Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(145 produits)
- Bcr-Abl(102 produits)
- EGFR(572 produits)
- FAK(72 produits)
- FLT(92 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(170 produits)
- JAK(245 produits)
- PDGFR(126 produits)
- RAAS(86 produits)
- Src(78 produits)
- Syk(38 produits)
- Thrombine(47 produits)
- VDA(2 produits)
- VEGFR(268 produits)
Affichez 6 plus de sous-catégories
1414 produits trouvés pour "Angiogenèse"
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BLK-IN-1
CAS :<p>BLK-IN-1 selectively blocks BLK and BTK with IC50s of 18.8 and 20.5 nM, used in cancer research.</p>Formule :C29H23F3N6O3Couleur et forme :SolidMasse moléculaire :560.53EGFR-IN-31
CAS :<p>EGFR-IN-31: Potent EGFR inhibitor, targets mutations & overexpression in NSCLC; potential cancer research compound. (WO2021185298A1, 2)</p>Formule :C32H36FN7O2Couleur et forme :SolidMasse moléculaire :569.67FLT3/D835Y-IN-1
CAS :<p>FLT3/D835Y-IN-1, an oral FLT3 inhibitor (IC50: FLT3 - 0.26 nM, D835Y - 0.18 nM), shows anticancer potential in AML research.</p>Formule :C22H21N5O3Couleur et forme :SolidMasse moléculaire :403.43EGFR-IN-60
CAS :<p>EGFR-IN-60: oral anticancer drug, inhibits EGFR/JAK3, effective on H1975/A431 cells, promotes apoptosis.</p>Formule :C28H28Cl2N6OCouleur et forme :SolidMasse moléculaire :535.47ZT55
CAS :<p>ZT55: Oral JAK2 inhibitor, IC50: 0.031 μM, hinders JAK2 V617F HEL cell growth, induces apoptosis, arrests cell cycle, effective in mice HEL tumor studies.</p>Formule :C17H16N2O3Couleur et forme :SolidMasse moléculaire :296.32VEGFR-2-IN-24
CAS :<p>VEGFR-2-IN-24 is a potent inhibitor of VEGFR-2 (IC50: 0.22 μM) and can be used to study tumors.</p>Formule :C28H23N3O6SCouleur et forme :SolidMasse moléculaire :529.56FGFR4-IN-11
CAS :<p>FGFR4-IN-11: selective, covalent FGFR4 inhibitor; IC50=2.1 nM; blocks FGF19 pathway; anticancer.</p>Formule :C29H29N5O5Couleur et forme :SolidMasse moléculaire :527.57c-Met-IN-14
CAS :<p>c-Met-IN-14: selective c-Met kinase inhibitor, IC50 2.89 nM, anticancer, stops G2/M phase, induces A549 cell apoptosis.</p>Formule :C34H38ClFN4O7SCouleur et forme :SolidMasse moléculaire :701.2EGFR-IN-26
CAS :<p>EGFR-IN-26 is an EGFR inhibitor that can be used in cancer research.</p>Formule :C29H34N6O3Couleur et forme :SolidMasse moléculaire :514.62TRK/ALK-IN-1
<p>TRK/ALK-IN-1: Potent dual TRK & ALK inhibitor; IC50s: 2.2nM (TRKA), 9.3nM (ALK WT), 38nM (ALK L1196M); cancer research potential.</p>Formule :C31H35ClF2N8O2SCouleur et forme :SolidMasse moléculaire :657.18FGFR3-IN-1
CAS :<p>FGFR3-IN-1 (compound 1) is a fibroblast growth factor receptor (FGFR) inhibitor that inhibits FGFR1 (IC50: 40 nM), FGFR2 (IC50: 5.1 nM) and FGFR3 (IC50: 12 nM).</p>Formule :C28H39N9O3SCouleur et forme :SolidMasse moléculaire :581.73EGFR-IN-49
CAS :<p>EGFR-IN-49 selectively inhibits EGFR mutations T790M (IC50: 65 nM) & T790M/L858R (IC50: 13.6 nM), triggering apoptosis dose-dependently.</p>Formule :C22H15N5O2SCouleur et forme :SolidMasse moléculaire :413.45TIE-2/VEGFR-2 kinase-IN-1
CAS :<p>TIE-2/VEGFR-2 kinase-IN-1 synthesizes inhibitors for angiogenesis-related disease research.</p>Formule :C13H11N3O2Couleur et forme :SolidMasse moléculaire :241.25Erbstatin
CAS :<p>Erbstatin is a tyrosine-protein kinase inhibitor. When combined with foroxymithine, it has antineoplastic activity against L-1210 leukemia.</p>Formule :C9H9NO3Couleur et forme :SolidMasse moléculaire :179.17PD-173956
CAS :<p>PD-173956 is an inhibitor of the Src family tyrosine kinases.</p>Formule :C20H13Cl2FN4OCouleur et forme :SolidMasse moléculaire :415.25EGFR-IN-55
CAS :<p>"EGFR-IN-55 targets EGFRWT (70 nM IC50) & EGFRL858R/T790M (3.9 nM IC50), halts NCI-H1975 cell cycle in G0/G1, showing anticancer properties."</p>Formule :C25H25Cl2N7O2Couleur et forme :SolidMasse moléculaire :526.42CP-690550A
CAS :<p>Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.</p>Formule :C15H21N5O2Couleur et forme :SolidMasse moléculaire :303.36Nazartinib mesylate
CAS :<p>Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).</p>Formule :C27H35ClN6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.12MDK5466
CAS :<p>MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death.</p>Formule :C21H23N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.49HIV-IN-6
CAS :<p>HIV-IN-6, an anti-HIV agent, blocks replication by targeting SFKs like Hck involved with Nef protein.</p>Formule :C20H16N4O3SDegré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :392.43Lavendustin C6
CAS :<p>Lavendustin C6 is a effective tyrosine kinase inhibitor.</p>Formule :C20H25NO5Couleur et forme :SolidMasse moléculaire :359.42TRK II-IN-1
CAS :<p>TRK II-IN-1: potent type II TRK inhibitor; IC50s: TRKA (3.3 nM), TRKB (6.4 nM), TRKC (4.3 nM), TRKA G667C (9.4 nM); also targets FLT3, RET, VEGFR2.</p>Formule :C29H31F3N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.6EGFR-IN-88
CAS :<p>EGFR-IN-88 (Compound 4i), an EGFR inhibitor with an IC50 of 87 nM, exhibits cytotoxic effects on A549 cells at an IC50 of 3.902 μM and can induce cell apoptosis</p>Formule :C22H18Cl2N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.37BAY 2476568
CAS :<p>BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).</p>Formule :C24H27FN4O4Couleur et forme :SolidMasse moléculaire :454.49FGFR4-IN-5
CAS :<p>FGFR4-IN-5: potent, selective FGFR4 inhibitor, IC50 6.5 nM, strong in vivo anti-tumor effect, for liver cancer research.</p>Formule :C23H23Cl2N5O5Couleur et forme :SolidMasse moléculaire :520.37DPPY
CAS :<p>DPPY inhibits EGFR, BTK, JAK3 (IC50<10 nM), curbs B-cell lymphoma growth, and may be studied for IPF treatment.</p>Formule :C25H26ClN7O3Couleur et forme :SolidMasse moléculaire :507.97PDGFRα/FLT3-ITD-IN-1
CAS :<p>PDGFRα/FLT3-ITD-IN-1 are potent inhibitors of PDGFRα/FLT3, and their IC50 values are greater than 0.036 and 0.003 μM, respectively.</p>Formule :C27H39N9OCouleur et forme :SolidMasse moléculaire :505.66KRC-108
CAS :<p>KRC-108 is a potent kinase inhibitor targeting Ron, Flt3, TrkA, and c-Met with strong anti-proliferative effects on various cancer cells.</p>Formule :C20H20N6OCouleur et forme :SolidMasse moléculaire :360.41YF-452
CAS :<p>YF-452 inhibits tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling.</p>Formule :C24H26BrN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.39Multi-kinase-IN-3
CAS :<p>Multi-kinase-IN-3 (compound 2) is a potent inhibitor of angiokinase and inhibits VEGFR-2 (IC50: 58.3 nM) and PDGFRβ (IC50: 55 nM).</p>Formule :C33H33N5O3Couleur et forme :SolidMasse moléculaire :547.65VEGFR-2-IN-30
<p>VEGFR-2-IN-30: VEGFR-2 inhibitor, IC50 66 nM; blocks PDGFR, EGFR & FGFR1; halts cancer cell cycle, induces apoptosis.</p>Formule :C28H23ClN6O4S2Couleur et forme :SolidMasse moléculaire :607.1VEGFR-2-IN-21
CAS :<p>VEGFR-2-IN-21 is a potent inhibitor of VEGFR-2 (IC50: 0.10 μM) and exhibits anticancer effects.</p>Formule :C28H24ClN7O3SCouleur et forme :SolidMasse moléculaire :574.05VEGFR-2-IN-22
CAS :<p>VEGFR-2-IN-22 blocks VEGFR-2/beta-tubulin, IC50=19.82 nM, induces apoptosis.</p>Formule :C26H24ClFN4O6Couleur et forme :SolidMasse moléculaire :542.94SYK/JAK-IN-1
CAS :<p>SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.</p>Formule :C24H26N8O3Couleur et forme :SolidMasse moléculaire :474.52FGFR-IN-7
CAS :<p>FGFR-IN-7: Oral FGFR modulator, crosses blood-brain barrier, neuroprotective, phospholipidosis-resistant, useful for neurodegeneration study.</p>Formule :C16H21ClF2N4O2Couleur et forme :SolidMasse moléculaire :374.81EMI56
CAS :<p>EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].</p>Formule :C21H20N2O3Couleur et forme :SolidMasse moléculaire :348.4EGFR-IN-39
CAS :<p>EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.</p>Formule :C24H25ClN6O3Couleur et forme :SolidMasse moléculaire :480.95EMI48
CAS :<p>EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].</p>Formule :C21H20N2O3Couleur et forme :SolidMasse moléculaire :348.4Lck Inhibitor III
CAS :<p>Lck Inhibitor III, a potent inhibitor of Lck, exhibits an IC50 value of 867 nM.</p>Formule :C25H30N6O4Couleur et forme :SolidMasse moléculaire :478.54K 00546
CAS :<p>K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).</p>Formule :C15H13F2N7O2S2Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :425.44EGFR/BRAFV600E-IN-1
CAS :<p>EGFR/BRAFV600E-IN-1 inhibits EGFR (0.08 μM) & BRAFV600E (0.15 μM), affects A-549, MCF-7, Panc-1 & HT-29 (IC50: 0.79-1.3 μM).</p>Formule :C24H24ClN3O3Couleur et forme :SolidMasse moléculaire :437.92PF-00956980
CAS :<p>PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.</p>Formule :C18H26N6OCouleur et forme :SolidMasse moléculaire :342.44Debio 0617B
CAS :<p>Debio 0617B inhibits kinases for AML stem cell treatment, targeting JAK, ABL, SRC, and STAT3-related tumours.</p>Formule :C28H23ClF3N7O2Couleur et forme :SolidMasse moléculaire :581.98FAK/aurora kinase-IN-1
CAS :<p>FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].</p>Formule :C23H24ClN7O3Couleur et forme :SolidMasse moléculaire :481.93GW694590A
CAS :<p>GW694590A (UNC10112731) functions as a MYC protein stabilizer that enhances the levels of endogenous MYC protein. It also acts on receptor tyrosine kinases, inhibiting DDR2, KIT, and PDGFRα by 81%, 68%, and 67% at a concentration of 1 μM, respectively. As a protein kinase inhibitor, GW694590A affects both ATP-dependent and ATP-independent luciferases, potentially influencing the Fluc reporter gene [1].</p>Formule :C22H19N5O4Couleur et forme :SolidMasse moléculaire :417.42EGFR mutant-IN-2
CAS :<p>EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].</p>Formule :C27H27F3N6O2SCouleur et forme :SolidMasse moléculaire :556.6Rac-ZINC4085554
CAS :<p>Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620</p>Formule :C20H19N3O7Degré de pureté :90%Couleur et forme :SolidMasse moléculaire :413.38VI 16832
CAS :<p>VI 16832 is a broad-spectrum Type I kinase inhibitor used to quantify relative kinase abundance and study signaling across SILAC-encoded cancer cell lines.</p>Formule :C22H25N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :391.47EGFR-IN-2
CAS :<p>EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.</p>Formule :C26H33N9O3SDegré de pureté :98.52% - 99.79%Couleur et forme :SolidMasse moléculaire :551.66Nimotuzumab
CAS :<p>Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).</p>Degré de pureté :95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)Couleur et forme :LiquidENMD-1198
CAS :<p>ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.</p>Formule :C20H25NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.42WDR5-IN-4
CAS :<p>WIN site inhibitor 1 is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM), with anti-cancer activity.</p>Formule :C25H22Cl2FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.38Glufanide disodium
CAS :<p>Glufanide disodium is an immunomodulator.</p>Formule :C16H17N3O5Na2Couleur et forme :SolidMasse moléculaire :377.3SB-220025 trihydrochloride
CAS :<p>SB-220025 trihydrochloride is an effective and specific human p38 mitogen-activated protein kinase inhibitor.</p>Formule :C18H22Cl3FN6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :447.77WB-308
CAS :<p>WB-308 is an EGFR inhibitor that acts by decreasing NSCLC cell proliferation and colony formation and causing G2/M arrest and apoptosis.</p>Formule :C19H17FN2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :308.35Tyrphostin AG 568
CAS :<p>Tyrphostin AG 568 promotes Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity. It also induces K562 to differentiate.</p>Formule :C13H9N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.24KRCA-0713
CAS :<p>KRCA-0713 is a ALK inhibitor.</p>Formule :C26H32ClN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :530.08BGB659
CAS :<p>BGB659 is effective inhibitor of RAF.</p>Formule :C29H29F3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.564-DAMP
CAS :<p>4-DAMP (4-DAMP methiodide) is a selective muscarinic M1 and M3 subtype receptor antagonist used in the study of allergic rhinitis and cardiovascular disease.</p>Formule :C21H26INO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :451.34PF-06465469
CAS :<p>PF-06465469 is a covalent ITK inhibitor(IC50: 2 nM).</p>Formule :C30H33N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.63EGA
CAS :<p>EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.</p>Formule :C16H16BrN3ODegré de pureté :98% - 99.6%Couleur et forme :SolidMasse moléculaire :346.22JG26
CAS :<p>JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively,</p>Formule :C19H22Br2N4O6SDegré de pureté :98.79% - 99.08%Couleur et forme :SolidMasse moléculaire :594.27DS21360717
CAS :<p>DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.</p>Formule :C21H23N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.45E-4177
CAS :<p>E-4177 is an angiotensin II type 1 receptor (AT1R) antagonist and can be used to study cardiovascular diseases.</p>Formule :C24H21N3O2Degré de pureté :98.67% - 99.57%Couleur et forme :SolidMasse moléculaire :383.44MG-262
CAS :<p>MG-262 is a reversible proteasome inhibitor with multiple biological activities [1] [2] [3].</p>Formule :C25H42BN3O6Couleur et forme :SolidMasse moléculaire :491.43BI1002494
CAS :<p>BI1002494 is an effective and selective Syk inhibitor.</p>Formule :C23H25N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.46Burixafor hydrobromide
CAS :<p>Burixafor hydrobromide is an oral CXCR4 blocker with anti-angiogenic properties, potentially treating choroid neovascularization.</p>Formule :C27H52BrN8O3PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.644Lorpucitinib
CAS :<p>Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal diseases.</p>Formule :C22H28N6O2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :408.5ZK-261991
CAS :<p>ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).</p>Formule :C24H25N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.5CAY10583
CAS :<p>CAY10583 is a selective BLT2 agonist that increases TGF-β1 and bFGF, promotes keratinocyte migration, accelerates wound healing in diabetic mice.</p>Formule :C25H25NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.47JAK3-IN-1
CAS :<p>JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.</p>Formule :C26H30ClN7O2Couleur et forme :SolidMasse moléculaire :508.02Rogaratinib
CAS :<p>Rogaratinib (BAY1163877) is an aberrant inhibitor of fibroblast growth factor receptor (FGFR).</p>Formule :C23H26N6O3SDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :466.56FGFR2-IN-2
CAS :<p>FGFR2-IN-2 is a specific FGFR2 inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used in the study of cancer and cardiovascular disease.</p>Formule :C23H22N4ODegré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :370.45Tarlox-TKI
CAS :<p>Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.</p>Formule :C19H18BrClN6ODegré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :461.74VEGFR-2-IN-6
CAS :<p>VEGFR-2-IN-6 (WO 02/059110, example 64) is a potent inhibitor of VEGFR2, a crucial receptor involved in the regulation of angiogenesis [1].</p>Formule :C20H21N7O2SDegré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :423.49Tafetinib
CAS :<p>Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.</p>Formule :C24H29FN4O2Degré de pureté :96.23%Couleur et forme :SolidMasse moléculaire :424.51CHMFL-EGFR-202
CAS :<p>CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases).</p>Formule :C25H24ClN7O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :489.96BMS-605541
CAS :<p>BMS-605541 is a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) kinase activity(Ki=49 nM).</p>Formule :C19H17F2N5OSDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :401.43WDR5-0102
CAS :<p>WDR5-0102 inhibits WDR5-MLL1 (Kd=4 μM), blocks MLL1 HMT activity, but doesn't affect SETD7 and 6 other HMTs.</p>Formule :C18H19ClN4O3Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :374.82Cloperastine fendizoate
CAS :<p>Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).</p>Formule :C40H38ClNO5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :648.19A-935142
CAS :<p>A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.</p>Formule :C18H19F3N2O2Degré de pureté :98.97% - 99.91%Couleur et forme :SolidMasse moléculaire :352.35PKI-166
CAS :<p>PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth & spread of many human cancers, including pancreatic.</p>Formule :C20H18N4ODegré de pureté :99.2%Couleur et forme :SolidMasse moléculaire :330.38HIF-2α-IN-3
CAS :<p>HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.</p>Formule :C12H6ClN5O5Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :335.66STS-E412
CAS :<p>STS-E412 is a tissue-protective and selective EPOR/CD131 receptor activator for the study of neurological disorders.</p>Formule :C15H15ClN4O2Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :318.76A 419259 trihydrochloride
CAS :<p>A 419259 trihydrochloride (RK 20449 trihydrochloride) is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn).</p>Formule :C29H37Cl3N6ODegré de pureté :99.75% - 99.96%Couleur et forme :SolidMasse moléculaire :592SI-2 hydrochloride
CAS :<p>SI-2 hydrochloride, an SRC-3 inhibitor, induces breast cancer cell death (IC50: 3-20 nM) with good oral bioavailability.</p>Formule :C15H16ClN5Degré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :301.77H-9 dihydrochloride
CAS :<p>H-9 dihydrochloride: Strong PKA inhibitor, curbs 5-HT response and EGF signaling, affects pharyngeal function.</p>Formule :C11H15Cl2N3O2SDegré de pureté :97.3%Couleur et forme :SolidMasse moléculaire :324.23CTA 056
CAS :<p>CTA 056 is an ITK inhibitor that inhibits the growth of MOLT-4 xenograft tumors in mice and can be used to study autoimmune disorders.</p>Formule :C35H34N6ODegré de pureté :97.22% - 97.76%Couleur et forme :SolidMasse moléculaire :554.68MBM-55
CAS :<p>MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM.</p>Formule :C28H27FN6O2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :498.55Tyrphostin A25
CAS :<p>Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.</p>Formule :C10H6N2O3Degré de pureté :98.76%Couleur et forme :Yellow Green Powder /Off-White SolidMasse moléculaire :202.17JNJ-49095397
CAS :<p>JNJ-49095397 (RV568) is a p38 MAPK-α and p38 MAPK-γ kinase inhibitor for the study of respiratory syncytial virus infection.</p>Formule :C34H36N6O4Degré de pureté :98.33% - 99.04%Couleur et forme :SolidMasse moléculaire :592.69TC-S 7009
CAS :<p>TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization & gene expression.</p>Formule :C12H6ClFN4O3Degré de pureté :99.46% - 99.71%Couleur et forme :SolidMasse moléculaire :308.65EGFR-IN-11
CAS :<p>EGFR-IN-11 selectively blocks EGFR-tyrosine kinase and promotes apoptosis; targets EGFRL858R/T790M/C797S, IC50=18 nM; halts cell cycle at G0/G1.</p>Formule :C29H35N9O2SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :573.71NX-2127
CAS :<p>NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferative</p>Formule :C39H45N9O5Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :719.83P505-15 Acetate
CAS :<p>P505-15 Acetate inhibits spleen tyrosine kinase, reduces immune response and inflammation, and lowers arthritis severity.</p>Formule :C21H27N9O3Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :453.5Butyzamide
CAS :<p>Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.</p>Formule :C29H32Cl2N2O5SDegré de pureté :99.51% - 99.83%Couleur et forme :SoildMasse moléculaire :591.55TP0427736 hydrochloride
CAS :<p>TP0427736 hydrochloride is a novel and selective ALK5 inhibitor, capable of inhibiting Smad2/3 phosphorylation in A549 cells.</p>Formule :C14H11ClN4S2Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :334.85c-Fms-IN-3
CAS :<p>c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.</p>Formule :C23H30N6ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :406.52Dasatinib hydrochloride
CAS :<p>Dasatinib hydrochloride is an oral Src/Bcr-Abl inhibitor with potent antitumor effects, Ki values of 16 pM (Src) and 30 pM (Bcr-Abl).</p>Formule :C22H27Cl2N7O2SDegré de pureté :99.88% - 99.98%Couleur et forme :SolidMasse moléculaire :524.47PI3K/VEGFR2-IN-1
CAS :<p>PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting both PI3K and VEGFR2 with IC50 values of 2.21 μM for PI3K and 68 μM for VEGFR2, respectively.</p>Formule :C17H14ClN3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :343.83
