167 (2010), Kumar, R., et al.: Eur. J. Med. Chem., 45, 2265 (2010), Cai, W., et al.: Bioorg. Med. Chem., 18, 1899 (2010),<br></p>

<p>Applications Potent crosslinking inhibitors.<br>References Sloan, J., et al.: J. Biol. Chem., 274, 23740 (1999).<br></p>

<p>Applications A metabolite of Malatonin.<br>References Young, I., et al.: J. Clin. Endocrinol. Metab., 60, 114 (1985), Barrenetxe, J., et al.: J. Physiol. Biochem., 60, 61 (2004),<br></p>

<p>Applications An important metabolite of Benzene.<br></p>

<p>Applications CEL and CML are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions.<br>References Fu, M.X., et al.: J. Biol. Chem., 271, 9982 (1996), Ahmed M.U., et al.: Biochem.J., 324, 565 (1997), Schleicher, E.D., et al.: J. Clin. Invest., 99, 457 (1997), Shibayama, R., et al.: Diabetes, 48, 1842 (1999),<br></p>

<p>Stability Hygroscopic<br>Applications Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Israel, et al.: J. Med. Chem., 7, 710 (1964), Janne, J., et al.: Biochim. Biophys. Acta, 473, 241 (1978). Theoharides, T.C., et al.: Life Sci., 27, 703 (1980), Horn, Y., et al.: Cancer Res., 42, 3248 (1982),<br></p>

<p>Applications Labelled 2-Methylbutyrylglycine (M294340). 2-Methylbutyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).<br>References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),<br></p>