Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65924 productos de "Derivados de Quinazolina y Quinolina"
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4-[4-[[(2R)-3-Chloro-2-hydroxypropyl]amino]phenyl]-3-morpholinone
CAS:Producto controlado<p>Impurity Rivaroxaban Impurity E<br>Applications 4-[4-[[(2R)-3-Chloro-2-hydroxypropyl]amino]phenyl]-3-morpholinone (Rivaroxaban Impurity E) is an impurity of Rivaroxaban (R538000), which is a antithrombotic agent and a FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C13H17ClN2O3Forma y color:NeatPeso molecular:284.74Nateglinide
CAS:Producto controlado<p>Applications An amino-acid derivative that stimulates insulin secretion. Used as an antidiabetic.<br>References Shinkai, H., et al.: J. Med. Chem., 32, 1436 (1989), Sato, Y., et al.: Diabetes Res. Clin. Pract., 12, 53 (1991), Vicent, D., et al.: J. Clin. Invest., 111, 1373 (2003), Ceriello, A., et al.: Diabet. Med., 21, 171 (2004),<br></p>Fórmula:C19H27NO3Forma y color:White To Off-WhitePeso molecular:317.421,2-Diphenyl Hydrazine
CAS:Producto controlado<p>Stability Air Sensitive (Oxidize)<br>Applications Impurity in the production of Phenylbutazone (P319570). Hydrazobenzene is a metabolic intermediate of Azobenzene.Carcinogenic.<br>References Chung, K., et al.: Mutation Res., 114, 269 (1983), Kawanishi, S., et al.: J. Biol. Chem., 261, 5952 (1986), Floyd, R., et al.: Carcinogenesis, 11, 1447 (1990), Shibutani, S., et al.: Nature, 349, 431 (1991),<br></p>Fórmula:C12H12N2Forma y color:OrangePeso molecular:184.24L-Phenylacetyl Carbinol
CAS:Producto controlado<p>Applications L-Phenylacetylcarbinol ( (L-PAC) obtained by biotransformation of benzaldehyde.<br>References Ellaiah, P., et al.: Ind. Drugs, 24, 192 (1987), Nikolova, P., et al.: Biotechnol. Bioeng., 38, 493 (1991), Shin, H., et al.: Biotechnol. Bioeng., 49, 52 (1996),<br></p>Fórmula:C9H10O2Forma y color:NeatPeso molecular:150.175-Methoxy-2-(4-methoxy-3,5-dimethylpyridin-2-yl)-1H-benzo[d]imidazole
CAS:Producto controlado<p>Applications 5-Methoxy-2-(4-methoxy-3,5-dimethylpyridin-2-yl)-1H-benzo[d]imidazole is an impurity of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983), Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984), Morii, M., et al.: J. Biol. chem., 268, 21553 (1993), Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Fórmula:C16H17N3O2Forma y color:NeatPeso molecular:283.33Rebamipide
CAS:Producto controlado<p>Applications Shows antiulcer activity in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Uchida, M., et al.: Chem. Pharm. Bull., 33, 3775 (1985), Yamasaki, K., et al.: Eur. J. Pharmacol., 142, 23 (1987),<br></p>Fórmula:C19H15ClN2O4Forma y color:Off-WhitePeso molecular:370.79Demethyl Chlorpromazine Hydrochloride
CAS:Producto controlado<p>Impurity Chlorpromazine EP Impurity D<br>Applications A metabolite of Chlorpromazine (C424750).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Neuhoff, E., et al.: Archiv. der Pharmazie, 288, 400 (1955), Tomita, M., et al.: Chem. Pharm. Bull., 16, 688 (1968),<br></p>Fórmula:C16H17ClN2S·ClHForma y color:WhitePeso molecular:341.304,6-Dimethyl-2-hydroxypyrimidine
CAS:Producto controlado<p>Applications 4,6-Dimethyl-2-hydroxypyrimidine is a component of Nicarbazine (N394530), a coccidiostat, which is an antiprotozoal agent that acts upon Coccidia parasites.<br>References Ksenija Sinigoj, G., et al.: Slovenski Kemijski Dnevi, (2012); Kyung-Woo, L., et al.: Han'guk Kagum Hakhoechi, 39, 17 (2012);<br></p>Fórmula:C6H8N2OForma y color:NeatPeso molecular:124.145-(4-Nitrophenyl)-2-furaldehyde Azine
CAS:Producto controladoFórmula:C22H14N4O6Forma y color:NeatPeso molecular:430.37Reserpic Acid Methyl Ester
CAS:Producto controlado<p>Applications Reserpine (R144600) derivative, an alkaloid found in Rauwolfia.<br>References Itoh, A. et al.: J. Nat. Prod. 68, 848 (2005)<br></p>Fórmula:C23H30N2O5Forma y color:NeatPeso molecular:414.49Tolcapone-d4
CAS:Producto controlado<p>Applications Orally active inhibitor of central and peripheral catechol-O-methyltransferase (COMT). Antiparkinsonian.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dingemanse, J., et al.: Clin. Pharmacol. Ther., 57, 508 (1995), Keating, K.A., Drugs, 19, 165 (2005),<br></p>Fórmula:C14H7D4NO5Forma y color:NeatPeso molecular:277.27(±)-Mianserin-d3 Hydrochloride (methyl-d3)
CAS:Producto controlado<p>Applications (±)-Mianserin-d3 HCl (methyl-d3) (CAS# 1219804-97-3) is a useful isotopically labeled research compound.<br></p>Fórmula:C18D3H17N2·ClHForma y color:NeatPeso molecular:303.84424-Methyl Erlotinib Hydrochloride
CAS:Producto controlado<p>Applications Erlotinib (E625000) derivative as internal standard for HPLC.<br></p>Fórmula:C23H25N3O4·ClHForma y color:NeatPeso molecular:443.9232O-Desmethyl Carvedilol
CAS:Producto controlado<p>Applications A metabolite of Carvedilol (C184625), a nonselective β-adrenergic blocker with α1-blocking activity.<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., et al.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Clohs, L., et al.: J. Pharm. Biomed. Anal., 31, 407 (2003),<br></p>Fórmula:C23H24N2O4Forma y color:NeatPeso molecular:392.455-Amino-1-(5-chloro-2-pyridinyl)-1H-pyrazole-4-carbonitrile
CAS:Fórmula:C9H6ClN5Pureza:95.0%Forma y color:SolidPeso molecular:219.63N-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl-L-proline
CAS:Producto controlado<p>Applications N-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl-L-proline, is a metabolite of Vildagliptin (V305000), a class of oral anti-hyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase.<br>References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),<br></p>Fórmula:C17H26N2O4Forma y color:NeatPeso molecular:322.399(R)-Lercanidipine-d3 Hydrochloride
CAS:Producto controladoFórmula:C36H39D3ClN3O6Forma y color:NeatPeso molecular:651.21Loxoprofen-d3
CAS:Producto controlado<p>Applications Loxoprofen-d3, is the labeled analogue of Loxoprofen (L472905), which is non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation.<br>References Masahide H. et al.: J Clin Biochem Nutr., 47, 138 (2010); Noguchi, M. et al.: Biolog. Pharmac. Bull., 28, 2075 (2005); Hyun, J. et al.: Arch. Pharm. Res., 24, 541 (2001);<br></p>Fórmula:C15H15D3O3Forma y color:NeatPeso molecular:249.32Efavirenz Pent-3-ene-1-yne (cis/trans Mixture)
Producto controlado<p>Applications Efavirenz Pen-3-ene-1-yne is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Fórmula:C14H9ClF3NO2Forma y color:NeatPeso molecular:315.672-(Descyclohexylcarbonyl)-2-benzoyl Praziquantel
CAS:Producto controlado<p>Impurity Praziquantel USP Related Compound A<br>Applications 2-(Descyclohexylcarbonyl)-2-benzoyl Praziquantel is used in the synthesis of Praziquantel (P702095), anthelmintic, effective against flatworms. Praziquantel USP Related Compound A<br>References Liu, H. et al.: Chem. Biol. Drug Des., 79, 470 (2012);<br></p>Fórmula:C19H18N2O2Forma y color:NeatPeso molecular:306.362-(2-CHLORO-4-MORPHOLINOTHIENO[3,2-D]PYRIMIDIN-6-YL)PROPAN-2-OL
CAS:Pureza:95.0%Peso molecular:313.79998779296875N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
CAS:Producto controladoFórmula:C16H13Cl2N5OSForma y color:NeatPeso molecular:394.28Descarboxyl Levofloxacin
CAS:Producto controlado<p>Impurity Levofloxacin Descarboxy Impurity<br>Applications A degradation product of Levofloxacin (L360000).<br>References Wong, F., et al.: J. Pharm. Biomed. Anal., 15, 765 (1997), Singh, G., et al.: Pharmazie, 43, 134 (1988), Radi, A., et al.: Talanta, 58, 319 (2002),<br></p>Fórmula:C17H20FN3O2Forma y color:Off-White To Light YellowPeso molecular:317.36Levetiracetam-d3 (contains d0)
CAS:Producto controlado<p>Applications The labelled (S)-enantiomer of Etiracetam (E932970) and the ethyl analog of Piracetam (P500800). Used as an anticonvulsant.<br>References Gower, A.J., et al.: Eur. J. Pharmacol., 222, 193 (1992), Kasteleijn-Noist Trenite, D.G.A., et al.: Epilepsy Res., 25, 225 (1996), Patsalos, P.N., et al.: Pharmacol. Ther., 85, 77 (2000),<br></p>Fórmula:C8H11D3N2O2Forma y color:NeatPeso molecular:170.21N-Nitrosoephedrine-D3
CAS:Producto controladoFórmula:C10D3H11N2O2Forma y color:White To Off-WhitePeso molecular:197.249Valsartan-d3
CAS:Producto controladoFórmula:C24H26D3N5O3Forma y color:Off-WhitePeso molecular:438.5423-[4-(2-Methoxyethyl)phenoxy]-1,2-propanediol
CAS:Producto controlado<p>Impurity Metoprolol EP Impurity D<br>Applications 3-[4-(2-Methoxyethyl)phenoxy]-1,2-propanediol (Metoprolol EP Impurity D) is a new byproduct detected in Metoprolol tartrate. Metoprolol (M338790) impurity.<br>References Erickson, M., et al.: J. Pharmac. Biomed. Anal., 13, 567 (1995),<br></p>Fórmula:C12H18O4Forma y color:WhitePeso molecular:226.27rac-Praziquanamine
CAS:Producto controlado<p>Applications Praziquanamine, as the main intermediate for synthesizing antiparasitic agent Praziquantel (P702095).<br>References Dong, Y., et al.: Bioorg. Med. Chem. Lett., 20(8), 2481 (2010)<br></p>Fórmula:C12H14N2OForma y color:NeatPeso molecular:202.2524N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS:Producto controlado<p>Applications N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a substance used in the identification of related substances in the degradation products of tofacitinib citrate using LC-MS technique for process monitoring and quality assurance. A reagent for the synthesis of Tofacitinib (CP-690,550), a Janus tyrosine kinase (JAK3) specific inhibitor.<br>References Wu, X., et al.: J. Pharm. Biomed. Anal., 143, 17 (2017); Marican, A., et al.: Tetrahedron Lett., 54, 5096 (2013)<br></p>Fórmula:C13H19N5Forma y color:WhitePeso molecular:245.32Boc-(S)-3-Amino-4-(2,4,5-trifluorophenyl)butyric Acid
CAS:Producto controlado<p>Applications Boc-(S)-3-Amino-4-(2,4,5-trifluorophenyl)butyric Acid is a reactant used in the preparation of peptidase IV inhibitors.<br>References Park, W. et al.: Bioorg. Med. Chem. Lett., 21, 1366 (2011);<br></p>Fórmula:C15H18F3NO4Forma y color:NeatPeso molecular:333.3N-Nitrosomorpholine-d8
CAS:Producto controlado<p>Applications N-Nitrosomorpholine-d8 (CAS# 1219805-76-1) is a useful isotopically labeled research compound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C42H8N2O2Forma y color:Light YellowPeso molecular:124.17Deshydroxyethoxy Ticagrelor
CAS:<p>Applications Deshydroxyethoxy Ticagrelor analog of Ticagrelor (T437700) an antiplatelet agent, and preventative in the treatment of heart attacks, myocardial infarction, and other pulmonary diseases.<br>References Zhang, H. et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012);<br></p>Fórmula:C21H24F2N6O3SForma y color:White To Off-WhitePeso molecular:478.52cis-(Z)-Flupentixol Dihydrochloride
CAS:Producto controlado<p>Applications Neuroleptic agent related structurally to thiothixene. Antipsychotic; neuroleptic agent; dopamine receptor antagonist.<br>References Nielsen, et al.: Acta Pharmacol. Toxicol., 32, 363 (1973), Post, M.L., et al.: Nature, 256, 342 (1975), Peuch, et al.: Neuropharmacology, 20, 1279 (1981),<br></p>Fórmula:C23H27Cl2F3N2OSForma y color:NeatPeso molecular:507.44PTC-124
CAS:Producto controlado<p>Applications PTC-124 is a nonaminoglycoside that has been reported to induce ribosomes to read through premature nonsense stop signals on mRNA, allowing the production of full-length functional proteins,<br>References Yu, H. et al.: Int. J. Mol. Med., 33, 729 (2014); Aditya, S. et al.: J. Biomed. Pharm. Res., 2, 21 (2013);<br></p>Fórmula:C15H9FN2O3Forma y color:White To Off-WhitePeso molecular:284.248-Bromo-3-methyl-7-(2-butynyl)-xanthine
CAS:Producto controladoFórmula:C10H9BrN4O2Forma y color:NeatPeso molecular:297.108Afatinib Dimaleate
CAS:Producto controlado<p>Applications Afatinib Dimaleate is a salt of Afatinib {BIBW 2992) (B377000), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. An anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity.<br>References D, Li. et al.: Oncogene., 27, 4702 (2008); Wang, X. et al.: Cancer Res., 74, 4431 (2014);<br></p>Fórmula:C24H25ClFN5O3·2C4H4O4Forma y color:NeatPeso molecular:718.084-[6-(4-Methoxy-phenyl)-pyridin-3-yl]-pyrimidin-2-ylamine
Pureza:95.0%Peso molecular:278.31500244140625Pamabrom
CAS:Producto controlado<p>Applications A diuretic used to reduce menstrual pains.<br>References Varga, J., et al.: Mol. Immunol., 28, 641 (1991), Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 2881 (2005), Ibrahim, H., et al.: Drug Discov. Ther., 3, 168 (2009),<br></p>Fórmula:C7H7BrN4O2·C4H11NOForma y color:NeatPeso molecular:348.203’-Anhydro Ezetimibe
CAS:Producto controladoFórmula:C24H19F2NO2Forma y color:NeatPeso molecular:391.41Uvinul A Plus
CAS:<p>Applications Uvinul A Plus is a component of cosmetic emulsion with UV protection.<br>References Chang, M., et al.: J. Food Drug Anal., 9, 199 (2001), Simeoni, S., et al.: J. Pharm. Biomed. Anal., 38, 250 (2005), Vielhaber, G., et al.: Photochem. Photobiol. Sci., 5, 275 (2006), Lee, S., et al.: J. Cosmet. Sci., 59, 469 (2008),<br></p>Fórmula:C24H31NO4Forma y color:White To YellowPeso molecular:397.51Anastrozole
CAS:Producto controlado<p>Applications An aromatase inhibitor. Used as an antineoplastic.<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>Fórmula:C17H19N5Forma y color:NeatPeso molecular:293.37Eltrombopag Olamine
CAS:<p>Stability Hygroscopic<br>Applications Eltrombopag is an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008)<br></p>Fórmula:C25H22N4O4·2C2H7NOForma y color:Dark RedPeso molecular:564.63Telmisartan-d4
CAS:Producto controlado<p>Applications Telmisartan-d4 is deuterium labelled Telmisartan (T017000). Telmisartan is an angiotensin II receptor antagonist.<br>References Wienen, W. et al.: Br. J. Pharmacol., 110, 245 (1993); Neutel, J.M. et al: Adv. Therap., 15, 206 (1998)<br></p>Fórmula:C33D4H26N4O2Forma y color:NeatPeso molecular:518.64N-Desmethyl 4-Hydroxy Toremifene Hydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A metabolite of Toremifene (T547500).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Phillips, D., et al.: Carcinogenesis, 17, 89 (1996), Davies, R., et al.: Cancer Res., 57, 1288 (1997), Moorthy, B., et al.: Biochem. Pharmacol., 53, 663 (1997),<br></p>Fórmula:C25H27Cl2NO2Forma y color:NeatPeso molecular:444.39
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