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Angiogenèse

Angiogenèse

Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.

Sous-catégories appartenant à la catégorie "Angiogenèse"

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2266 produits trouvés pour "Angiogenèse"

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  • VEGFR2-IN-1

    CAS :
    VEGFR2-IN-1 is a VEGFR2 inhibitor with antitumor activity used in the study of breast cancer.
    Formule :C22H18N6S
    Degré de pureté :98.15%
    Couleur et forme :Solid
    Masse moléculaire :398.48

    Ref: TM-T61899

    1mg
    164,00€
    5mg
    389,00€
    10mg
    532,00€
    25mg
    820,00€
  • FGFR1 inhibitor-15

    CAS :
    FGFR1inhibitor-15 (Compound 23) is an FGFR1 inhibitor with an IC50 value of 27 μM, useful for tumor research.
    Formule :C17H13FN4O
    Couleur et forme :Solid
    Masse moléculaire :308.31

    Ref: TM-T205729

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  • JAK/HDAC-IN-3

    CAS :
    JAK/HDAC-IN-3 (13a), a dual inhibitor of JAK and HDAC, exhibits IC50 values of 25.36 nM for JAK2, 0.2 μM for HDAC, and 0.43 μM for HDAC1, respectively [1].
    Formule :C28H37FN6O5S
    Couleur et forme :Solid
    Masse moléculaire :588.69

    Ref: TM-T86754

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  • mG2N001

    CAS :
    mG2N001, a negative allosteric modulator (NAM) of the metabotropic glutamate receptor mGluR2, has an IC50 of 93 nM and binds to mGluR2 as an antagonist with a Ki of 63 nM. This compound is microparticle- and plasma-stable, and its radioisotope [11C] mG2N001 can be utilized in PET imaging. [11C] mG2N001 exhibits good brain heterogeneity and penetration, selectively accumulating in mGluR2-rich regions to produce high-contrast brain images [1].
    Formule :C18H19FN2O3
    Couleur et forme :Solid
    Masse moléculaire :330.35

    Ref: TM-T86893

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  • Tyk2-IN-15

    CAS :

    Tyk2-IN-15 (Compound 97) is a selective inhibitor of tyrosine kinase 2 (Tyk2) with an IC50 value ≤ 10 nM for Tyk2-JH2. It is utilized in the research of inflammatory and autoimmune diseases [1].

    Formule :C21H25F2N7O
    Couleur et forme :Solid
    Masse moléculaire :429.47

    Ref: TM-T87584

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  • (3S,4R)-Tofacitinib

    CAS :
    (3S,4R)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM).
    Formule :C16H20N6O
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :312.37

    Ref: TM-T13427

    25mg
    1.639,00€
    50mg
    2.142,00€
    100mg
    2.790,00€
  • Ten01


    Ten01 exhibits a 5.0 nM inhibition of JAK1 kinase.
    Formule :C18H20F6N4O
    Couleur et forme :Solid
    Masse moléculaire :422.37

    Ref: TM-T62257

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • Multi-kinase inhibitor 4

    CAS :
    Multi-kinase inhibitor 4 (compound 14) serves as an orally effective inhibitor targeting FLT1, KDR, FLT3, FLT4, PDGFRα, and PDGFRβ, exhibiting IC50 values of 1.97 nM, 1.04 nM, 0.33 nM, 1.44 nM, 0.18 nM, and 0.89 nM respectively. This compound plays a crucial role in cancer research.
    Formule :C25H24N6O2
    Couleur et forme :Solid
    Masse moléculaire :440.50

    Ref: TM-T201144

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  • BTK-IN-38

    CAS :
    BTK-IN-38 (Example 125) is an efficacious inhibitor of BTK. It effectively suppresses the proliferation of DOHH2 and BT474 cells, with IC50 values of 114 nM and 340 nM, respectively.
    Formule :C27H26F2N4O2
    Couleur et forme :Solid
    Masse moléculaire :476.52

    Ref: TM-T201231

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  • TQ-3959

    CAS :
    TQ-3959 is an orally active BTKPROTAC degrader, with a DC50 of 14.6 nM. It exhibits antiproliferative activity against both wild-type BTK and BTK C481S mutant cell lines. TQ-3959 demonstrates tumor growth inhibition in female NOD-SCID mice with TMD-8 xenografts. This compound is applicable in the study of B-cell malignancies, such as lymphoma.
    Formule :C40H47N11O5
    Couleur et forme :Solid
    Masse moléculaire :761.87

    Ref: TM-T212293

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  • EGFR-IN-134


    EGFR-IN-134 (compound 3f) is a triazolo[3,4-a]quinoline derivative and functions as a potent EGFR inhibitor with an IC50 of 0.023 µM. It induces apoptosis and necrosis in cells, and causes cell cycle arrest in the G2/M and pre-G1 phases. EGFR-IN-134 modulates the expression of apoptosis-regulating proteins by downregulating anti-apoptotic protein Bcl2 and upregulating pro-apoptotic proteins p53, Bax, and caspases 3, 8, and 9, demonstrating significant antiproliferative and anticancer activities.
    Formule :C36H30N6O5
    Couleur et forme :Solid
    Masse moléculaire :626.66

    Ref: TM-T201573

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  • NS-062

    CAS :
    NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.
    Formule :C28H30Cl2F2N6O4
    Couleur et forme :Solid
    Masse moléculaire :623.48

    Ref: TM-T201773

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  • Tyk2-IN-14

    CAS :
    Tyk2-IN-14, a small molecule inhibitor of TYK2, is significant in treating inflammatory diseases and conditions linked to hypersecretion of IFNa and interferons [1].
    Formule :C22H21N9O2
    Couleur et forme :Solid
    Masse moléculaire :443.46

    Ref: TM-T87583

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  • EGFR-IN-160

    CAS :
    EGFR-IN-160 is an EGFR inhibitor with IC50 values of 1.62, 0.49, and 0.98 μM for EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S, respectively. It can induce cell cycle arrest at the G2/M and S phases and apoptosis (Apoptosis) in NCI-H522 cells, demonstrating anticancer properties. Additionally, EGFR-IN-160 exhibits antioxidant activity against DPPH (IC50: 12.11 µM) and H2O2 (IC50: 8.89 µM).
    Formule :C15H12N2O4
    Couleur et forme :Solid
    Masse moléculaire :284.27

    Ref: TM-T207600

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  • JAK1/TYK2-IN-4

    CAS :
    JAK1/TYK2-IN-4 serves as a dual inhibitor targeting both JAK and TYK2, displaying IC50 values of 39 nM and 21 nM, respectively. It is also orally bioavailable [1].
    Formule :C17H23N7O
    Couleur et forme :Solid
    Masse moléculaire :341.41

    Ref: TM-T86755

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  • Tyk2-IN-17

    CAS :
    Tyk2-IN-17 (compound 185) effectively inhibits TYK2 [1].
    Formule :C20H20F2N8O
    Couleur et forme :Solid
    Masse moléculaire :426.42

    Ref: TM-T87586

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  • DHFR-IN-4

    CAS :
    DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumour activity, inhibits EGFR and HER2 and can be used to study pancreatic cancer.
    Formule :C18H21N5O2S
    Degré de pureté :99.41%
    Couleur et forme :Solid
    Masse moléculaire :371.46

    Ref: TM-T61486

    1mg
    197,00€
    5mg
    495,00€
    10mg
    625,00€
    25mg
    812,00€
    50mg
    1.108,00€
    100mg
    1.504,00€
    200mg
    2.025,00€
  • TX2-121-1

    CAS :
    TX2-121-1 targets HER3 for proteasome-mediated degradation to inhibit HER3-dependent signalling and growth.
    Formule :C42H52N8O3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :716.91

    Ref: TM-T29024

    25mg
    3.600,00€
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  • VVD-118313

    CAS :
    VVD-118313 (5a) is a potent JAK1 inhibitor targeting allosteric cysteine, blocking cytokine signaling for cancer research.
    Formule :C19H22Cl2N2O3S
    Couleur et forme :Solid
    Masse moléculaire :429.36

    Ref: TM-T62361

    25mg
    4.905,00€
    50mg
    6.803,00€
    100mg
    10.232,00€
  • JAK2-IN-11

    CAS :
    JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with potent antitumor activity, exhibiting an IC50 of ≤10 nM against JH2 BIND WT/V617F. This compound effectively suppresses tumor growth.
    Formule :C31H31F3N8O4
    Couleur et forme :Solid
    Masse moléculaire :639.64

    Ref: TM-T201601

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  • FAK-IN-21

    CAS :
    FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.
    Formule :C22H22F2N8O3S
    Couleur et forme :Solid
    Masse moléculaire :516.52

    Ref: TM-T201079

    25mg
    1.369,00€
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    1.783,00€
    100mg
    2.250,00€
  • PNU-145156E

    CAS :
    PNU-145156E is a noncytotoxic molecule inhibiting growth and angiogenic factors, suppress tumor angiogenesis, support anti-angiogenic research strategies.
    Formule :C45H40N10O17S4
    Couleur et forme :Solid
    Masse moléculaire :1121.12

    Ref: TM-T70412

    25mg
    2.108,00€
    50mg
    2.768,00€
    100mg
    3.715,00€
  • JAK1/TYK2-IN-3


    JAK1/TYK2-IN-3, orally active, selectively inhibits TYK2 (IC50: 6 nM), JAK1 (37 nM), JAK2 (140 nM), JAK3 (362 nM), and has anti-inflammatory effects.
    Couleur et forme :Solid

    Ref: TM-T64265

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • W23-1006

    CAS :
    W23-1006 is a selective covalent ALKBH5 inhibitor. It binds to the ALKBH5 C200 residue with an IC50 value of 3.848 μM. The inhibitory activity of W23-1006 is approximately 30 times stronger than that of FTO and 8 times greater than that of ALKBH3. W23-1006 is applicable for research in triple-negative breast cancer (TNBC).
    Formule :C17H12BrN3O5
    Couleur et forme :Solid
    Masse moléculaire :418.198

    Ref: TM-T205034

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  • EGFR-IN-146

    CAS :
    EGFR-IN-146 is an EGFR inhibitor that suppresses the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway. It effectively reduces blood glucose levels and body weight, showing great potential in the study of diabetes and obesity.
    Formule :C20H16N4
    Couleur et forme :Solid
    Masse moléculaire :312.368

    Ref: TM-T206146

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  • Protein Kinase Inhibitor 12

    CAS :
    Protein Kinase Inhibitor 12 (compound 1-91) is protein kinase inhibitor,PIM-1, CDK-2, GSK-3, and SRC mammalian protein kinases.
    Formule :C14H14N4OS
    Degré de pureté :98.06%
    Couleur et forme :Solid
    Masse moléculaire :286.35

    Ref: TM-T204404

    1mg
    175,00€
    5mg
    434,00€
    10mg
    622,00€
    25mg
    973,00€
    50mg
    1.341,00€
    100mg
    1.773,00€
    200mg
    2.422,00€
  • EGFR/HER2/DHFR-IN-1


    Potent EGFR/HER2/DHFR inhibitor for MCF-7 breast cancer; IC50: 0.153/0.108/0.291 μM; arrests G1/S phase, triggers apoptosis.
    Formule :C14H11BrN4O2S
    Couleur et forme :Solid
    Masse moléculaire :379.23

    Ref: TM-T61596

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • Protein kinase inhibitor 11

    CAS :
    Protein kinase inhibitor 11 (Compound I-96) is an agent that inhibits the activity of PIM-1, CDK-2, GSK-3, and SRC. It shows potential for research in cancer, autoimmune diseases, and neurodegenerative disorders.
    Formule :C21H18FN5O2S
    Couleur et forme :Solid
    Masse moléculaire :423.463

    Ref: TM-T205016

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  • VEGFR-2-IN-15


    VEGFR-2-IN-15 (Compound 14b) is a potent inhibitor of VEGFR-2. VEGFR-2-IN-15 inhibits the growth of HepG2 cells in the Pre-G1 phase and induces apoptosis.
    Formule :C23H18ClN3O4S
    Couleur et forme :Solid
    Masse moléculaire :467.92

    Ref: TM-T63002

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • EGFR-IN-126

    CAS :
    EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.
    Formule :C28H28BrFN4O3
    Couleur et forme :Solid
    Masse moléculaire :567.45

    Ref: TM-T200496

    25mg
    1.476,00€
    50mg
    1.998,00€
    100mg
    2.467,00€
  • FAK-IN-23

    CAS :
    FAK-IN-23 (Compound II) is an inhibitor of focal adhesion kinase (FAK).
    Formule :C32H38F3N5O8
    Couleur et forme :Solid
    Masse moléculaire :677.668

    Ref: TM-T204586

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  • JP-153

    CAS :
    JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.
    Formule :C21H19NO5
    Couleur et forme :Solid
    Masse moléculaire :365.379

    Ref: TM-T206442

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  • HSN748

    CAS :
    HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.
    Formule :C27H24F3N7O
    Couleur et forme :Solid
    Masse moléculaire :519.521

    Ref: TM-T204396

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  • CDD-1115

    CAS :
    CDD-1115 is a potent and selective BMPR2 inhibitor, with an IC50 of 1.8 nM and a Kiapp of 6.2 nM. It effectively suppresses gene expression mediated by bone morphogenetic proteins (BMPs). BMPs regulate cellular processes in various tissue types, such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.
    Formule :C32H30N6O3
    Couleur et forme :Solid
    Masse moléculaire :546.619

    Ref: TM-T205172

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  • Anticancer agent 69


    Anticancer agent 69 targets PC3 cells (IC50=26 nM), raises ROS, lowers EGFR, and induces apoptosis.
    Formule :C19H26N8S
    Couleur et forme :Solid
    Masse moléculaire :398.53

    Ref: TM-T61902

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • (Rac)-PT2399

    CAS :
    (Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
    Formule :C17H10F5NO4S
    Couleur et forme :Solid
    Masse moléculaire :419.32

    Ref: TM-T12675

    5mg
    313,00€
    25mg
    888,00€
    50mg
    1.224,00€
    100mg
    1.972,00€
  • Dual Cathepsin L/JAK-IN-1

    CAS :
    DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).
    Formule :C19H18ClN5
    Couleur et forme :Solid
    Masse moléculaire :351.833

    Ref: TM-T205041

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  • Lomonitinib

    CAS :

    Lomonitinib is a potent and selective pan-FLT3/IRAK4 inhibitor with antitumor properties. It shows promise for research in myeloid leukemia.

    Formule :C27H24N4O2
    Couleur et forme :Solid
    Masse moléculaire :436.505

    Ref: TM-T205470

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  • Protein kinase inhibitor 10

    CAS :
    Protein kinase inhibitor 10 is a protein kinase inhibitor with IC50 values of 28.9 μM, 13.6 μM, and 2.41 μM for TAM receptors, FAK, and KIT, respectively. It can inhibit abnormal and excessive cell proliferation, showing potential for research in the field of cancer treatment.
    Formule :C14H9FN6S2
    Couleur et forme :Solid
    Masse moléculaire :344.39

    Ref: TM-T205111

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  • VEGFR-2/DHFR-IN-1


    Compound 8b inhibits VEGFR-2/DHFR, combats various bacteria, and fights cancer cells.
    Formule :C20H18ClNO4
    Couleur et forme :Solid
    Masse moléculaire :371.81

    Ref: TM-T61489

    25mg
    1.444,00€
    50mg
    1.882,00€
    100mg
    2.375,00€
  • (R)-9b

    CAS :
    (R)-9b is an effective inhibitor of the ACK1 tyrosine kinase (IC50=56 nM) and exhibits anticancer activity. It selectively targets ACK1 but also inhibits kinases in the JAK family, specifically JAK2 and Tyk2. (R)-9b is used in research related to hormone-regulated cancers, such as prostate cancer and breast cancer.
    Formule :C20H27ClN6O
    Couleur et forme :Solid
    Masse moléculaire :402.92

    Ref: TM-T201776

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  • MM-589

    CAS :
    MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.
    Formule :C28H44N8O5
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :572.70

    Ref: TM-T12091

    25mg
    2.583,00€
    50mg
    3.402,00€
    100mg
    4.680,00€
  • CEE321

    CAS :
    CEE321 is an effective pan-JAK inhibitor with an IC50 of 54 nM. It effectively inhibits biomarkers associated with atopic dermatitis.
    Formule :C18H16ClN5O
    Couleur et forme :Solid
    Masse moléculaire :353.806

    Ref: TM-T204824

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  • Tyrphostin 63

    CAS :
    Tyrphostin 63 (compound 13) is an epidermal growth factor receptor (EGFR) inhibitor, with an IC50 of 375 μM and a Ki of 123 μM.
    Formule :C10H8N2O
    Couleur et forme :Solid
    Masse moléculaire :172.183

    Ref: TM-T204167

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  • EGFR-IN-23

    CAS :
    EGFR-IN-23, identified as compound 8 in WO2021244502A1, is a potent EGFR tyrosine kinase inhibitor (TKI) demonstrating an inhibitory concentration (IC50) of 8.
    Formule :C36H44BrN10O3P
    Couleur et forme :Solid
    Masse moléculaire :775.68

    Ref: TM-T73104

    25mg
    2.043,00€
    50mg
    2.682,00€
    100mg
    3.600,00€
  • Vatalanib hydrochloride

    CAS :
    Vatalanib hydrochloride (PTK787 hydrochloride) is an orally available and highly potent tyrosine kinase (VEGF) inhibitor that reduces the number and size of Aβ plaques in the cortex of 5xFAD mice, which may be useful in the study of Alzheimer's disease and cancer.
    Formule :C20H16Cl2N4
    Degré de pureté :99.7%
    Couleur et forme :Solid
    Masse moléculaire :383.27

    Ref: TM-T87609

    1mg
    140,00€
    5mg
    335,00€
    10mg
    502,00€
    25mg
    810,00€
    50mg
    1.111,00€
    100mg
    1.501,00€
    200mg
    2.023,00€
  • NDI-034858

    CAS :
    NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases
    Formule :C23H24N8O3
    Degré de pureté :>99.99%
    Couleur et forme :Solid
    Masse moléculaire :460.49

    Ref: TM-T62902

    1mg
    236,00€
    5mg
    710,00€
    10mg
    1.134,00€
    25mg
    1.684,00€
    50mg
    2.277,00€
    100mg
    3.052,00€
  • JDTic

    CAS :
    JDTic, a 4-phenylpiperidine derivative distantly related to analgesics like meperidine and ketobemidone and more closely to the mu opioid antagonist alvimopan, exhibits a notably long duration of action, maintaining effects in animals for weeks following a single dose. This duration is not due to irreversible binding to the kappa opioid receptor but rather to altered activity of c-Jun N-terminal kinases. As a highly selective antagonist for the κ-opioid receptor, without influencing the μ- or δ-opioid receptors, JDTic has shown potential in animal studies for producing antidepressant and anxiolytic effects. It also demonstrates promise in treating addiction to substances such as cocaine and morphine, distinguishing itself structurally from other kappa antagonists like norbinaltorphimine.
    Formule :C28H39N3O3
    Couleur et forme :Solid
    Masse moléculaire :465.63

    Ref: TM-T11721

    5mg
    1.735,00€
    50mg
    3.509,00€
    100mg
    4.803,00€
  • XMD-17-51 Trifluoroacetate

    CAS :
    XMD-17-51 Trifluoroacetate is a pyrimido-diazepinone compound that regulates protein kinases.
    Formule :C23H25F3N8O3
    Degré de pureté :99.65%
    Couleur et forme :Solid
    Masse moléculaire :518.49

    Ref: TM-T9191

    1mg
    71,00€
    5mg
    152,00€
    10mg
    236,00€
    25mg
    401,00€
    50mg
    580,00€
    100mg
    797,00€
    1mL*10mM (DMSO)
    168,00€
  • JAK2-IN-7

    CAS :
    JAK2-IN-7 selectively inhibits JAK2 (IC50: 3 nM), shows 14-fold selectivity over JAK1/3, FLT3, induces G0/G1 arrest, apoptosis, and has antitumor effects.
    Formule :C26H33N7O
    Degré de pureté :99.54%
    Couleur et forme :Solid
    Masse moléculaire :459.59

    Ref: TM-T35900

    1mg
    145,00€
    5mg
    354,00€
    10mg
    630,00€
    25mg
    1.301,00€
    50mg
    1.738,00€
    100mg
    2.357,00€
    1mL*10mM (DMSO)
    358,00€
  • Ibrutinib Racemate

    CAS :
    Ibrutinib is a selective, irreversible Btk inhibitor (IC50: 0.5 nM). Ibrutinib Racemate is the racemate of Ibrutinib.
    Formule :C25H24N6O2
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :440.5

    Ref: TM-T16440

    Produit arrêté
  • TLC9995-0188

    CAS :
    Tyrosine-protein kinase ABL, IC50: 1500 nM
    Formule :C16H15N5
    Couleur et forme :Yellow Solid
    Masse moléculaire :277.331
  • Nimotuzumab (powder)

    CAS :

    Nimotuzumab (powder) is a humanized IgG1 monoclonal antibody that specifically targets the epidermal growth factor receptor (EGFR), possessing a dissociation constant (KD) of 0.21 nM. It blocks the binding to its ligand by targeting the extracellular domain of EGFR. Nimotuzumab exhibits strong antitumor activity by inducing both antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), exerting cytolytic effects on target tumors.

    Couleur et forme :Liquid
  • (3R,4S)-Tofacitinib

    CAS :
    (3R,4S)-Tofacitinib, the less active enantiomer of Tofacitinib, is a JAK3 inhibitor with an IC50 of 1 nM.
    Formule :C16H20N6O
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :312.37

    Ref: TM-T13426

    Produit arrêté
  • ENMD-2076 tartrate

    CAS :
    ENMD-2076 is an orally active kinase inhibitor. It also has antiangiogenic and antiproliferative mechanisms of action.
    Formule :C25H31N7O6
    Couleur et forme :Solid
    Masse moléculaire :525.56

    Ref: TM-T2358L

    Produit arrêté
  • XMU-MP-3

    CAS :
    XMU-MP-3 is a robust, non-covalent inhibitor of BTK, exhibiting exceptional potency with IC50 values of 10.7 nM and 17.0 nM for BTK WT and BTK C481S mutation, respectively, in the presence of 10 μM ATP. Moreover, XMU-MP-3 elicits apoptosis.
    Formule :C27H27F3N8O
    Couleur et forme :Solid
    Masse moléculaire :536.563

    Ref: TM-T39430

    Produit arrêté
  • Imbotolimod


    Imbotolimod, a humanized monoclonal antibody of the immunoglobulin G1-kappa class, exhibits both anti-ERBB2 and antineoplastic activities.
    Couleur et forme :Odour Liquid
  • HMBD-001


    HMBD-001 is a humanized IgG1 monoclonal antibody inhibitor that targets HER3. By inhibiting the dimerization of HER3, HMBD-001 suppresses the growth and proliferation of tumor cells. It holds potential for research in cancer treatments, specifically for pancreatic cancer and non-small cell lung cancer.

    Couleur et forme :Odour Liquid
  • Dihydrodiol-Ibrutinib

    CAS :
    PCI 45227 is an active metabolite of the Bruton's tyrosine kinase inhibitor ibrutinib .1PCI 45227 is formed from ibrutinib by the cytochrome P450 (CYP) isoform CYP3A. 1.Veeraraghavan, S., Viswanadha, S., Thappali, S., et al.Simultaneous quantification of lenalidomide, ibrutinib and its active metabolite PCI-45227 in rat plasma by LC-MS/MS: Application to a pharmacokinetic studyJ. Pharm. Biomed. Anal.107151-158(2015)
    Formule :C25H26N6O4
    Couleur et forme :Solid
    Masse moléculaire :474.521

    Ref: TM-T36429

    Produit arrêté
  • PM-8002


    PM-8002 is a bispecific antibody that targets PD-L1 and VEGF-A. It is applicable for research on solid tumors.

    Couleur et forme :Odour Liquid
  • Olmutinib

    CAS :
    Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
    Formule :C26H26N6O2S
    Degré de pureté :99.14%
    Couleur et forme :Solid
    Masse moléculaire :486.59
  • Desidustat

    CAS :

    Desidustat is an inhibitor of HIF hydroxylase.

    Formule :C16H16N2O6
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :332.31
  • PF-03814735

    CAS :
    PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.
    Formule :C23H25F3N6O2
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :474.48

    Ref: TM-T6936

    Produit arrêté
  • Duligotuzumab

    CAS :

    Duligotuzumab (MEHD-7945A) is a bispecific humanised IgG-κ monoclonal antibody targeting HER3 and EGFR, solid tumours, head and neck cancer,colorectal cancer.

    Degré de pureté :95%
    Couleur et forme :Liquid
  • 3,3',4,4'-Tetrabromobiphenyl

    Produit contrôlé
    CAS :

    Applications 3,3',4,4'-Tetrabromobiphenyl is multi-persistent organic pollutants analyzed in breast milk of first time mothers. An environmental pollutant that affects copper and molybdenum metabolism in rats. Also, it is derived from 1-Bromo-2- nitrobenze (B686175), which is an organic building block used for the synthesis of various pharmaceutical compounds. It is an intermediate for the synthesis of novel Diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity.
    References Tlustos, C., et al.: Organohalogen Compd., 75, 1185-1188 (2013); Salman, K. N., et al.: Environ. Sci. Pollut. R., 21, 6400-6409 (2014); Dao, P., et al.: Bioorg. Med. Chem. Lett., 23, 4552 (2013);

    Formule :C12H6Br4
    Couleur et forme :Off-White To Light Brown
    Masse moléculaire :469.79

    Ref: TR-T291333

    Produit arrêté
  • VEGFR-IN-1

    CAS :
    VEGFR inhibitor
    Formule :C19H16ClN3O
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :337.8