JAK2-IN-7

CAS: 2593402-36-7

Ref. TM-T35900

Información del producto

• Nombre: JAK2-IN-7
• Sinónimos: JAK2IN7, JAK-2-IN-7
• CAS: 2593402-36-7

Descripción

JAK2-IN-7, a selective inhibitor targeting Janus Kinase 2 (JAK2), exhibits inhibitory concentrations (IC50) of 3 nM for JAK2, 11.7 nM for SET-2 cells, and 41 nM for Ba/F3 V617F cells, indicative of its potency and selectivity. This compound demonstrates more than 14-fold selectivity against JAK1, JAK3, and FLT3, underlining its specificity. JAK2-IN-7 effectively induces cell cycle arrest at the G0/G1 phase and promotes apoptosis in tumor cells, manifesting significant antitumor activities [1].

• Marca: Targetmol

Propiedades químicas

• Peso molecular: 459.59
• Fórmula: C₂₆H₃₃N₇O
• Pureza: 98%
• Color/Forma: Solid