Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65630 productos de "Derivados de Quinazolina y Quinolina"
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N,N’-Bis[Des(5-chloro-2-carvoxythienyl) Rivaroxaban] Urea
CAS:Producto controladoFórmula:C29H32N6O9Forma y color:WhitePeso molecular:608.606-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride
CAS:Producto controlado<p>Impurity Risperidone EP Impurity M; Paliperidone USP Related Compound B<br>Applications 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride (Risperidone EP Impurity M; Paliperidone USP Related Compound B) is a novel antiproliferative agent.<br>References Benaka P. et al.: Invest. New Drugs., 27, 534 (2009);<br></p>Fórmula:C12H13FN2O·ClHForma y color:NeatPeso molecular:256.70MEK 162
CAS:Producto controlado<p>Applications MEK 162 is a MEK1/2 inhibitor allowing it to be a effective anti-cancer medication.<br>References Kopetz,S., et al.: N. Engl., 381, 1632-1643<br></p>Fórmula:C17H15BrF2N4O3Forma y color:NeatPeso molecular:441.23Nepafenac
CAS:<p>Applications A non-steroidal anti-inflammatory with analgesic activity; selective COX-2 inhibitor. Prodrug of Amfenac.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Walsh, D.A., et al.: J. Med. Chem., 33, 2296 (1990), Gamache, D.A., et al.: Inflammation, 24, 357 (2000), Lindstrom, R., et al.: Curr. Med. Res. Opin., 22, 397 (2006),<br></p>Fórmula:C15H14N2O2Forma y color:NeatPeso molecular:254.288-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane Bromide
CAS:Producto controlado<p>Impurity Aripiprazole Impurity 12<br>Applications 8-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane Bromide is an intermediate used in the preparation of Aripiprazole (A771000), a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. Antipsychotic. Aripiprazole Impurity 12<br>References Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998), Oshiro, Y., et al.: J. Med. Chem., 41, 658 (1998),<br></p>Fórmula:C14H19Cl2N2·BrForma y color:NeatPeso molecular:366.12Hydroxymethoxy-N-desmethyl Toremifene
Fórmula:C26H28ClNO3Pureza:>80%Forma y color:NeatPeso molecular:437.96Mavoglurant
CAS:Producto controlado<p>Applications Mavoglurant is a non-competitive metabotropic glutamate receptor 5 (mGlu5) receptor antagonist.<br>References Vranesic, I., et al.; Bioorg. Med. Chem., 22, 5790 (2014); Kubas, H., et al.: Bioorg. Med. Chem. Lett., 23, 6370 (2013)<br></p>Fórmula:C19H23NO3Forma y color:NeatPeso molecular:313.39MDV 3100 (Enzalutamide)
CAS:Producto controlado<p>Applications MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.<br>References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011);<br></p>Fórmula:C21H16F4N4O2SForma y color:WhitePeso molecular:464.443-Chloromethyl-5-methylpyridine Hydrochloride
CAS:Producto controlado<p>Applications 3-Chloromethyl-5-methylpyridine is an intermediate in the synthesis of Rupatadine (R701650).<br>References Merlos, M., et al.: Pharmacol. Exp. Therap., 280, 114 (1997), Bell, I., et al.: J. Med. Chem., 41, 2146 (1998),<br></p>Fórmula:C7H8ClN·ClHForma y color:White To BeigePeso molecular:178.06Macitentan
CAS:Producto controlado<p>Applications Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.<br>References Emoto, N. Ensho to Men'eki, 20, 487 (2012);<br></p>Fórmula:C19H20Br2N6O4SForma y color:White To Off-WhitePeso molecular:588.27Ketoconazole-d8
CAS:Producto controlado<p>Applications Deuterated Ketoconazole, an inhibitor of cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)<br></p>Fórmula:C26H20D8Cl2N4O4Forma y color:White To BeigePeso molecular:539.483’-(2-Fluorophenyl) Ezetimibe
CAS:Producto controlado<p>Impurity Ezetimibe o-Fluorobenzene Isomer (USP)<br>Applications 3’-(2-Fluorophenyl) Ezetimibe is an impurity of Ezetimibe (E975005), an antihyperlipoproteinemic and a cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Fórmula:C24H21F2NO3Forma y color:White To Off-WhitePeso molecular:409.43Afatinib-d6
CAS:Producto controladoFórmula:C24H19D6ClFN5O3Forma y color:Light Yellow SolidPeso molecular:491.98Stiripentol-d9
CAS:Producto controlado<p>Applications An labelled epilepsy drug. It has been used as co-therapy for treatment of epilepsy. It inhibits the enzymes responsible for metabolism of other anti-convulsant agents.<br>References Laurie, D., et al.: J. Neurosci., 12, 4151 (1992), Smith, A., et al.: J. Pharmacol. Exp. Therap., 311, 601 (2004), Trojnar, M., et al.: Pharm. Rep., 57, 154 (2005), Drafts, B., et al.: J. Pharm. Exp. Ther., 318, 1094 (2006), Picton, A., et al.: Brain Res., 1165, 40 (2007),<br></p>Fórmula:C14H9D9O3Forma y color:White SolidPeso molecular:243.35Methyl 2-Methyl-6-(3-nitrophenyl)-4-oxo-2-cyclohexene-1-carboxylate
CAS:<p>Applications Methyl 2-Methyl-6-(3-nitrophenyl)-4-oxo-2-cyclohexene-1-carboxylate is a nicardipine impurity. Also, it is derived from Methyl Acetoacetate (O848425), which is a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.<br>References Vaghela, B. K., et al.: J. Liq. Chromatogr. Related Technol., 36, 2166-2181 (2013);<br></p>Fórmula:C15H15NO5·C16H17NO5Forma y color:NeatPeso molecular:592.596-methoxy-N-(pyridin-3-ylmethyl)-1,3-benzothiazol-2-amine
CAS:Pureza:95.0%Peso molecular:271.33999633789062-Methoxy Phenothiazine
CAS:<p>Applications An impurity of Methotrimeprazine (M260785).A derivative of Phenothiazine (P318040) exhibits tuberculostatic activity.<br>References Waisser, K., et al.: Folia. Pharm. Univ. Carol., 18, 41 (1995)<br></p>Fórmula:C13H11NOSForma y color:Grey To BrownPeso molecular:229.30Lercanidipine-d3
CAS:Producto controlado<p>Applications Lercanidipine-d3 is a labeled dihydropyridine calcium channel blocker.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bianchi, G., et al.: Pharmacol. Res., 21, 193 (1989); Rimoldi, E., et al.: Acta Therap., 200, 23 (1994)<br></p>Fórmula:C36H38D3N3O6Forma y color:NeatPeso molecular:614.75Everolimus
CAS:Producto controlado<p>Impurity Everolimus EP Impurity C<br>Stability Hygroscopic<br>Applications Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002),<br></p>Fórmula:C53H83NO14Pureza:~90%Forma y color:NeatPeso molecular:958.22Amisulpride-d5 N-Oxide
CAS:Producto controlado<p>Applications Labelled Amisulpride N-Oxide (A633265). Amisulpride N-Oxide is an impurity of Amisulpride (A633250). Amisulpride N-Oxide was identified as a photodegradation product of Amisulpride.<br>References Moulin, A., et al.: Eur. J. Drug Metab. Pharmcokinet., 3, 507 (1991), Chatterjee, B., et al.: J. Biotechnol., 3, 235 (2008), Breier, A., et al.: J. Pharm. Biomed. Anal., 46, 250 (2008),<br></p>Fórmula:C17H22D5N3O5SForma y color:WhitePeso molecular:390.511-(3,4-Dichlorophenyl)piperazine
CAS:Producto controladoFórmula:C10H12Cl2N2Forma y color:NeatPeso molecular:231.12Ebastine
CAS:<p>Applications A nonsedating type histamine H1-receptor antagonist. Antihistaminic.<br>References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Inomata, N., et al.: J. Dermatol., 36, 224 (2009), Carvajal, A., et al.: Clin. Pharmacol. Ther., 85, 481 (2009), Yamashita, S., et al.: Mol. Pharm., 6, 48 (2009),<br></p>Fórmula:C32H39NO2Forma y color:White To Off-WhitePeso molecular:469.66Sibutramine, Hydrochloride Monohydrate
CAS:Producto controladoFórmula:C17H26ClN·ClH·H2OForma y color:Off White SolidPeso molecular:334.324-[2-[1-(4-Methylphenyl)ethylidene]hydrazinyl]benzenesulfonamide
CAS:<p>Applications 4-[2-[1-(4-Methylphenyl)ethylidene]hydrazinyl]benzenesulfonamide is an impurity of Celecoxib (C251000), a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Fórmula:C15H17N3O2SForma y color:White To Light YellowPeso molecular:303.38Boc-3-hydroxy-1-adamantyl-D-glycine
CAS:Producto controlado<p>Applications Boc-3-hydroxy-1-adamantyl-D-glycine is used in the preparation of a Saxagliptin intermediate.<br>References Hanson, R.L., et. al.: Adv. Scyn. Catal., 349, 1369 (2007)<br></p>Fórmula:C17H27NO5Forma y color:NeatPeso molecular:325.42-[[(3-Methyl-4-nitro-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
CAS:Producto controlado<p>Applications 2-[[(3-Methyl-4-nitro-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole is a drug impurity of Lansoprazole, which is a proton pump inhibitor and used to treat stomach and intestinal ulcers.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000); Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001); Barradell, L.B., et al.: Drugs, 44, 225 (1992); Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002); Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006)<br></p>Fórmula:C14H12N4O3SForma y color:NeatPeso molecular:316.34Tazarotene Sulfone
CAS:Producto controlado<p>Applications Tazarotene Sulfone is a derivative of Tazarotene (T010050) that has been used for treating skin disorders.<br></p>Fórmula:C21H21NO4SForma y color:NeatPeso molecular:383.464-Phenyl-2-(4-pyridyl)thiazole-5-carboxylic acid
CAS:Forma y color:SolidPeso molecular:282.32000732421875Ref: 10-F656645
1gA consultar2gA consultar5gA consultar100mgA consultar250mgA consultar500mgA consultar2,2'-Dithiobis[N-methyl-benzamide]
CAS:<p>Applications Benzamide, 2,2'-dithiobis[N-methyl- (cas# 2527-58-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C16H16N2O2S2Forma y color:Light Yellow To Light BeigePeso molecular:332.4442-O-tert-Butyldimethylsilyloxyethyl Rapamycin
CAS:<p>Stability Hygroscopic<br>Applications 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin is a useful synthetic intermediate in the synthesis of Everolimus (E945400); an immunosuppressant macrolide and analog of the parent drug Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation.<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001); Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002); Venkata, S.P., et al.: PCT Int. Appl. WO 2012066502 A1 20120524. May 24, 2012<br></p>Fórmula:C59H97NO14SiForma y color:NeatPeso molecular:1072.48Hydroxydehydro Nifedipine Carboxylate
CAS:Producto controladoFórmula:C16H14N2O7Forma y color:NeatPeso molecular:346.297-Hydroxy Quetiapine
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.<br>References Newton, D., et al.: Drug Metab. Dispos., 23, 154 (1995), Tanaka, E., et al.: J. Clin. Pharm. Ther., 24, 7 (1999)<br></p>Fórmula:C21H25N3O3SForma y color:WhitePeso molecular:399.51Ranolazine Dihydrochloride
CAS:<p>Stability Hygroscopic<br>Applications Ranolazine Dihydrochloride is an anti-ischemic agent which modulates myocardial metabolism. Antianginal.<br>References Chaitman, B.R., et al.: J. Am. Coll. Cardial., 43, 1375 (2004); McCormack, J.G., et al.: Gen. Pharmacol., 30, 639 (1998); Schofield, J.A.H., et al.: Expert Opin. Invest. Drugs, 11, 117 (2002)<br></p>Fórmula:C24H35Cl2N3O4Forma y color:NeatPeso molecular:500.46Ondansetron-d3
CAS:Producto controlado<p>Applications Ondansetron-d3 is a labeled specific serotonin (5-HT3) receptor antagonist. Antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988); Faris, P..L., et al.: Lances, 355, 792 (2000)<br></p>Fórmula:C18H16D3N3OForma y color:NeatPeso molecular:296.381-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine
CAS:Producto controlado<p>Applications 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine is an intermediate used to prepare nonracemic γ-bicyclic heteroarylpiperazine- and heteroarylpiperidine-substituted prolinylthiazolidines as selective and orally active dipeptidylpeptidase 4 inhibitors for use as antidiabetic agents.<br>References Yoshida, T., et al.: Bioorg. Med. Chem., 20, 5705 (2012)<br></p>Fórmula:C14H18N4Forma y color:NeatPeso molecular:242.32Maropitant Citrate Salt
CAS:<p>Applications Maropitant is a neurokinin type 1 (NK-1) receptor antagonist. Recent studies show that Maropitant decreased the anesthetic requirements during visceral stimulation of the ovary and ovarian ligament in dogs.<br>References Boscan, P. et al.: Am. J. Vet. Res., 72, 1576 (2011);<br></p>Fórmula:C32H40N2O·C6H8O7Forma y color:Off White SolidPeso molecular:660.85-Aminoimidazole-4-carboxamide
CAS:<p>Applications A metabolite of Temozolomide.<br>References Jaeken, J., et al.: Lancet, 2, 1058 (1984), Baggott, J., et al.: Biochem. J., 236, 193 (1986), Baggott, J., et al.: Arch. Dermatol., 135, 813 (1999),<br></p>Fórmula:C4H6N4OForma y color:White To Off-WhitePeso molecular:126.12Diethyl Rivastigmine
CAS:Producto controlado<p>Applications An impurity in Rivastigmine (R541000), a cholinesterase inhibitor.<br>References Tse, F., et al.: Pharm. Res., 15, 1614 (1998), Melchiorre, C., et al.: J. Med. Chem., 47, 5945 (2004), Srinivasu, M., et al.: J. Pharm. Biomed. Anal., 37, 57 (2005),<br></p>Fórmula:C15H24N2O2Forma y color:NeatPeso molecular:264.3633Fenfluthrin
CAS:Producto controlado<p>Applications Fenfluthrin can be used in agricultural use and as analyte in analytical/biological study of retrospective screening of relevant pesticide metabolites in food using liquid chromatography high resolution mass spectrometry and accurate-mass databases of parent molecules and diagnostic fragment ions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Polgar, L., et al.: J. Chromatogr. A., 1249, 83-91 (2012)<br></p>Fórmula:C15H11Cl2F5O2Forma y color:Off-WhitePeso molecular:389.14Benzhydrol
CAS:<p>Impurity Diphenhydramine EP Impurity D<br>Applications Intermediate in the preparation of Modafinil (M482500).<br>References Kumar, C., et al.: Eur. J. Med. Chem., 44, 1223 (2009),<br></p>Fórmula:C13H12OForma y color:WhitePeso molecular:184.23
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