Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65630 productos de "Derivados de Quinazolina y Quinolina"
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Loratadine-d5 (ethyl-d5)
CAS:Producto controlado<p>Applications Loratadine-d5 (ethyl-d5) (CAS# 1398065-63-8) is a useful isotopically labeled research compound.<br></p>Fórmula:C22D5H18ClN2O2Forma y color:NeatPeso molecular:387.92N-Nitrosomorpholine-13C4
CAS:Producto controladoFórmula:C4H8N2O2Forma y color:NeatPeso molecular:120.09Nitroso Valsartan Methyl Ester
CAS:Producto controlado<p>Applications Nitroso Valsartan Methyl Ester is an impurity of Valsartan (V095750) a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Fórmula:C20H22N6O3Forma y color:NeatPeso molecular:394.427N-Desmethyl-4'-hydroxy Tamoxifen-d3 (E/Z Mixture)
CAS:Producto controlado<p>Applications A labelled metabolite of the anti-cancer drug Tamoxifen (T006000).<br>References Heiman, D., et al.: J. Med. Chem., 23, 994 (1980), Kier, L., et al.: Pharm. Res., 7, 801 (1990),<br></p>Fórmula:C25H24D3NO2Forma y color:NeatPeso molecular:376.51Ticagrelor Acetate
CAS:Producto controlado<p>Applications Ticagrelor Acetoxide is an acetoxy impurity of Ticagrelor (T437700). Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>Fórmula:C25H30F2N6O5SForma y color:White To Off-WhitePeso molecular:564.61-[6-(2-propenyl)-ergoline-8β-carbonyl]-3-methyl-perhydropyrimidine-2-one Methanolate
Producto controladoFórmula:C24H32N4O3Forma y color:NeatPeso molecular:424.545-Ethenyl-2-pyrrolidinone
CAS:Producto controlado<p>Impurity Vigabatrin USP Related Compound A<br>Applications Vigabatrin (V253000) impurity. Vigabatrin USP Related Compound A.<br>References Durham, S. et al.: Drug Metab. Dispos. 21, 480 (1993).<br></p>Fórmula:C6H9NOForma y color:Colourless To BrownPeso molecular:111.14Dronedarone-d6 Hydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008), Hoy, S., et al.: Drugs, 69, 1647 (2009), Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009),<br></p>Fórmula:C31H39D6ClN2O5SForma y color:NeatPeso molecular:599.25(4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone
CAS:Producto controlado<p>Applications (4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is used in the synthesis of Ezetimibe (E975000), an antihyperlipoproteinemic; a cholesterol absorption inhibitor.<br>References Bankowski, K., et. al.: Przemysl Chemiczny, 91, 289 (2012); van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Fórmula:C39H46F2N2O5Si2Forma y color:NeatPeso molecular:716.961Ethyl (2R,4S)-4-Methylpipecolate, 90%
CAS:Producto controlado<p>Applications Ethyl (2R,4S)-4-Methylpipecolate is an intermediate in the preparation of Argatroban (A769000).<br>References Hilpert, K. et al.: J. Med. Chem., 37, 3889 (1994), Kim, K. et al.: Med. Chem. Res., 6, 377 (1996),<br></p>Fórmula:C9H17NO2Pureza:>90%Forma y color:NeatPeso molecular:171.24N-Nitroso Amodiaquine-D10
Producto controladoFórmula:C20D10H11ClN4O2Forma y color:NeatPeso molecular:394.9214-Desfluoro-2-Fluoro Droperidol
CAS:<p>Applications 4-Desfluoro-2-Fluoro Droperidol is an impurity of Droperidol (D679500), a D1, D2 dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic.<br>References Yelnosky, J., et al.: Toxicol. Appl. Pharmacol., 6, 37 (1964), Janicki, C.A., et al.: Anal. Profiles Drug Subs., 7, 171 (1978), Hamik, et al.: Cancer Chemother. Pharmacol., 24, 307 (1989), Heyer, E.J., et al.: Brain Res., 863, 20 (2000),<br></p>Fórmula:C22H22FN3O2Forma y color:NeatPeso molecular:379.4274Granisetron
CAS:Producto controlado<p>Applications Granisetron is a selective 5HT-3 antagonist.<br></p>Fórmula:C18H24N4OForma y color:NeatPeso molecular:312.412-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
CAS:Producto controlado<p>Applications 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one, is an impurity of Eltrombopag (E508000), which is agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Fórmula:C12H14N2OForma y color:NeatPeso molecular:202.25Thalidomide
CAS:Producto controlado<p>Applications Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. There is now a growing clinical interest in Thalidomide, and it is introduced as an immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References D’Amato, r.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 4082 (1994), Makonkawkeyoon, S., et al.: Proc. Natl. Acad. Sci. USA, 90, 5974 (1993), Schumacher, H., et al.: J. Pharmacol. Exp. Therap., 160, 189 (1968)<br></p>Fórmula:C13H10N2O4Forma y color:NeatPeso molecular:258.23rac O-Desmethyl Naproxen-d3
CAS:Producto controladoFórmula:C13D3H9O3Forma y color:Dark RedPeso molecular:219.25Varenicline-d2,15N2 Dihydrochloride
CAS:Producto controlado<p>Applications Varenicline-d2,15N2 Dihydrochloride, is the labelled dihydrochloride salt of Varenicline (V098492), a nicotinic α4β2 acetylcholine receptor partial agonist. Aids in smoking cessation.<br>References Benowitz, N., et al.: Clin. Pharmacol. Ther., 44, 23 (1988), Cohen, C., et al.: J. Pharmacol. Exp. Ther., 306, 407 (2003), Tapper, A., et al.: Science, 306, 1029 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Obach, R., et al.: Drug Metab. Disp., 34, 121 (2006),<br></p>Fórmula:C13H13D2Cl2N15N2Forma y color:Light Beige SolidPeso molecular:288.18Methyl 5,6,7,8-Tetradehydro Risperidone
CAS:Producto controlado<p>Applications An internal standard for Risperidone (R525000).<br>References Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988), Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990), Green, B.: Curr. Med. Res. Opin., 16, 57 (2000)<br></p>Fórmula:C24H25FN4O2Forma y color:White To Off WhitePeso molecular:420.48(alphaR)-α-Methyl-N-[3-[4-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine Hydrochloride Salt
CAS:Producto controladoFórmula:C22H22F3N·ClHForma y color:NeatPeso molecular:393.87Tipelukast
CAS:Producto controlado<p>Applications Tipelukast a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model.<br>References Rajasekaran, M., et. al.: BJU Int., 98, 430 (2006)<br></p>Fórmula:C29H38O7SForma y color:NeatPeso molecular:530.67N’-Benzylidene-2-ethoxybenzimidohydrazide Hydroiodide
Producto controladoFórmula:C16H17N3O·HIForma y color:Off-WhitePeso molecular:395.238rac-Sitagliptin (S)-Maleate Adduct (mixture of diastereomers)
Producto controladoFórmula:C20H19F6N5O5Forma y color:NeatPeso molecular:523.39Tavaborole (>90%)
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Tavaborole is a topical treatment of toenail onychomycosis.<br>References Toledo-Bahena, M.E. et. al.: J. Drugs Dermatol., 13, 1124 (2014)<br></p>Fórmula:C7H6BFO2Pureza:>90%Forma y color:NeatPeso molecular:151.93N-(4-Methoxybenzyl)-4-chloro-2-(trifluoroacetyl)aniline
CAS:Producto controladoFórmula:C16H13ClF3NO2Forma y color:NeatPeso molecular:343.731-Hydroxy-3-nitrodeamino Fingolimod
CAS:Producto controlado<p>Applications An impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Fórmula:C19H31NO5Forma y color:NeatPeso molecular:353.455-Methyl-1,3-benzenediacetonitrile
CAS:<p>Impurity Anastrozole 1,3-Dicyanomethyl Impurity<br>Applications 5-Methyl-1,3-benzenediacetonitrile is an Anastrozole intermediate. Anastrozole 1,3-Dicyanomethyl Impurity. Anastrozole is an aromatase inhibitor and used as an antineoplastic.<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>Fórmula:C11H10N2Forma y color:NeatPeso molecular:170.21Efavirenz 1-Desamine-1-oxy
Producto controlado<p>Applications Efavirenz 1-Desamine-1-oxy is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Fórmula:C14H8ClF3O3Forma y color:NeatPeso molecular:316.66N-Cyano-N’,N”-bis[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine
CAS:Producto controlado<p>Applications N-Cyano-N’,N”-bis[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine is an impurity of Cimetidine (C441650)<br>References Ellis, D. R., et al.: J. Chromatogr. A, 808, 269-275 (1998)<br></p>Fórmula:C16H24N8S2Forma y color:NeatPeso molecular:392.54Clonidine
CAS:Producto controlado<p>Applications Clonidine is an α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983); Glassman, A.H., et al.: Science, 226, 864 (1984); Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992);<br></p>Fórmula:C9H9Cl2N3Forma y color:NeatPeso molecular:230.09Indomethacin 1-Glycerin Ester
CAS:<p>Applications Indometacin 1-Glycerin Ester was synthesized and evaluated for anti-flammatory activity in the rate paw carrageenin edema essay.<br>References Paris, Gerard. , et al.: J. Med. Chem, 23, 9 (1980)<br></p>Fórmula:C22H22ClNO6Forma y color:NeatPeso molecular:431.87Desacetyl Diltiazem-d3
CAS:Producto controlado<p>Applications A labelled metabolite of Diltiazem (D460620).<br>References Shallcross, H., et al.: Br. Med. J., 295, 1236 (1987), Yeung, P.K.F., et al.: Drug Metab. Dispos., 18, 1055 (1990), Cashman, J.R., et al.: J. Med. Chem., 34,2049 (1991),<br></p>Fórmula:C20H21D3N2O3SForma y color:NeatPeso molecular:375.5Fenspiride N-Oxide
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Fenspiride N-Oxide is an impurity of Fenspiride (F265000),an bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action.<br>References Arnone, A., et al.: Tetrahedron., 54, 7831 (1998);<br></p>Fórmula:C15H20N2O3Forma y color:NeatPeso molecular:276.33Everolimus NHS-carbonate (>85%)
Producto controlado<p>Applications Everolimus NHS-carbonate is a derivative of Everolimus (E945400), a macrolide immunosuppressant.<br></p>Fórmula:C58H86N2O18Pureza:>85%Forma y color:NeatPeso molecular:1099.306Gabapentin Ethyl Ester Hydrochloride
CAS:Producto controlado<p>Applications Protected Gabapentin (G117250). Amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.<br>References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>Fórmula:C11H21NO2·ClHForma y color:NeatPeso molecular:235.75Chlor Cyclizine Hydrochloride
CAS:Producto controlado<p>Applications An antihistaminic drug. A drug analog of Cyclizine (C987805).<br>References Leurs, R., et al.: Pharmacol. Ther., 66, 413 (1995), Hu, Q., et al.: J. Biol. Chem., 274, 33995 (1999), Church, M., et al.: Clin. Exp. Allergy, 31, 1341 (2001),<br></p>Fórmula:C18H21ClN2·ClHForma y color:Off-WhitePeso molecular:337.292-Bromomethyl-6-nitrobenzoic Acid Methyl Ester
CAS:Producto controladoFórmula:C9H8BrNO4Forma y color:Light YellowPeso molecular:274.07Tilidine-d6 Hydrochloride (100μg/ml in Methanol)
CAS:Producto controladoFórmula:C172H6H17NO2·ClHForma y color:ColourlessPeso molecular:315.87Dipyridamole Mono-O-b-D-glucuronide
CAS:Producto controlado<p>Applications A metabolite of Dipyridamole.<br>References Zak, S.B., et al.: J. Pharmacol. Exp. Ther., 141, 392 (1963),<br></p>Fórmula:C30H48N8O10Forma y color:NeatPeso molecular:680.75(R)-(+)-Tolvaptan
CAS:Producto controlado<p>Applications An enantiomer of Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>Fórmula:C26H25ClN2O3Forma y color:Off White SolidPeso molecular:448.94(D,L)-erythro-α-Phenyl-2-piperidineacetamide
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Intermediate in the preparation of D-threo-Methylphenidate (Ritalin)<br></p>Fórmula:C13H18N2OForma y color:NeatPeso molecular:218.293-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one
CAS:Producto controlado<p>Applications 3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one is a reactant used in the synthesis of Zatebradine analogues as potential blockers od hyperpolarization-activated current.<br>References Romanelli, M. et al.: Bioorg. med. CHem., 13, 1211 (2005);<br></p>Fórmula:C15H18ClNO3Forma y color:NeatPeso molecular:295.76N-(S)-Glycidylphthalimide
CAS:Producto controlado<p>Applications N-(S)-Glycidylphthalimide is a phthalimide derivative used as an intermediate in the preparation of the antibiotic Linezolid (L466500).<br>References Rajesh, T. et al.: Pharm. Chem., 3, 168 (2011);<br></p>Fórmula:C11H9NO3Forma y color:WhitePeso molecular:203.193-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin
CAS:Producto controlado<p>Applications 3-Amino-4-(2,4,5-trifluorophenyl)butanyl Sitagliptin is an impurity of Sitagliptin (S490990). Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006)<br></p>Fórmula:C26H23F9N6O2Forma y color:NeatPeso molecular:622.48541H-1-Ethyl Candesartan
CAS:Producto controlado<p>Applications Candesartan (C175575) impurity.<br></p>Fórmula:C26H24N6O3Forma y color:WhitePeso molecular:468.51Thiorphan Disulfide
CAS:Producto controlado<p>Applications Thiorphan Disulfide is an impurity of Racecadotril (R070600); an antidiarrheal and enkephalinase inhibitor that reduces the amount of water and electrolytes into the intestine.<br>References Cezard, J., et al.: Gastroenterol., 120, 799 (2001); Sato, T., et al.: J. Med. Chem., 51, 7705 (2008); Lakshmana, P., et al.: J. Pharm. Res., 8, 39 (2009); Fournie-Zaluski<br></p>Fórmula:C24H28N2O6S2Forma y color:NeatPeso molecular:504.62Elvitegravir-d6 (Major)
CAS:Producto controlado<p>Applications A novel labelled inhibitor of human immunodeficiency virus type 1 integrase.<br>References Chou, T., et al.: Eur. J. Biochem., 115, 207 (1981), Baba, M., et al.: Antimicrob. Agents Chemother., 31, 1613 (1987), Craigie, R., et al.: J. Biol. Chem., 276, 23213 (2001), Chen, X., et al.: J. Mol. Biol., 380, 504 (2008),<br></p>Fórmula:C23H17D6ClFNO5Forma y color:NeatPeso molecular:453.916a-Naloxol
CAS:Producto controlado<p>Applications 6α-Naloxol is a metabolite of Naloxone (N285000), a specific opioid antagonist. Narcotic antagonist.<br>References Chatterjie, N., et al.: J. Med. Chem., 18, 490 (1975); Bilsky, E., et al.: J. Pharmacol. Exp. Ther., 277, 484 (1996); Blokhina, E., et al.: Eur. J, Pharmacol., 406, 227 (2000); Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967); McNicholas, L.F., et al.: Drugs, 27, 81 (1984); Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985); Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993)<br></p>Fórmula:C19H23NO4Forma y color:NeatPeso molecular:329.392-Amino-3-benzyloxypyridine
CAS:Producto controlado<p>Applications 2-Amino-3-benzyloxypyridine is used in preparation of pyridinyl/pyridazinyloxymethyl substituted Raf kinase inhibitors.<br>References Jen, T., et al.: J. Med. Chem., 20, 1258 (1977), Chung, D., et al.: Antican. Res., 11, 1373 (1991),<br></p>Fórmula:C12H12N2OForma y color:NeatPeso molecular:200.24N’-[2-[2,4-(Dimethylphenyl)thio]phenyl] Vortioxetine
Producto controlado<p>Applications N’-[2-[2,4-Dimethylphenyl)thio]phenyl] Vortioxetine is an impurity of Vortioxetine (V766000, HBr salt) which is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT.<br>References Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011); Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012); Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013)<br></p>Fórmula:C32H34N2S2Forma y color:NeatPeso molecular:510.76Isoproturon-d3
CAS:Producto controlado<p>Applications Labelled Isoproturon. Pre-and post-emergence herbicide for control of annual grasses and broad-leaved weeds. Herbicide.<br>References Fournier, J.-C., et al.: Chemosphere, 4, 207 (1975), Gonzales, P., et al.: Weed Res., 23, 39 (1983),<br></p>Fórmula:C122H3H15N2OForma y color:White To Off-WhitePeso molecular:209.301H-1-Ethyl-d5 Candesartan
CAS:Producto controlado<p>Applications Labelled Candesartan (C175575) impurity.<br></p>Fórmula:C26H19D5N6O3Forma y color:Off-White To Light YellowPeso molecular:473.544-(Methylamino)-3-nitrobenzoic Acid
CAS:Producto controlado<p>Applications 4-(Methylamino)-3-nitrobenzoic Acid (cas# 41263-74-5) is a compound useful in organic synthesis.<br></p>Fórmula:C8H8N2O4Forma y color:NeatPeso molecular:196.16a,a,a-Trifluorotoluene
CAS:Producto controlado<p>Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);<br></p>Fórmula:C7H5F3Forma y color:ColourlessPeso molecular:146.11Ticagrelor Sulfone
CAS:Producto controlado<p>Applications Ticagrelor Sulfone is an impurity of ticagrelor (T437700). Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Fórmula:C23H28F2N6O6SForma y color:NeatPeso molecular:554.574,5-Dichlorothiophene-2-carboxylic Acid
CAS:Producto controlado<p>Applications 4,5-Dichlorothiophene-2-carboxylic Acid is used in the preparation of compounds that have therapeutic BACE1 and BACE2 inhibitors which are used for the treatment of Alzheimer’s disease, type 2 diabetes and other metabolic disorders.<br>References Banner, D., et al.: PCT Int. Appl., 2011:1438553 (2013)<br></p>Fórmula:C5H2Cl2O2SForma y color:NeatPeso molecular:197.04Zileuton-d4 (major)
CAS:Producto controlado<p>Applications An inhibitor of 5-lipoxygenase, the initial enzyme in the biosynthesis of leukotrienes from Arachidonic Acid. Used as an antiasthmatic.<br>References Carter, G.W., et al.: J. Pharmacol. Exp. Ther., 256, 929 (1991), Weinblatt, M.E., et al.: J. Rheumatol., 19, 1537 (1992), McGill, K and Busse, W.W.: Lancet, 348, 519 (1996)<br></p>Fórmula:C112H4H8N2O2SForma y color:NeatPeso molecular:240.31(2,5-Difluorophenyl)(piperidin-4-yl)methanone Hydrochloride
CAS:Producto controladoFórmula:C12H13F2NO·HClForma y color:NeatPeso molecular:261.70Ethyl 3,4-Dihydroxybenzoate
CAS:Producto controladoFórmula:C9H10O4Forma y color:NeatPeso molecular:182.17N10-Monodesmethyl Rizatriptan
CAS:Producto controlado<p>Impurity Rizatriptan EP Impurity I<br>Applications N10-Monodesmethyl Rizatriptan (Rizatriptan EP Impurity I) is a metabolite of Rizatriptan.<br>References Dechant, K., et al.: Drugs, 43, 776 (1992), Castro, J., et al.: Bioorg. Med. Chem. Lett., 3, 993 (1993), Lee, Y., et al.: Biopharm. Drug Dispos., 19, 577 (1998), Chen, J., et al.: J. Pharm. Biomed. Anal., 35, 639 (2004),<br></p>Fórmula:C14H17N5Forma y color:NeatPeso molecular:255.32Benzo[b]thien-2-yl Ketone (Zileuton Impurity)
CAS:Producto controlado<p>Applications Benzo[b]thien-2-yl ketone is an impurity of Zileuton (Z420000), an inhibitor of 5-lipoxygenase that is used to treat patients with asthma. Benzo[b]thien-2-yl ketone is used as a reagent to synthesize Bis(1H-2-indolyl)methanone, compounds that inhibit the activity of growth factor receptor kinase. Benzo[b]thien-2-yl ketone is also used as a reagent to prepare annulated oligothiophenes, compounds that are used in organic light-emitting devides (OLEDs).<br>References Israel, E., et al.: JAMA, 275, 931 (1996); Mahboobi, S., et al.: J. Med. Chem., 45, 1002 (2002); Mitschke, U. & Bäuerle, P.: J. Chem. Soc. Perk. Trans., 1, 740 (2001); Nenajdenko, V., et al.: Russ. Chem. Bull., 61, 1456 (2012)<br></p>Fórmula:C17H10OS2Forma y color:NeatPeso molecular:294.392,5-Bis-(3,4-dihydroxyphenyl)piperazine Dihydrochloride
Producto controladoFórmula:C16H18N2O4•2(HCl)Forma y color:BrownPeso molecular:302.3323646Ethyl 2-Methoxy-5-sulfamoylbenzoate
CAS:Producto controlado<p>Impurity Sulpiride EPimpurity C<br>Applications ethyl 2-methoxy-5-sulfamoylbenzoate (cas# 33045-53-3) is a useful research chemical.<br></p>Fórmula:C10H13NO5SForma y color:NeatPeso molecular:259.283-Chloro-1,2-propanediol-d5 (10 ug/mL in methanol)
CAS:Producto controladoFórmula:C32H5H2ClO2Forma y color:ColourlessPeso molecular:115.57Losartan Trityl Ether
CAS:<p>Impurity Losartan EP Impurity I<br>Applications Losartan Trityl Ether (Losartan EP Impurity I) is an impurity of Losartan.<br>References Duncia, J.V., et al.: J. Med. Chem., 33, 1312 (1990),<br></p>Fórmula:C41H37ClN6OForma y color:NeatPeso molecular:665.23cis-Hydroxy Solifenacin N-Oxide(Mixture of Diastereomers)
Producto controlado<p>Applications Solifenacin (S676700) metabolite.<br></p>Fórmula:C23H26N2O4Forma y color:NeatPeso molecular:394.462,6-Dichloro-7-deazapurine
CAS:Producto controladoFórmula:C6H3Cl2N3Forma y color:NeatPeso molecular:188.01Deshydroxymethyl Losartan Trifluoroacetic Acid Salt
CAS:Producto controlado<p>Applications Losartan Impurity C.<br>References Duncia, J.V., et al.: J. Med. Chem., 33, 1312 (1990),<br></p>Fórmula:C21H21ClN6·C2HF3O2Forma y color:White To Off-WhitePeso molecular:506.91R-Mirtazapine
CAS:Producto controlado<p>Applications R-Mirtazapine is an enantiomer of Mirtazapine (M365000); an antidepressant. R-Mirtazapine showed antinociceptive effects in acute thermal nociception, whereas S-Mirtazapine showed pronociceptive effects.<br>References Muth-Selbach, Uta., et al.: Brain Res. Bull., 79(1), 63-68 (2009); Smith, Donald F., et al.: Psychopharmacology, 200(2), 273-279 (2008); Freynhagen, Rainer., et al.: Brain Res. Bull., 69(2), 168-173 (2006)<br></p>Fórmula:C17H19N3Forma y color:NeatPeso molecular:265.35Indigo Carmine 5,7'-Isomer (~90%)
CAS:<p>Applications Indigo Carmine 5,7’-Isomer is an analog of 5,5’-Indigodisulfonic Acid Disodium Salt (I521300) and synthesized from Indigo (I512250). Indigo is a chemical compound used as a dye in industrial clothing and textile processes. Also used in the synthesis of organic semiconductors.<br>References He, B. et al.: J. Am. Chem. Soc., 136, 15093 (2014); Pitayatanakul, O. et al.: J. mat. Chem. C., Mat. Op. Elec. Dev., 9311 (2014);<br></p>Fórmula:C16H8N2Na2O8S2Pureza:~90%Forma y color:Dark Blue SolidPeso molecular:466.353,3-Diphenyl-oxiranecarboxylic Acid Methyl Ester
CAS:<p>Applications Ambrisentan intermediate.<br>References Amberg, W., et al.: J. Med. Chem., 42, 3026 (1999),<br></p>Fórmula:C16H14O3Forma y color:NeatPeso molecular:254.28Paliperidone N-Oxide
CAS:Producto controlado<p>Impurity Paliperidone USP Related Compound D<br>Applications One of the major degradation product of Risperidone in bulk drug and pharmaceutical dosage forms. Paliperidone USP Related Compound D.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leysen, J., et al.: J. Pharmacol. Exp. Ther., 247, 661 (1988), Huang, M., et al.: Pharm. Drug Dispos., 54, 257 (1993), Smyth, W., et al.: Anal. Bioanal. Chem., 378, 1305 (2004),<br></p>Fórmula:C23H27FN4O4Forma y color:NeatPeso molecular:442.484-Amino-2-fluoro-N-methylbenzamide
CAS:Producto controlado<p>Stability Moisture Sensitive<br>Applications 4-Amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors<br>References Ivachtchenko, A. V., et al.: Eur. J. Med. Chem., 99, 51 (2015); Zhang, D., et al.: Bioorg. Med. Chem. Lett., 23, 2408 (2013)<br></p>Fórmula:C8H9FN2OForma y color:NeatPeso molecular:168.172-Hydroxy Nevirapine-d3
CAS:Producto controlado<p>Applications A labelled metabolite of Nevirapine (N391275).<br>References Rettie, A., et al.: J. Biol. Chem., 263, 13733 (1988), Lamson, M., et al.: Biopharm. Drug Dispos., 20, 285 (1999), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001), Lu, W., et al.: Drug Metab. Dispos., 36, 1624 (2008),<br></p>Fórmula:C15H11D3N4O2Forma y color:NeatPeso molecular:285.324-epi-Ritonavir
CAS:Producto controlado<p>Impurity Ritonavir EP Impurity O<br>Applications 4-epi-Ritonavir (Ritonavir EP Impurity O) is an isomer of Ritonavir (R535000), a selective HIV protease inhibitor. It is a COVID19-related research product.<br>References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788(2006)<br></p>Fórmula:C37H48N6O5S2Forma y color:NeatPeso molecular:720.94Hydroxynorketamine Hydrochloride
CAS:Producto controlado<p>Applications Hydroxynorketamine is a metabolite of Ketamine (K165300, HCl salt) which is a medication used mainly for starting and maintaining anesthesia.<br>References Adams, J., et al.: Biomed. Mass Spec., 11, 527 (1981); Sass, W.C., et al.: Anal. Profiles Drug Subs., 6, 297 (1977); Reich, D.L., et al.: Can. J. Anaesth., 36, 186 (1989)<br></p>Fórmula:C12H15Cl2NO2Forma y color:White To Off-WhitePeso molecular:276.162,2’-Methylene Bis[Ranitidine]
CAS:Producto controlado<p>Impurity Ranitidine EP Impurity I<br>Stability Light Sensitive, Temperature Sensitive<br>Applications 2,2’-Methylene Bis[Ranitidine] (Ranitidine EP Impurity I) is an impurity of histamine H2-receptor antagonist Ranitidine (R120000).<br>References Jones, M.D. et al.: J. Sep. Sci., 29, 2409 (2006); Kelly, M.A. et al.: J. Chrom. A, 798, 297 (1998);<br></p>Fórmula:C27H44N8O6S2Forma y color:NeatPeso molecular:640.822-(1-aminocyclohexyl)acetic acid
CAS:Producto controladoFórmula:C8H15NO2Forma y color:NeatPeso molecular:157.214'-(Bromomethyl)-[1,1'-biphenyl]-2-carboxamide
CAS:Producto controlado<p>Impurity Telmisartan Bromo Amide Impurity<br>Applications An impurity in the preparation of the angiotensin II receptor antagonist Telmisartan (T017000).<br>References Wienen, W., et al.: Brit. J. Pharmacol., 110, 245 (1993), Neutel, J.M., and Smith, D.H.G.: Adv. Ther., 15, 206 (1998)<br></p>Fórmula:C14H12BrNOForma y color:WhitePeso molecular:290.16Tianeptine Metabolite MC5-d4 Sodium Salt
CAS:Producto controlado<p>Applications Labelled, primary metabolite of Tianeptine.<br>References Dresse, A., et al.: J. Clin. Pharmacol., 28, 1115 (1988), Grislain, L., et al.: Drug Metab. Dispos., 18, 804 (1990),<br></p>Fórmula:C19H16D4ClN2NaO4SForma y color:NeatPeso molecular:434.911-(6-Methylpyridin-3-yl)-2-((4-(2-(6-methylpyridin-3-yl)-2-oxoethyl)phenyl)sulfonyl)ethanone
CAS:Producto controladoFórmula:C22H20N2O4SForma y color:NeatPeso molecular:408.47rac Viloxazine Hydrochloride
CAS:Producto controladoFórmula:C13H19NO3·ClHForma y color:WhitePeso molecular:273.76Methylene-Bis Paroxetine Dihydrochloride
CAS:Producto controlado<p>Impurity Paroxetine EP Impurity F<br>Applications Methylene-Bis Paroxetine Dihydrochloride (Paroxetine EP Impurity F) is used in the chiral HPLC method for chiral purity determination of Paroxetine drug substance.<br>References Zukowski, J., et al.: Chirality, 15, 600 (2003),<br></p>Fórmula:C39H42Cl2F2N2O6Forma y color:NeatPeso molecular:743.66trans-Hydroxy Praziquantel-d5
CAS:Producto controlado<p>Applications Labelled trans-Hydroxy Praziquantel (H952405). The main cis-monohydroxylated metabolite of Praziquantel (P702095).<br>References Buehring, K., et al.: Eur. J. Drug Metab. Pharm., 3, 179 (1978), Moldeus, P., et al.: Methods Enzymol., 52, 60 (1978), Cioli, D., et al.: Pharmacol. Ther., 68, 35 (1995),<br></p>Fórmula:C19H19D5N2O3Forma y color:NeatPeso molecular:333.442-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol
CAS:Producto controlado<p>Applications 2-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol is used as a reagent in the synthesis of Ticagrelor (T437700) derivatives as antiplatelet agents.<br>References Zhang, H., et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012)<br></p>Fórmula:C17H27ClN4O4SForma y color:NeatPeso molecular:418.94Eltenac-13C,d3
CAS:Producto controlado<p>Applications Labelled Eltenac (E507000). A nonsteroidal anti-inflammatory drug.<br>References Allen, A., et al.: Gut, 21, 249 (1980), Tobin, T., et al.: J. Vet. Pharmacol. Therap., 9, 1 (1986),<br></p>Fórmula:CC11H7Cl2D2NO2SForma y color:NeatPeso molecular:302.182,2'-Ethylenedianiline
CAS:Producto controlado<p>Applications 2,2'-Ethylenedianiline is used as a reagent to synthesize Oxcarbazepine (O869250), a broad-specturm, second-generation anticonvulsant drug that is used to treat partial and complex partial seizures in children and adults. 2,2'-Ethylenedianiline is also used as a reagent to prepare a series of triterpines (e.g. Lupeol [L474850]), compounds that have chemopreventative activity.<br>References Asmaa, M., et al.: Pac. J. Cancer Prevent., 15, 475 (2014); Kalis, M. & Huff, N.: Clin. Ther., 23, 680 (2001); Malke, S., et al.: Pharm. Sci., 69, 211 (2007); Schmidt, D. & Elger, C.: Epil. Beh., 5, 627 (2004)<br></p>Fórmula:C14H16N2Forma y color:NeatPeso molecular:212.29Plerixafor Hydrochloride (1:8)
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>Fórmula:C28H54N8·8ClHForma y color:NeatPeso molecular:794.474-{[(p-Fluorophenyl)imino]methyl}phenol
CAS:Producto controlado<p>Applications 4-{[(p-Fluorophenyl)imino]methyl}phenol is used in the preparation of benzylacetones which promote anti-fungal activity.<br>References Sandhar, R. et al.: J. Ind. Council Chem., 22, 32 (2005);<br></p>Fórmula:C13H10FNOForma y color:NeatPeso molecular:215.225-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS:Producto controlado<p>Applications 5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione is an impurity of the DPP-IV inhibitor Sitagliptin (S491000).<br>References Ye, F. et al.: Hech. Huax., 18, 767 (2010); Ahn, J.H, et al.: Bioorg. Med. Chem. Lett., 17, 2622 (2007);<br></p>Fórmula:C14H11F3O5Forma y color:NeatPeso molecular:316.23rac Methotrimeprazine Sulfoxide
CAS:Producto controlado<p>Applications A metabolite of Methotrimeprazine (M260785).<br>References Haddad, P., et al.: Drugs, 62, 1649 (2002),<br></p>Fórmula:C19H24N2O2SForma y color:NeatPeso molecular:344.47Repirinast (>80%)
CAS:Producto controladoFórmula:C20H21NO5Pureza:>80%Forma y color:NeatPeso molecular:355.38Trazodone 1,4-Di-N-Oxide
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A possible metabolite of Trazodone-HCl (T718500).<br></p>Fórmula:C19H22ClN5O3Forma y color:NeatPeso molecular:403.862-Hydroxy Imipramine-d6
CAS:Producto controlado<p>Applications A labelled metabolite of Imipramine.<br>References De Jongh, G.D., et al.: Drug Metab. Dispos., 2, 48 (1981), Suckow, R.F., et al.: J. Pharm. Sci., 73, 1745 (1984), Fraser, A.D., et al.: J. Anal. Toxicol., 11,168 (1987),<br></p>Fórmula:C19H18D6N2OForma y color:NeatPeso molecular:302.44
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