FLT
Les inhibiteurs de la tyrosine kinase FLT (Fms-like) sont des composés qui ciblent les récepteurs FLT, impliqués dans la régulation de l'angiogenèse via la voie du VEGF (facteur de croissance endothélial vasculaire). Les récepteurs FLT jouent un rôle crucial dans le développement de nouveaux vaisseaux sanguins dans les tumeurs. L'inhibition des récepteurs FLT peut réduire efficacement l'angiogenèse et la croissance tumorale, ce qui rend ces inhibiteurs importants en thérapie anticancéreuse. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de FLT de haute qualité pour soutenir vos recherches en oncologie, biologie vasculaire et angiogenèse.
87 produits trouvés pour "FLT".
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FLT3-IN-3
CAS :FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively.Formule :C27H38N8ODegré de pureté :99.25%Couleur et forme :White SolidMasse moléculaire :490.6436MRX-2843
CAS :MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively).Formule :C29H40N6ODegré de pureté :98.59% - 99.63%Couleur et forme :Yellow SolidMasse moléculaire :488.6675PROTAC FLT-3 degrader 3
PROTACFLT-3degrader 3 (compound 35) is a PROTAC degrader of FLT. It exhibits antiproliferative activity, with an IC50 value of 7.55 nM in MV4-11 cells.Formule :C48H44Cl2N10O6Couleur et forme :SolidMasse moléculaire :926.28223PROTAC FLT3/GSPT1/IKZF1/3 degrader-1
PROTACFLT3/GSPT1/IKZF1/3 degrader-1 is an FLT3 PROTAC degrader with DC50 = 1.2 nM. It functions as a molecular glue to degrade its brain substrates and exhibits antiproliferative activity against resistant acute myeloid leukemia (AML) cells, showing potential applications in AML research.Couleur et forme :Odour SolidFLT3-IN-23
FLT3-IN-23 (compound 15), a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3), exhibits an IC 50 value of 7.42 nM and demonstrates antiproliferative effectsCouleur et forme :Odour Solid2-Butenamide
CAS :2-Butenamide, FLT3 inhibitor. Affordable Excellence: Reliable Quality You Can TrustFormule :C4H7NOCouleur et forme :SolidMasse moléculaire :85.1045FLT3/HDAC-IN-2
Compound 25h, also known as FLT3/HDAC-IN-2, is a dual inhibitor of FLT3/HDAC. It exhibits antiproliferative activity against MOLM-13 cells and is used in the study of acute myeloid leukemia.Couleur et forme :Odour SolidFLT3-IN-22
FLT3-IN-22 (compound 22f) is a potent inhibitor of FLT3, demonstrating IC50 values of 0.941 nM for FLT3 and 0.199 nM for the FLT3/D835Y mutant.Formule :C24H22N6O2Couleur et forme :SolidMasse moléculaire :426.47Pacritinib citrate
CAS :Pacritinib (SB1518) citrate effectively inhibits wild-type JAK2 (IC50 =23 nM) and the JAK2 V617F mutant (IC50 =19 nM). It also targets FLT3 (IC50 =22 nM) and the FLT3 D835Y mutant (IC50 =6 nM). This compound is utilized in the study of acute myeloid leukemia (AML) and myelofibrosis (MF) [1] [2] [3].Formule :C34H40N4O10Couleur et forme :SolidMasse moléculaire :664.7PF15 TFA
PF15 TFA, a PROTAC targeting FLT3 kinase and CRBN, exhibits selective degradation of FLT3-ITD with a DC50 of 76.7 nM.Formule :C46H50F3N13O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :969.97FLT3-ITD-IN-2
FLT3-ITD-IN-2 (Compound A1) is an inhibitor of the FLT3-ITD kinase, exhibiting an IC50 of 2.12 nM. It effectively suppresses the proliferation of the FLT3-dependent human AML cell line MOLM-13, with an IC50 of 25.65 nM. FLT3-ITD-IN-2 demonstrates antitumor activity against acute myeloid leukemia.Formule :C39H50N8O6Couleur et forme :SolidMasse moléculaire :726.86E6201
CAS :E6201, a dual kinase inhibitor, blocks MEK1/FLT3 and has anti-tumor/psoriasis effects with low IC50s: ERK2 (5.2 nM), JNK (91 nM), p38 MAPK (19 nM).Formule :C21H27NO6Couleur et forme :SolidMasse moléculaire :389.44Flt-3L-Ig (hum/hum)
Flt-3L-Ig (hum/hum) (hFlt3L) is a Flt3 activator. It enhances the release of inflammatory cytokines from myeloid and dendritic cells in BRGSF-CBC mice induced by OKT3, as well as affects the quantity and distribution of human immune cells, exhibiting cytokine release syndrome (CRS).HSK205
HSK205 is a dual FLT3 and haspin inhibitor, exhibiting potent antitumor activity [1], with an IC50 of 0.187 nM for FLT3.Couleur et forme :Odour Solid3-Hydroxy Midostaurin
CAS :3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of roughly 132 nM inFormule :C35H30N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.6365FLT3 Ligand-Linker Conjugate 1
CAS :FLT3 Ligand-Linker Conjugate 1 consists of an FLT3 ligand and a PROTAC linker that can recruit E3 ligase VHL. This conjugate is useful for synthesizing PROTAC RSS0680, a bifunctional compound designed for targeted protein degradation of kinases.Formule :C29H34N6O4S2Couleur et forme :SolidMasse moléculaire :594.748PF15
CAS :PF15, a PROTAC for FLT3-ITD, degrades FLT3 kinase. DC50: 76.7 nM; hinders FLT3-ITD+ cell growth; potential in leukemia.Formule :C44H49N13O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :855.94JAK3-IN-14
CAS :JAK3-IN-14 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively.Formule :C18H13N3ODegré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :287.3153FLT3-IN-20
FLT3-IN-20 (compound 34f) is a potent FLT3 inhibitor, demonstrating IC50 values of 1 nM for FLT3-D835Y and 4 nM for FLT3-ITD.Formule :C28H33N7O2SCouleur et forme :SolidMasse moléculaire :531.67FLT3-IN-24
FLT3-IN-24 (compound 24) is a potent and selective inhibitor of FLT3 kinase, with an IC50 of 7.94 nM. It also exhibits anti-proliferative effects on cells.Formule :C23H20N6O2SCouleur et forme :SolidMasse moléculaire :444.13685
