Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65576 productos de "Derivados de Quinazolina y Quinolina"
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(R)-Propranolol-d7 Hydrochloride
CAS:Producto controlado<p>Applications The labelled R-enantiomer of Propranolol (P831800). β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Bond, et al.: Nature, 213, 721 (1967), Hansteen, V., et al.: Br. Med. J., 284, 155 (1982), Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),<br></p>Fórmula:C16H15D7ClNO2Forma y color:NeatPeso molecular:302.85rac N-Methyl Epinephrine-d6 Hydrochloride (>90%)
CAS:Producto controlado<p>Applications Labelled N-Methylepinephrine, the N-methylated analogue of the sympathomimetic hormone Epinephrine (E588585). Recent studies suggest that N-Methylepinephrine may be synthesized from Epinephrine by phenylethanolamine N-methyltransferase present in the brain.<br>References Kajita, M. et al.: Nip. Iyo Masu Sup. Gak. Kon., 19, 107 (1994); Plummer, C.J. et al.: Eur. J. Med. Chem., 148, 481 (1988);<br></p>Fórmula:C10H9D6NO3•HClPureza:>90%Forma y color:Off-White To Light GreenPeso molecular:203.273646Niclosamide Piperazinesalt
CAS:Producto controladoFórmula:C13H8Cl2N2O4·C4H10N2Forma y color:NeatPeso molecular:413.26rac-Bromo-Descyanobicalutamide
Producto controlado<p>Applications Descyano-Bromo-Bicalutamide is related to Bicalutamide(B382000). A non-steroidal androgen receptor antagonist that binds the androgen receptor and prevents its activation<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990)<br></p>Fórmula:C17H14BrF4NO4SForma y color:NeatPeso molecular:484.26Benperidol
CAS:<p>Applications Benperidol is an antipsychotic which can be used for the treatment of schizophrenia, but is primarily used to control antisocial hypersexual behaviour.<br>References Bobon, J., et al.: Acta Neurol Belg, 63, 839-43 (1963);<br></p>Fórmula:C22H24FN3O2Forma y color:White To Off-WhitePeso molecular:381.444-Methyl Irinotecan
Producto controlado<p>Applications 4-Methyl Irinotecan, is an impurity of Irinotecan (I767500), a DNA topoisomerase inhibitor.<br>References Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987), Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993)<br></p>Fórmula:C34H40N4O6Forma y color:NeatPeso molecular:600.70Repirinast (>80%)
CAS:Producto controladoFórmula:C20H21NO5Pureza:>80%Forma y color:NeatPeso molecular:355.38Desalkyl Ebastine-d5
CAS:Producto controlado<p>Applications A labelled metabolite of Ebastine.<br>References Wiseman, L., et al.: Drugs, 51, 260 (1996), Takanori, H., et al.: Drug Metab. Dispos., 26, 566 (1998), Moss, A., et al.: Clin. Exp. Allergy 1999, 29, 200 (1999), Simons, F., et al.: Clin. Pharmacokinet., 36, 329 (1999), Hashizume, T., et al.: J. Pharmacol. Exp. Theor., 300, 298 (2002),<br></p>Fórmula:C18H16D5NOForma y color:NeatPeso molecular:272.45-Chloro-6-(piperidin-1-yl)pyrimidine-2,4-diamine
CAS:Producto controlado<p>Applications 5-Chloro-6-(piperidin-1-yl)pyrimidine-2,4-diamine is used for biological studies and has potential use in pharmaceutical compositions.<br>References Xiang, F.: Faming Zhuanli Shenqing. 39 pp. (2019)<br></p>Fórmula:C9H14ClN5Forma y color:NeatPeso molecular:227.694-Butyrylamino-3-methyl-5-nitrobenzoic Acid Methyl Ester
CAS:Producto controlado<p>Applications 4-Butyrylamino-3-methyl-5-nitrobenzoic Acid Methyl Ester is a useful synthetic intermediate in the production of Telmisartan, an antihypertensive drug. 4-Butyrylamino-3-methyl-5-nitrobenzoic Acid Methyl Ester is part of a more efficient process of synthesizing Telmisartan in terms of impurity, yield, cost, and large-scale production.<br>References Reddy, K., et al.: Org. Process Res. Dev., 11, 81 (2007)<br></p>Fórmula:C13H16N2O5Forma y color:NeatPeso molecular:280.285-Hydroxy Propranolol Hydrochloride
CAS:Producto controlado<p>Applications A metabolite of Propranolol.<br>References Otton, S., et al.: Br. J. Clin. Pharmacol., 30, 751 (1990), Fujita, S., et al.: J. Pharmacol. Exp. Ther., 264, 226 (1993), Bichara, N., et al.: Drug Metab. Dispos., 24, 112 (1996), Tasaki, T., et al.: J. Biochem., 123, 162 (1998),<br></p>Fórmula:C16H21NO3·HClForma y color:NeatPeso molecular:311.8041-Dehydroxy Terfenadine
CAS:Producto controladoFórmula:C32H41NOForma y color:NeatPeso molecular:455.676-Des(diethanolamino)-6-chloro Dipyridamole
CAS:Producto controlado<p>Impurity Dipyridamole EP Impurity C<br>Applications 6-Des(diethanolamino)-6-chloro Dipyridamole (Dipyridamole EP Impurity C) is a Dipyridamole (D492625) impurity. An antitumor nucleoside pyrimido pyrimidine.<br>References Fontani, F., et al.: J. Chromatogr., 280, 181 (1983),<br></p>Fórmula:C20H30ClN7O2Forma y color:NeatPeso molecular:435.95N-(S)-Glycidylphthalimide
CAS:Producto controlado<p>Applications N-(S)-Glycidylphthalimide is a phthalimide derivative used as an intermediate in the preparation of the antibiotic Linezolid (L466500).<br>References Rajesh, T. et al.: Pharm. Chem., 3, 168 (2011);<br></p>Fórmula:C11H9NO3Forma y color:WhitePeso molecular:203.192,2'-((6,6'-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide)
CAS:Producto controlado<p>Applications 2,2'-((6,6'-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide) is an impurity of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.<br>References Wasser, K., et al.: Eur. Radiol., 13, 80 (2003), Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002), Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003),<br></p>Fórmula:C44H36N8O2S2Forma y color:BeigePeso molecular:722.94N-Nitrosodabigatran Etexilate-d11
Producto controladoFórmula:C35H33D11N8O9SForma y color:NeatPeso molecular:763.914-Defluoro-4-(1H-1,2,4-triazol-1-yl) Fluconazole
CAS:Producto controlado<p>Impurity Fluconazole EP Impurity B / Fluconazole USP Related Compound A<br>Applications 4-Defluoro-4-(1H-1,2,4-triazol-1-yl) Fluconazole (Fluconazole EP Impurity B) is an impurity of the antifungal agent Fluconazole (F421000).<br>References Ramesh, B. et al.: J. Pharm. Res., 4, 1401 (2011); Al-Rimawi, F.: Jor. J. Chem., 4, 357 (2009);<br></p>Fórmula:C15H14FN9OForma y color:NeatPeso molecular:355.33O-Desmorpholinopropyl-O-methyl-gefitinib
CAS:Producto controlado<p>Applications O-Desmorpholinopropyl-O-methyl-gefitinib is a anilinoquinazoline derivative of which acts as an inhibitor of tyrosine kinases and found to be allosteric inhibitors of the enzyme frutose 1,6-bisphosphatase. It serves as a lead to further drug design.<br>References Wright, S. W., Bioorganic & Medicinal Chemistry Letters, 11, 17-21, (2000)<br></p>Fórmula:C16H13ClFN3O2Forma y color:White To Off-WhitePeso molecular:333.743-Oxo-4-aza-5-androstene-17β-carboxylic Acid
CAS:Producto controladoFórmula:C19H27NO3Forma y color:NeatPeso molecular:317.427-[4-[4-(3,4-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
CAS:Producto controladoFórmula:C23H27Cl2N3O2Forma y color:NeatPeso molecular:448.38Bis(3-methylthien-2-yl)methanone
CAS:Producto controlado<p>Applications Bis(3-methylthien-2-yl)methanone is an impurity of Tiagabine (T436400), a GABA uptake inhibitor and nticonvulsant agent.<br>References Zhang, J.G., et al.: Chem. Res. Chin. Uni., 22, 351 (2006); Callen, G., et al.: Heterocycles., 39, 293 (1994);<br></p>Fórmula:C11H10OS2Forma y color:NeatPeso molecular:222.33(1R,3R)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carbo
CAS:Producto controlado<p>Applications (1R,3R)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Hydrochloride is an impurity of Tadalafil (T004500) and is a β-carboline derivative. (1R,3R)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Hydrochloride can be used to produce Tadalafil.<br>References Lek Pharmaceuticals d.d., Slovenia: Eur. Pat. Appl., EP 2107059 A1 20091007 (2009)<br></p>Fórmula:C19H16N2O4·HClForma y color:Off White SolidPeso molecular:372.85-(Ethoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic Acid
CAS:Producto controladoFórmula:C17H18N2O6Forma y color:NeatPeso molecular:346.33Zomepirac Sodium Salt
CAS:Producto controlado<p>Applications Zomepirac is an analgesic, anti-inflammatory drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sofia, R., et al.: Pharmacol. Res. Commun., 11, 179 (1979), Grindel, J.M., et al.: Drug Metab. Dispos., 8, 343 (1980), Steele, C.E., et al.: Curr. Med. Res. Opin., 8, 382 (1983),<br></p>Fórmula:C15H13ClNO3·NaForma y color:Off White SolidPeso molecular:313.714'-Nitro-3'-(trifluoromethyl)acetanilide
CAS:<p>Applications 4’-Nitro-3’-(trifluoromethyl)acetanilide is a metabolite of the nonsteroidal antiandrogen drug, Flutamide (F598850).<br>References Kang, P. et al.: Drug Metab. Dispos., 36, 1425 (2008); Takashima, E. et al.: Biol. Pharmac. Bull., 26, 1455 (2003); Katchen, B. et al.: J. Invest. Dermatol., 66, 379 (1976);<br></p>Fórmula:C9H7F3N2O3Forma y color:NeatPeso molecular:248.162-Nitroso Riluzole
Producto controlado<p>Applications 2-Nitroso Riluzole is an impurity of Riluzole (R510000); is a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant. Neuroprotective agent.<br>References Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)<br></p>Fórmula:C8H3F3N2O2SForma y color:Dark GreenPeso molecular:248.182Dehydro Silodosin
CAS:Producto controlado<p>Applications Dehydro Silodosin is an impurity of Silodosin (S465000).<br>References Moriyama., et al.: Eur. J. Pharmacol., 331, 39 (1997), Zhu, J., et al.: Br. J. Pharmacol., 131, 546 (2000),<br></p>Fórmula:C25H30F3N3O4Forma y color:NeatPeso molecular:493.524-Chloro Perphenazine
CAS:Producto controlado<p>Applications 4-Chloro Perphenazine is an impurity of Perphenazine (P291100), an D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic.<br>References Briggs, K., et al.: Toxicology, 231, 113 (2007), Toga, T., et al.: J. Pharmacol. Sci., 105, 207 (2007),<br></p>Fórmula:C21H26ClN3OSForma y color:NeatPeso molecular:403.97(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one
CAS:Producto controlado<p>Applications (S)-4-(4-(5-(AMINOMETHYL)-2-OXOOXAZOLIDIN-3-YL)PHENYL)MORPHOLIN-3-ONE (cas# 446292-10-0) is a useful research chemical.<br></p>Fórmula:C14H17N3O4Forma y color:White To Off-WhitePeso molecular:291.30N-Desmethyl Prochlorperazine-d8 Dimaleate
CAS:Producto controladoFórmula:C27H22D8ClN3O8SForma y color:NeatPeso molecular:600.11Eltrombopag Methyl Ester
CAS:<p>Applications Eltrombopag Methyl Ester, is a metabolite of Eltrombopag (E508000), which is an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Fórmula:C26H24N4O4Forma y color:NeatPeso molecular:456.494-Chloro-6,7-dimethoxyquinoline
CAS:<p>Applications 4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.<br>References Fu, Y., Zhongguo Xinyao Zazhi, 22, 26 (2013); Liu, M., Adv. Mat. Res., 396, 1490 (2012); Camp, R., et al.: Cancer, 86, 2259 (1999);<br></p>Fórmula:C11H10ClNO2Forma y color:NeatPeso molecular:223.666-Hydroxy-7-methoxy-4(1H)-quinazolinone
CAS:Producto controlado<p>Applications 6-Hydroxy-7-methoxy-4(1H)-quinazolinone is a reactant used in the preparation of 4-anilinoquinazoline derivatives that have shown antitumor activities. 6-Hydroxy-7-methoxy-4(1H)-quinazolinone was also used as a reactant in the synthetic preparation of 2-arylbenzothiazoles as kinase inhibitors.<br>References Chandregowda, V., et al.: Eur. J. Med. Chem., 44, 3046 (2009); Tasler, S., et al.: Bioorg. Med. Chem. Lett., 17, 6728 (2009);<br></p>Fórmula:C9H8N2O3Forma y color:BeigePeso molecular:192.17Nilvadipine
CAS:Producto controlado<p>Applications Used as an antihypertensive and antianginal.<br>References Gross, G.J., et al.: Gen. Pharmacol., 14, 677 (1983), Molyvdas, P.A. and Sperelakis, N.: J. Cardiovasc. Pharmacol., 8, 449 (1986), Mizuno, K., et al.: Res. Comm. Chem. Pathol. Pharmacol., 52, 3 (1986)<br></p>Fórmula:C19H19N3O6Forma y color:NeatPeso molecular:385.37Prochlorperazine Sulfoxide
CAS:Producto controlado<p>Applications A metabolite of Prochlorperazine.<br>References Finn, A., et al.: J. Clin. Pharmacol., 45, 1383 (2005),<br></p>Fórmula:C20H24ClN3OSForma y color:NeatPeso molecular:389.94(S)-2-Chloro-1-(3,4-difluorophenyl)ethanol
CAS:Producto controlado<p>Applications (S)-2-Chloro-1-(3,4-difluorophenyl)ethanol is a building block used in organic synthesis including bein an intermediate in the synthesis of Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel.<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Fórmula:C8H7ClF2OForma y color:NeatPeso molecular:192.59N-Desmethyl N-Nitroso Olopatadine-d3
Producto controladoFórmula:C20D3H17N2O4Forma y color:NeatPeso molecular:355.402N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide
CAS:Producto controlado<p>Applications N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide was used in the study to discover a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide is an impurity of Intedanib (I666650), which is an antitumor agent.<br>References Edupuganti, R., et al.: Bioorg. Med. Chem., 25, 2609 (2017); Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Fórmula:C29H31N5O2Forma y color:NeatPeso molecular:481.59Plerixafor Hydrochloride (1:8)
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>Fórmula:C28H54N8·8ClHForma y color:NeatPeso molecular:794.472-(1-Amino-1-methylethyl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide
CAS:Producto controlado<p>Applications An intermediate in the preparation of HIV-integrase inhibitors<br>References Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),<br></p>Fórmula:C16H19FN4O3Forma y color:NeatPeso molecular:334.35O-Desmethyl Indomethacin-d4
CAS:Producto controlado<p>Applications The major labelled metabolite of Indomethacin.<br>References Lewis, R., et al.: J. Clin. Invest., 53, 1607 (1974), Alvan, G., et al.: Clin. Pharmacol. Ther., 18, 364 (1975), Mungall, D., et al.: J. Pharm. Sci., 73, 1000 (1984), Baldwin, S., et al.: Xenobiotica, 25, 261 (1995),<br></p>Fórmula:C18H10D4ClNO4Forma y color:NeatPeso molecular:347.794-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
CAS:Producto controlado<p>Applications 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.<br>References Liao, H., et al.: Tetrahedron: Asymmetry, 28, 105, (2017)<br></p>Fórmula:C13H10ClN3O2SForma y color:NeatPeso molecular:307.76S-(+)-Arundic Acid
CAS:Producto controlado<p>Applications The S-enantiomer of Arundic Acid. An astrocyte modulating agent, in acute ischemic stroke. A therapeutic agent for the treatment of neurodegenerative diseases including Alzheimer's disease and Parkinson’s disease.<br>References Uchida, Y., et al.: Brain Res., 481, 190 (1989), Tokunaga, M., et al.: Science, 277, 936 (1997), Sorbera, L., et al.: Drugs Future, 29, 441 (2004),<br></p>Fórmula:C11H22O2Forma y color:NeatPeso molecular:186.29O-De(3-fluorobenzyl) Lapatinib Ditosylate Salt
CAS:Producto controlado<p>Applications A reactive metabolite of Lapatinib (L175800) which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites.<br>References He, K., et al.: Chem. Res. Toxicol., 11, 252 (1998), Rusnuk, D., et al.: Cancer Res., 61, 7196 (2001), Li, X., et al.: Drug Metab. Dispos., 37, 1242 (2009),<br></p>Fórmula:C36H37ClN4O10S3Forma y color:NeatPeso molecular:817.35trans-Hydroxy Praziquantel-d5
CAS:Producto controlado<p>Applications Labelled trans-Hydroxy Praziquantel (H952405). The main cis-monohydroxylated metabolite of Praziquantel (P702095).<br>References Buehring, K., et al.: Eur. J. Drug Metab. Pharm., 3, 179 (1978), Moldeus, P., et al.: Methods Enzymol., 52, 60 (1978), Cioli, D., et al.: Pharmacol. Ther., 68, 35 (1995),<br></p>Fórmula:C19H19D5N2O3Forma y color:NeatPeso molecular:333.442,3-Bis[(acetyloxy)methyl]-1-oxoquinoxalin-1-ium-4(1H)-olate
CAS:Producto controlado<p>Applications 2,3-Bis[(acetyloxy)methyl]-1-oxoquinoxalin-1-ium-4(1H)-olate is an antibiotic.<br>References Marrero-Ponce, Yovani, et al.: Bioorg. & Med. Chem., 13(8), 2881-2899 (2005)<br></p>Fórmula:C14H14N2O6Forma y color:NeatPeso molecular:306.27Methylene-Bis Paroxetine Dihydrochloride
CAS:Producto controlado<p>Impurity Paroxetine EP Impurity F<br>Applications Methylene-Bis Paroxetine Dihydrochloride (Paroxetine EP Impurity F) is used in the chiral HPLC method for chiral purity determination of Paroxetine drug substance.<br>References Zukowski, J., et al.: Chirality, 15, 600 (2003),<br></p>Fórmula:C39H42Cl2F2N2O6Forma y color:NeatPeso molecular:743.662-Hydroxy Imipramine β-D-Glucuronide
CAS:Producto controlado<p>Applications A metabolite of Imipramine.<br>References Gram, L.F., et al.: Clin. Pharmacol. Therap., 17, 555 (1975), Hackett, A.M., et al.: Xenobiotica, 14, 491 (1984), Chiba, M., et al.: Biochem. Pharmacol., 39, 367 (1990),<br></p>Fórmula:C25H32N2O7Forma y color:NeatPeso molecular:472.53Haloperidol pyridinium Chloride Impurity
CAS:Producto controlado<p>Applications Haloperidol pyridinium Chloride is a neurotoxic pyridinium metabolite of haloperidol that is formed in the liver and found in the brain. Haloperidol pyridinium Chloride is a substrate for human organic cation transporters.<br>References Kang, H. et. al.: Drug Metab. Dispos., 34, 1145 (2006)<br></p>Fórmula:C21H18Cl2FNOForma y color:NeatPeso molecular:390.28(E/Z)-Chlorprothixene-d6 Hydrochloride(Mixture)
CAS:Producto controlado<p>Applications Labelled cis/trans-Chlorprothixene (C424850). Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 63 (1973), Bagli, M., et al.: Arzneim.-Forsch., 46, 247 (1996),<br></p>Fórmula:C18H13D6Cl2NSForma y color:NeatPeso molecular:358.365-(2-Fluorophenyl)-5-oxovaleric Acid
CAS:Producto controlado<p>Applications 5-(2-Fluorophenyl)-5-oxovaleric Acid is used as a reagent in the preparation of indole derivatives which act as cell protective agents. It is also used as a reagent in the catalytic N-nitroso aldol reaction of γ,δ-unsaturated δ-lactones.<br>References Yamamoto, I., et al.: Preparation of indole derivatives as cell protective agents, WO Patent 9745410, Dec 4, 1997; Yanagisawa, A., et al.: Org. Lett., 14, 2434 (2012);<br></p>Fórmula:C11H11FO3Forma y color:NeatPeso molecular:210.21-(6-Methylpyridin-3-yl)-2-((4-(2-(6-methylpyridin-3-yl)-2-oxoethyl)phenyl)sulfonyl)ethanone
CAS:Producto controladoFórmula:C22H20N2O4SForma y color:NeatPeso molecular:408.47O-Desmethylsulpiride
CAS:Producto controladoFórmula:C14H21N3O4SForma y color:NeatPeso molecular:327.40Hydroxynorketamine Hydrochloride
CAS:Producto controlado<p>Applications Hydroxynorketamine is a metabolite of Ketamine (K165300, HCl salt) which is a medication used mainly for starting and maintaining anesthesia.<br>References Adams, J., et al.: Biomed. Mass Spec., 11, 527 (1981); Sass, W.C., et al.: Anal. Profiles Drug Subs., 6, 297 (1977); Reich, D.L., et al.: Can. J. Anaesth., 36, 186 (1989)<br></p>Fórmula:C12H15Cl2NO2Forma y color:White To Off-WhitePeso molecular:276.165-Methyl-1,3-benzenediacetonitrile
CAS:<p>Impurity Anastrozole 1,3-Dicyanomethyl Impurity<br>Applications 5-Methyl-1,3-benzenediacetonitrile is an Anastrozole intermediate. Anastrozole 1,3-Dicyanomethyl Impurity. Anastrozole is an aromatase inhibitor and used as an antineoplastic.<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>Fórmula:C11H10N2Forma y color:NeatPeso molecular:170.21rac 6-Chloro-1,4-dihydro-4-(1-pentynyl)-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
CAS:Producto controlado<p>Applications An Efavirenz (E425000) impurity.<br></p>Fórmula:C14H11ClF3NO2Forma y color:Off White SolidPeso molecular:317.69N-Methylthiophene-2-carboxamide
CAS:Producto controladoFórmula:C6H7NOSForma y color:NeatPeso molecular:141.19Atazanavir-d9
CAS:Producto controlado<p>Applications Atazanavir-d9 is the deuterated analog of Atazanavir (A790051), a azapeptide HIV protease inhibitor derivative. Atazanavir have been investigated as potential treatment of human immunodeficiency virus (HIV) and for anticancer purposes.<br>References Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),<br></p>Fórmula:C382H15H37N6O7Forma y color:NeatPeso molecular:719.952-Methyl-5-nitroaniline
CAS:Producto controlado<p>Applications 2-Methyl-5-nitroaniline is used as a reagent in the synthesis of imatinib base derivatives which show antibacterial and antifungal activity. Also used as a reagent in the synthesis of pyrimidinylaminobenzene derivatives which exhibit antiproliferative activity against melanoma. Dyes and metabolites, Environmental Testing. It is a COVID19-related research product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Patoliya, M.J., et al.: J. Chem., no vol., no pp. (2013); Kim, H.J., et al.: B. Korean Chem. Soc., 34, 2311 (2013)<br></p>Fórmula:C7H8N2O2Forma y color:YellowPeso molecular:152.152-(4-(Methylsulfonamido)phenyl)acetic Acid
CAS:Producto controlado<p>Applications 2-(4-(Methylsulfonamido)phenyl)acetic Acid acts as a reagent for resiniferatoxin analogs preparation as metabolically stable TRPV1 agonists and potential analgesics. Preparation and structure-activity relationships of 2,6-diaryl-4-(phenacylamino)pyrimidines as selective adenosine A2A antagonists.<br>References Choi, H., et al.: Bioorg. Med. Chem. , 17, 690 (2009); Moorjani, M., et al.: Bioorg. Med. Chem. Lett., 18, 1269 (2008)<br></p>Fórmula:C9H11NO4SForma y color:NeatPeso molecular:229.25ent-Rotigotine
CAS:<p>Applications It is a non-ergot dopamine agonist drug and is indicated for the treatment of Parkinson’s disease.<br>References Loschmann, P., et al.: Eur. J. Pharmacol., 166, 373 (1989), Edgar, D., et al.: J. Pharmacol. Exp. Ther., 283, 757 (1997), Ferreira, J., et al.: Lancet, 355, 1333 (2000), Arnulf, I., et al.: Neurology, 58, 1019 (2002), Wisor, J., et al.: Neuroscience, 132, 1027 (2005),<br></p>Fórmula:C19H25NOSForma y color:Brown OilyPeso molecular:315.47Ambroxol Cycloimine Impurity
CAS:Producto controlado<p>Applications 4-(6,8-Dibromo-3(4H)-quinazolinyl)-cyclohexanol is an impurity of Ambroxol (A575900), a bronchosecretolytic drug.<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>Fórmula:C14H16Br2N2OForma y color:NeatPeso molecular:388.09762-(6-Methoxy-2-naphthyl)acetonitrile
CAS:Producto controlado<p>Applications 2-(6-Methoxy-2-naphthyl)acetonitrile (cas# 71056-96-7) is a compound useful in organic synthesis.<br></p>Fórmula:C13H11NOForma y color:NeatPeso molecular:197.23N-[4-(Aminocarbonyl)-3-fluorophenyl]-2-methylalanine Methyl Ester
CAS:Producto controladoFórmula:C12H15FN2O3Forma y color:NeatPeso molecular:254.26N-Cyano-N’,N”-bis[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine
CAS:Producto controlado<p>Applications N-Cyano-N’,N”-bis[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine is an impurity of Cimetidine (C441650)<br>References Ellis, D. R., et al.: J. Chromatogr. A, 808, 269-275 (1998)<br></p>Fórmula:C16H24N8S2Forma y color:NeatPeso molecular:392.542,3,3a,12b-Tetradehydro Asenapine
CAS:Producto controladoFórmula:C17H12ClNOForma y color:NeatPeso molecular:281.746-Amino-1-methyl-5-nitrosouracil
CAS:Producto controlado<p>Stability Light and temperature sensitive<br>Applications 6-Amino-1-methyl-5-nitrosouracil is known to exhibit anitmicrobial activity and form complexation with platinum (II).<br>References Gaballa, A.S., et al.: Molec. Biomolec. Spectro. 75A, 146 (2010);<br></p>Fórmula:C5H6N4O3Forma y color:NeatPeso molecular:170.13[3-(9H-Carbazol-4-yloxy)-2-hydroxy]propyl Carvedilol
CAS:Producto controladoFórmula:C39H39N3O6Forma y color:NeatPeso molecular:645.74Nifekalant Hydrochloride
CAS:<p>Applications Nifekalant Hydrochloride is a class III antiarrhythmic agent. Nifekalant Hydrochloride is used in the treatment of patients with extensive anterior infarction and severe ventricular dysfunction.<br>References Takenaka, K. Jap. Circ. J., 65, 60 (2001); Igawa, M. et al.: J. Cardio. Pharmacol., 40, 735 (2002); Washizuka, T. et al.: Circ. J., 69, 1508 (2005);<br></p>Fórmula:C19H27N5O5·ClHForma y color:Light Yellow SolidPeso molecular:441.9091Thiorphan Disulfide
CAS:Producto controlado<p>Applications Thiorphan Disulfide is an impurity of Racecadotril (R070600); an antidiarrheal and enkephalinase inhibitor that reduces the amount of water and electrolytes into the intestine.<br>References Cezard, J., et al.: Gastroenterol., 120, 799 (2001); Sato, T., et al.: J. Med. Chem., 51, 7705 (2008); Lakshmana, P., et al.: J. Pharm. Res., 8, 39 (2009); Fournie-Zaluski<br></p>Fórmula:C24H28N2O6S2Forma y color:NeatPeso molecular:504.62Triciribine
CAS:Producto controlado<p>Applications Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.<br>References Garrett, C.R. et al.: Invest. New Drugs, 29, 1381 (2011); Ptak, R.G. et al.: AIDS Res. Human Retrovir., 14, 1315 (1998); Bennett, L.L. et al.: BIochem. Pharmacol., 27, 233 (1978);<br></p>Fórmula:C13H16N6O4Forma y color:NeatPeso molecular:320.30N-Despropyl Ropinirole-d3
CAS:Producto controlado<p>Applications An isotopically Labelled metabolite of Ropinirole.<br>References Coldwell, M., et al.: Br. J. Pharmacol., 127, 1135(1999), Ramji, J., et al.: Xenobiotica, 29, 311 (1999)<br></p>Fórmula:C13H15D3N2OForma y color:NeatPeso molecular:221.314-[3-(Methylamino)-1-(2-thienyl)propyl]-1-naphthalenol Hydrochloride (Duloxetine Impurity)
CAS:Producto controlado<p>Impurity D721000<br>Applications Duloxetine impurity; also a related compound of Duloxetine metabolite.<br></p>Fórmula:C18H19NOS·ClHForma y color:NeatPeso molecular:333.88Defluoro-MDV 3100 (Defluoro-enzalutamide)
CAS:Producto controlado<p>Applications Defluoro-MDV 3100 (Defluoro-enzalutamide) is an impurity of Enzalutamide (M199800), which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. Enzalutamide has been shown to induce tumor cell apoptosis, and is used for the treatment of castration-resistant prostate cancer.<br>References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011); Ma, X., et al.: J. Pharm. Biomed. Anal., 131, 436 (2016);<br></p>Fórmula:C21H17F3N4O2SForma y color:Light YellowPeso molecular:446.45(2R,5R)-1,6-Diphenylhexane-2,5-diamine Dihydrochloride
CAS:Producto controladoFórmula:C18H24N2·2ClHForma y color:NeatPeso molecular:341.3184rac Timolol Maleate
CAS:Producto controlado<p>Applications Antihypertensive; antiarrhythmic (class II); antianginal; antiglaucoma agent.<br>References Wasson, et al.: J. Med. Chem., 15, 651 (1972), Franciosa, et al.: Clin. Pharmacol. Ther., 13, 138 (1972), Heel, R.C., et al.: Drugs, 17, 38 (1979), Rofman, B.A., et al.: Hypertension, 2, 643 (1980), Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 16, 641 (1987),<br></p>Fórmula:C13H24N4O3S·C4H4O4Forma y color:NeatPeso molecular:432.492H-2-Ethyl-d5 Candesartan Cilexetil
CAS:Producto controlado<p>Applications Labelled Candesartan Cilexetil impurity.<br>References Cagigal, E., et al.: J. Chromatogr., 26, 477 (2001), Bakshi, M., et al.: J. Pharm. Biomed. Anal., 28, 1011 (2002),<br></p>Fórmula:C35H33D5N6O6Forma y color:WhitePeso molecular:643.743-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS:Producto controlado<p>Applications 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is a useful synthetic intermediate in the synthesis of Ibrutinib (I124970); a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor.<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011); Li, X., et al.: J. Med. Chem., 58, 9625 (2015)<br></p>Fórmula:C17H13N5OForma y color:Light Brown To BrownPeso molecular:303.324-(1-Methylethenyl)-2-propyl-1H-imidazole-5-carboxylic Acid Ethyl Ester
CAS:Producto controlado<p>Applications Olmesartan intermediate.<br>References Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996),<br></p>Fórmula:C12H18N2O2Forma y color:NeatPeso molecular:222.28Chlor Cyclizine Hydrochloride
CAS:Producto controlado<p>Applications An antihistaminic drug. A drug analog of Cyclizine (C987805).<br>References Leurs, R., et al.: Pharmacol. Ther., 66, 413 (1995), Hu, Q., et al.: J. Biol. Chem., 274, 33995 (1999), Church, M., et al.: Clin. Exp. Allergy, 31, 1341 (2001),<br></p>Fórmula:C18H21ClN2·ClHForma y color:Off-WhitePeso molecular:337.29Aprepitant-13C2,d2 (Major)
CAS:Producto controlado<p>Applications This product is deuterated at the 1 position and on the ajacent methyl. The 1 position is the benylic position of the bis(trifluoromethyl) phenyl. This compound has a mixture of 1 to 4 deuterium atoms, there is no detectable unlabeled material.Aprepitant is a structurally novel substance P neurokinin 1 (NK1) receptor antagonist. In vitro studies using human liver microsomes indicate that aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1.<br>References Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Van Belle, S., et al.: Cancer, 94, 3032 (2002), Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006),<br></p>Fórmula:C2113C2H19D2F7N4O3Forma y color:Off White SolidPeso molecular:538.42Irbesartan N-β-D-Glucuronide
CAS:<p>Applications A metabolite of Irbesartan (M8).<br>References Cazaubon, C., et al.: J. Pharmacol. Exp. Ther., 265, 826 (1993), Eberhardt, R., et al.: J. Clin. Pharmacol., 33, 1023 (1993), Huskey, S., et al.: Drug Metab. Dispos., 21, 792 (1993), van Den Meiracker, A., et al.: Hypertension, 25, 22 (1995),<br></p>Fórmula:C31H36N6O7Forma y color:NeatPeso molecular:604.65m-Salicylic Acid
CAS:Producto controlado<p>Applications m-Salicylic Acid is widely used in organic synthesis. It is also an important active metabolite of aspirin (A187780).<br>References Haynes, M., et al.: CRC H.b Chem. Phys., 92, 306 (2011)<br></p>Fórmula:C7H6O3Forma y color:Off-WhitePeso molecular:138.12rac Methotrimeprazine Hydrochloride
CAS:Producto controlado<p>Applications Analgesic.<br>References Haddad, P., et al.: Drugs, 62, 1649 (2002), Chiu, P., et al.: J. Pharmacol. Sci., 95, 311 (2004), Dubin, A., et al.: J. Biomol. Screen, 10, 168 (2005),<br></p>Fórmula:C19H24N2OS·HClForma y color:NeatPeso molecular:364.93Decarboxyl Norfloxacin
CAS:Producto controladoFórmula:C15H18FN3OForma y color:NeatPeso molecular:275.32(4-Methyl-1H-imidazol-5-yl)methanol Hydrochloride
CAS:Producto controlado<p>Applications (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride (cas# 38585-62-5) is a useful research chemical.<br></p>Fórmula:C5H8N2O·ClHForma y color:NeatPeso molecular:148.59Desmethyl Cariprazine
CAS:<p>Applications Desmethyl Cariprazine, is a derivative of Cariprazine (C183490) which is an orally active D2/D3 dopamine receptor antagonist (1,2,3). Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression.<br>References Gruender, G.: Curr. Opin. Invest. Drugs, 11, 823 (2010); Seneca, N. et al.: Psychopharmacology, 218, 579 (2011); Kiss, B. et al.: J. Pharmacol. Exp. Therap., 333, 328 (2010)<br></p>Fórmula:C20H30Cl2N4OForma y color:NeatPeso molecular:413.38Valdecoxib Sulfonyl Chloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Valdecoxib Sulfonyl Chloride is an impurity in the preparation of the cyclooxygenase-2 inhibitor, Valdecoxib (V090000) and its metabolites.<br>References Erdelyi, P. et al.: Bioorg. Med. Chem., 16, 5322 (2008);<br></p>Fórmula:C16H12ClNO3SForma y color:NeatPeso molecular:333.79Lodoxamide
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Lodoxamide is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.<br>References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)<br></p>Fórmula:C11H6ClN3O6Forma y color:NeatPeso molecular:311.63Everolimus Isomer C (>60%, contains everolimus)
CAS:Producto controlado<p>Stability Unstable in solution, revert back to Everolimus<br>Applications Everolimus Isomer C is an isomer of Everolimus (E945400), a derivative of Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation.<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001); Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002)<br></p>Fórmula:C53H83NO14Forma y color:NeatPeso molecular:958.221-Phenyl-2-propen-1-one (Contains ~1% BHT as stabilizer)
CAS:<p>Stability Light and Temperature Sensitive<br>Applications 1-Phenyl-2-propen-1-one is a chemical reagent used in the synthesis of pharmaceutical agents. Used in the preparation of functionalized aminoindolizines as well as pyrano[3,2-x]coumarins.<br>References Wang, D. et al.: Asian J. Org. Chem., 2, 480 (2013); Gohain, M. et al.: Tetrahedron Lett., 54, 3773 (2013);<br></p>Fórmula:C9H8OForma y color:NeatPeso molecular:132.159Ivabradine-d3 Hydrochloride
CAS:Producto controlado<p>Stability very hygroscopic<br>Applications Labelled Ivabradine (I940500). Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Thollon,C., et al.: Br. J. Pharmacol., 112, 37 (1994), Ragueneau, I., et al.: Clin. Pharmacol. Ther., 64, 192 (1998), Borer, J.S., et al.: Circulation, 107, 817 (2003), DiFrancesco, D., et al.: Drugs, 64, 1757 (2004),<br></p>Fórmula:C272H3H33N2O5·ClHForma y color:NeatPeso molecular:508.061-(2,5-Dimethylphenyl)ethanol
CAS:Producto controlado<p>Applications 1-(2,5-Dimethylphenyl)ethanol can be used as a reagent in reactions or as a aroma compound<br>References Zhou, J., et al.: Yuanyi Xuebao., 37, 1621-1628 (2010)<br></p>Fórmula:C10H14OForma y color:NeatPeso molecular:150.22N-Benzyl Epinephrine-d3
CAS:Producto controlado<p>Applications Labelled analogue of N-Benzyl Epinephrine, an impurity of Epinephrine (E588580).<br></p>Fórmula:C16H16D3NO3Forma y color:NeatPeso molecular:276.35Fenpropimorph
CAS:Producto controlado<p>Applications Systemic fungicide for control of powdery mildew, rust in cereal crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baloch, R.I., et al.: Phytochemistry, 23, 2219 (1984), Pommer, E.-H., et al.: Pestic. Sci., 15, 285 (1984),<br></p>Fórmula:C20H33NOForma y color:ColourlessPeso molecular:303.482-Amino-3-benzyloxypyridine
CAS:Producto controlado<p>Applications 2-Amino-3-benzyloxypyridine is used in preparation of pyridinyl/pyridazinyloxymethyl substituted Raf kinase inhibitors.<br>References Jen, T., et al.: J. Med. Chem., 20, 1258 (1977), Chung, D., et al.: Antican. Res., 11, 1373 (1991),<br></p>Fórmula:C12H12N2OForma y color:NeatPeso molecular:200.24Isoproturon-d3
CAS:Producto controlado<p>Applications Labelled Isoproturon. Pre-and post-emergence herbicide for control of annual grasses and broad-leaved weeds. Herbicide.<br>References Fournier, J.-C., et al.: Chemosphere, 4, 207 (1975), Gonzales, P., et al.: Weed Res., 23, 39 (1983),<br></p>Fórmula:C122H3H15N2OForma y color:White To Off-WhitePeso molecular:209.304-(Diphenylmethyl)-1-nitrosopiperidine
CAS:Producto controladoFórmula:C18H20N2OForma y color:NeatPeso molecular:280.37Dasatinib-d8 N-Oxide
CAS:Producto controlado<p>Applications The labelled oxidative metabolite of Dasatinib (M5 metabolite). It is a COVID19-related research product.<br>References Cashman, J.R., et al.: Chem. Res. Toxicol., 8, 165 (1995), Aasmoe, L., et al.: Toxicol. Appl. Pharmacol., 150, 86 (1998), Galetin, A., et al.: J. Pharmacol. Exp. Ther., 314, 180 (2005), Christopher, L.J., et al.: Drug Metab. Dispos., 36, 1357 (2008),<br></p>Fórmula:C22H18D8ClN7O3SForma y color:NeatPeso molecular:512.05Methyl 5,6,7,8-Tetradehydro Risperidone
CAS:Producto controlado<p>Applications An internal standard for Risperidone (R525000).<br>References Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988), Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990), Green, B.: Curr. Med. Res. Opin., 16, 57 (2000)<br></p>Fórmula:C24H25FN4O2Forma y color:White To Off WhitePeso molecular:420.48Varenicline-d2,15N2 Dihydrochloride
CAS:Producto controlado<p>Applications Varenicline-d2,15N2 Dihydrochloride, is the labelled dihydrochloride salt of Varenicline (V098492), a nicotinic α4β2 acetylcholine receptor partial agonist. Aids in smoking cessation.<br>References Benowitz, N., et al.: Clin. Pharmacol. Ther., 44, 23 (1988), Cohen, C., et al.: J. Pharmacol. Exp. Ther., 306, 407 (2003), Tapper, A., et al.: Science, 306, 1029 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Obach, R., et al.: Drug Metab. Disp., 34, 121 (2006),<br></p>Fórmula:C13H13D2Cl2N15N2Forma y color:Light Beige SolidPeso molecular:288.18Sulcotrione-d7
CAS:Producto controladoFórmula:C14D7H6ClO5SForma y color:Light Yellow SolidPeso molecular:335.815-Dehydro Tolvaptan
CAS:Producto controlado<p>Applications 5-Dehydro Tolvaptan is an impurity of Tolvaptan (T536650), a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH g<br>References Yin, L., et al.: Tetrahedron, Asym., 21, 2390 (2010); Torisawa, Y., et al.: Bioorg. Med. Chem. Lett., 17, 6455 (2007); Kondo, K., et al.: Bioorg. Med. Chem., 7, 1743 (1999);<br></p>Fórmula:C26H23ClN2O3Forma y color:NeatPeso molecular:446.932-(Dimethylamino)thioacetamide Hydrochloride
CAS:<p>Impurity Nizatidine EP Impurity H<br>Applications 2-(Dimethylamino)thioacetamide (Nizatidine EP Impurity H) is used in the preparation of thiazole derivatives. 2-(Dimethylamino)thioacetamide is an impurity of the histamine H2-receptor antagonist Nizatidine (N598500).<br>References Johnson, R.A. et al.: J. Org. Chem., 57, 2869 (1992):<br></p>Fórmula:C4H10N2S·ClHForma y color:NeatPeso molecular:154.663-Ethyl Haloperidol
CAS:Producto controladoFórmula:C23H27ClFNO2Forma y color:NeatPeso molecular:403.922-Acetylbutyrolactone
CAS:Producto controlado<p>Applications An intermediate in the synthesis of 2,4-disubstituted pyridines. A fluorogenic reagent for the spectrofluorimetric determination of primary amines.<br>References Toche, R.B. et al.: H. Heterocyclic Chem., 45, 1711 (2008); Sabry, S.M., J. Pharm. Biomed. Anal., 40, 1057 (2006);<br></p>Fórmula:C6H8O3Forma y color:NeatPeso molecular:128.13N-[1,1-Bis[(acetyloxy)methyl]-3-(4-octylphenyl)propyl]acetamide
CAS:Producto controlado<p>Applications N-[1,1-Bis[(acetyloxy)methyl]-3-(4-octylphenyl)propyl]acetamide is derived from Diethyl 2-Acetamidomalonate (D443130), which is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds. It is an intermediate for the preparation of Novobiocin (N888500) analogues as potential heat shock protein 90 inhibitors.<br>References Gunaherath, G. M., et al.: Bioorg. Med. Chem., 21, 5118 (2013);<br></p>Fórmula:C25H39NO5Forma y color:NeatPeso molecular:433.58Methyl 3-chlorosulfonylthiophene-2-carboxylate
CAS:Producto controlado<p>Applications Methyl 3-chlorosulfonylthiophene-2-carboxylate<br></p>Fórmula:C6H5ClO4S2Forma y color:NeatPeso molecular:240.687-Demethyl Ivabradine Hydrochloride
CAS:Producto controlado<p>Applications Ivabradine (I940500) metabolite.<br>References Duffull, S., et al.: Eur. J. Pharm. Sci., 10, 285 (2000), Portoles, A., et al.: J. Clin. Pharmacol., 46, 1195 (2006),<br></p>Fórmula:C26H34N2O5·HClForma y color:NeatPeso molecular:491.022,6-Dichloro-7-deazapurine
CAS:Producto controladoFórmula:C6H3Cl2N3Forma y color:NeatPeso molecular:188.01N-Methyl-4-[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide
CAS:Producto controlado<p>Applications N-Methyl-4-[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide is an impurity of Sorafenib (S676850); a multiple kinase inhibitor targeting both RAF and receptor tyrosine kinases that promote angiogenesis. Also antineoplastic.<br>References Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003); Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004); Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004); Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006)<br></p>Fórmula:C21H17F3N4O3Forma y color:Off White To Light BrownPeso molecular:430.38N-Nitroso Amodiaquine
Producto controladoFórmula:C20H21ClN4O2Forma y color:NeatPeso molecular:384.859Moxonidine
CAS:Producto controlado<p>Applications Moxonidine is an antihypertensive agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rayment, S., et al.: Brit. J. Pharmacol., 160, 1727 (2010), Taksande, B., et al.: Eur. J. Pharmacol., 637, 89 (2010), Nasr, M., et al.: Vas. Pharmacol., 53, 53 (2010),<br></p>Fórmula:C9H12ClN5OForma y color:NeatPeso molecular:241.685-Ethoxy-2-pyrrolidone
CAS:Producto controlado<p>Applications 5-Ethoxy-2-pyrrolidone is an intermediate in the synthesis of rac-Vigabatrin (V253005), a novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic.<br>References Vajda, F., et al.: Clin. Neurosci., 7, 88 (2000), Beghi, E., et al.: Lancet. Neurol., 3, 618 (2004), Sagirli, O., et al.: J. Pharmaceut. Biomed., 42, 618 (2006),<br></p>Fórmula:C6H11NO2Pureza:>90%Forma y color:NeatPeso molecular:129.162,5-Bis(trifluoromethyl)aniline
CAS:Producto controlado<p>Applications 2,5-Bis(trifluoromethyl)aniline is a haloalkul substituted aniline used in the preparation of anti-benign prostatic hyperplasia drug, Dutasteride (D735000).<br>References Liang, Y. et al.: Jil. Dax. Xueb. Lixeub., 45, 1035 (2007);<br></p>Fórmula:C8H5F6NForma y color:ColourlessPeso molecular:229.12(R)-9-Hydroxy Risperidone
CAS:Producto controlado<p>Applications The R-enantiomer metabolite of Risperidone (R525000), a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),<br></p>Fórmula:C23H27FN4O3Forma y color:NeatPeso molecular:426.483-(tert-Butyldimethylsilyl)morphinone
CAS:Producto controlado<p>Applications Protected Morphinone (M652350), a toxic metabolite of Morphine.<br>References James, R., et al.: J. Pharmacol. Exp. Ther., 221, 708 (1982), Yamano, S., et al.: J. Biol. Chem., 260, 5259(1985), Ishida, T., et al.: Drug Metab. Dispos., 17, 77 (1989), Yamano, S., et al.: Xenobiotica, 27, 645 (1997),<br></p>Fórmula:C23H31NO3SiForma y color:NeatPeso molecular:397.58N-Nitroso Amodiaquine-D10
Producto controladoFórmula:C20D10H11ClN4O2Forma y color:NeatPeso molecular:394.921N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfide
CAS:Producto controlado<p>Applications Rabeprazole (R070500) N-aralkyl impurity.<br>References Fujisaki, H., et al.: Biochem. Pharmacol., 42, 321 (1991), Morri, M., et al.: J. Biol. Chem., 268, 21553 (1993), Pingili, R., et al.: Pharmazie, 60, 814 (2005),<br></p>Fórmula:C29H36N4O4SForma y color:NeatPeso molecular:536.69N-Nitroso-Vildagliptin carboxylic acid Impurity
Producto controladoFórmula:C17H25N3O5Forma y color:NeatPeso molecular:351.397Lacidipine Monomethyl Ester
CAS:Producto controlado<p>Applications Lacidipine Monomethyl Ester is an impurity of Lacidipine (L098000); a dihydropyridine calcium channel blocker. Antihypertensive.<br>References Mohan, Arivozhi., et al.: J. AOAC Int., 94(6), 1800-1806 (2011); Safar, M., et al.: Clin. Pharmacol. Ther., 46, 94 (1989); Kharat, V.R., et al.: J. Pharm. Biomed. Anal., 28, 789 (2002); McCormack, A.J., et al.: Drugs, 63, 2327 (2003)<br></p>Fórmula:C25H31NO6Forma y color:NeatPeso molecular:441.52rac 4-(3-Aminobutyl)phenol
CAS:Producto controlado<p>Applications A metabolite of the antihypertensive agent, Labetalol (L096500).<br>References Gal, J., et al.: Res. Comm. Chem. Pathol. Pharmacol., 62, 3 (1988),<br></p>Fórmula:C10H15NOForma y color:NeatPeso molecular:165.231-Ethyl-2-[(methylamino)methyl]pyrrolidine
CAS:<p>Applications 1-Ethyl-2-[(methylamino)methyl]pyrrolidine is an intermediate of the neuroleptic drug Amisulpride (A633250).<br>References Tahara, T., et al.: Chem. Pharmaceut. Bull., 38, 1609 (1990);<br></p>Fórmula:C8H18N2Forma y color:Colourless OilyPeso molecular:142.242Iguratimod
CAS:Producto controlado<p>Applications Iguratimod acts as an anti-inflammatory agent, used primarily in the treatment of rheumatoid arthritis.<br>References Estellat, C. et al.: Arch. Int. Med., 172, 237 (2012); Du, F. et al.: Arth. Res. Ther., 10 (2008); Tanaka, K. et al.: Rheumatol. Rep., 1, 11 (2009);<br></p>Fórmula:C17H14N2O6SForma y color:NeatPeso molecular:374.37N-Hydroxy Pomalidomide
CAS:<p>Applications N-Hydroxy Pomalidomide can be involved in pharmacological activity, biological study, and synthetic preparation and anti-tumor activity of nitrogen-substituted thalidomide analogs.<br>References Shah, J., et al.: PCT Int. Appl., WO 2003014315 A2 20030220 (2003)<br></p>Fórmula:C13H11N3O5Forma y color:Light YellowPeso molecular:289.24Lodoxamide-15N2,d2
CAS:Producto controlado<p>Applications Lodoxamide-15N2,d2 is the labelled form of Lodoxamide which is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.<br>References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)<br></p>Fórmula:C11H4D2ClN15N2O6Forma y color:NeatPeso molecular:315.633-[2-[4-(4-Fluoro-2-hydroxybenzoyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
CAS:Producto controlado<p>Applications 3-[2-[4-(4-Fluoro-2-hydroxybenzoyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one is an intermediate used in the synthesis of Bicyclo Risperidone (B382800), which is an impurity of Risperidone (R525000); a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br>References Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988); Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990); Green, B.: Curr. Med. Res. Opin., 16, 57 (2000)<br></p>Fórmula:C23H28FN3O3Forma y color:NeatPeso molecular:413.49Levetiracetam-d6
CAS:Producto controlado<p>Applications The labelled (S)-enantiomer of Etiracetam (E932970) and the ethyl analog of Piracetam (P500800). Used as an anticonvulsant.<br>References Gower, A.J., et al.: Eur. J. Pharmacol., 222, 193 (1992); Kasteleijn-Noist Trenite, D.G.A., et al.: Epilepsy Res., 25, 225 (1996); Patsalos, P.N., et al.: Pharmacol. Ther., 85, 77 (2000),<br></p>Fórmula:C82H6H8N2O2Forma y color:BeigePeso molecular:176.25Valsartan Decarboxylic Acid
CAS:Producto controladoFórmula:C23H29N5OForma y color:NeatPeso molecular:391.5093Dehydroxydehydro Terfenadine
CAS:Producto controladoFórmula:C32H39NOForma y color:NeatPeso molecular:453.66N-Nitrosomorpholine-13C4
CAS:Producto controladoFórmula:C4H8N2O2Forma y color:NeatPeso molecular:120.09Ofloxacin N-Oxide Hydrochloride
CAS:Producto controladoFórmula:C18H20FN3O5·ClHForma y color:Off-WhitePeso molecular:413.832-Amino-3-hydroxypyridine
CAS:Producto controlado<p>Applications 2-Amino-3-hydroxypyridine (cas# 16867-03-1) is a compound useful in organic synthesis.<br></p>Fórmula:C5H6N2OForma y color:NeatPeso molecular:110.11cis-Hydroxy Solifenacin N-Oxide(Mixture of Diastereomers)
Producto controlado<p>Applications Solifenacin (S676700) metabolite.<br></p>Fórmula:C23H26N2O4Forma y color:NeatPeso molecular:394.46Haloperidol Octanoate
CAS:Producto controladoFórmula:C29H37ClFNO3Forma y color:NeatPeso molecular:502.06Hydroxy Vildagliptin
<p>Applications Hydroxy Vildagliptin is an impurity of Vildagliptin (V305000). Vildagliptin is a DPP-4 enzyme inhibitor, has anti-oxidant properties and used as an apoptotic agent on pancreatic cancer . Vildagliptin is used to treat type 2 diabetes mellitus (T2DM) and improve the endothelial function of patients.<br>References Amritha, C.A., et al.: J. Clin. Diagn. Res., 9, FC14 (2015); Cosenso-Martin, L.N., et al.: Diabetol. Metab. Syndr., 7, 70/1 (2015)<br></p>Fórmula:C17H25N3O3Forma y color:NeatPeso molecular:319.407,8-Dihydro-1-naphthalenol
CAS:<p>Stability Light Sensitive, Air (oxygen) Sensitive<br>Applications 7,8-Dihydro-1-naphthalenol can be used as reagent/reactant in stereoselective preparation of indanes via chiral hypervalent iodine - mediated ring contraction of dihydronaphthalenes<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahmed, A., & Silva, L. F,: J. Org. Chem., 81, 2174-2181 (2016)<br></p>Fórmula:C10H10OForma y color:White To Light YellowPeso molecular:146.192-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) 2-(2-(2-Acetylhydrazinyl)-2-oxoacetamide) Raltegravir
CAS:<p>Applications 2-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) 2-(2-(2-Acetylhydrazinyl)-2-oxoacetamide) Raltegravir is an impurity of a potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug.<br>References Wade, K., et al.: J. Pharmacol. Biomed. Anal., 8, 401 (1990), Hazuda, D., et al.: Science, 287, 646 (2000), Williams, J., et al.: Drug Metab. Dispos., 32, 1201 (2004), Duckett, C., et al.: Xenobiotica, 36, 59 (2006), Miners, J., et al.: Biochem. Pharmacol., 71, 1531 (2006), Summa, V., et al.: J. Med. Chem., 49, 6646 (2006),<br></p>Fórmula:C20H23FN6O6Forma y color:Off-WhitePeso molecular:462.43Phenylbutazone(diphenyl-d10)
CAS:Producto controlado<p>Applications Phenylbutazone(diphenyl-d10) is the isotope labelled analog of Phenylbutazone (P319570); a non-steroidal anti-inflammatory compound and an inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ali, S.L., Anal. Profiles Drug Subs., 11, 483 (1982); Hughes, M.F., et al.: Mol. Pharmacol., 34, 186 (1988)<br></p>Fórmula:C192H10H10N2O2Forma y color:Off White CrystallinePeso molecular:318.44Zileuton-d4 (major)
CAS:Producto controlado<p>Applications An inhibitor of 5-lipoxygenase, the initial enzyme in the biosynthesis of leukotrienes from Arachidonic Acid. Used as an antiasthmatic.<br>References Carter, G.W., et al.: J. Pharmacol. Exp. Ther., 256, 929 (1991), Weinblatt, M.E., et al.: J. Rheumatol., 19, 1537 (1992), McGill, K and Busse, W.W.: Lancet, 348, 519 (1996)<br></p>Fórmula:C112H4H8N2O2SForma y color:NeatPeso molecular:240.31(S)-3-(Boc-amino)piperidine
CAS:Producto controlado<p>Applications Useful intermediate for the synthesis of a variety of chiral aminopiperidinyl quinolones as potent antibacterial agents against resistant pathogens; and alkynylpyrimidine amide derivatives as orally available inhibitors of Tie-2 kinase.<br>References Hu, X., et al.: J. Med. Chem., 46, 3655 (2003), Cee, V., et al.: J. Med. Chem., 50, 627 (2007),<br></p>Fórmula:C10H20N2O2Forma y color:NeatPeso molecular:200.28Indomethacin Ethyl Ester
CAS:Producto controladoFórmula:C21H20ClNO4Forma y color:Off-WhitePeso molecular:385.84Hydroxy Iloperidone-d4
CAS:Producto controlado<p>Applications A hydroxylated labelled metabolite of Iloperidone (I267200).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mutlib, A., et al.: Drug Metab. Dispos., 23, 951 (1995), Westerink, B., et al.: Eur. J. Pharmacol., 412, 127 (2001),<br></p>Fórmula:C24H25D4FN2O4Forma y color:Off White SolidPeso molecular:432.521-Hydroxy-3,4-dihydroquinolin-2(1H)-one
CAS:Producto controladoFórmula:C9H9NO2Forma y color:NeatPeso molecular:163.17(D,L)-erythro-α-Phenyl-2-piperidineacetamide
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Intermediate in the preparation of D-threo-Methylphenidate (Ritalin)<br></p>Fórmula:C13H18N2OForma y color:NeatPeso molecular:218.29N-Aminocarbonyl Felbamate
CAS:Producto controlado<p>Applications N-Aminocarbonyl Felbamate is an impurity of Felbamate (F231000), an antiepileptic, structurally similar to meprobamate.<br></p>Fórmula:C12H15N3O5Forma y color:NeatPeso molecular:281.26trans-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol
CAS:Producto controlado<p>Applications trans-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol is an impurity of Ketoconazole (K186000).<br>References Ryu, J., et al. Bull. Korean Chem. Soc., 24, 460 (2003)<br></p>Fórmula:C14H14Cl2N2O3Forma y color:NeatPeso molecular:329.18Isopropyl 4-Hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide (Piroxicam Impurity I)
CAS:Producto controlado<p>Impurity Piroxicam EP Impurity I<br>Applications Piroxicam impurity I.<br>References Lombardino, J., et al.: J. Med. Chem., 14, 1171 (1971), Turck, D., et al.: Clin. Drug Invest., 9, 270 (1995),<br></p>Fórmula:C12H13NO5SForma y color:NeatPeso molecular:283.35-(4-methylphenyl)imidazolidine-2,4-dione
CAS:Producto controlado<p>Applications 5-(4-methylphenyl)imidazolidine-2,4-dione (cas# 69489-37-8) is a useful research chemical.<br></p>Fórmula:C10H10N2O2Forma y color:NeatPeso molecular:190.203-Des(2-methoxyethyl) 3-(1-Methylethyl) Ester Nimodipine
CAS:Producto controlado<p>Impurity Nimodipine EP Impurity B<br>Applications 3-Des(2-methoxyethyl) 3-(1-Methylethyl) Ester Nimodipine (Nimodipine EP Impurity B) can be used in synthetic preparation of dihydropyridinedicarboxylic acid esters by methylimidazolium trifluoroacetate-catalyzed Hantzsch cyclocondensation reaction of oxo-carboxylic acid esters with aldehydes and ammonium acetate. It can also be used as an analyte for analytical study in developing and optimizing a validated isocratic reversed-phase high-performance liquid chromatograhy separation of nimodipine and impurities in tablets using experimental. design methodology. It is an impurity of the drug Nimodipine (N478200).<br>References Avalani, J. R., et al.: J. Chem. Sci., 124, 1091-1096 (2012); Barmpalexis, P., et al.: J. Pharmaceut. Biomed., 49, 1192-1202 (2009)<br></p>Fórmula:C21H26N2O6Forma y color:NeatPeso molecular:402.445-Ethyl-5-phenyl-2-(1-phenylpropyl)dihydropyrimidine-4,6(1H,5H)-dione (Mixture of Diastereomers)
CAS:Producto controlado<p>Impurity Primidone EP Impurity F<br>Applications An impurity arising in the synthesis of Primidone.<br>References Pippenger, C.E., et al.: J. Anal. Toxicol., 1, 118 (1977),<br></p>Fórmula:C21H24N2O2Forma y color:NeatPeso molecular:336.43L-Valinol
CAS:Producto controlado<p>Applications L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.<br>References Chen, N., et al.: Phosphorus Sulfur, 190, 112 (2015); Zhao, Y., et al.: J. Med. Chem., 58, 1038 (2015)<br></p>Fórmula:C5H13NOForma y color:WhitePeso molecular:103.1632,2'-(4,4'-(Oxybis(butane-4,1-diyl))bis(piperazine-4,1-diyl))dipyrimidine Dihydrochloride
Producto controlado<p>Impurity Buspirone<br>Applications 2,2'-(4,4'-(Oxybis(butane-4,1-diyl))bis(piperazine-4,1-diyl))dipyrimidine is an impurity of anxiolytic drug Buspirone (B689855) that acts as 5-hydroxytryptamine (5-HT1) receptor agonist.<br>References Wu, Y.H., et al.: J. Med. Chem., 15, 477 (1972); Allen, L.E., et al.: Arzneim.-Forsch., 24, 917 (1974); Goa, K.L., et al.: Drugs, 32, 114 (1986);<br></p>Fórmula:C24H38N8O·2(HCl)Forma y color:White To Off-WhitePeso molecular:527.54(2,5-Difluorophenyl)(piperidin-4-yl)methanone Hydrochloride
CAS:Producto controladoFórmula:C12H13F2NO·HClForma y color:NeatPeso molecular:261.703-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl] Balsalazide Sodium Salt (>90%)
CAS:Producto controlado<p>Applications An impurity of the anti-inflammatory drug Balsalazide (B116300).<br></p>Fórmula:C27H24N6O9xNaPureza:>90%Forma y color:NeatPeso molecular:576.51(free acid)4’-Bromomethylbiphenyl-2-carboxylic Acid, Methyl Ester
CAS:Producto controladoFórmula:C15H13BrO2Forma y color:NeatPeso molecular:305.174-[[3-[2-(3-Chlorophenyl)ethyl]-2-pyridinyl]carbonyl]-1-piperidinecarboxylic AcidEthyl Ester
CAS:Producto controlado<p>Applications Loratadine intermediate, as antiallergic agent.<br></p>Fórmula:C22H25ClN2O3Forma y color:NeatPeso molecular:400.90Vortioxetine Hydrobromide (1 mg/mL in Methanol)
CAS:Fórmula:C18H22N2S·BrHForma y color:Single SolutionPeso molecular:379.358Ethyl 3,4-Dihydroxybenzoate
CAS:Producto controladoFórmula:C9H10O4Forma y color:NeatPeso molecular:182.173-O-Benzyl-4,5-O-(1-methylethyldiene)-β-D-fructopyranose
CAS:Producto controlado<p>Applications Intermediate in the preparation of 2,3-Desisopropylidene Topiramate, a metabolite of Topiramate<br></p>Fórmula:C16H22O6Forma y color:NeatPeso molecular:310.341-[1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indole-3-acetate]β-D-Glucopyranuronic Acid
CAS:Producto controlado<p>Stability Hygroscopic, Moisture Sensitive<br>Applications 1-[1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indole-3-acetate]β-D-Glucopyranuronic Acid is an analog of Indomethacin Acyl-β-D-glucuronide a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.<br>References Abid, A., et al.: Biochem. Pharmacol., 50, 557 (1995), Gamage, N., et al.: Toxicol. Sci., 90, 5 (2006), Cerveny, L., et al.: Drug Metab. Dispos., 35, 1032 (2007), Hayeshi, R., et al.: Eur. J. Pharm. Sci., 35, 383 (2008),<br></p>Fórmula:C24H22ClNO10Forma y color:NeatPeso molecular:519.8910-Acetyloxy Oxcarbazepine
CAS:Producto controlado<p>Applications An intermediate in the preparation of Carbamazepine metabolites.<br>References Heckendorn, R., et al.: Helv. Chimica Acta, 70, 1955 (1987),<br></p>Fórmula:C17H14N2O4Forma y color:NeatPeso molecular:310.305’-Hydroxyphenyl Carvedilol
CAS:<p>Applications A metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Fórmula:C24H26N2O5Forma y color:NeatPeso molecular:422.47N-Nitroso-(1S,2R)-ephedrine
CAS:Producto controladoFórmula:C10H14N2O2Forma y color:NeatPeso molecular:194.23Indomethacin 1-Menthol ester
CAS:Producto controlado<p>Applications Indomethacin terpenoids' esters were synthesized and assessed both in vitro and in vivo as indomethacin dermal prodrugs.<br>References Bonina,, Francesco. , et al.: European Journal of Pharmaceutical Sciences, 14, 123 (2001),<br></p>Fórmula:C29H34ClNO4Forma y color:NeatPeso molecular:496.0383-Ethynylaniline
CAS:Producto controlado<p>Stability Light Sensitive<br>Applications Reagent in the preparation of a metabolite of Erlotinib (E625000).<br></p>Fórmula:C8H7NForma y color:Colourless To Dark RedPeso molecular:117.15Dronedarone-d6 Hydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008), Hoy, S., et al.: Drugs, 69, 1647 (2009), Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009),<br></p>Fórmula:C31H39D6ClN2O5SForma y color:NeatPeso molecular:599.25N-Ethyl-N-nitroso-2-propanamine (100 μg/mL in Methanol)
CAS:Producto controladoFórmula:C5H12N2OForma y color:ColourlessPeso molecular:116.1616Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8.5% Ethanol)
CAS:Fórmula:C18H16ClFN4O2Forma y color:NeatPeso molecular:374.8N-Des(4-Fluorophenyl)-N-(3-chlorophenyl)-ezetimibe
CAS:Producto controladoFórmula:C24H21ClFNO3Forma y color:NeatPeso molecular:425.88Pimavanserin N-Oxide
CAS:Producto controlado<p>Applications Pimavanserin N-Oxide is an impurity of Pimavanserin (P441800), a drug used in the treatment of Parkinson’s disease and psychosis.<br>References Snigdha, S., et al.: J. Pharmacol. Exper. Ther., 332, 622 (2010); Meltzer, H., et al.: Neuropsychopharmacol., 35, 881 (2010);<br></p>Fórmula:C25H34FN3O3Forma y color:NeatPeso molecular:443.55(R)-(+)-α-Methylbenzylamine (>85%)
CAS:Producto controladoFórmula:C8H11NPureza:>85%Forma y color:NeatPeso molecular:121.182-(Trifluoroacetyl)-4-chloroaniline, Hydrochloride Hydrate
CAS:Producto controlado<p>Applications HIV reverse transcriptase inhibitor.<br></p>Fórmula:C8H5ClF3NO·ClHForma y color:NeatPeso molecular:260.04Plerixafor-d4
CAS:Producto controlado<p>Stability Very Hygroscopic<br>Applications Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>Fórmula:C28H50D4N8Forma y color:Off White SolidPeso molecular:506.813,3'-Disulfanediylbis[(2S)-2-methylpropanoic] Acid
CAS:Producto controladoFórmula:C8H14O4S2Forma y color:NeatPeso molecular:238.32Hydroxy Varenicline N-Trifluoroacetic Acid Salt
CAS:Producto controlado<p>Applications Protected Varenicline metabolite.<br></p>Fórmula:C15H12F3N3O2Forma y color:NeatPeso molecular:323.27N-Methyl Omeprazole-d3 (Mixture of isomers with the methylated nitrogens of imidazole)
CAS:Producto controlado<p>Applications Labelled Omeprazole (O635000) impurity.<br>References Allenmark, S., et al.: Anal. Biochem., 136, 293 (1984), Besancon, M., et al.: J. Biol. Chem., 272, 22438 (1997),<br></p>Fórmula:C18H18D3N3O3SForma y color:NeatPeso molecular:362.46Carboxyamidotriazole
CAS:Producto controlado<p>Applications Carboxyamidotriazole is an orally active calcium channel blocker. Carboxyamidotriazole also exhibits inhibition of pro-inflammatory cytokines in tumor associated macrophages as potential anti-cancer mechanism.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ju, R., et al.: Euro. J. Cancer., 48, 1085 (2012); Corrado, C., et al.: Cancer. lett., 300, 205 (2011);<br></p>Fórmula:C17H12Cl3N5O2Forma y color:NeatPeso molecular:424.672-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) (E)-2-(N,N-Dimethylformimidamide) Raltegravir
CAS:Producto controlado<p>Applications 2-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) (E)-2-(N,N-Dimethylformimidamide) Raltegravir is an impurity of Raltegravir (R100300), a potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug.<br>References Wade, K., et al.: J. Pharmacol. Biomed. Anal., 8, 401 (1990), Hazuda, D., et al.: Science, 287, 646 (2000), Williams, J., et al.: Drug Metab. Dispos., 32, 1201 (2004), Duckett, C., et al.: Xenobiotica, 36, 59 (2006), Miners, J., et al.: Biochem. Pharmacol., 71, 1531 (2006), Summa, V., et al.: J. Med. Chem., 49, 6646 (2006),<br></p>Fórmula:C19H24FN5O3Forma y color:NeatPeso molecular:389.424-Desfluoro-2-Fluoro Droperidol
CAS:<p>Applications 4-Desfluoro-2-Fluoro Droperidol is an impurity of Droperidol (D679500), a D1, D2 dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic.<br>References Yelnosky, J., et al.: Toxicol. Appl. Pharmacol., 6, 37 (1964), Janicki, C.A., et al.: Anal. Profiles Drug Subs., 7, 171 (1978), Hamik, et al.: Cancer Chemother. Pharmacol., 24, 307 (1989), Heyer, E.J., et al.: Brain Res., 863, 20 (2000),<br></p>Fórmula:C22H22FN3O2Forma y color:NeatPeso molecular:379.42744-{[(p-Fluorophenyl)imino]methyl}phenol
CAS:Producto controlado<p>Applications 4-{[(p-Fluorophenyl)imino]methyl}phenol is used in the preparation of benzylacetones which promote anti-fungal activity.<br>References Sandhar, R. et al.: J. Ind. Council Chem., 22, 32 (2005);<br></p>Fórmula:C13H10FNOForma y color:NeatPeso molecular:215.22Deschloro-4’-chloro Clomiphene Hydrochloride
CAS:Producto controlado<p>Applications An impurity of Clomiphene (C587025).<br></p>Fórmula:C26H29Cl2NOForma y color:NeatPeso molecular:442.424-(2-Nitrophenyl)morpholin-3-one
CAS:Producto controlado<p>Applications 4-(2-Nitrophenyl)morpholin-3-one is an intermediate in the synthesis of 4-(2-Aminophenyl)-3-morpholinone (A625985). 4-(2-Aminophenyl)-3-morpholinone is a reagent used in the preparation of various Morpholine based pharmaceuticals.<br>References Mederski, W., et al.: Bioorg. Med. Chem. Lett., 14, 3763 (2004); Roehrig, S., et al.: J. Med. Chem., 48, 5900 (2005)<br></p>Fórmula:C10H10N2O4Forma y color:NeatPeso molecular:222.22-Nitrodeamino Fingolimod
CAS:Producto controlado<p>Applications An impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Fórmula:C19H31NO4Forma y color:NeatPeso molecular:337.45Lisinopril (8R,S)-Diketopiperazine (Mixture of Diastereomers)Mps1-IN-1 dihydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Lisinopril (L468985) impurity.<br>References Drummer, O., et al.: Arzneim.-Forsch. Drug Res., 38, 647 (1988), Simpson, K., et al.: Drugs, 59, 1149 (2000),<br></p>Fórmula:C21H29N3O4Forma y color:NeatPeso molecular:387.47(S)-Rivastigmine
CAS:<p>Applications S-Rivastigmine is an isomer of Rivastigmine ( an acetylcholinesterase inhibitor used in the treatment of neurological disorders such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howes, L et al.: Drug. Safe., 37, 391 (2014); Shahar, O. et al.: Nucl. Acids Res., 42, 5869 (2014);<br></p>Fórmula:C14H22N2O2Forma y color:ColourlessPeso molecular:250.344-(4-Amino-1-oxoisoindolin-2-yl)-4-carbamoyl Butyric Acid
CAS:Producto controladoFórmula:C13H15N3O4Forma y color:Off WhitePeso molecular:277.28Hydroxy Atrazine-d5
CAS:Producto controlado<p>Applications Labelled Hydroxy Atrazine (H828600). Hydroxy Atrazine is a major metabolite of Atrazine (A794600).<br>References Thurman, E., et al.: Environ. Sci. Technol., 26, 2440 (1992), Evgenidou, E., et al.: J. Agric. Food Chem., 50, 6423 (2002), Namiesnik, J., et al.: Anal. Bioanal. Chem., 381, 279 (2005), Hultgren, S., et al.: Anal. Bioanal. Chem., 393, 929 (2009),<br></p>Fórmula:C82H5H10N5OForma y color:NeatPeso molecular:202.27Nintedanib Acetyl Impurity
CAS:Producto controlado<p>Applications An impurity of Nintedanib, which is an antifibrotic drug.<br>References Holdsworth, G.; et al.: Scientific Reports, 7, 1 (2017)<br></p>Fórmula:C26H23N3O4Forma y color:NeatPeso molecular:441.493-Methyl-8-quinolinesulfonyl Chloride
CAS:Producto controlado<p>Stability Moisture Sensitive - Store Under Inert Atmosphere<br>Applications 3-Methyl-8-quinolinesulfonyl Chloride (cas# 74863-82-4) is a compound useful in organic synthesis.<br></p>Fórmula:C10H8ClNO2SForma y color:NeatPeso molecular:241.69Loratadine-d5
CAS:Producto controlado<p>Applications Loratadine-d5 is the labeled analogue of Loratadine (L469575), a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989); Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Fórmula:C22H18D5ClN2O2Forma y color:NeatPeso molecular:387.91Olanzapine Dimer Impurity
Producto controlado<p>Applications An impurity of Olanzapine (O253750), a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic. Neuroprotective product.<br>References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)<br></p>Fórmula:C29H28N6S2Forma y color:NeatPeso molecular:524.703
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