Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65578 productos de "Derivados de Quinazolina y Quinolina"
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Omeprazole-d3
CAS:Producto controlado<p>Applications Labelled Omeprazole, which binds covalently to proton pump, it inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983), Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984), Morii, M., et al.: J. Biol. chem., 268, 21553 (1993), Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Fórmula:C172H3H16N3O3SForma y color:NeatPeso molecular:348.43Valsartan n-Propyl Impurity
CAS:Producto controlado<p>Impurity Valsartan Related Compound B<br>Applications Valsartan n-Propyl is an impurity in the synthesis of Valsartan (V095750). Valsartan USP Related Compound B.<br>References Hillaert, S., et al.: J. Pharm. Biomed. Anal., 31, 329 (2003), Carlucci, G., et al.: Anal. Lett., 33, 2491 (2000), Cagigal, E., et al.: Talanta, 54, 1121 (2001),<br></p>Fórmula:C23H27N5O3Forma y color:WhitePeso molecular:421.49O-Desmethyl Astemizole
CAS:Producto controlado<p>Applications A metabolite of Astemizole.<br>References Nagata, K., et al.: J. Biol. Chem., 268, 24720 (1993), Benton, R., et al.: Clin. Pharmacol. Ther., 59, 383 (1996), Hashizume, T., et al.: Drug Metab. Dispos., 26, 566 (1998), Scarborough, P., et al.: Drug Metab. Rev., 31, 205 (1999),<br></p>Fórmula:C27H29FN4O·ClHForma y color:NeatPeso molecular:481.005-(Aminosulfonyl)-2-methoxy-benzoic Acid Methyl Ester
CAS:<p>Impurity Sulpiride EP impurity B<br>Applications A reactant used in the preparation of many pharmaceutical compounds used as anticoagulants, HCV NS5B polymerase inhibitors, therapeutic drugs for treatment of neurodegenerative diseases and oral hypoglycemic agents.<br></p>Fórmula:C9H11NO5SForma y color:White To Off-WhitePeso molecular:245.252-Methyl-N-[3-(trifluoromethyl)phenyl]propanamide
CAS:Producto controladoFórmula:C11H12F3NOForma y color:NeatPeso molecular:231.213’-Amino-2’-Hydroxy-[1,1’]biphenyl-3-carboxylic Acid
CAS:Producto controlado<p>Applications 3’-Amino-2’-Hydroxy-[1,1’]Biphenyl-3-carboxylic Acid is used in the synthesis of monoethanolamine salts. A hydrazine cleavage product from Eltrombopag (E508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Fórmula:C13H11NO3Forma y color:NeatPeso molecular:229.231rac-Naproxen-13C,d3
CAS:Producto controlado<p>Applications Labelled Naproxen. An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harrison, I.T., et al.: J. Med. Chem., 13, 203 (1970)<br></p>Fórmula:CC132H3H11O3Forma y color:NeatPeso molecular:234.272-Chloro Phenothiazine
CAS:Producto controlado<p>Impurity Chlorpromazine EP Impurity E<br>Applications Metabolite of Chloropromazine<br>References Motohashi, N., et al.: Anticancer Res., 17, 4403 (1997), Azuine, M., et al.: Pharmacol. Res., 49, 161 (2004), Touil, F., et al.: J. Pharm. Biomed. Anal., 40, 822 (2006),<br></p>Fórmula:C12H8ClNSForma y color:GreyPeso molecular:233.72Dehydro Nifedipine
CAS:Producto controlado<p>Impurity Nifedipine EP Impurity A<br>Applications The main Nifedipine metabolite in human plasma.This compound is a contaminant of emerging concern (CECs).<br>References Guengerich, F., et al.: J. Biol. Chem., 261, 5051 (1986), Bork, R., et al.: J. Biol. Chem., 264, 910 (1989), Kerla, V., et al.: Biochem. Pharmacol., 44, 1745 (1992),<br></p>Fórmula:C17H16N2O6Forma y color:Light YellowPeso molecular:344.321-[(1-Oxopentyl)amino]-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-cyclopentanecarboxamide
CAS:Producto controlado<p>Impurity Irbesartan EP Impurity A; Irbesartan USP Related Compound A; Irbesartan Metabolite<br>Applications 1-[(1-Oxopentyl)amino]-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-cyclopentanecarboxamide (Irbesartan EP Impurity A; Irbesartan USP Related Compound A; Irbesartan Metabolite) is a metabolite of Irbesartan (I751000), an angiotensin II type 1 (AII1)-receptor antagonist.<br>References Alexandre, V., et. al.: J. Mol. Catal. B-Enzym., 29, 173 (2004); Rao, D.D., et. al.: J. Liq. Chromatogr. R. T., 35, 1973 (2012)<br></p>Fórmula:C25H30N6O2Forma y color:NeatPeso molecular:446.54O-Desmethyl Mebeverine Acid
CAS:Producto controladoFórmula:C15H23NO3Forma y color:NeatPeso molecular:265.35Pyrazinecarboxylic Acid-d3
CAS:Producto controlado<p>Applications Labelled analogue of Pyrazinecarboxylic Acid, a very potent urate retaining drug. Pyrazinecarboxylic Acid is a metabolite of the antibacterial agent Pyrazinamide (P840600).<br>References Fanelli, G.M. et al.: J. Clin. Invest., 52, 1946 (1973): Fanelli, G.M. et al.: J. Pharmacol. Exp. Therap., 200, 413 (1977); Lacroix, C. et al.: Arzneim.-Forsch., 40, 76 (1990); Kraemer, H.-J. et al.: J. Chrom. B Niomed. Sci. Appl., 706, 319 (1998);<br></p>Fórmula:C5HD3N2O2Forma y color:White To Light YellowPeso molecular:127.12Nevirapine-d3
CAS:Producto controlado<p>Applications Labelled Nevirapine (N391275), a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Antiviral.<br>References Hargrave, K.D., et al.: J. Med. Chem., 34, 2231 (1991), Cheeseman, S.H., et al.: Antimicrob. Agents Chemother., 37, 178 (1993), Guay, L.A., et al.: Lancet, 354, 795 (1999),<br></p>Fórmula:C15H11D3N4OForma y color:White To Light BeigePeso molecular:269.32Nifursol-15N2,d2
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Labelled Nifursol (N458702). A medicinal, prophylactic additive in animal feeds, protecting poultry from histomoniasis.Environmental contaminants; Food contaminants; Heat processing contaminants<br>References Kowalski, P., et al.: J. Pharm. Biomed. Anal., 32, 937 (2003), Khlebnikov, A., et al.: Bioorg. Med. Chem., 16, 9302 (2008), Schepetkin, I., et al.: Mol. Pharmacol., 74, 392 (2008),<br></p>Fórmula:C12H5D2N315N2O9Forma y color:NeatPeso molecular:369.21Enzalutamide Carboxylic Acid
CAS:<p>Applications Enzalutamide Carboxylic Acid is used as hormone therapies to prevent androgen-fuled growth of castrate-resistant prostate cancer.<br>References Tomasz, M.B., et al.: New Engl, J. Med., 424, 371 (2014);<br></p>Fórmula:C20H13F4N3O3SForma y color:NeatPeso molecular:451.39(S)-Bicalutamide
CAS:Producto controlado<p>Applications (S)-Enantiomer of Bicalutamide. Used as an antiandrogen, antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>Fórmula:C18H14F4N2O4SForma y color:WhitePeso molecular:430.37Fenoterol-d6 Hydrobromide
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Labelled Fenoterol (F248850). An β2-adrenergic agonist. Bronchodilator; tocolytic.<br>References Schuster, B., et al. Arzneim.-Forsch., 19, 1905 (1969), Gerris, J., et al.: Eur. J. Clin. Pharmacol., 18, 443 (1980), Heel, R.C., et al.: Drugs, 15, 3 (1978),<br></p>Fórmula:C17D6H15NO4·BrHForma y color:Off White To BrownPeso molecular:390.30(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran
CAS:Producto controlado<p>Applications (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran is used as a reactant in the efficient synthesis of empagliflozin inhibitor of SGLT-2 utilizing AlCl3-promoted silane reduction of β-glycopyranoside.<br>References Wang, X., et al.: Org. Lett., 16, 4090 (2014);<br></p>Fórmula:C17H16BrClO2Forma y color:Off-WhitePeso molecular:367.66O-Desisopropyl-O-methoxyethyl Nimodipine
CAS:Producto controlado<p>Impurity Nimodipine EP Impurity C; Nimodipine USP Related Compound B<br>Applications O-Desisopropyl-O-methoxyethyl Nimodipine (Nimodipine EP Impurity C) is an impurity in the synthesis of Nimodipine (A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral). Nimodipine USP Related Compound B.<br>References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),<br></p>Fórmula:C21H26N2O8Forma y color:NeatPeso molecular:434.44R-(-)-Deprenyl Hydrochloride
CAS:Producto controlado<p>Applications Monoamine oxidase-B inhibitor related structurally to Pargyline. Used to alleviate the symptoms of Parkinsons disease.<br>References Magyar, K., et al.: Acta Physiol. Acad. Sci. Hung., 32, 377 (1967), Heinonen, E.H., et al.: Acta Neurol. Scand., 84, 44 (1991), Schneider, L.S., et al.: Am. J. Psychiatry, 150, 321 (1993),<br></p>Fórmula:C13H17N·ClHForma y color:White To Off-WhitePeso molecular:223.743-Hydroxy Ropivacaine
CAS:Producto controlado<p>Applications A major metabolite of Ropivacaine (R675000).<br>References Ekstrom, G., et al.: Drug Metab. Dispos., 24, 955 (1996), Arvidsson, T., et al.: Biomed. Chromatogr., 13, 286 (1999), Shah, V., et al.: Pharm. Res., 17, 1551 (2000),<br></p>Fórmula:C17H26N2O2Forma y color:NeatPeso molecular:290.42,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]
CAS:Producto controlado<p>Applications An impurity in the synthesis of Silodosin (S465000), an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.<br>References Barve, I. et al.: Tetra., 69, 2834 (2013); Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995), Murata, S., et al.: J. Urol., 164, 578 (2000),<br></p>Fórmula:C25H30F3N3O3Forma y color:Light YellowPeso molecular:477.52(2R,4R)-rel-1,2,3,4-Tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylic Acid Methyl Ester
CAS:Producto controlado<p>Stability Light Sensitive<br>Applications (2R,4R)-rel-1,2,3,4-Tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylic Acid Methyl Ester is an impurity of Nifedipine (N457000); a dihydropyridine calcium channel blocker. Also used as an antihypertensive and antianginal.<br>References Karancsi, T., et al.: Acta Pharm. Hung., 66, 21 (1996); Poetter, H., et al.: J. Pharmaceut. Biomed., 6, 115 (1988); Ali, S.L., et al.: Anal. Profiles Drug Subs., 18, 221 (1989); Soons, P.A., et al.: J. Pharm. Biomed. Anal., 9, 475 (1991); Brown, M.J., et al.: Lancet, 356, 366 (2000)<br></p>Fórmula:C19H18N4O6Forma y color:NeatPeso molecular:398.373-[(4-Fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoic Acid
CAS:Producto controlado<p>Impurity Bicalutamide EP Impurity M<br>Applications 3-[(4-Fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoic Acid is an impurity of Bicalutamide (B382000); a non-steroidal peripherally active antiandrogen. Also used as an antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988); Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990); Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993); McKillop, D., et al.: Xenobiotica, 25, 623 (1995)<br></p>Fórmula:C10H11FO5SForma y color:NeatPeso molecular:262.25Deferiprone 3-O-β-D-Glucuronide Sodium Salt
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A metabolite of Deferiprone (D474000).<br>References Choudhury, R., et al.: Drug Metab. Dispos., 23, 314 (1995),<br></p>Fórmula:C13H16NNaO8Forma y color:Yellow To Dark YellowPeso molecular:337.264-Desmethyl-4-ethylimidazolyl Nilotinib
CAS:Producto controladoFórmula:C29H24F3N7OForma y color:Light Beige To Light BrownPeso molecular:543.54Methyl 4-Acetamido-5-bromo-2-methoxybenzoate
CAS:Producto controlado<p>Applications Methyl 4-Acetamido-5-bromo-2-methoxybenzoate is an impurity of bromopride (B686645), which is an antimetic.<br>References Fontaine, J., et al.: Arch. Int. Pharmacodyn. Ther., 213, 322 (1975), Lucker, P.W., et al.: Arzneim.-Forsch., 33, 453 (1983)<br></p>Fórmula:C11H12BrNO4Forma y color:Off-WhitePeso molecular:302.12(R)-Tamsulosin-d4 Hydrochloride
CAS:Producto controlado<p>Applications (R)-Tamsulosin-d4 Hydrochloride is the labeled analogue of (R)-Tamsulosin Hydrochloride (T006350), a specific α1-adrenoceptor antagonist. It is used in the treatment of benign prostatic hypertrophy.<br>References Kawabe, K., et al.: J. Urol., 144, 908 (1990); Abrams, P., et al.: Br. J. Urol., 76, 325 (1995); Michel, M.C., Expert Opin. Pharmacother., 5, 151 (2004)<br></p>Fórmula:C20H25D4ClN2O5SForma y color:NeatPeso molecular:449.0N1,N3-Bis[2-(3,4-dimethoxyphenyl)ethyl]-N1,N3-dimethyl-1,3-propanediamine Dihydrochloride
CAS:Producto controlado<p>Impurity Verapamil EP Impurity A DIHCL<br>Stability Hygroscopic<br>Applications N1,N3-Bis[2-(3,4-dimethoxyphenyl)ethyl]-N1,N3-dimethyl-1,3-propanediamine Dihydrochloride (Verapamil EP Impurity A DIHCL) is an impurity of Verapamil (V125000), a calcium channel blocker. Antihypertensive; antianginal; antiarrhythmic (class IV).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Atlas, D, and Adler, M.: Proc. Natl. Acad. Sci. USA, 78, 1237 (1981), Janis, R., et al.: Adv. Drug. Res., 16, 309 (1987)<br></p>Fórmula:C25H38N2O4·2ClHForma y color:NeatPeso molecular:503.511-(1-BENZYL-1H-PYRAZOL-4-YL)-1H-INDOLE-3-CARBOXYLIC ACID
Pureza:90.0%Peso molecular:317.34799194335942-(3-Chloro-thiophen-2-yl)-1H-benzoimidazole-5-carboxylic acid
CAS:Forma y color:SolidPeso molecular:278.7099914550781De-4-fluoro 5-Fluoro Chidamide
CAS:<p>Applications De-5-fluoro 4-Fluorochidamide is an analogue of Chidamide (CAS 743420-02-0), a hitsone deacetylase inhibitor (HDACI) that enhances gemcitabine (G305000) cytotoxicity in pancreatic cancer cells.<br>References Qiao, Z., et. al.: Biochem. Bioph. Res. Co., 434, 95 (2013)<br></p>Fórmula:C22H19FN4O2Forma y color:Off White PowderPeso molecular:390.413-(1H-2-INDOLYL)-4-(4-METHOXYPHENYL)-1-METHYL-1H-2-QUINOLINONE
CAS:Pureza:97.0%Peso molecular:380.44699096679694-Chloro-7-methoxy-2-phenylquinoline
CAS:Pureza:98.0%Forma y color:SolidPeso molecular:269.7300109863281(R)-4-Hydroxy Propranolol Hydrobromide
CAS:Producto controlado<p>Applications The main metabolite of (R)-Propranolol.<br>References Shwed, J., et al.: Xenobiotica, 22, 973 (1992), Fujita, K., et al.: Biol. Pharm. Bull., 22, 446 (1999), Walle, U., et al.: Drug Metab. Dispos., 30, 564 (2002),<br></p>Fórmula:C16H21NO3·HBrForma y color:NeatPeso molecular:356.253-Chloro-4-nitropyridine N-oxide
CAS:Fórmula:C5H3ClN2O3Pureza:95%Forma y color:SolidPeso molecular:174.54Primidone
CAS:<p>Applications Primidone is an Anticonvulsant.<br>References Bogue, C., et al.: Br. J. Pharmacol., 8, 230 (1953), Daley, R.D., Anal. Profiles Drug Subs., 2, 409 (1973),<br></p>Fórmula:C12H14N2O2Forma y color:White To Off-WhitePeso molecular:218.25Tris(2-ethylhexyl) 4,4',4''-((1,3,5-triazine-2,4,6-triyl)tris(azanediyl))tribenzoate
CAS:Pureza:97.0%Forma y color:Liquid, No data available.Peso molecular:823.0919799804688Ref: 10-F545236
1gA consultar5gA consultar10gA consultar25gA consultar100gA consultar500gA consultar100mgA consultar500mgA consultar4-Hydroxy Omeprazole Sulfide
CAS:Producto controlado<p>Stability Light Sensitive<br>Applications An intermediate in the preparation of Omeprazole metabolites.<br>References Hoffmann, K., et al.: Drug Metab. Disposition, 14, 341 (1986), Andersson, T., et al.: Brit. J. Clin. Pharmacol., 36, 521 (1993),<br></p>Fórmula:C16H17N3O2SForma y color:NeatPeso molecular:315.39(6,7-Dimethyl-3-phenyl-quinoxalin-2-yl)-phenyl-methanone
Pureza:95.0%Peso molecular:338.41000366210944’-Hydroxy Toremifene (~8% E isomer)
CAS:Producto controlado<p>Applications 4’-Hydroxy Toremifene is a metabolite of Toremifene (T547500).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jones, R.M. et al.: Biomed. Chrom., 16, 361 (2002);<br></p>Fórmula:C26H28ClNO2Forma y color:NeatPeso molecular:421.96Chlorpromazine N-Oxide Maleic Acid Salt
CAS:Producto controlado<p>Applications Chlorpromazine N-Oxide Maleic Acid Salt is an impurity of Chlorpromazine (C424750) which has antiemetic; antipsychotic properties.<br>References Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970), Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990)<br></p>Fórmula:C21H23ClN2O5SForma y color:NeatPeso molecular:450.94
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