Ácidos Grasos y Derivados Lipídicos

<p>Applications Lomitapide is a drug used in the treatment of obesity and aids in lowering LDL cholesterol and overall cholesterol levels in subjects.<br>References Cuchel, M. et al.: Lancet., 381, 40 (2013); Stefanutti, C. et al.: Atherosclero. Suppl., 14, 19 (2013);<br></p>

<p>Applications Sulfolithocholic Acid is an derivative of Lithocholic Acid (L469180), a cholic acid derivative and TGR5 modulator found in ox bile, human bile, rabbit bile, and in ox and pig gallstones.<br>References Kelsey, M. I., et al.: Chem. Carcinogen., 14, 205 (1981);<br></p>

<p>Applications Labeled Lauric Acid which may be used in combination with drug loading to reduce side effects, such as irritation with clarithromycin.<br>References Liu, X. et al.: Int. J. Pharma., 443, 318 (2013);<br></p>

<p>Applications The N-oxide impurity of the selective serotonin reuptake inhibitor Dapoxetine (D185700).<br></p>

<p>Applications Octanoic Acid, is found naturally in the milk of various mammals. Its esters can be used in perfumery and also in the manufacture of dyes. It is also an antimicrobial pesticide used as a food contact surface sanitizer. Caprylic acid is also used in the treatment of some bacterial infections.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lide, D. R., et al.: CRC Handbook chem. Phys., 70th Ed. (1990); Beare-Rogers, J., et al.: Pue Appl. Chem., 73 (4), 685 (2001);<br></p>

<p>Applications Misoprostol (M368750) impurity.<br>References Lee, H.K., et al.: J. Pharma. Sci., 73, 306 (1984),<br></p>

<p>Applications Tauro 6-Ethlchenodeoxycholic Acid Sodium Salt can be otained from 6-Ethylchenodeoxycholic Acid (E899810) which is a derivative of the bile acid Chenodeoxycholic Acid (C291900). 6-Ethylchenodeoxycholic Acid (E899810) is a potent activator of the farnesoid X nuclear receptor which reduces liver fat and fibrosis in animal models of fatty liver disease.<br>References Neuschwander-Tetri, B.A., et al.: Lancet., 385, 956 (2015)<br></p>

<p>Applications Simvastatin impurity.<br>References Vuletic, M., et al.: J. Pharm. Biomed. Anal., 37, 715 (2005),<br></p>

<p>Impurity Bezafibrate EP Impurity D<br>Applications Bezafibrate Ethyl Ester is a derivative of Bezafibrate (B341000); an antilipemic.<br>References Zimmerman, R., et al.: Atherosclerosis 29, 477 (1978); Monk, J.P., et al.: Drugs, 33, 539 (1987)<br></p>

<p>Applications 1,3-Bis(2,5-dimethylphenoxy)propane is a metaboolite of gemfibrozil (G305750). Gemfibrozil is a serum lipid regulating agent used as an antihyperlipoproteinemic.<br>References Kissebach, A.H., et al.: Atherosclerosis, 24, 199 (1976), Lewis, J.E., et al.: Pract. Cardiol., 9, 99 (1983), Rubins, H.B., et al.: N. Engl. J. Med., 341, 410 (1999)<br></p>

<p>Applications A metabolite of Ezetimibe. Antilipemic.<br>References Shah, V., et al.: J. Pharm. Sci., 17, 1551 (2000), Van Heek, M., et al.: Br. J. Pharmacol., 134, 409 (2001), Patrick, J., et al.: Drug Metab. Dispos., 30, 430 (2002),<br></p>

<p>Impurity Tadalafil EP Impurity A N-Desmethyl Impurity<br>Applications (6R,12aS)-N-Desmethyl Tadalafil (Tadalafil EP Impurity A N-Desmethyl Impurity) is an intermediate in the synthesis of novel potent arylated analogues of tadalafil (T004500).<br>References Beghyn, T., et al.: Bioorg. Med. Chem. Lett., 17, 789 (2007);<br></p>

<p>Impurity Rosuvastatin EP Impurity A T-Butyl Ester<br>Applications S-Desmethyl-S-(2-hydroxy-2-methylpropyl) Rosuvastatin tert-Butyl Ester (Rosuvastatin EP Impurity A T-Butyl Ester) is an intermediate in the synthesis of Rosuvastatin (R700500) related compounds.<br></p>

<p>Applications Vardenafil Intermediate.<br>References Terrett, N.K., et al.: Bioorg. Med. Chem. Lett., 6, 1819, (1996)<br></p>

<p>Stability Hygroscopic<br>Applications ω-Muricholic Acid is used in the regulation of weight gain and lipid metabolism by bacterial bile acid modification in gut for the control of obesity and hypercholesterolemia.<br>References Joyce, Susan A., et al.: Proc. Natl. Acad. Sci. USA, 111, 7421 (2014)<br></p>

<p>Applications Formic Acid is used as a potential energy source in the preparation of fuel cells. Also used in chemical synthesis of various anti-inflammatory and anti-microbial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yu, X. et al.: J. Power Source., 182, 124 (2008); Bekhit, A. et al.: Bioorg. Med. Chem., 12, 1935 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications Tadalafil Hydroxypiperidone, is an impurity of Tadalafil (T004500), a phosphodiesterase 5-inhibitor used for the treatment of erectile dysfunction.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005),<br></p>

<p>Applications Erucic acid is a long-chain alcohol that acts as an inhibitor of fatty acid oxidation in the heart. Erucic acid originates in rapeseed plants, and is the major fatty acid constituent of rapeseed plant oil extracts and canola oil.<br>References Christophersen, B. &amp; Bremer, J.: BBA-Lipid. Lipid Met., 280, 506 (1972); Ecke, W., et al.: Theor. Appl. Gen., 91, 972 (1995); Metz, J., et al.: Plant Phys., 122, 635 (2000)<br></p>

<p>Applications Atorvastatin-d5 tert-Butyl Ester is the labeled analogue of Atorvastatin tert-Butyl Ester (A791740), an impurity arising in the synthesis of Atorvastatin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)<br></p>

<p>Impurity Atorvastatin 2-Hydroxy Lactone<br>Stability Hygroscopic<br>Applications A metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br></p>

<p>Applications Isoallolithocholic Acid is used as a steroid compound as T regulatory lymphocyte modulators and uses for treatment of inflammatory or autoimmune disorders.<br>References Littman, D. R., et al.: PCT Int. Appl. 160pp. (2020)<br></p>

<p>Applications A novel C-11 epoxy fatty acid, from timothy chokes, stromata of E. typhina, has antifungal activity against Cladosporium herbarum.<br>References Koshino, H., et al.: Agric. Biol. Chem., 53, 2527 (1989),<br></p>

<p>Applications Tadalafil (T004500) derivative. Used in the preparation of pyrazinopyridoindole derivatives for their PDE5 inhibitory activity.<br>References Beghyn, T. et al.: Bioorgan. Med. Chem. Lett. 17, 789(2007)<br></p>

<p>Applications A related dimeric impurity of Sildenafil (S435000).<br></p>

<p>Applications Labelled Tolfenamic Acid. Non-steroidal anti-inflammatory drugs (NSAIDs). A derivative of anthranilic acid, related structurally to Mefenamic and Flufenamic acids. Anti-inflammatory, analgesic.<br>References Pentikaeinen, P., et al.: Eur. J. Clin. Pharmacol., 19, 359 (1981), Bundscherer, A., et al.: Oncol. Rep., 19, 547 (2008), Elwood, P., et al.: Lancet, 373, 1301 (2009),<br></p>

<p>Applications S-Desethylpiperidino S-[2-Carboxyl-2-oxo-ethyl-(2-aminoethyl)amino] Vardenafil is an impurity of Vardenafil (V098001, 2HCl); a selective phosphodiesterase type 5 (PDE5) inhibitor.<br>References Bischoff, E., et al.: J. Urol., 165, 1316 (2001); Kim, N.N., et al.: Life Sci., 69, 2249 (2001); Kendirci, M., et al.: Expert Opin. Pharmacother., 5, 923 (2004)<br></p>

<p>Applications Tauro 6-Ethlchenodeoxycholic Acid-d5 Sodium Salt is the labelled version of Tauro 6-Ethlchenodeoxycholic Acid Sodium Salt (T009025) which can be otained from 6-Ethylchenodeoxycholic Acid (E899810), a derivative of the bile acid Chenodeoxycholic Acid (C291900). 6-Ethylchenodeoxycholic Acid (E899810) is a potent activator of the farnesoid X nuclear receptor which reduces liver fat and fibrosis in animal models of fatty liver disease.<br>References Neuschwander-Tetri, B.A., et al.: Lancet., 385, 956 (2015)<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications An Atorvastatin (A791750) derivative which have improved stability.<br></p>

<p>Applications Triphenylphosphine is used in the synthesis of Chlorambucil with cytotoxicity in breast and pancreatic cancers. Also used in the preparation of α-Tocopherol analogues for monitoring antioxidant status.<br>References Millard, M. et al.: J. Med. Chem., 56, 9170 (2013); Krumova, K. et al.: J. Am. Chem. Soc., 135, 17135 (2013);<br></p>

<p>Impurity Simvastatin Impurity K<br>Applications 4α,5-Dihydro Simvastatin is an impurity in the synthesis of Simvastatin (S485000), a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.<br>References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),<br></p>

<p>Applications Palmitoleic Acid is a polyunsaturated fatty acid which contributes to reduced protein oxidation in mammals.<br>References Mendez, L. et al.: Free Rad. Biol. Med., 55, 8 (2013);<br></p>

<p>Applications 4-{[(p-Fluorophenyl)imino]methyl}phenol is used in the preparation of benzylacetones which promote anti-fungal activity.<br>References Sandhar, R. et al.: J. Ind. Council Chem., 22, 32 (2005);<br></p>

<p>Applications N-Desmethyl analog of Rosuvastatin Lactone (R700550); an intermediate in the production of Rosuvastatin (R700500) derivatives.<br></p>

<p>Applications Hydroxy Vildagliptin is an impurity of Vildagliptin (V305000). Vildagliptin is a DPP-​4 enzyme inhibitor, has anti-oxidant properties and used as an apoptotic agent on pancreatic cancer . Vildagliptin is used to treat type 2 diabetes mellitus (T2DM) and improve the endothelial function of patients.<br>References Amritha, C.A., et al.: J. Clin. Diagn. Res., 9, FC14 (2015); Cosenso-Martin, L.N., et al.: Diabetol. Metab. Syndr., 7, 70/1 (2015)<br></p>

<p>Stability Very Hygroscopic, Unstable in Solution<br>Applications A metabolite of Clofibric Acid.<br>References Ding, A., et al.: Drug. Metab. Dispos., 23, 369 (1995), Sallustio, B., et al.: Toxicol. Appl. Pharmacol., 147, 459 (1997), Akira, K., et al.: Drug Metab. Dispos., 26, 457 (1998), Sallustio, B., et al.: Curr. Drug Metab., 1, 163 (2000),<br></p>

<p>Applications An isomeric impurity of Orlistat (O686500) with modulatory activity on endocannabinoid 2-arachidonoylglycerol metabolism.<br>References Ortar, G. et al.: J. Med. Chem., 51, 6970 (2008);<br></p>

<p>Applications Labelled Lubiprostone is a bicyclic fatty acid metabolite analog of Prostaglandin E1. It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, increase gastrointestinal transit, and improve symptoms of constipation.<br>References Farthing, M., et al.: Drugs, 56, 11 (1998), Pare, P., et al.: Am. J. Gastroenterol., 96, 3130 (2001), Sloots, C., et al.: Aliment. Pharmacol. Ther., 16, 759 (2002), Coremans, G., et al.: Digestion, 67, 82 (2003),<br></p>

<p>Applications Ontazolast is a leukotriene biosynthesis inhibitor.<br>References Lazer, E., et al.: J. Med. Chem., 37, 913 (1994); Hauss, D., et al.: J. Pharm. Sci., 87, 164 (1998);<br></p>

<p>Applications (±)-α-Lipoamide may be used in treatment of insulin resistance by stimulating mitochondrial biogenesis. When used in combination with Alprostadil, it has shown to have a good therapeutic effect on early diabetic nephropathy.<br>References Shen, W., et al.: MCBU, 31, 93 (2012); Li, Z., et al.: Chongqing Yixue, 40, 2514 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications A labelled metabolite from endophytes of the medicinal plant Erythrina crista-galli.<br>References Stadler, M., et al.: Planta Med., 60, 128 (1994), Kopcke, B., et al.: Phytochemistry, 60, 709 (2002), Chu, M., et al.: J. Nat. Prod., 66, 1527 (2003), Weber, D., et al.: J. Antibiot., 57, 559 (2004),<br></p>

<p>Applications Obeticholic Acid Methyl Ester is a bile acid derivative useful in research.<br>References Pellicciari, R., et al.: Journal of Medicinal Chemistry, 50, 4265 (2007)<br></p>

<p>Applications (2Z)-2,3-Dehydroxy Atorvastatin is an intermediate in synthesizing (2E)-2,3-Dehydroxy Atorvastatin (D230045), which is an impurity in the synthesis of Atorvastatin (A791750).<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996);<br></p>

<p>Applications Tadalafil-13C2,d3 is labelled Tadalafil (T004500) which is used for the treatment of erectile dysfunction. It is a phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005)<br></p>

<p>Applications Acyl Glucuronide is a bile acid and steroid conjugate.<br>References Maekawa, M., et al.: Steroids, 80, 80 (2014); Goto, J., et al.: Steroids, 63, 180 (1998); Murao, N., et al.: Chromatography, 19, 276 (1998)<br></p>

<p>Applications 4’-Fluoroacetophenone is an intermediate used for the synthetic preparation of various pharmaceutical good and agricultural products.<br>References Xiao, Z.J., et al.: Chem. Eng. Sci., 84, 695 (2012); Vitale, P., et al.: Tetrahedron., 22, 1985 (2011); Kawano, S., et al.: Biosci. Biotech. Biochem., 75, 1055 (2011);<br></p>

<p>iso-Gemfibrozil is a natural, synthetic drug product. It is an impurity standard for the pharmacopoeia and analytical standards for HPLC. iso-Gemfibrozil is metabolized in the liver to its active form, gemfibrozil. Impurities are not detected by HPLC and can be found in low levels in the API impurity standard. It has been used as a research and development candidate in clinical studies on atherosclerosis, hyperlipidemia, and diabetes mellitus.</p>

<p>N-Formyl-D-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester is a research and development impurity standard that is used to assist in the production of high purity drug products. It is a synthetic compound that is metabolized in vivo to form N-formylglycine. This impurity standard can be used as a reference material for pharmacopoeia, drug development, and metabolic studies.</p>

<p>(betaR,deltaR)-2,3-Bis(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt is an impurity that is used in the production of a drug product. This product is metabolized to (betaR,deltaR)-2,3-bis(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-4-[(phenylamino)carbonyl]-1H-pyrrole 1 heptanoic acid which is used as an analytical standard for HPLC.</p>

<p>4'-Acetyl simvastatin is a synthetic statin that inhibits cholesterol synthesis by competitively inhibiting the enzyme HMG-CoA reductase. The reaction yield of 4'-acetyl simvastatin is high, and it has been shown to be effective at a lower dose than other statins. Impurities are not detected in this drug, and it has a low toxicity profile. Some impurities may be formed during the synthesis process due to reactions with acid catalysts, esterases, or expressed chloride. Other impurities such as hydroxyanisole and amination reaction products can be found in this drug due to its manufacturing process, which includes methyl alcohol and chemoenzymatic reactions.</p>

<p>Please enquire for more information about Rosuvastatin EP Impurity C sodium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Atorvastatin is a potent inhibitor of the enzyme HMG-CoA reductase, which is responsible for the conversion of HMG-CoA to mevalonate. This inhibition reduces the production of cholesterol and other lipids in the liver. Metabolism studies have shown that atorvastatin undergoes extensive presystemic metabolism by cytochrome P450 enzymes, primarily CYP3A4 and CYP2C9. The drug is converted to inactive metabolites that are eliminated primarily through renal excretion. Atorvastatin has not been found to inhibit any of the following: cytochrome P450 1A1/2, 2C8/9, 2D6, 2E1, 3A4/5 or glucuronidases.</p>

<p>Simvastatin 4'-methyl ether is a metabolite of simvastatin. It is an impurity in the drug product and can be used as an analytical standard for HPLC. It is not a drug product or a pharmaceutical ingredient, but it can serve as an impurity standard for pharmacopoeia.</p>

<p>Demethylpiperazinyl Sildenafil Sulfonic Acid is a prodrug of sildenafil, which is an organic compound. It is used in the treatment of erectile dysfunction and pulmonary arterial hypertension. This drug is metabolized by hydrolysis to form sildenafil citrate, which then acts as an inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5). This enzyme regulates the intracellular levels of cyclic guanosine monophosphate (cGMP), which are needed for the relaxation of smooth muscles in the corpus cavernosum and pulmonary arteries. Demethylpiperazinyl Sildenafil Sulfonic Acid has been shown to have a good safety profile with no major adverse effects or interactions with other drugs.</p>

<p>Atorvastatin N-(3,5-dihydroxy-7-heptanoic acid)amide calcium salt is a synthetic drug product that belongs to the class of statins. It has been used in research and development as a standard for HPLC analysis. The metabolite atorvastatin 3,5-dihydroxy-7-heptanoic acid (CAS No. 1105067-87-5) is also available from Sigma Aldrich. The impurity standards atorvastatin calcium salt and amorphous calcium sulfate are also available from Sigma Aldrich. Atorvastatin N-(3,5-dihydroxy-7-heptanoic acid)amide calcium salt is an API impurity in the synthesis of atorvastatin sodium (CAS No. 120781-93-1).</p>

<p>(3R,5R)-Pitavastatin Calcium Salt is a drug product that is used in the development of pharmaceuticals. It is a synthetic compound with an impurity standard and a metabolite impurity. The CAS number for this product is 254452-96-5. (3R,5R)-Pitavastatin Calcium Salt has been shown to be metabolized by CYP2C9 and CYP2C8 enzymes, which may result in a decrease in potency or activity. This product also has been shown to have anti-inflammatory properties and inhibit the production of inflammatory mediators such as prostaglandins and leukotrienes. (3R,5R)-Pitavastatin Calcium Salt was prepared by solid phase synthesis using a fluorous biphasic approach.</p>

<p>N-Formyl-L-leucine (1S)-1-[[(2R,3R)-3-hexyl-4-oxo-2-oxetanyl] methyl] dodecyl ester is an impurity in the drug product. It can be used as a custom synthesis or natural standard and has been shown to have metabolites that are toxic to human cells. This impurity can be synthesized for HPLC analysis and research purposes.</p>

<p>(3S,5R)-Atorvastatin calcium is an analytical standard for the drug atorvastatin. It has a purity of 99.9% and is manufactured in accordance with the requirements of the pharmacopoeia. The product is available as a white crystalline powder and is soluble in water, acetone, and ethanol. (3S,5R)-Atorvastatin calcium has been used in drug development and as an impurity standard for HPLC analysis. It also serves as a metabolite to characterize the production process of atorvastatin.</p>

<p>Please enquire for more information about Tadalafil spiro-urethane impurity (EP impurity F) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Oxo Simvastatin is a synthetic drug product that belongs to the class of statins. It is used as a research and development impurity standard in pharmacopoeia, and as a high-purity analytical standard in niche applications. Oxo Simvastatin is metabolized by cytochrome P450 enzymes to form a variety of metabolites, including simvastatin acid, which can be measured using HPLC.</p>

<p>(S)-3''-Hydroxy pravastatin sodium salt is a drug product that is custom synthesized. It is the sodium salt of (S)-3''-hydroxypravastatin, which has been shown to be a natural product with high purity. The metabolite of (S)-3''-hydroxypravastatin sodium salt is 3'-hydroxypravastatin. This product can be used for analytical purposes as well as in pharmacopoeia, drug development, and research and development. It can also be used as an impurity standard for HPLC and GC analysis.</p>

<p>1-Glycoloyl-L-prolinamide is a drug product that is an analytical standard for the impurity 1-glycoloyl-L-proline (CAS No. 96166-39-1) in the API 1,4,5,6-tetrahydrobenzothiazole (CAS No. 86687-93-0). It has been synthesized to be used as an impurity standard and is provided at a purity of 98.0% or greater by weight. This chemical compound can be used in research and development for the production of drugs as well as in pharmaceutical manufacturing.</p>

<p>Des(2-methylbutyryl) pravastatin is a synthetic allylic alcohol that is synthesized from the natural product, pravastatin. It has been shown to have carboxylic acid and carboxylic functional groups as well as two hydrogens on the allylic side of the molecule. In addition, des(2-methylbutyryl) pravastatin has two allylic alcohols with two hydrogens on the allylic side of the molecule. The synthesis of this compound is done by reacting 2-methylbutanoic acid with an allyl bromide in a reaction catalyzed by sodium methoxide. This reaction produces a mixture of products that includes des(2-methylbutyryl)pravastatin.</p>

<p>5-Oxo Rosuvastatin is a drug product that has been synthesized from natural ingredients. It is an analytical standard for the impurity, 5-oxo-rosuvastatin, which is a potential impurity in the API, rosuvastatin. This drug product has been custom synthesized in order to provide an Impurity Standard for HPLC. This drug product is also used as a Synthetic Reference Standard for Drug Development and Research and Development.</p>

<p>(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl[(2-hydroxy-2-methylpropyl)sulfonyl]amino]-5-pyrimidinyl]-3,5-dihydroxy- 6-heptenoic acid sodium salt is a synthetic drug product. It is an impurity standard in the synthesis of Metabolism studies. The CAS number is 1714147-50-8 and the chemical name is (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl[(2-hydroxy-2 methylpropyl)sulfonyl]amino]-5-pyrimidinyl]-3,5dihydroxyheptenoic acid sodium salt. The molecular weight is 781</p>

<p>((3R,5S,6E)-Methyl-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin -3-yl)-3,5-dihydroxyhept-6-enoate is a metabolite of the drug product. It is a white to off-white crystalline powder that is soluble in methanol and insoluble in water. This compound has been shown to be an impurity standard for HPLC analysis of the drug product. ((3R,5S,6E)-Methyl-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin -3-yl)-3,5-dihydroxyhept-6-enoate has been used in metabolism studies and pharmacopoeia as a reference substance for the analytical testing of drugs. It can also be synthesized for research purposes.</p>

<p>N-Formyl-L-leucine (3S,4S,6S)-3-hexyltetrahydro-2-oxo-6-undecyl-2H-pyran-4-yl ester is a synthetic compound that has been used as an impurity standard and as a pharmacopoeia. It is also used in drug development and metabolism studies. The CAS number of this compound is 130676-65-2. HPLC analysis of this compound is available upon request.</p>

<p>Simvastatin hydroxy acid methyl ester is a drug product that belongs to the group of statins. It is an impurity standard for synthetic simvastatin as well as a natural metabolite formed from simvastatin through oxidation and hydroxylation. This impurity is used in analytical and pharmacopoeia testing for simvastatin, and has been shown to inhibit the production of cholesterol by blocking the synthesis of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR).</p>

<p>Atorvastatin is a synthetic drug product. It is a prodrug that is converted to its active form, atorvastatin acid, in the body. Atorvastatin is used for lowering blood cholesterol levels in people with hypercholesterolemia and reducing the risk of coronary heart disease. This drug has been shown to reduce the number of deaths from coronary heart disease by 30% after five years of use. Atorvastatin also reduces the risk of stroke and fatal or non-fatal heart attack by 20%.</p>

<p>N-(3-hydroxytricyclo[3.3.1.1]dec-1-yl)glycyl-L-prolinamide is a metabolite that is formed when the drug product, ticagrelor, undergoes metabolism in the liver. Ticagrelor is a prodrug that requires conversion to its active form, which is N-(3-hydroxytricyclo[3.3.1.1]dec-1-yl)glycyl-L-prolinamide, before it can be used as a platelet inhibitor and antiplatelet agent for the prevention of thrombotic events such as heart attack and stroke. It has been shown to have an excellent stability profile and high purity when produced by HPLC or synthesized using the latest methodology under GMP conditions.</p>

<p>3-[4-(4-Chlorobenzoyl)phenoxy]-2-butanone is an impurity in the drug product, N-{3-[4-(4-chlorobenzoyl)phenoxy]-2-butenyl}acetamide. It can be used as an analytical reference standard for determining the presence of impurities in pharmaceutical products. 3-[4-(4-Chlorobenzoyl)phenoxy]-2-butanone is not a natural component of the API and is typically synthesized with high purity. This compound has been shown to be metabolized by human liver microsomes and rat lung microsomes. The metabolic pathways are unknown but may include oxidation, hydrolysis, or conjugation reactions.</p>

<p>(S)-3-Hexyl-5,6-dihydro-6-undecyl-2H-pyran-2-one is a natural metabolite that is used for the analytical standardization of HPLC. It is also used in research and development for drug development and as an impurity in pharmaceuticals. This compound has a purity of 99% and a CAS number of 130676-64-1. (S)-3-Hexyl-5,6-dihydro-6-undecyl-2H-pyran-2one is synthesized from 2,4,5,7 tetrahydrobenzofuran.</p>