Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65630 productos de "Derivados de Quinazolina y Quinolina"
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4’-Bromomethylbiphenyl-2-carboxylic Acid, Methyl Ester
CAS:Producto controladoFórmula:C15H13BrO2Forma y color:NeatPeso molecular:305.17rac Felodipine-d3
CAS:Producto controlado<p>Applications A labelled dihydropyridine calcium channel blocker.<br>References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981), Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002), O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006),<br></p>Fórmula:C182H3H16Cl2NO4Forma y color:NeatPeso molecular:387.272-Chloro Loratadine
CAS:Producto controlado<p>Applications 2-Chloro Loratadine is an impurity of Loratadine (L469575), a nonsedating-type histamine H1-Receptor blocker.<br>References U.S. (1998), US 5719148 A 19980217. PCT Int. Appl. (1995), WO 9510515 A1 19950420.<br></p>Fórmula:C22H22Cl2N2O2Forma y color:NeatPeso molecular:417.33Dapoxetine N-Oxide (90%)
CAS:Producto controlado<p>Applications The N-oxide impurity of the selective serotonin reuptake inhibitor Dapoxetine (D185700).<br></p>Fórmula:C21H23NO2Pureza:90%Forma y color:NeatPeso molecular:321.41Haloperidol pyridinium Chloride Impurity
CAS:Producto controlado<p>Applications Haloperidol pyridinium Chloride is a neurotoxic pyridinium metabolite of haloperidol that is formed in the liver and found in the brain. Haloperidol pyridinium Chloride is a substrate for human organic cation transporters.<br>References Kang, H. et. al.: Drug Metab. Dispos., 34, 1145 (2006)<br></p>Fórmula:C21H18Cl2FNOForma y color:NeatPeso molecular:390.28(E)-Thiothixene
CAS:Producto controlado<p>Applications (E)-Thiothixene is an antipsychotic agent used in the treatment of psychological disorders.<br>References Andorn, A. et al.: Brain Res., 971, 66 (2003); Seeman, P. et al.: Mol. Pharmacol. 28, 391 (1985);<br></p>Fórmula:C23H29N3O2S2Forma y color:NeatPeso molecular:443.632-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid
CAS:Producto controlado<p>Applications 2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid (cas# 1289942-66-0) is a useful research chemical.<br></p>Fórmula:C12H15FN2O3Forma y color:NeatPeso molecular:254.26(3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl Acetate
CAS:Producto controlado<p>Impurity Lansoprazole<br>Applications (3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl Acetate is an impurity of Lansoprazole (L175000). Lansoprazole is used as a gastric proton pump inhibitor and an antiulcerative. It May limit the severity of tuberculosis.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000); Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001); Barradell, L.B., et al.: Drugs, 44, 225 (1992); Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002); Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006); Chem. and Eng. News. p. 28 July 20 (2018)<br></p>Fórmula:C11H12F3NO3Forma y color:NeatPeso molecular:263.2136,8-Dioxo Apalutamide
CAS:Producto controlado<p>Applications 6,8-Dioxo Apalutamide is an impurity of Apalutamide (A726120). Apalutamide is a second-generation antiandrogen used in the treatment of prostate cancer.<br>References Li, Huifang, et al.: J. of Chem. Info. and Model., 53(1), 123-130 (2013);Joseph, James D., et al.: Cancer Disc., 3(9), 1020-1029 (2013)<br></p>Fórmula:C21H15F4N5O3Forma y color:NeatPeso molecular:461.385-(2-Fluorophenyl)-5-oxovaleric Acid
CAS:Producto controlado<p>Applications 5-(2-Fluorophenyl)-5-oxovaleric Acid is used as a reagent in the preparation of indole derivatives which act as cell protective agents. It is also used as a reagent in the catalytic N-nitroso aldol reaction of γ,δ-unsaturated δ-lactones.<br>References Yamamoto, I., et al.: Preparation of indole derivatives as cell protective agents, WO Patent 9745410, Dec 4, 1997; Yanagisawa, A., et al.: Org. Lett., 14, 2434 (2012);<br></p>Fórmula:C11H11FO3Forma y color:NeatPeso molecular:210.2Nafronyl 2-(Ethyl(nitroso)amino)
CAS:Producto controlado<p>Applications Nafronyl 2-(Ethyl(nitroso)amino) is an impurity of Nafronyl (N215000). Nafronyl is a selective inhibitor of serotonin receptors. Nafronyl is a vasodilator used in the treatment of intermittent claudication.<br>References Fontaine, et al.: Chim. Ther., 4, 44 (1969), Bessin, P., et al.: Eur. J. Med. Chem., 10, 291 (1975), Clyne, C.A., et al.: Br. J. Surg., 67, 347 (1980),<br></p>Fórmula:C22H28N2O4Forma y color:NeatPeso molecular:384.47Perampanel-d5
CAS:Producto controlado<p>Applications Perampanel-d5, is the labeled analogue of Perampanel (P285520), an antiepileptic drug.<br>References Shih, J., et al.: Therap. Clinical Risk Management, 9, 285 (2013); Rogawski, M. A., et al.: Epilepsy Curr., 11, 56 (2011);<br></p>Fórmula:C23D5H10N3OForma y color:Light Orange Colour SolidPeso molecular:354.42N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfide
CAS:Producto controlado<p>Applications Rabeprazole (R070500) N-aralkyl impurity.<br>References Fujisaki, H., et al.: Biochem. Pharmacol., 42, 321 (1991), Morri, M., et al.: J. Biol. Chem., 268, 21553 (1993), Pingili, R., et al.: Pharmazie, 60, 814 (2005),<br></p>Fórmula:C29H36N4O4SForma y color:NeatPeso molecular:536.694-Desfluoro-3-Fluoro Bicalutamide
CAS:Producto controlado<p>Impurity Bicalutamide USP Related Compound B/ Bicalutamide EP Impurity B<br>Applications 3-Fluorophenyl Bicalutamide (Bicalutamide USP Related Compound B) is a steroisomer of Bicalutamide (B382000), non-steroidal peripherally active anti-androgen. Used as an antiandrogen, antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>Fórmula:C18H14F4N2O4SForma y color:NeatPeso molecular:430.374,5-Dehydro Apixaban
CAS:Producto controlado<p>Applications 4,5-Dehydro Apixaban is an impurity of Apixaban (A726700), a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011)<br></p>Fórmula:C25H23N5O4Forma y color:NeatPeso molecular:457.48Nitroso Norquetiapine-d8
Producto controladoFórmula:C17D8H8N4OSForma y color:NeatPeso molecular:348.4494-Ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydro-imidazo[5,1-f][1,2,4]-triazin-2-yl)benzene-sulfonyl Chloride
CAS:Producto controlado<p>Applications Vardenafil Intermediate.<br>References Terrett, N.K., et al.: Bioorg. Med. Chem. Lett., 6, 1819, (1996)<br></p>Fórmula:C17H19ClN4O4SForma y color:NeatPeso molecular:410.88Haloperidol Decanoate N-Oxide
Producto controladoFórmula:C31H41ClFNO4Forma y color:NeatPeso molecular:546.114-[4-[(5R)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride (>90%)
CAS:Producto controlado<p>Applications 4-[4-[(5R)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride is an intermediate in the synthesis of ent-Rivaroxaban (R538005), the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent.<br>References Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C14H17N3O4·HClPureza:>90%Forma y color:White To Off-WhitePeso molecular:291.31 + (36.46)5-(4-methylphenyl)imidazolidine-2,4-dione
CAS:Producto controlado<p>Applications 5-(4-methylphenyl)imidazolidine-2,4-dione (cas# 69489-37-8) is a useful research chemical.<br></p>Fórmula:C10H10N2O2Forma y color:NeatPeso molecular:190.204-[3-(Methylamino)-1-(2-thienyl)propyl]-1-naphthalenol Hydrochloride (Duloxetine Impurity)
CAS:Producto controlado<p>Impurity D721000<br>Applications Duloxetine impurity; also a related compound of Duloxetine metabolite.<br></p>Fórmula:C18H19NOS·ClHForma y color:NeatPeso molecular:333.88Dacomitinib
CAS:Producto controlado<p>Applications Dacomitinib is an Erb-inhibitor, or an inhibitor of the members of the epidermal growth factor receptor family. Used as an ant-cancer agent due to observation of over-expressed epidermal growth factor receptor in nearly all cases of squamous cell carcinoma in the head and neck.<br>References Williams, J. et al.: PLoS., 9, e98557 (2014); Peters, S. et al.: Canc. Treatment Rev., 40, 917 (2014);<br></p>Fórmula:C24H25ClFN5O2Forma y color:NeatPeso molecular:469.943-Chloro-1,2-propanediol-d5 (10 ug/mL in methanol)
CAS:Producto controladoFórmula:C32H5H2ClO2Forma y color:ColourlessPeso molecular:115.571-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene
CAS:Producto controlado<p>Applications 1-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene is used in the synthesis of novel histone deacetylase 1 inhibitors (HDAC 1). Also used in the synthesis of antibacterial gemifloxacin derivatives.<br>References Sun, Q. et al.L: Bioorg. Med. Chem. Lett., 23, 3295 (2013); Feng, L. et al. Eur. J. Med. Chem., 55, 125 (2012);<br></p>Fórmula:C9H10Br2O2Forma y color:NeatPeso molecular:309.98N-Nitrososotalol-d6
CAS:Producto controladoFórmula:C12D6H13N3O4SForma y color:Off-WhitePeso molecular:307.3992-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
CAS:<p>Impurity Nizatidine EP Impurity D<br>Applications 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole (Nizatidine EP Impurity D) is a Nizatidine intermediate.<br></p>Fórmula:C9H17N3S2Forma y color:NeatPeso molecular:231.38Bicalutamide Sulfoxide
CAS:Producto controlado<p>Impurity Bicalutamide USP Related Compound A<br>Applications Bicalutamide Sulfoxide is a derivative of Bicalutamide (B382000), non-steroidal peripherally active antiandrogen. Used as an antiandrogen, antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>Fórmula:C18H14F4N2O3SForma y color:NeatPeso molecular:414.37o-Nitrofluorobenzene
CAS:Producto controlado<p>Applications o-Nitrofluorobenzene is an intermediate in the synthetic preparations of various pharmaceutical goods.<br>References Ma. W., et al.: QSAR. Combin. Sci., 25, 895 (2006); Sutton, P.G., et al.: Analyst., 124, 877 (1999); Yi, W.B., et al.: J. Fluorine. Chem., 129, 524 (2008);<br></p>Fórmula:C6H4FNO2Forma y color:NeatPeso molecular:141.1(Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide (~90%)
CAS:Producto controlado<p>Applications (Z)-4-Hydroxy Tamoxifen O-β-D-Glucuronide is an active metabolite of Tamoxifen (T006000).<br>References Ogura, K. et al.: Biochem. Pharmacol., 71, 1358 (2006); Nishiyama, T. et al.: Biochem. Pharmacol., 63, 1817 (2002); McCague, R. et al.: Biochem. Pharmacol., 39, 1459 (1990);<br></p>Fórmula:C32H37NO8Pureza:~90%Forma y color:NeatPeso molecular:563.64Leflunomide EP Impurity G
CAS:Producto controladoFórmula:C12H12N2O2Forma y color:NeatPeso molecular:216.24Des(isopropylthiazolyl) Hydantoin Ritonavir (>90%)
CAS:<p>Impurity Ritonavir EP Impurity F<br>Applications Des(isopropylthiazolyl) Hydantoin Ritonavir (Ritonavir EP Impurity F) is a Ritonavir (R535000) derivative with potential use in the treatment of viral infections. Cytochrome P450 oxidase inhibitor. It is a COVID19-related research product.<br>References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994); Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003);<br></p>Fórmula:C29H34N4O5SPureza:>90%Forma y color:NeatPeso molecular:550.67N-Methylthiophene-2-carboxamide
CAS:Producto controladoFórmula:C6H7NOSForma y color:NeatPeso molecular:141.19Apatinib-d8 25-N-Oxide Dihydrochloride
CAS:Producto controlado<p>Applications Labelled Apatinib 25-N-Oxide (A726160). Apatinib 25-N-Oxide is a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br>References Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>Fórmula:C24H15D8N5O2•2HClForma y color:NeatPeso molecular:421.5223646Sitagliptin N-Sulfate Sodium Salt
CAS:Producto controlado<p>Applications A metabolite of Sitagliptin.<br>References Beconi, M.G. , et al.: Drug Metab. Dispos., 35, 525 (2007),<br></p>Fórmula:C16H15F6NaN5O4SForma y color:NeatPeso molecular:509.36Ebastine N-Oxide
CAS:<p>Stability -20°C Freezer<br>Applications Ebastine N-Oxide is an impurity of Ebastine (E320000). Ebastine impurity F and G (mixture of cis/trans).<br>References Yardley, J., et al.: J. Med. Chem., 33, 2899 (1990), Johnson, R., et al.: J. Antibiot., 49, 788 (1996), Takekawa, K., et al.: Xenobiotica, 31, 11 (2001), Chen, Z., et al.: Bioorg. Med. Chem. Lett., 14, 5275 (2004),<br></p>Fórmula:C32H39NO3Forma y color:NeatPeso molecular:485.66Fimasartan
CAS:Producto controlado<p>Applications Fimasartan is a new angiotensin II receptor blocker antagonist and also functions as an antihypertensive agent.<br>References Lee, H., et al.: Drugs, 76, 1015 (2016)<br></p>Fórmula:C27H31N7OSForma y color:NeatPeso molecular:501.65α-Phenyl-2-pyridineacetamide
CAS:Producto controlado<p>Applications α-Phenyl-2-pyridineacetamide (cas# 7251-52-7) is a compound useful in organic synthesis.<br></p>Fórmula:C13H12N2OForma y color:NeatPeso molecular:212.25Rotigotine Hydrochloride
CAS:<p>Applications It is a non-ergot dopamine agonist drug and is indicated for the treatment of Parkinson’s disease.<br>References Loschmann, P., et al.: Eur. J. Pharmacol., 166, 373 (1989), Edgar, D., et al.: J. Pharmacol. Exp. Ther., 283, 757 (1997), Ferreira, J., et al.: Lancet, 355, 1333 (2000), Arnulf, I., et al.: Neurology, 58, 1019 (2002), Wisor, J., et al.: Neuroscience, 132, 1027 (2005),<br></p>Fórmula:C19H25NOS·ClHForma y color:White To Off-WhitePeso molecular:351.93Loxapine, Succinate
CAS:Producto controlado<p>Applications A D2/D4-Dopamine receptor antagonist. A serotonergic receptor antagonist. A dibenzoxazepine antipsychotic agent.<br>References Shen, Y., et al.: J. Biol. Chem., 268, 18200 (1993), Fiorella, D., et al.: Psychopharmacology, 121, 347 (1995), Glusa, E., et al.: Br. J. Pharmacol., 130, 692 (2000)<br></p>Fórmula:C18H18ClN3O·C4H6O4Forma y color:WhitePeso molecular:445.90cis-Hydroxy Solifenacin N-Oxide(Mixture of Diastereomers)
Producto controlado<p>Applications Solifenacin (S676700) metabolite.<br></p>Fórmula:C23H26N2O4Forma y color:NeatPeso molecular:394.46Palbociclib
CAS:<p>Applications Palbociclib (also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009);<br></p>Fórmula:C24H29N7O2Forma y color:NeatPeso molecular:447.533,3'-Disulfanediylbis[(2S)-2-methylpropanoic] Acid
CAS:Producto controladoFórmula:C8H14O4S2Forma y color:NeatPeso molecular:238.322-(Bromomethyl)-3-nitrobenzoic Acid Methyl Ester
CAS:Producto controlado<p>Applications 2-(Bromomethyl)-3-nitrobenzoic Acid Methyl Ester (cas# 98475-07-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C9H8BrNO4Forma y color:Off-White To Light YellowPeso molecular:274.07(6R,12aS)-N-Desmethyl ent-Tadalafil
CAS:Producto controlado<p>Impurity Tadalafil EP Impurity A N-Desmethyl Impurity<br>Applications (6R,12aS)-N-Desmethyl Tadalafil (Tadalafil EP Impurity A N-Desmethyl Impurity) is an intermediate in the synthesis of novel potent arylated analogues of tadalafil (T004500).<br>References Beghyn, T., et al.: Bioorg. Med. Chem. Lett., 17, 789 (2007);<br></p>Fórmula:C21H17N3O4Forma y color:NeatPeso molecular:375.381-(4-(4-(tert-Butyl)phenyl)-4-hydroxybutyl)piperidine-4-carboxylic Acid
Producto controladoFórmula:C20H31NO3Forma y color:NeatPeso molecular:333.465Hydroxy Iloperidone-d4
CAS:Producto controlado<p>Applications A hydroxylated labelled metabolite of Iloperidone (I267200).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mutlib, A., et al.: Drug Metab. Dispos., 23, 951 (1995), Westerink, B., et al.: Eur. J. Pharmacol., 412, 127 (2001),<br></p>Fórmula:C24H25D4FN2O4Forma y color:Off White SolidPeso molecular:432.52Repirinast (>80%)
CAS:Producto controladoFórmula:C20H21NO5Pureza:>80%Forma y color:NeatPeso molecular:355.38rac Methotrimeprazine Hydrochloride
CAS:Producto controlado<p>Applications Analgesic.<br>References Haddad, P., et al.: Drugs, 62, 1649 (2002), Chiu, P., et al.: J. Pharmacol. Sci., 95, 311 (2004), Dubin, A., et al.: J. Biomol. Screen, 10, 168 (2005),<br></p>Fórmula:C19H24N2OS·HClForma y color:NeatPeso molecular:364.93Loxapine N-Glucuronide Chloride
CAS:Producto controladoFórmula:C24H27ClN3O7·ClForma y color:NeatPeso molecular:540.3934-Fluoro-2-(hydroxymethyl)phenylboronic Acid
CAS:Producto controlado<p>Applications 4-Fluoro-2-(hydroxymethyl)phenylboronic Acid is a compound used in the preparation of 4,5-dihydro-1H-pyrazole derivatives as cholesterol 24 hydroxylase inhibitors.<br>References Kaku, T., et al.: Preparation of 4,5-dihydro-1H-pyrazole derivatives as cholesterol 24 hydroxylase inhibitors, WO 2010110400 (2010);<br></p>Fórmula:C7H8BFO3Forma y color:NeatPeso molecular:169.95cis-Hydroxy Solifenacin (Mixture of Diastereomers)
CAS:Producto controlado<p>Applications Solifenacin (S676700) metabolite.<br>References Naito, R., et al.: J. Med. Chem., 48, 6597 (2005), Krauwinkel, W., et al.: Int. J. Clin. Pharmacol. Ther., 43, 227 (2005),<br></p>Fórmula:C23H26N2O3Forma y color:NeatPeso molecular:378.46N-Benzyl Epinephrine-d3
CAS:Producto controlado<p>Applications Labelled analogue of N-Benzyl Epinephrine, an impurity of Epinephrine (E588580).<br></p>Fórmula:C16H16D3NO3Forma y color:NeatPeso molecular:276.35Clonidine
CAS:Producto controlado<p>Applications Clonidine is an α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983); Glassman, A.H., et al.: Science, 226, 864 (1984); Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992);<br></p>Fórmula:C9H9Cl2N3Forma y color:NeatPeso molecular:230.097-Hydroxyquinoline-(1H)-2-one
CAS:Producto controladoFórmula:C9H7NO2Forma y color:NeatPeso molecular:161.16Prochlorperazine Sulfoxide
CAS:Producto controlado<p>Applications A metabolite of Prochlorperazine.<br>References Finn, A., et al.: J. Clin. Pharmacol., 45, 1383 (2005),<br></p>Fórmula:C20H24ClN3OSForma y color:NeatPeso molecular:389.94Ethyl 2-[N-[(2'-Cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate
CAS:<p>Applications Ethyl 2-[N-[(2'-Cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate is a useful reagent in synthesis of candesartan cilexitil.<br>References Zhu, Y., et al.: Zhongguo Yaowu Huaxue Zazhi, 13, 31 (2003); Cao, R., et al.: Zhongguo Yiyao Gongye Zazhi, 34, 425 (2003);<br></p>Fórmula:C23H19N3O4Forma y color:NeatPeso molecular:401.413-Bromo-2-methylpropionic Acid
CAS:<p>Impurity Captopril EP Impurity D<br>Stability Hygroscopic<br>Applications 3-Bromo-2-methylpropionic Acid (Captopril EP Impurity D) is used in the preparation of captopril selenium analogs as antioxidants and ACE inhibitors used as antihypertensive drugs.<br>References Bhuyan, B. et al.: Org. Biomol. Chem., 9, 1356 (2011);<br></p>Fórmula:C4H7BrO2Forma y color:Colourless LiquidPeso molecular:167.004-Hydroxy-2-methyl- 1,1-dioxide-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide
CAS:Producto controladoFórmula:C8H8N2O4S2Forma y color:NeatPeso molecular:260.292,2'-((6,6'-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide)
CAS:Producto controlado<p>Applications 2,2'-((6,6'-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide) is an impurity of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.<br>References Wasser, K., et al.: Eur. Radiol., 13, 80 (2003), Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002), Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003),<br></p>Fórmula:C44H36N8O2S2Forma y color:BeigePeso molecular:722.94rac Methyl Efavirenz (Mixture of Diastereomers)
CAS:Producto controlado<p>Applications Efavirenz (E425000) potential synthetic impurity and degradation product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Phelan, P., et al.: J. Chromatogr. Sci., 19, 13 (1981), Mangia, A., et al.: Anal. Chim. Acta., 149, 349 (1983), Careri, M., et al.: J. Chromatogr., 647, 79 (1993), van Beek, T., et al.: Phytochem. Anal., 6, 1 (1995),<br></p>Fórmula:C15H11ClF3NO2Forma y color:NeatPeso molecular:329.70Eltenac-13C,d3
CAS:Producto controlado<p>Applications Labelled Eltenac (E507000). A nonsteroidal anti-inflammatory drug.<br>References Allen, A., et al.: Gut, 21, 249 (1980), Tobin, T., et al.: J. Vet. Pharmacol. Therap., 9, 1 (1986),<br></p>Fórmula:CC11H7Cl2D2NO2SForma y color:NeatPeso molecular:302.18Methyl 3,4,5-Tris(benzyloxy)benzoate
CAS:Producto controlado<p>Applications Intermediate in the production of Gallic Acid derivatives.<br>References Dodo, K., et al.: Bioorg. Med. Chem., 16, 7975 (2008), Dodo, K., et al.: Chem. Pharm. Bull., 57, 190 (2009),<br></p>Fórmula:C29H26O5Forma y color:NeatPeso molecular:454.51Benperidol
CAS:<p>Applications Benperidol is an antipsychotic which can be used for the treatment of schizophrenia, but is primarily used to control antisocial hypersexual behaviour.<br>References Bobon, J., et al.: Acta Neurol Belg, 63, 839-43 (1963);<br></p>Fórmula:C22H24FN3O2Forma y color:White To Off-WhitePeso molecular:381.444-Oxo-1,4-dihydroquinoline Carboxylic Acid
CAS:Producto controlado<p>Applications 4-Oxo-1,4-dihydroquinoline Carboxylic Acid is a novel HIV-1 integrase strand transfer inhibitor.<br>References Shinkai, H. et al.: Antivir. Drugs. 197 (2011); Liao, C. et al.: ChemMedChem., 5, 1053 (2010);<br></p>Fórmula:C10H7NO3Forma y color:NeatPeso molecular:189.174-Amino-2-fluoro-N-methylbenzamide
CAS:Producto controlado<p>Stability Moisture Sensitive<br>Applications 4-Amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors<br>References Ivachtchenko, A. V., et al.: Eur. J. Med. Chem., 99, 51 (2015); Zhang, D., et al.: Bioorg. Med. Chem. Lett., 23, 2408 (2013)<br></p>Fórmula:C8H9FN2OForma y color:NeatPeso molecular:168.172,2'-Ethylenedianiline
CAS:Producto controlado<p>Applications 2,2'-Ethylenedianiline is used as a reagent to synthesize Oxcarbazepine (O869250), a broad-specturm, second-generation anticonvulsant drug that is used to treat partial and complex partial seizures in children and adults. 2,2'-Ethylenedianiline is also used as a reagent to prepare a series of triterpines (e.g. Lupeol [L474850]), compounds that have chemopreventative activity.<br>References Asmaa, M., et al.: Pac. J. Cancer Prevent., 15, 475 (2014); Kalis, M. & Huff, N.: Clin. Ther., 23, 680 (2001); Malke, S., et al.: Pharm. Sci., 69, 211 (2007); Schmidt, D. & Elger, C.: Epil. Beh., 5, 627 (2004)<br></p>Fórmula:C14H16N2Forma y color:NeatPeso molecular:212.29N-Methyl Topiramate
CAS:Producto controlado<p>Impurity Topiramate N-methyl impurity<br>Applications N-Methyl Topiramate, is an impurity of Topiramate (T540250); which is an anticonvulsant (antiepilepsy) drug, that has been approved for weight loss by FDA.<br>References Maryanoff, B.E., et al.: J. Med. Chem., 30, 880 (1987), Bialer, M.: Clin. Pharmacokinet., 24, 441 (193),<br></p>Fórmula:C13H23NO8SForma y color:NeatPeso molecular:353.39(S)-Propyl Pramipexole
CAS:Producto controlado<p>Applications (S)- Propyl Pramipexole is (S)-Pramipexole (P700750) analogue. (S)-Pramipexole (P700750) is a dopamine-D2-receptor agonist. Antiparkinsonian. Pramipexole (Mirapex, Mirapexin, Sifrol) is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson's disease (PD) and restless legs syndrome (RLS).[1] It is also sometimes used off-label as a treatment for cluster headache and to counteract the problems with sexual dysfunction experienced by some users of the selective serotonin reuptake inhibitor (SSRI) antidepressants.<br>References Mierau, J., et al.: J. Med. Chem., 30, 494 (1987);Schilling, J.C., et al.: Clin. Pharmacol. Ther., 51, 541 (1992);Kieburtz, K., et al.: J. Am. Med. Assoc., 278, 125 (1997);<br></p>Fórmula:C13H23N3SForma y color:NeatPeso molecular:253.41Rilmazafone Hydrochloride
CAS:<p>Applications Rilmazafone Hydrochloride can be used in biological study of nitrazepam or rilmazafone hydrochloride combined with ethanol effects on human memory. It is also used as sleep aid medication.<br>References Suzuki, M., et al.: Neurosciences (Okayama, Japan), 20, 43 (1994)<br></p>Fórmula:C21H20Cl2N6O3·HClForma y color:NeatPeso molecular:475.33 + (36.46)3-O-Benzyl-4,5-O-(1-methylethyldiene)-β-D-fructopyranose
CAS:Producto controlado<p>Applications Intermediate in the preparation of 2,3-Desisopropylidene Topiramate, a metabolite of Topiramate<br></p>Fórmula:C16H22O6Forma y color:NeatPeso molecular:310.341-Hydroxy-3,4-dihydroquinolin-2(1H)-one
CAS:Producto controladoFórmula:C9H9NO2Forma y color:NeatPeso molecular:163.17N,N’-Desethylene Levofloxacin Hydrochloride
CAS:<p>Impurity Levofloxacin USP Related Compound E<br>Applications Levofloxacin (L360000) impurity. A photodegradation product of Levofloxacin (L360000) in aqueous solution. Levofloxacin USP Related Compound E.<br>References Yoshida, Y., et al.: Arzneim.-Forsch., 43, 601 (1993),<br></p>Fórmula:C16H18FN3O4·ClHForma y color:Off White SolidPeso molecular:371.792,4-Difluorobenzoic Acid
CAS:Producto controlado<p>Applications 2,4-Difluorobenzoic Acid (cas# 1583-58-0) is a compound useful in organic synthesis.<br></p>Fórmula:C7H4F2O2Forma y color:NeatPeso molecular:158.10rac O-Acetyl Pseudoephedrine Hydrochloride
CAS:Producto controlado<p>Applications rac O-Acetyl Pseudoephedrine is a racemic O-acetylated analogue of the non-selective adrenergic agonist Pseudoephedrine (P839350).<br>References Snopek, J. et al.: J. Chrom., 438, 211 (1988);<br></p>Fórmula:C12H17NO2·ClHForma y color:WhitePeso molecular:243.733-Hydroxy-4-methoxybenzaldehyde
CAS:Producto controladoFórmula:C8H8O3Forma y color:NeatPeso molecular:152.15(S)-Carisbamate
CAS:<p>Applications Carisbamate is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizure models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models.<br>References Novak GP, et al. 2007. Neurotherapeutics. Jan;4(1):106-9Nau C, 2004. J Membr Biol. Sep 1;201(1):1-8Codd EE, 2008. Pain. Feb;134(3):254-62. Epub 2007 May 25<br></p>Fórmula:C9H10ClNO3Forma y color:NeatPeso molecular:215.634'-Desmethoxy Omeprazole
CAS:Producto controlado<p>Applications 4'-Desmethoxy Omeprazole is one of two impurities in the synthesis of Esomeprazole, an anti-ulcerative drug for treatment of acid-related diseases.<br>References Liu, X., et al.: Lat. Am. J. Pharm., 34, 1265-1268 (2015);<br></p>Fórmula:C16H17N3O2SForma y color:NeatPeso molecular:315.39Hydrolyzed Pomalidomide M10
CAS:Producto controlado<p>Applications Hydrolyzed Pomalidomide M10 is an impurity of pomalidomide (P688200), which is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.<br>References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)<br></p>Fórmula:C13H13N3O5Forma y color:NeatPeso molecular:291.26Ezetimibe-13C6
CAS:Producto controlado<p>Applications Labelled Ezetimibe (E975000), an antihyperlipoproteinemic. A Cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Fórmula:C1813C6H21F2NO3Forma y color:NeatPeso molecular:415.38N-Desmethyl-4-hydroxy Tamoxifen β-D-Glucuronide (E/Z Mixture)
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A novel active metabolite of the anti-cancer drug Tamoxifen (T006000).<br>References Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003), Zheng, Y., et al.: Drug Metab. Dispos., 35, 1942 (2007),<br></p>Fórmula:C31H35NO8Forma y color:NeatPeso molecular:549.613-(Trifluoromethoxy)aniline
CAS:Producto controlado<p>Applications 3-(Trifluoromethoxy)aniline is reactant in the synthesis of pyrazolone-quinazolone hybrids as human hydroxyphenylpyruvate dioxygenase inhibitors which is a potential treatment for type I tyrosinemia.<br>References Xu, Y., et. al.: Bioorg. Med. Chem., 22, 5194 (2014)<br></p>Fórmula:C7H6F3NOForma y color:NeatPeso molecular:177.121-[6-(2-propenyl)-ergoline-8β-carbonyl]-3-methyl-perhydropyrimidine-2-one Methanolate
Producto controladoFórmula:C24H32N4O3Forma y color:NeatPeso molecular:424.54Ambrisentan-d10
CAS:Producto controlado<p>Applications Ambrisentan-d10, is the labeled analogue of Ambrisentan (A575860), a nonpeptide endothelin ETA receptor antagonist. Antihypertensive.<br>References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),<br></p>Fórmula:C22H12D10N2O4Forma y color:NeatPeso molecular:388.482-(4-Amino-1-oxoisoindolin-2-yl)pentanediamide
CAS:Producto controladoFórmula:C13H16N4O3Forma y color:Light YellowPeso molecular:276.3Hydroxymethyl Dasatinib
CAS:Producto controlado<p>Applications An oxidative metabolite of Dasatinib (M24 metabolite); used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br>References Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991), Shah, N., et al.: Science, 305, 399 (2004), O'Hare, T., et al.: Cancer Res., 65, 4500 (2005), Das, J., et al.: J. Med. Chem., 49, 6819 (2006), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008),<br></p>Fórmula:C22H26ClN7O3SForma y color:NeatPeso molecular:504.00Diphenhydramine-d6 N-Oxide
CAS:Producto controlado<p>Applications A labelled metabolite of Diphenhydramine (D486900) in humans.<br>References Breyer-Pfaff, U., et al.: Drug Metab. Dispos., 25, 340 (1997),<br></p>Fórmula:C17H15D6NO2Forma y color:NeatPeso molecular:277.39Losartan Carboxylic Acid Acyl-β-D-Glucuronide, 90%
CAS:Producto controlado<p>Applications A metabolite of Losartan (L470500).<br></p>Fórmula:C28H29ClN6O8Pureza:90%Forma y color:NeatPeso molecular:613.023-(2-Chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
CAS:<p>Applications An intermediate in the synthesis of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brown, T., et al.: J. Med. Chem., 33, 527 (1990), Yapi, A., et al.: Chem. Pharm. Bull., 48, 1886 (2000), Yapi, A., et al.: Arch. Pharm., 339, 201 (2006); Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988); Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990); Green, B.: Curr. Med. Res. Opin., 16, 57 (2000);<br></p>Fórmula:C11H11ClN2OForma y color:NeatPeso molecular:222.671,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Diethyl Ester
CAS:Producto controladoFórmula:C19H22N2O6Forma y color:YellowPeso molecular:374.396-Oxo-(S,S)-Palonosetron (~90%)
CAS:Producto controlado<p>Applications 6-Oxo-(S,S)-Palonosetron is an impurity of (S,S)-Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.<br>References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),<br></p>Fórmula:C19H22N2O2Pureza:~90%Forma y color:NeatPeso molecular:310.394-Hydroxy Flecainide
CAS:Producto controlado<p>Applications 4-Hydroxy Flecainide is an analogue of Flecainide (F390000).<br>References Blom, Y., et al.: J. Chromatogr., 653, 138 (1993),<br></p>Fórmula:C17H20F6N2O4Forma y color:NeatPeso molecular:430.34N-[3-Methyl-1-(1-phenylcyclobutyl)butyl]-N,N-dimethylamine Hydrochloride
CAS:Producto controlado<p>Applications N-[3-Methyl-1-(phenylcyclobutyl)butyl]-N,N-dimethylamine Hydrochloride is an impurity of Sibutramine Hydrochloride (S422500), a serotonin and noradrenaline reuptake inhibitor.<br>References Hanotin, C., et al.: Int. J. Obesity, 22, 32 (1998)<br></p>Fórmula:C17H27N·ClHForma y color:NeatPeso molecular:281.86Desfluoro Bicalutamide
CAS:Producto controlado<p>Impurity Bicalutamide EP Impurity A<br>Applications Desfluoro Bicalutamide (Bicalutamide EP Impurity A) is an impurity of Bicalutamide, a nonsteroidal antiandrogen.<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988),<br></p>Fórmula:C18H15F3N2O4SForma y color:NeatPeso molecular:412.383-Bromo-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
CAS:Fórmula:C16H11BrN2OForma y color:Light Brown To Dark BrownPeso molecular:327.183-Amino-5-chloro Salicylic Acid Methyl Ester
CAS:<p>Applications Intermediate in the preparation of Azasetron.<br>References Kawakita, T., et al.: Chem. Pharm. Bull., 40, 624 (1992),<br></p>Fórmula:C8H8ClNO3Forma y color:NeatPeso molecular:201.615-Ethoxy-2-pyrrolidone
CAS:Producto controlado<p>Applications 5-Ethoxy-2-pyrrolidone is an intermediate in the synthesis of rac-Vigabatrin (V253005), a novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic.<br>References Vajda, F., et al.: Clin. Neurosci., 7, 88 (2000), Beghi, E., et al.: Lancet. Neurol., 3, 618 (2004), Sagirli, O., et al.: J. Pharmaceut. Biomed., 42, 618 (2006),<br></p>Fórmula:C6H11NO2Pureza:>90%Forma y color:NeatPeso molecular:129.16
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