Antibióticos naturales y semisintéticos

<p>Cefazolin is a semi-synthetic cephalosporin that has a broad spectrum of antibacterial activity and inhibits the synthesis of bacterial cell walls.</p>

<p>Oxytetracycline Dihydrate (Terramycin Dihydrate) is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.</p>

Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.

<p>Gamithromycin (ML-1709460) is a macrolide compound with antibacterial activity.</p>

<p>Clindamycin hydrochloride (Clinimycin HCl) inhibits protein synthesis by acting on the 50S ribosomal. Clindamycin is a chlorinated broad-spectrum antibiotic.</p>

Tebipenem Pivoxil (Orapenem) , an orally activity carbapenem antibiotic, is utilized in treating otolaryngologic and respiratory infections.

<p>Cefoselis Sulfate is a widely used beta-lactam antibiotic.</p>

<p>Cefazedone (Refosporen) is a semisynthetic first-generation cephalosporin with activity against Gram-positive and Gram-negative bacteria[1].</p>

<p>Flucloxacillin sodium (floxacillin sodium) is a highly active antibiotic against Gram-negative and Gram-positive bacteria.</p>

<p>Retapamulin (SB-275833), a Pleuromutilin Antibacterial, binds to both E. coli and S. aureus ribosomes with similar potencies (Kd: 3 nM).</p>

<p>Clindamycin is a semisynthetic antibiotic that blocks bacterial protein synthesis by detaching peptidyl-tRNA from ribosomes.</p>

Ticarcillin sodium: a semisynthetic, broad-spectrum antibiotic effective against various aerobic and anaerobic bacteria.

<p>Ertapenem sodium (MK-826) is a long-acting carbapenem antibiotic effective against a wide range of bacteria, including ESBL producers.</p>

<p>Doripenem is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens.</p>

<p>Cadazolid (ACT-179811) is an oxazolidinone-type antibiotic, with activity against gram-positive bacteria, including Clostridium difficile.</p>

<p>Nitrocefin is an antibiotic. It being sensitive to hydrolysis by all lactamases produced by gram-positive and gram-negative bacteria.</p>

<p>Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FKBP to form a complex.</p>

<p>Faropenem sodium: Oral penem antibiotic for tuberculosis, pneumonia.</p>

<p>Ceftiofur is a semisynthetic antibiotic, with activity against various gram-positive/negative, anaerobic and aerobic bacteria encountered by domestic animals.</p>

<p>Valnemulin hydrochloride (Valnemulin HCl), a broad-spectrum bacteriostatic agent, inhibits protein synthesis in bacteria by binding to the peptidyl transferase.</p>

<p>Tiamulin (Thiamutilin) is a semisynthetic pleuromutilin antibiotic</p>

<p>Fumagillin (Amebacilin) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat</p>

<p>Tilmicosin phosphate, a macrolide antibiotic, is used to treat cattle for pathogens that cause Bovine Respiratory Disease.</p>

<p>Carbenicillin disodium (BRL-2064) is a broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity.</p>

Terbinafine, an allylamine, blocks ergosterol synthesis via squalene epoxidase, inhibiting fungal growth.

<p>Amifloxacin (Win49375) is a synthetic antibacterial compound and showed moderate activity against Staphylococcus aureus, with MICs of less than or equal to 2</p>

<p>Ledipasvir (acetone) (GS-5885 acetone) is an HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection.</p>

<p>Oritavancin diphosphate, a novel semisynthetic glycopeptide antibiotic, targets serious Gram-positive infections.</p>

<p>Impurity Moxidectin EP Impurity K<br>Applications 5-O-(4-nitrobenzoyl)moxidectin is an impurity of moxidectin (M744800), a macrocyclic lactone and semisynthetic derivative of nemadectin. Moxidectin is a parasiticide used for the prevention and control of heartworm and intestinal worms. Moxidectin is found in veterinary medicine used to treat animals such as dogs, cats, horses, cattle and sheep.<br>References Bisset, S.A. et al.: New Zeal. Vet. J., 40, 97 (1992); Monahan, C.M. et al.: Vet. Parasitol., 63, 225 (1996); Glickman, L.T. et al.: Int. J. Appl. Res. Vet. Med., 3, 49 (2005);<br></p>

<p>Stability Light Sensitive<br>Applications An intermediate in the synthesis of Terbinafine (T107500).<br></p>

<p>Applications L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase.<br></p>

<p>Applications 6-Chloro-6-defluoro Ciprofloxacin is an impurity of Ciprofloxacin (C482500), which is a fluorinated quinolone antibacterial.<br>References Hoffken, G., et al.: Antimicrob. Ag. Chemother., 27, 375 (1985), Scully, B.E., et al.: Lancet, 1, 819 (1986)<br></p>

<p>Impurity Cefixime EP Impurity A<br>Stability Light Sensitive, Temperature Sensitive<br>Applications Cefixime Impurity is an impurity of Cefixime (C242800); an orally active third generation cephalosporin antibiotic.<br>References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984); Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985); Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986)<br></p>

<p>Stability Light Sensitive<br>Applications Moxidectin-d3 is a the labelled form of Moxidectin (M744800). Moxidectin is a macrocyclic lactone and semisynthetic derivative of nemadectin. Moxidectin is a parasiticide used for the prevention and control of heartworm and intestinal worms. Moxidectin is found in veterinary medicine used to treat animals such as dogs, cats, horses, cattle and sheep.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bisset, S.A. et al.: New Zeal. Vet. J., 40, 97 (1992); Monahan, C.M. et al.: Vet. Parasitol., 63, 225 (1996); Glickman, L.T. et al.: Int. J. Appl. Res. Vet. Med., 3, 49 (2005)<br></p>

<p>Applications Spiramycin is a macrolide antibiotics.<br>References Patil, S., et al.: World J. Pharm. Res., 5, 1529 (2016)<br></p>

<p>Applications (9E)-Erythromycin A Oxime is a metabolite of Roxithromycin (R700850) in humans. It has anti-Helicobacter pylori activity<br>References Nam, G. et al.: Bioorg. Med. Chem. Lett., 16, 569 (2006); Zhong, D. et al.: Drug Metab. Dispos., 28, 552 (2000); Yamazaki, H. et al.: Drug. Metab. Dispos., 26, 1053 (1998)<br></p>

<p>Applications 25-Deacetyl-21-acetyl Rifampicin is a structural isomer, and impurity, of Rifampicin (R508000), a semisynthetic antibiotic. Antibacerial (tuberculostatic).<br>References Furesz, et al.: Antibiot. Chemother., 16, 316 (1970), Gallo, G.G., et al.: Anal. Profiles Drug Subs., 5, 467 (1976),<br></p>

<p>Applications Intermediate in the synthesis of Linezolid (L466500).<br></p>

<p>Stability Light Sensitive<br>Applications (Z)-Desbutyl Lumefantrine is a metabolite of Lumefantrine (L474000).<br>References Lefevre, G., et al.: Br. J. Clin. Pharmacol., 54, 485 (2002); Schepers, U., et al.: J. Pharm. Biomed. Anal., 310 (2005)<br></p>

<p>Applications Labelled Cycloserine. Antibacterial (tuberculostatic).<br>References Lamb., J.W., et al.: Anal. Profiles Drug Subs., 1, 53 (1972), Gentry-Weeks, C., et al.: J. Biol. Chem., 268, 7298 (1993), Alexander, F., et al.: Eur. J. Biochem., 219, 953 (1994), Auger, S., et al.: Biochimie, 87, 231 (2005),<br></p>

<p>Applications Retapamulin is an antibacterial agent used as a substitute for the more commonly known Penicillin (P223505).<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Dunham, J.M., et al.: Anal. Profiles Drug Subs., 1, 249 (1972),<br></p>

<p>Applications Amoxicillin is an antibiotic used in the treatment of various bacterial infections.<br></p>

<p>Applications 1-butylpiperidine-2-carboxylic acid (cas# 856838-98-7) is a useful research chemical.<br></p>

<p>Impurity USP Azithromycin Related Impurity H /Azithromycin EP Impurity H<br>Stability Hygroscopic<br>Applications 3'-N-[[4-(acetylamino)phenyl]sulfonyl]-3'-N-demethyl Azithromycin is an impurity of Azithromycin (A927000).<br>References Debremaeker, D. et al.: Rap. Comm. Mass. Spec., 17, 342 (2003);<br></p>

<p>Applications Validamycin A (&gt;70%) Hydrochloride Salt is a metabolite of Validamycin A (&gt;70%) (V943430) which is an antibiotic fungicide that inhibits trehalase activity in plants, insects, and fungi.<br></p>

<p>Applications Desmycosin is a 16-membered macrolide antibiotic and a metabolite of Tylosin (T947650). Desmycosin is also a precursor to Tilmicosin (T440500).<br>References Wal, J.M. et al.: J. Antibiot., 26, 687 (1973); Hu, D. et al.: Environ. Toxicol. Chem., 26, 884 (2007); Min, Y. et al.: Proc. Biochem., 42, 729 (2007);<br></p>

<p>Impurity Ceftazidime EP Impurity A<br>Stability Hygroscopic, Light Sensitive<br>Applications ∆2-Ceftazidime, 90% (Ceftazidime EP Impurity A) is a Ceftazidime isomer, an impurity of Ceftazidime (C244100).<br>References Vilanova, B., et al.: Helv. Chim. Acta, 76, 2789 (1993), Zhou, M., et al.: J. Pharm. Sci., 84, 534 (1995), Baertschi, S., et al.: Chemother. 8, 353 (1997), Porra, R., et al.: J. Pharm. Biomed. Anal., 18, 241 (1998),<br></p>

<p>Applications Fumagillol is an analog of Fumagillin (F862650), a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an an anti-infective and antiangiogenic agent.<br>References Molina, J.M. et al.: N. Eng. J. Med., 346, 1963 (2002); Hou, L. et al.: Pathol. Int., 59, 448 (2009); Ingber, D. et al.: Nature, 348, 555 (1990);<br></p>

<p>Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)<br></p>

<p>Applications A key intermediate in the manufacturing of Cephalosporin compounds.<br>References Choi, K., et al.: J. Antibio., 50, 279 (1997),<br></p>

<p>Applications Semisynthetic Erythromycin derivative. Antibacterial.This compound is a contaminant of emerging concern (CECs).<br>References Jones, R.N., et al.: Antimicrob. Agents Chemother., 24, 209 (1983), Barry, A.L., et al.: Eur. J. Clin. Microbiol., 5, 536 (1986), Grassi, C., et al.: Chemioterapia, 6, 41 (1987),<br></p>

<p>Stability Hygroscopic<br>Applications Cefixime EP Impurity B Acetic Acid Salt is an impurity of the third generation cephalosporin antibiotic, Cefixime (C242800).<br>References Bian, L. et al.: Yao. Fen. Zaz., 30, 872 (2010);<br></p>

<p>Applications A metabolite of carboxylic acid.<br>References Bardsley, W., et al.: Biochem. J., 122, 557 (1971), Kim, J., et al.: Biosci. Biotechnol. Biochem., 69, 1331 (2005), Kopka, J., et al.: J. Biotechnol., 124, 312 (2006),<br></p>