Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65924 productos de "Derivados de Quinazolina y Quinolina"
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Etoricoxib-d6
CAS:Producto controlado<p>Applications Etoricoxib-d6 is the labelled analog of Etoricoxib (E934100), a specific inhibitor of COX-2 .<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McGeer, P.L., et al.: Exp. Gerontol., 37, 925 (2002), Chenevard, R., et al.: Circulation, 107, 405 (2003)<br></p>Fórmula:C18H9D6ClN2O2SForma y color:NeatPeso molecular:364.881-Chloro Dihydro Dutasteride
CAS:<p>Impurity Dutasteride EP Impurity F<br>Applications 1-Chloro Dihydro Dutasteride (Dutateride EP Impurity F) is a 3-oxo-4-aza-5α-androstene-17β-carboxylic acid derivative and an impurity of Dutasteride (D735000).<br></p>Fórmula:C27H31ClF6N2O2Forma y color:NeatPeso molecular:564.99rac Normetanephrine Hydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A metabolite of Epinephrine ((E588585). A naturraly occurring derivative of Epinephrine, found together with Metanephrine in urine and in certain tissues.<br>References Eisenhofer, G., et al.: J. Clin. Endocrinol. Metab., 82, 3864 (1997), Akiyama, T., et al.: Cardiovasc. Res., 49, 78 (2001), Burke, W., et al.: Brain Res., 891, 218 (2001),<br></p>Fórmula:C9H13NO3·ClHForma y color:White To Light BrownPeso molecular:219.672,6-Dichloroformanilide
CAS:Producto controlado<p>Applications 2,6-Dichloroformanilide is an intermediate in the synthesis of N-(2,6-Dichlorophenyl)-carbonimidic Dichloride (D436565). N-(2,6-dichlorophenyl)-carbonimidic Dichloride is an impurity of clonidine (C587130). Chlonidine is α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983), Glassman, A.H., et al.: Science, 226, 864 (1984), Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992),<br></p>Fórmula:C7H5Cl2NOForma y color:NeatPeso molecular:190.03N-Demethyl Olanzapine
CAS:Producto controlado<p>Applications A metabolite of Olanzapine.<br></p>Fórmula:C16H18N4SForma y color:BrownPeso molecular:298.4117α-Dutasteride
CAS:Producto controlado<p>Impurity Dutateride EP Impurity E<br>Applications 17α-Dutasteride (Dutateride EP Impurity E) is an impurity of Dutasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000).<br></p>Fórmula:C27H30F6N2O2Forma y color:Dark Orange Colour SolidPeso molecular:528.53Thioridazine Hydrochloride
CAS:Producto controlado<p>Applications Thioridazine HCl is a dopamine receptor blocker and antipsychotic. It is the parent compound of sulforidazine and mesoridazine. This compound has been reported to bind strongly to dopamine receptors on cancer stem cells and cause differentiation leaving normal cells alone (see Can. Chem. News 12 July/August 2012).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goldenthal, E.I., Toxicol. Appl. Pharmacol., 18, 185 (1971), Abdel-Moety, E.M., et al.: Anal. Profile Drug Subs., 18, 459 (1989),<br></p>Fórmula:C21H26N2S2·ClHForma y color:Light YellowPeso molecular:407.04Axitinib
CAS:Producto controladoFórmula:C22H18N4OSForma y color:Off-White To BeigePeso molecular:386.47Phenylephrone Hydrochloride
CAS:<p>Impurity Phenylephrine EP Impurity C; Phenylephrine USP Related Compound C (1-(3-Hydroxyphenyl)-2-(methylamin<br>Applications Phenylephrine Hydrochloride (Phenylephrine EP Impurity C; Phenylephrine USP Related Compound C (1-(3-Hydroxyphenyl)-2-(methylamino)ethan-1-one Hydrochloride)) is an impurity C of Phenylephrine.<br>References Bodor, N., et al.: J. Med. Chem., 31, 100 (1988), Goskonda, V., et al.: J. Pharm. Sci., 88, 180 (1999),<br></p>Fórmula:C9H11NO2·ClHForma y color:Off-White To BeigePeso molecular:201.65Propylthiouracil-d5
CAS:Producto controlado<p>Applications Labelled antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen.<br>References Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 6, 457 (1977), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984),<br></p>Fórmula:C7H5D5N2OSForma y color:Off-WhitePeso molecular:175.26Benidipine 5-(1-Benzylpiperidin-3-yl)
CAS:Producto controlado<p>Stability Moisture Sensitive<br>Applications Benidipine 5-(1-Benzylpiperidin-3-yl) is an impurity of Benidipine (B157500), a dihydropyridine calcium channel blocker. Antihypertensive.<br>References Suzuki, T., et al.: Cardiovasc. Drug Rev., 7, 25 (1989); Hirayama, N., et al.: Acta Crystallogr., C47, 458 (1991)<br></p>Fórmula:C39H44N4O6Forma y color:NeatPeso molecular:664.79rac-Ruxolitinib-d9 (major)
CAS:Producto controlado<p>Applications Labelled racemic analogue of Ruxolitinib (R702000). Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.<br>References Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R.A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010);<br></p>Fórmula:C17H9D9N6Forma y color:White To Light YellowPeso molecular:315.42Tolvaptan
CAS:Producto controlado<p>Applications Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006);<br></p>Fórmula:C26H25ClN2O3Forma y color:White To Off-WhitePeso molecular:448.941,4-Dibromobenzene
CAS:<p>Applications 1,4-Dibromobenzene is used in the synthesis of triarylamines as well as trans-stilbenes. Also used in the synthesis of calcium channel blockers for inhibition of TRPV6-mediated calcium transport.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Corriu, R. et al.: J. Chem. Soc. Chem. Comm., 3, 144 (1972); Lambert, C. et al.: J. Am. Chem. Soc., 121, 8434 (1999); Hofer, A. et al.: Bioorg. Med. Chem., 21, 3202 (2013);<br></p>Fórmula:C6H4Br2Forma y color:Light YellowPeso molecular:235.90Epinephrine 4-O-Sulfate Ester
CAS:Producto controlado<p>Applications Epinephrine (E588585) derivative.<br>References Imai, K., et al.: Chem. Pharm. Bull., 16, 1854 (1968),<br></p>Fórmula:C9H13NO6SForma y color:NeatPeso molecular:263.272,3:4,5-Di-O-isopropylidene-β-D-fructopyranose
CAS:Producto controlado<p>Applications 2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose (cas# 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-II).<br>References Maryanoff, B. E., et al.: J. Med. Chem., 48, 1941 (2005)<br></p>Fórmula:C12H20O6Forma y color:White To Off-WhitePeso molecular:260.282-Oxazolidinone
CAS:Producto controlado<p>Applications An oxazole derivative used as an antibiotic. It is also used in the preparation of compounds with antitumor activity. A metabolite of Furazolidone (F864100).<br>References Miyahara, M. et al.: CHem. Pharmac. Bull., 29, 2366 (1981); Hunder, G. et al.: Arch. Toxicol., 61, 161 (1987); Roloff, T. et al.: Med. Monat. Pharrm., 22, 370 (1999);<br></p>Fórmula:C3H5NO2Forma y color:NeatPeso molecular:87.082-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-bromopropan-2-ol
CAS:Producto controlado<p>Impurity Fluconazole EP Impurity H<br>Applications 2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-bromopropan-2-ol (Fluconazole EP Impurity H) is an impurity of the antifungal agent Fluconazole (F421000).<br>References Bourichi, H., et al.: STP Pharma Pratiques, 18, 285 (2008); Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985)<br></p>Fórmula:C11H10BrF2N3OForma y color:Off-WhitePeso molecular:318.12Benzophenone
CAS:Producto controlado<p>Impurity Diphenhydramine EP Impurity E<br>Applications It is used in the manufacturing of antihistamines, hypnotics, insecticides.This compound is a contaminant of emerging concern (CECs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wallace, W., et al.: Environ. Toxicol. Chem., 19, 962 (2000), Hayashi, T., et al.: Toxicol. Lett., 167, 1 (2006), Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008),<br></p>Fórmula:C13H10OForma y color:ColourlessPeso molecular:182.222-Hydroxy Imiquimod
CAS:Producto controlado<p>Applications 1-(4-Amino-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol, has been shown to activate a toll-like receptor 7/8 Independent Cytokine, which can be used in the design of immunomodulating agents for use as vaccine adjuvants and anticancer treatments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shi, C., et al.: ACS Med. Chem. Lett., 3, 501 (2012);<br></p>Fórmula:C14H16N4OForma y color:NeatPeso molecular:256.3Furazolidone
CAS:<p>Applications Antimicrobial.Environmental contaminants; Food contaminants; Heat processing contaminants<br>References Yurchenco, J.A., et al.: Antimicrob. Chemother., 3, 1035 (1953), Sharma, C., et al.: J. Clin. Microbiol., 36, 756 (1998),<br></p>Fórmula:C8H7N3O5Forma y color:YellowPeso molecular:225.162-(Acetylamino)-6-[[[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]amino]carbonyl]-benzoic Acid
CAS:Producto controladoFórmula:C22H26N2O8SForma y color:NeatPeso molecular:478.527-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid, 90%
CAS:Producto controlado<p>Impurity Norfloxacin EP Impurity A; Norfloxacin USP Related Compound A (7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-d<br>Applications 7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid (Norfloxacin EP Impurity A) is a Norfloxacin intermediate. Norfloxacin EP Impurity A; Norfloxacin USP Related Compound A (7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid).<br>References Piganeau, N., et al.: J. Mol. Biol., 312, 1177 (2001), Rameshkumar, N., et al.: Eur. J. Med. Chem., 38, 1001 (2003), You, Q., et al.: J. Med. Chem., 52, 5649 (2009),<br></p>Fórmula:C12H9ClFNO3Pureza:90%Forma y color:NeatPeso molecular:269.664-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
CAS:Producto controlado<p>Applications 4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide is a compound used as a reagent to synthesize Regorafenib (R143000), a multikinase inhibitor that is used to treat patients with advanced colorectal cancer.<br>References Mross, K., et al.: Clin. Cancer Res., 18, 2658 (2012); Stiehl, J., et al. Process for Preparation of Regorafenib. PCT Int. Appl. 2011128261. Oct 20, 2011; Van Cutsem, E., et al.: J. Clin. Oncol., 30, 3502 (2012)<br></p>Fórmula:C13H12FN3O2Forma y color:Dark Orange To Red BrownPeso molecular:261.25rac Kynurenine
CAS:Producto controlado<p>Applications A tryptophan metabolite, is a precursor of kynurenic acid, which is an antagonist of N-methyl-aspartate receptor. An amino acid produced in the body from tryptophan.<br>References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990), Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003), Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003), Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007),<br></p>Fórmula:C10H12N2O3Forma y color:NeatPeso molecular:208.214-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-[4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]phenyl]-1-butanone
CAS:<p>Applications 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-[4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]phenyl]-1-butanone is an impurity of Haloperidol (H103700), an antipsychotic agent.<br>References Morris, A.P., et al.: Drug. Meta. Lett., 2, 275 (2008); Morris, A.P., et al.: Int. J. Pharma., 367, 44 (2009);<br></p>Fórmula:C32H36Cl2N2O3Forma y color:NeatPeso molecular:567.551-Methylindazole-3-carboxylic Acid (Granisetron Impurity D)
CAS:Producto controlado<p>Impurity Granisetron EP Impurity D<br>Applications Granisetron Impurity D.<br>References Bermudez, J., et al.: J. Med. Chem., 33, 1924 (1990),<br></p>Fórmula:C9H8N2O2Forma y color:Off White SolidPeso molecular:176.17Flunarizine-d8 Dihydrochloride
CAS:Producto controlado<p>Applications Calcium channel blocker; fluorinated derivative of Cinnarizine. Vasodilator (cerebral and peripheral). This is the labeled analog.<br>References Desmedt, L.K., et al.: Arzneim.-Forsch., 25, 1408 (1975), Godfraind, T., et al.: Eur. J. Pharmacol., 53, 273 (1979), Nihard, P., et al.: Angiology, 33, 37 (1982), Holmes, B., et al.: Drugs, 27, 6 (1984),<br></p>Fórmula:C26H20D8Cl2F2N2Forma y color:NeatPeso molecular:485.47N-[4-Nitro-3-(trifluoromethyl)phenyl]-propanamide
CAS:Producto controlado<p>Applications N-[4-Nitro-3-(trifluoromethyl)phenyl]-propanamide is an impurity of flutamide (F598850). Flutamide is a nonsteroidal antiandrogen drug; antineoplastic (hormonal).<br>References Neri, et al.: Endocrinology, 91, 427 (1972), Sogani, P.C., et al.: J. Urol., 122, 640 (1979), Greenway, B.A., et al.: Br. Med. J., 316, 1935 (1998),<br></p>Fórmula:C10H9F3N2O3Forma y color:Light Yellow SolidPeso molecular:262.19Desethyl Terbuthylazine-d9
CAS:Producto controladoFórmula:C72H9H3ClN5Forma y color:Off White SolidPeso molecular:210.718-Hydroxy Mirtazapine β-D-Glucuronide 90%
CAS:<p>Applications A metabolite of Mirtazapine (M365000). This compounds contains some of the alpha anomer.<br>References Sandker, G., et al.: Xenobiotica, 24, 143 (1994), Dahl, M., et al.: Clin. Drug Invest., 13, 37 (1997),<br></p>Fórmula:C23H27N3O7Pureza:90%Forma y color:NeatPeso molecular:457.48(R)-Sitagliptin rac-Fumarate Adduct (mixture of diastereomers)
CAS:<p>Impurity Sitagliptin Tablets EP Impurity FP-A<br>Applications Sitagliptin Fumarate Adduct is an impurity of Sitagliptin (S491000), a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem. 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)<br></p>Fórmula:C20H19F6N5O5Forma y color:White To Off-WhitePeso molecular:523.38Orbifloxacin
CAS:<p>Applications Orbifloxacin is a fluoroquinolone antibiotic used in veterinary medicine, mainly for the treatment of staphylococcal infections in dogs.<br>References Ganiere, J.P. et al.: Res. Vet. Sci., 77, 67 (2004); Scott, D.W. et al.: Can. Vet. J., 47, 999 (2006); Rubin, J. et al.: Vet. Microbiol., 131, 164 (2008);<br></p>Fórmula:C19H20F3N3O3Forma y color:White To Light YellowPeso molecular:395.38Destriazolyl Bromo Propiconazole (Mixture of Diastereomers)
CAS:<p>Applications Destriazolyl Bromo Propiconazole is an impurity of Propiconazole (P770100).<br>References Godefroi, E.F., et al.: J. Med. Chem., 12, 784 (1969), Buchel, K.H., et al.: Arzneim.-Forsch., 22, 1260 (1972),<br></p>Fórmula:C13H15BrCl2O2Forma y color:NeatPeso molecular:354.071’-Hydroxy Bufuralol (Mixture of Diastereomers)
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A metabolite of Bufuralol, a β-Adrenergic blocker with peripheral vasodilating activity.<br>References Boobis, A.R., et al.: Biochem. Pharmacol., 34, 65 (1985), Yamazaki, H., et al.: Mol. Pharmacol., 46, 568 (1994), Mast, N., et al.: Biochem., 42, 14284 (2003),<br></p>Fórmula:C16H23NO3Forma y color:BeigePeso molecular:277.367-Amino-5-chloro-2(3H)-benzoxazolone
CAS:Producto controladoFórmula:C7H5ClN2O2Forma y color:NeatPeso molecular:184.58Myristicin Acid Methyl Ester
CAS:Producto controlado<p>Applications Myristicin Acid Methyl Ester is an intermediate in the synthesis of natural dihydrostilbenes with significant cytotoxicity toward human cancer cell lines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kobayashi, H., et al.: J. Antibiotics, 49, 873 (1996), Belguendouz, L., et al.: Biochem. Pharmacol., 53, 1347 (1997), Mu, F., et al.: J. Med. Chem., 46, 1670 (2003), Lee, J., et al.: Bioorg. Med. Chem., 14, 2022 (2006),<br></p>Fórmula:C10H10O5Forma y color:NeatPeso molecular:210.18Primidone-d5
CAS:Producto controlado<p>Applications Anticonvulsant.<br>References Bogue, C., et al.: Br. J. Pharmacol., 8, 230 (1953), Daley, R.D., Anal. Profiles Drug Subs., 2, 409 (1973),<br></p>Fórmula:C122H5H9N2O2Forma y color:Off-WhitePeso molecular:223.28Zaltoprofen
CAS:Producto controlado<p>Applications Zaltoprofen is a non-steroidal anti-inflammatory drug. It inhibits bradykinin-induced pain responses without blocking bradykinin receptors.<br>References Hirate, K., et al.: Nerosci. Res., 54, 288 (2006); Yamamoto, M., et al.: Chirality, 2, 280 (1990); Inoue, M., et al.: J Pharmacol. Exp. Ther., 293, 662 (2000); Graven-Nielsen, T., et al.: Clin. J. Pain, 17, 2 (2001)<br></p>Fórmula:C17H14O3SForma y color:NeatPeso molecular:298.36Nizatidine
CAS:Producto controlado<p>Applications Histamine H2-receptor antagonist related to Ranitidine (R120000). Antiulcerative.<br>References Callaghan, J.T., et al.: Clin. Pharmacol. Ther., 37, 162 (1985), Secor, J.W., et al.: Br. J. Clin. Pharmacol., 20, 710 (1985), Knadler, M.P., et al.: Drug Metab. Dispos., 14, 175 (1986), Wozniak, T.J., et al.: Anal. Profiles Drug Subs., 19, 397(1990)<br></p>Fórmula:C12H21N5O2S2Forma y color:Off-White To Light YellowPeso molecular:331.462-[3,5-Dichloro-4-[(4-chlorophenyl)methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione
CAS:Producto controlado<p>Applications An anticoccidal triazine used for the treatment of coccidiosis in chickens. An impurity of Diclazuril (D436200).<br>References McFarland, J. et al.: J. Med. Chem., 35, 2543 (1992);<br></p>Fórmula:C16H10Cl3N3O2Forma y color:NeatPeso molecular:382.63Eltrombopag-13C4
CAS:Producto controladoFórmula:C2113C4H22N4O4Forma y color:Light Yellow To Dark OrangePeso molecular:446.44Flumequine-13C3
CAS:Producto controlado<p>Applications Fluorinated quinolone antibacterial.<br>References Stilwell, G., et al.: Antimicrob. Agents Chemother., 7, 483 (1975), Rohlfing, S.R., et al.: J. Antimicrob. Chemother., 3, 615 (1977),<br></p>Fórmula:C3C11H12FNO3Forma y color:Off-White To BeigePeso molecular:264.234-Hydroxy Omeprazole Sulfone
CAS:Producto controlado<p>Applications The major degradation product of 4-Hydroxy Omeprazole (H948860).<br></p>Fórmula:C16H17N3O4SForma y color:White SolidPeso molecular:347.39N-(4-Methyl-2-thiazolyl)-guanidine hydrochloride
CAS:Producto controlado<p>Applications N-(4-Methyl-2-thiazolyl)-guanidine hydrochloride is the hydrochloride base salt of N-(4-Methyl-2-thiazolyl)-guanidine which is used as a test compound for various studies involving permeability through the blood-brain barrier.<br>References Bolboaca, S.D., et al.: Int. J. Mol. Sci., 12, 4348-64 (2011); Dureja, H., et al.: Acta Pharm. 57, 451-67 (2007); Fu, X., et al.: nt. J. Mol. Sci., 10, 737-50 (2005)<br></p>Fórmula:C5H8N4S·HClForma y color:NeatPeso molecular:156.21 + (36.46)3-Hydroxy Carvedilol
CAS:Producto controlado<p>Applications A vascularly inactive metabolite of Carvedilol (C184625). A novel antihypertensive agent, is a potent antioxidant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Rapola, J., et al.: Lancet, 349, 1715 (1997), Gao, F., et al.: Eur. J. Pharmacol., 406, 109 (2000),<br></p>Fórmula:C24H26N2O5Forma y color:NeatPeso molecular:422.47(R)-Etiracetam Acid
CAS:Producto controlado<p>Applications Levetiracetam Acid can be used as reactant/reagent in synthesis, Aβ42/tau aggregation, acetylcholinesterase/butyrylcholinesterase inhibitory activities, acute toxicity, and docking studies of levetiracetam-huprine/tacrine hybrids as anti-Alzheimer's agents.<br>References Sola, I., et al.: J Med Chem, 58, 6018 (2015)<br></p>Fórmula:C8H13NO3Forma y color:Off-WhitePeso molecular:171.193-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]propanamide
CAS:Producto controlado<p>Impurity Famotidine EP Impurity D<br>Stability Hygroscopic<br>Applications 3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]propanamide is an impurity in the synthesis of Famotidine (F102250) histamine H2-receptor antagonist. Antiulcerative.<br>References Takeda, M., et al.: Arzneim.-Forsch., 32, 734 (1982), Miwa, M., et al.: J. Clin. Pharmacol. Ther. Toxicol., 22, 214 (1984), Takabatke, T., et al.: Eur. J. Clin. Pharmacol., 28, 327 (1985),<br></p>Fórmula:C8H13N5OS2Forma y color:NeatPeso molecular:259.354,5-Desisopropylidene Topiramate
CAS:Producto controlado<p>Impurity Topiramate Impurity B<br>Applications A metabolite of Topiramate.<br>References Maryanoff, B., et al.: J. Med. Chem., 30, 880 (1987), Shank, R., et al.: Epilepsia, 35, 450 (1994), Streeter, A., et al.: Drug Metab. Disp., 23, 90 (1995),<br></p>Fórmula:C9H17NO8SForma y color:WhitePeso molecular:299.30Pentoxifylline
CAS:Producto controladoFórmula:C13H18N4O3Forma y color:White To Off-WhitePeso molecular:278.31N-De(4-sulfonamidophenyl)-N’-(4-sulfonamidophenyl) Celecoxib
CAS:Producto controlado<p>Impurity Celecoxib EP Impurity B<br>Applications N-De(4-sulfonamidophenyl)-N’-(4-sulfonamidophenyl) Celecoxib (Celecoxib EP Impurity B) is an isomeric impurity of Celecoxib (C251000) with selective inhibitory activity against human cyclooxygenase-2. USP Celecoxib Related Compound B<br>References Talley, J.J. et al.: Actual. Chim. Therap., 25, 123 (1999); Rao, R. et al.: Anal. Sci., 22, 1257 (2006);<br></p>Fórmula:C17H14F3N3O2SForma y color:NeatPeso molecular:381.371-(2,6-Dimethylphenyl)-1,5,6,7-tetrahydro-2H-azepin-2-one
CAS:Producto controlado<p>Stability Light Sensitive<br>Applications 1-(2,6-Dimethylphenyl)-1,5,6,7-tetrahydro-2H-azepin-2-one is an impurity of the local anesthetic Levobupivacaine (B689546).<br></p>Fórmula:C14H17NOForma y color:NeatPeso molecular:215.29N-Formyl Trimetazidine
CAS:<p>Stability Hygroscopic<br>Applications N-Formyl Trimetazidine is an impurity of Trimetazidine (T795610).<br>References Szwed, H., et al.: Clin. Drug Invest., 19, 1 (2000), Thoppil, S., et al.: J. Pharm. Biomed. Anal., 25, 15 (2001), Wang, Z., et al.: Pharmazie, 62, 27 (2007),<br></p>Fórmula:C15H22N2O4Forma y color:NeatPeso molecular:294.354’-(Bromomethyl)biphenyl-2-carboxylic Acid tert-Butyl Ester
CAS:Producto controlado<p>Impurity Telmisartan EP Impurity H<br>Applications 4’-(Bromomethyl)biphenyl-2-carboxylic Acid tert-Butyl Ester (Telmisartan EP Impurity H) is a biphenyl derivative used in the preparation of angiotensin II receptor antagonists. T017000<br>References Wahhab, A. et al.: Arzneim.-Forsch., 43, 1157 (1993); Yanagisawa, H. et al.: J. Med. Chem., 39, 323 (1996);<br></p>Fórmula:C18H19BrO2Forma y color:NeatPeso molecular:347.25Lansoprazole Sulfide N-Oxide
CAS:<p>Applications Used in the preparation of Lansoprazole and its metabolite and impurities.<br>References Reddy, G. et al.; Synthetic Commun. 38, 3477 (2008)<br></p>Fórmula:C16H14F3N3O2SForma y color:Off White SolidPeso molecular:369.364-[4-[[(2R)-3-Chloro-2-hydroxypropyl]amino]phenyl]-3-morpholinone
CAS:Producto controlado<p>Impurity Rivaroxaban Impurity E<br>Applications 4-[4-[[(2R)-3-Chloro-2-hydroxypropyl]amino]phenyl]-3-morpholinone (Rivaroxaban Impurity E) is an impurity of Rivaroxaban (R538000), which is a antithrombotic agent and a FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C13H17ClN2O3Forma y color:NeatPeso molecular:284.74Nateglinide
CAS:Producto controlado<p>Applications An amino-acid derivative that stimulates insulin secretion. Used as an antidiabetic.<br>References Shinkai, H., et al.: J. Med. Chem., 32, 1436 (1989), Sato, Y., et al.: Diabetes Res. Clin. Pract., 12, 53 (1991), Vicent, D., et al.: J. Clin. Invest., 111, 1373 (2003), Ceriello, A., et al.: Diabet. Med., 21, 171 (2004),<br></p>Fórmula:C19H27NO3Forma y color:White To Off-WhitePeso molecular:317.421,2-Diphenyl Hydrazine
CAS:Producto controlado<p>Stability Air Sensitive (Oxidize)<br>Applications Impurity in the production of Phenylbutazone (P319570). Hydrazobenzene is a metabolic intermediate of Azobenzene.Carcinogenic.<br>References Chung, K., et al.: Mutation Res., 114, 269 (1983), Kawanishi, S., et al.: J. Biol. Chem., 261, 5952 (1986), Floyd, R., et al.: Carcinogenesis, 11, 1447 (1990), Shibutani, S., et al.: Nature, 349, 431 (1991),<br></p>Fórmula:C12H12N2Forma y color:OrangePeso molecular:184.243-Mercapto-2-methylpropanoic Acid
CAS:Producto controlado<p>Impurity Captopril EP Impurity C<br>Applications 3-Mercapto-2-methylpropanoic Acid (Captopril EP Impurity C) is a useful synthetic intermediate.<br>References Lewis, S.N. et al.: J. Het. Chem., 8, 571-580 (1971)<br></p>Fórmula:C4H8O2SForma y color:NeatPeso molecular:120.17Desamino Chloroimiquimod
CAS:Producto controlado<p>Impurity Imiquimod USP Related Compound C<br>Applications Desamino Chloroimiquimod (Imiquimod USP Related Compound C) is a pharmacologically active compound related to Imiquimod (I475000), an immune response modifier. It stimulates the production of Interferon-a.<br>References Megyeri, K., et al.: Mol. Cell Biol., 15, 2207, (1995), Witt, P.L., et al.: Cancer Res., 53, 5176 (1993), Edwards, L., et al.: Arch. Dermatol., 134, 25 (1998); Gerster, J. et al.: J. Med. Chem., 48, 3481 (2005);<br></p>Fórmula:C14H14ClN3Forma y color:NeatPeso molecular:259.73Atrazine
CAS:<p>Applications Selective herbicide. Potential symptoms of overexposure are irritation of eyes and skin; dermatitis, skin sensitization; dyspnea, weakness, incoordination, salivation; hypothermia; liver injury.This compound is a contaminant of emerging concern (CECs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dalgaard-Mikkelsen, S., et al.: Pharmacol. Rev., 14, 225 (1962), Muller, K., et al.: J. Environ. Qual., 31, 309 (2002), Backhaus, T., et al.: Environ. Toxicol. Chem., 23, 258 (2004),<br></p>Fórmula:C8H14ClN5Forma y color:ColourlessPeso molecular:215.683-Chloro Cathinone Hydrochloride
CAS:Producto controlado<p>Applications A metabolite of Bupropion (B689625).<br>References Milena, P., et al.: Eur. Congr. Biopharm. Pharmacokinet., 3rd, 2, 313 (1987),<br></p>Fórmula:C9H11Cl2NOForma y color:NeatPeso molecular:220.1Northiaden
CAS:Producto controlado<p>Applications A metabolite of Dothiepin.<br>References Atkinson, H., et al.: Clin. Pharmacokin., 18, 151 (1990), Hagg, S., et al.: Br. J. Clin. Pharmacol., 49, 286 (2000), Fleishaker, J., et al.: Adv. Drug Deliv. Rev., 55, 643 (2003), Katritzky, A., et al.: Bioorg. Med. Chem., 12, 3027 (2004),<br></p>Fórmula:C18H19NSForma y color:NeatPeso molecular:281.423,4-Dihydroagomelatine
CAS:Producto controlado<p>Impurity Agomelatine Impurity 1<br>Applications 3,4-Dihydroagomelatine is an impurity of Agomelatine (A430000) which is a melatoninergic agonist and selective antagonist of 5-HT2C receptors and used in the treatment of major depressive disorder. Agomelatine Impurity 1<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yous, S., et al.: J. Med. Chem., 35, 1484 (1992), Zhdanova, I., et al.: J. Clin. Endocrinol. Metab., 86, 4727 (2001), Cajochen, C., et al.: J. Pineal Res., 35, 149 (2003),<br></p>Fórmula:C15H19NO2Forma y color:NeatPeso molecular:245.32(E)-Chlorprothixene-d6 Hydrochloride
CAS:Producto controlado<p>Applications Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 63 (1973), Bagli, M., et al.: Arzneim.-Forsch., 46, 247 (1996),<br></p>Fórmula:C18H13D6Cl2NSForma y color:NeatPeso molecular:358.36S-(2-Guanidino-4-thiazolyl)methylisothiourea Dihydrochloride
CAS:Fórmula:C6H10N6S2·2ClHForma y color:NeatPeso molecular:303.236(R)-N-Desacryloyl N-Propionyl Ibrutinib
CAS:<p>Applications (R)-N-Desacryloyl N-Propionyl Ibrutinib is an inhibitor for bruton’s tyrosine kinase.<br>References Pan, Z., et al.: ChemMedChem (2007), 2(1), 58-61<br></p>Fórmula:C25H26N6O2Forma y color:NeatPeso molecular:442.512-(2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDIN-6-YL)PROPAN-2-OL
CAS:Pureza:95.0%Peso molecular:313.79998779296875N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
CAS:Producto controladoFórmula:C16H13Cl2N5OSForma y color:NeatPeso molecular:394.28Valsartan-d3
CAS:Producto controladoFórmula:C24H26D3N5O3Forma y color:Off-WhitePeso molecular:438.5423-[4-(2-Methoxyethyl)phenoxy]-1,2-propanediol
CAS:Producto controlado<p>Impurity Metoprolol EP Impurity D<br>Applications 3-[4-(2-Methoxyethyl)phenoxy]-1,2-propanediol (Metoprolol EP Impurity D) is a new byproduct detected in Metoprolol tartrate. Metoprolol (M338790) impurity.<br>References Erickson, M., et al.: J. Pharmac. Biomed. Anal., 13, 567 (1995),<br></p>Fórmula:C12H18O4Forma y color:WhitePeso molecular:226.27N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS:Producto controlado<p>Applications N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a substance used in the identification of related substances in the degradation products of tofacitinib citrate using LC-MS technique for process monitoring and quality assurance. A reagent for the synthesis of Tofacitinib (CP-690,550), a Janus tyrosine kinase (JAK3) specific inhibitor.<br>References Wu, X., et al.: J. Pharm. Biomed. Anal., 143, 17 (2017); Marican, A., et al.: Tetrahedron Lett., 54, 5096 (2013)<br></p>Fórmula:C13H19N5Forma y color:WhitePeso molecular:245.32cis-(Z)-Flupentixol Dihydrochloride
CAS:Producto controlado<p>Applications Neuroleptic agent related structurally to thiothixene. Antipsychotic; neuroleptic agent; dopamine receptor antagonist.<br>References Nielsen, et al.: Acta Pharmacol. Toxicol., 32, 363 (1973), Post, M.L., et al.: Nature, 256, 342 (1975), Peuch, et al.: Neuropharmacology, 20, 1279 (1981),<br></p>Fórmula:C23H27Cl2F3N2OSForma y color:NeatPeso molecular:507.44PTC-124
CAS:Producto controlado<p>Applications PTC-124 is a nonaminoglycoside that has been reported to induce ribosomes to read through premature nonsense stop signals on mRNA, allowing the production of full-length functional proteins,<br>References Yu, H. et al.: Int. J. Mol. Med., 33, 729 (2014); Aditya, S. et al.: J. Biomed. Pharm. Res., 2, 21 (2013);<br></p>Fórmula:C15H9FN2O3Forma y color:White To Off-WhitePeso molecular:284.248-Bromo-3-methyl-7-(2-butynyl)-xanthine
CAS:Producto controladoFórmula:C10H9BrN4O2Forma y color:NeatPeso molecular:297.108Afatinib Dimaleate
CAS:Producto controlado<p>Applications Afatinib Dimaleate is a salt of Afatinib {BIBW 2992) (B377000), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. An anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity.<br>References D, Li. et al.: Oncogene., 27, 4702 (2008); Wang, X. et al.: Cancer Res., 74, 4431 (2014);<br></p>Fórmula:C24H25ClFN5O3·2C4H4O4Forma y color:NeatPeso molecular:718.083-Hydroxy Medetomidine
CAS:Producto controlado<p>Applications A metabolite of Medetomidine (M203250).<br>References Salonen, J.S., et al.: Xenobiotica, 20, 471 (1990),<br></p>Fórmula:C13H16N2OForma y color:NeatPeso molecular:216.28Methyl 5-chloro-2-hydroxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate
CAS:Producto controlado<p>Applications Methyl 5-chloro-2-hydroxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate (cas# 144172-24-7) is a useful research chemical. It is an intermediate in the synthesis of IN-KG 433 (I627995). IN-KG 433 is an impurity of Indoxacarb (I654000), an oxadiazine pesticide that acts against lepidopteran larvae and is the active ingredient in a number of household insecticides including cockroach baits.<br>References Wang, H., et al.: Water. Sci. Technol., 61, 2733 (2010); Shono, T., et al.: Pesticide. Biochem. Physiol., 75, 1 (2003);<br></p>Fórmula:C11H9O4ClForma y color:NeatPeso molecular:240.634’-(Trifluoromethyl)valerophenone-(E)-O-2-(2-aminoethyl) Oxime Maleate
Producto controlado<p>Applications 4’-(Trifluoromethyl)valerophenone(E)-O-2-(2-aminoethyl) Oxime Maleate is an impurity in the synthesis of Fluvoxamine (F603500), a selective serotonin reuptake inhibitor (SSRI) used as an anti-depressant. Antiobsessional.<br>References Claassen, V., et al.: Br. J. Pharmacol., 60, 505 (1977), Koran, L.M., et al.: J. Clin. Psychopharmacol., 16, 121 (1996), Ware, M.R., et al.: J. Clin. Psychiatry, 58, Suppl. 5, 15 (1997), Inazu, M., et al.: Neurochem. Int., 39, 39 (2001)<br></p>Fórmula:C20H28F3N3O5Forma y color:NeatPeso molecular:447.45Risperidone Z-Oxime Impurity
CAS:Producto controlado<p>Impurity Risperidone EP Impurity B<br>Applications Risperidone Z-Oxime (Risperidone EP Impurity B) is an impurity of Risperidone (R525000). Risperidone impurity per USP.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988), Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990), Green, B.: Curr. Med. Res. Opin., 16, 57 (2000)<br></p>Fórmula:C23H28F2N4O2Forma y color:NeatPeso molecular:430.492-Chloro-10,11-dihydro-11-oxo-dibenzo[b,f][1,4]oxazepine
CAS:Producto controladoFórmula:C13H8ClNO2Forma y color:NeatPeso molecular:245.66(S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxamide
CAS:Producto controlado<p>Applications (S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxamide is used in the synthesis of Vildagliptin (V305000), an oral anti-diabetic drug, and its impurities (H971380) (Impurity A).<br>References Kumar, N., et al.: J. Pharmaceut. Biomed.,119, 114 (2016); Deng, Y., et al.: Lett. Org. Chem., 11, 780 (2014);<br></p>Fórmula:C7H11ClN2O2Forma y color:NeatPeso molecular:190.63(S)-(-)-Dropropizine N,N-Dioxide
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications (S)-(-)-Dropropizine N,N-Dioxide, is an impurity of (S)-(-)-Dropropizine (D681500), S-Form of Dropropizine. Cough suppressive phenylpiperazine derivative. Antitussive.<br>References Bakken, G., et al.: J. Med. Chem., 43, 4534 (2000), Salunkhe, M., et al.: Enz. Microb. Technol., 28, 333 (2001), Atul, B., et al.: J. Pharm. Sci., 91, 2067 (2002),<br></p>Fórmula:C13H20N2O4Forma y color:NeatPeso molecular:268.31Tolmetine
CAS:Producto controlado<p>Applications 1-Methyl-5-p-toluoylpyrrole-2-acetic acid (cas# 26171-23-3) is a useful research chemical.<br></p>Fórmula:C15H15NO3Forma y color:NeatPeso molecular:257.282-Hydroxypyridine
CAS:Producto controlado<p>Applications 2-Hydroxypyridine (cas# 142-08-5) is a compound useful in organic synthesis.<br></p>Fórmula:C5H5NOForma y color:White To Light BrownPeso molecular:95.10Propentofylline
CAS:Producto controladoFórmula:C15H22N4O3Forma y color:White To Off-WhitePeso molecular:306.364-Desmethyl-2-methyl Celecoxib
CAS:Producto controlado<p>Applications 4-Desmethyl-2-methyl Celecoxib is an analog of Celecoxib (C251000). It is a cyclooxygenase 2 inhibitor.<br>References Penning, T., et al.: J. Med. Chem., 40, 1347 (1997); Wesolowski, S., et al.: Bioorg. Med. Chem. Lett., 12, 267 (2002)<br></p>Fórmula:C17H14F3N3O2SForma y color:White To BeigePeso molecular:381.37
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