Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(167 produits)
- Bcr-Abl(118 produits)
- EGFR(581 produits)
- FAK(72 produits)
- FLT(86 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(180 produits)
- JAK(243 produits)
- PDGFR(129 produits)
- RAAS(89 produits)
- Src(82 produits)
- Syk(37 produits)
- Thrombine(57 produits)
- VDA(2 produits)
- VEGFR(242 produits)
Affichez 6 plus de sous-catégories
2386 produits trouvés pour "Angiogenèse"
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MJ04
CAS :MJ04 is a selective inhibitor of Janus Kinase 3 (JAK3) with an IC50 of 2.03 nM. It hinders T cell differentiation and suppresses pro-inflammatory cytokines in macrophages induced by Lipopolysaccharides. In mice, MJ04 exhibits favorable pharmacokinetic properties and promotes hair growth in a DHT-induced alopecia model in athymic mice, without notable toxicity (LD50>2 g/kg).Formule :C20H16FN5Couleur et forme :SolidMasse moléculaire :345.37EGFR-IN-50
CAS :EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.Formule :C24H26BrN3O4S2Couleur et forme :SolidMasse moléculaire :564.51TYK2-IN-12
CAS :TYK2-IN-12: selective oral TYK2 inhibitor (Ki: 0.51 nM), blocks IL-12-induced IFNγ; IC50: human 2.7 µM, mouse 7.0 µM, used for psoriasis research.Formule :C24H20F2N4O2Couleur et forme :SolidMasse moléculaire :434.44BIIB-057
CAS :BIIB-057 is a selective Syk inhibitor.Formule :C19H23N9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.45AN-019
CAS :AN-019 (NRC-019) is a Bcr-Abl kinase inhibitor with antitumor activity for the study of chronic myelogenous leukemia (CML) and breast cancer.Formule :C25H17F6N5ODegré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :517.43KBP-7018 HCl
CAS :KBP-7018 Hydrochloride is a novel, tyrosine kinase-selective inhibitor with potent effects on three fibrotic kinases (c-KIT, PDGFR, and RET).Formule :C31H31ClN4O5Couleur et forme :SolidMasse moléculaire :575.06OD36 hydrochloride
CAS :OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficientlyFormule :C16H16Cl2N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :367.23Ibrutinib-MPEA
CAS :Ibrutinib-MPEA is ibrutinib derivative. Ibrutinib is a covalent and irreversible BTK inhibitor that has been used to treat hematological malignancies.Formule :C32H39N9O2Couleur et forme :SolidMasse moléculaire :581.71TG-46
CAS :TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.Formule :C26H34N6O3SDegré de pureté :98.82% - 99.86%Couleur et forme :SolidMasse moléculaire :510.65PF-06672131
CAS :PF-06672131 is a selective EGFR kinase inhibitor.Formule :C23H21ClFN5O2Couleur et forme :SolidMasse moléculaire :453.9Lanraplenib monosuccinate
CAS :Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.Formule :C27H31N9O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.59Gefitinib N-oxide
CAS :Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.Formule :C22H24ClFN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.9NAMI-A
CAS :NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.Formule :C8H15Cl4N4ORuSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.18Sovleplenib
CAS :Sovleplenib (HMPL-523), oral SYK inhibitor, IC50 25 nM, targets tumors & ITP studies.Formule :C24H30N6O3SDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :482.6Ref: TM-T32088
1mg120,00€5mg289,00€1mL*10mM (DMSO)308,00€10mg434,00€25mg737,00€50mg1.153,00€100mg1.791,00€200mg2.412,00€ALK5-IN-26
CAS :ALK5-IN-26 (EX-22) is an ALK (Activin receptor-like kinase) inhibitor. ALK5-IN-26 inhibits ALK5 (IC50 ≤ 1 nM).Formule :C24H25FN8Couleur et forme :SolidMasse moléculaire :444.51EGFR-IN-89
CAS :EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM againstFormule :C26H31FN8O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.64VEGFR-2-IN-6
CAS :VEGFR-2-IN-6 (WO 02/059110, example 64) is a potent inhibitor of VEGFR2, a crucial receptor involved in the regulation of angiogenesis [1].Formule :C20H21N7O2SDegré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :423.49ALK-IN-5
CAS :ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).Formule :C24H25FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.49PF-00337210
CAS :PF-00337210, an oral VEGFR2 inhibitor, may hinder endothelial and tumor cell growth, reducing angiogenesis and potentially causing cancer cell death.Formule :C26H27N3O5Couleur et forme :SolidMasse moléculaire :461.51EGFR-IN-73
CAS :EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].Formule :C19H17ClFN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.81ER-27319
CAS :ER-27319, an acridone derivative, serves as a potent and selective inhibitor of spleen tyrosine kinase (SYK), effectively impeding both the tyrosineFormule :C20H22N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :370.4A-420983
CAS :A-420983 is a novel potent Lck inhibitor, exhibiting oral efficacy in animal models of delayed-type hypersensitivity and organ transplant rejection.Formule :C33H39N9O2Couleur et forme :SolidMasse moléculaire :593.72VEGFR-2-IN-20
CAS :VEGFR-2-IN-20 (Compound 7) is a highly effective VEGFR inhibitor with significant potential for cancer research [1].Formule :C20H20N4O3SCouleur et forme :SolidMasse moléculaire :396.46ALK2-IN-2
CAS :ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.Formule :C28H27N5O2SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :497.61Ref: TM-T10287
1mg44,00€5mg89,00€1mL*10mM (DMSO)99,00€10mg142,00€25mg216,00€50mg298,00€100mg411,00€200mg560,00€Mutated EGFR-IN-3
CAS :Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.Formule :C31H29FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.59PF-719 free base
CAS :PF-719 is a potent, selective Pyk2 inhibitor with IC50 of 17 nM.Formule :C22H27F3N6OCouleur et forme :SolidMasse moléculaire :448.48PH11
CAS :PH11, a FAK inhibitor, reactivates TRAIL apoptosis in PANC-1 cells by reducing c-FLIP and inhibiting FAK/PI3K/AKT.Formule :C22H22N6O5Couleur et forme :SolidMasse moléculaire :450.45ALK2-IN-5
CAS :ALK2-IN-5, a pyrazolopyrimidine compound, serves as an inhibitor of ALK2 and FGFR, targeting disorders linked with their activity, including cancer [1].Formule :C24H32N8O2Couleur et forme :SolidMasse moléculaire :464.56OICR-0547
CAS :OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429.Formule :C28H29F3N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :542.55SB-633825
CAS :SB-633825 can inhibit cancer cell growth and angiogenesis.Formule :C28H25N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :483.58Syk-IN-1
CAS :Syk-IN-11 is a selective Syk inhibitor.Formule :C18H22N8OCouleur et forme :SolidMasse moléculaire :366.42NSC114126
CAS :NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.Formule :C22H20O4Couleur et forme :SolidMasse moléculaire :348.39LBW242
CAS :LBW242: oral 3-mer Smac mimetic, IAP inhibitor, targets multiple myeloma, enhances TRAIL/chemo death in ovarian cancer, active on mutant FLT3 cells.Formule :C27H42N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.65ACP-5862
CAS :ACP-5862, active metabolite of Acalabrutinib, is a BTK inhibitor with an IC50 of 5.0 nM.Formule :C26H23N7O3Couleur et forme :SolidMasse moléculaire :481.51BKI-1369
CAS :BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).Formule :C23H27N7OCouleur et forme :SolidMasse moléculaire :417.51SDZ281-977
CAS :SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.Formule :C18H20O5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :316.35Esuberaprost Sodium
CAS :Famitinib (SHR1020), an oral drug, inhibits c-kit, VEGFR-2, and PDGFRβ (IC50: 2.3/4.7/6.6 nM) and triggers apoptosis in gastric cancer.Formule :C23H27FN4O2Couleur et forme :SolidMasse moléculaire :410.48AXL-IN-13
CAS :AXL-IN-13: potent, oral AXL inhibitor, IC50=1.6nM, Kd=0.26nM, anti-cancer, inhibits EMT, cell migration & invasion.Formule :C34H41FN6O5Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :632.72ZD4190 HCl
CAS :ZD-4190, a potent VEGFR inhibitor, prevents tumour outgrowth in a model of minimal residual carcinoma in deep tissues.Formule :C19H17BrClFN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :495.73RTC-5
CAS :RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.Formule :C24H22ClF3N2O3SDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :510.96Ref: TM-T12777
2mg35,00€5mg52,00€1mL*10mM (DMSO)55,00€10mg78,00€25mg149,00€50mg235,00€100mg376,00€200mg550,00€AC710 Mesylate
CAS :AC710 Mesylate is a potent PDGFR inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ).Formule :C32H46N6O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :658.81FM19G11
CAS :FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).
Formule :C23H17N3O8Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :463.4TGFBR1-IN-1
CAS :TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).Formule :C23H17N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :427.48TG 100572
CAS :TG 100572 is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2Formule :C26H26ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.97PD 166326
CAS :PD166326, a pyridopyrimidine inhibitor, targets Src & Abl tyrosine kinases (IC50: 6 nM & 8 nM) and exhibits antileukemic effects.Formule :C21H16Cl2N4O2Couleur et forme :SolidMasse moléculaire :427.28MS 154N
CAS :MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.Formule :C47H56ClFN8O8Couleur et forme :SolidMasse moléculaire :915.45T-1840383
CAS :T-1840383 blocks VEGFR-2 and c-Met phosphorylation in endothelial and cancer cells.Formule :C30H25ClFN5O4Couleur et forme :SolidMasse moléculaire :574c-ABL-IN-2
CAS :C-ABL-IN-2 is a potent c-Abl protein inhibitor, promising for research in cancer and neurodegenerative diseases like ALS and PD.Formule :C21H20N4OCouleur et forme :SolidMasse moléculaire :344.41EGFR-IN-68
CAS :EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.Formule :C24H22N2OCouleur et forme :SolidMasse moléculaire :354.44JAK3/BTK-IN-5
CAS :JAK3/BTK-IN-5 is a potent dual inhibitor targeting JAK3 and BTK with synergistic effects, valuable for related autoimmune disease research.Formule :C19H22ClN7O2Couleur et forme :SolidMasse moléculaire :415.88GW768505A free base
CAS :GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2 (pIC50: 7.81 for VEGFR2) with anti-angiogenic activity.Formule :C27H19F4N5O3Couleur et forme :SolidMasse moléculaire :537.47OD36
CAS :OD36: Potent RIPK2 inhibitor, IC50=5.3 nM; hinders ALK2 signaling and osteogenesis, KD=37 nM; targets ALK2 ATP pocket.Formule :C16H15ClN4O2Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :330.77DMPQ dihydrochloride
CAS :PDGFRβ inhibitorFormule :C16H16Cl2N2O2Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :339.22MMPP
CAS :MMPP is a VEGFR2 inhibitor with anti-inflammatory activity, inhibits STAT3 , inhibits angiogenesis, and can be used to alleviate myocardial injury.Formule :C17H18O3Degré de pureté :99.31% - 99.83%Couleur et forme :SolidMasse moléculaire :270.32JNJ-47117096 hydrochloride
CAS :JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.Formule :C21H23ClN4O2Couleur et forme :SolidMasse moléculaire :398.89FAK inhibitor 2
CAS :FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .Formule :C29H33F3N8O2S2Couleur et forme :SolidMasse moléculaire :646.75JAK-2/3-IN-2
CAS :JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).Formule :C19H19ClN2OSCouleur et forme :SolidMasse moléculaire :358.89Antiproliferative agent-30
CAS :Antiproliferative agent-30 (Compound 8g) demonstrates broad-spectrum antiproliferative activity, with IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM againstFormule :C24H26N4O4Couleur et forme :SolidMasse moléculaire :434.49GDC-0834 Racemate
CAS :GDC-0834 Racemate is the racemate form of GDC-0834, which is an effective and selective BTK inhibitorFormule :C33H36N6O3SCouleur et forme :SolidMasse moléculaire :596.74EGFR/HER2/CDK9-IN-2
CAS :EGFR/HER2/CDK9-IN-2 inhibits EGFR, HER2, CDK9 with IC50s: 145.35, 129.07, 117.13 nM; strong antitumor effects.Formule :C23H20N4O5S2Couleur et forme :SolidMasse moléculaire :496.56Epertinib
CAS :Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).Formule :C30H27ClFN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :560.02SSR128129E free acid
CAS :SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).Formule :C18H16N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.33CS12192
CAS :CS12192 enhances survival, boosts weight, and shows promise in GVHD research per patent CN112773802A.Formule :C25H23ClFN7O2Couleur et forme :SolidMasse moléculaire :507.95NSC-689857
CAS :NSC-689857 is an inhibitor that acts in the Skp2-Cks1 protein-protein interaction and p27Kip1 ubiquitination in vitro.Formule :C25H29NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.5AFN941
CAS :AFN941 is a staurosporine analog, acting as a Jak3-specific inhibitor.Formule :C28H30N4O3Couleur et forme :SolidMasse moléculaire :470.56Squarunkin A hydrochloride
CAS :Squarunkin A HCl inhibits UNC119-cargo binding, specifically blocks Src kinase activation, IC50=10 nm.Formule :C25H33ClF3N5O4Couleur et forme :SoildMasse moléculaire :560.02FLT3-IN-4
CAS :FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenousFormule :C23H25N7O2Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :431.49Ref: TM-T11299
1mg87,00€5mg215,00€1mL*10mM (DMSO)235,00€10mg318,00€25mg510,00€50mg692,00€100mg888,00€500mg1.783,00€TX-1123
CAS :TX-1123: PTK/COX inhibitor, Src/eEF2-K/PKA/EGFR-K/PKC targeted, IC50 of 1.16μM(COX2), 15.7μM(COX1), low mitochondrial toxicity.Formule :C20H24O3Couleur et forme :SolidMasse moléculaire :312.4MAX-40279 hemiadipate
CAS :MAX-40279 hemiadipate: Potent FLT3/FGFR inhibitor; potential in AML treatment. (Patent WO2021180032A1)Formule :C50H56F2N12O6S2Couleur et forme :SolidMasse moléculaire :1023.19RO9021
CAS :RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).Formule :C18H25N7ODegré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :355.44EGFR-IN-67
CAS :EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].Formule :C18H17N3SCouleur et forme :SolidMasse moléculaire :307.41(R)-Afatinib
CAS :(R)-Afatinib: oral ErbB inhibitor (EGFR/HER2), IC50 ≤14 nM. For ESCC, NSCLC, gastric cancer research.Formule :C24H25ClFN5O3Couleur et forme :SolidMasse moléculaire :485.94AZM475271
CAS :AZM475271 is a potent and selective inhibitor of Src kinase(IC50 : 5 nM)Formule :C23H27ClN4O3Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :442.94R916562
CAS :R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.Formule :C26H30ClN9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :536.09ULK1-IN-2
CAS :ULK1-IN-2, a potent anticancer agent, inhibits ULK1, induces apoptosis, blocks autophagy, and shows high cytotoxicity with an IC50 of 1.94 μM in A549 cells.Formule :C19H16BrFN4O6Degré de pureté :99.07% - 99.97%Couleur et forme :SolidMasse moléculaire :495.26JAK-IN-21
CAS :JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.Formule :C19H16N8ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :372.38RG 14467
CAS :RG 14467 is an antagonist of epidermal growth factor-urogastrone.Formule :C14H14N2O3Couleur et forme :SolidMasse moléculaire :258.27(E/Z)-CP-724714
CAS :(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].Formule :C27H27N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.54FAK-IN-8
CAS :FAK-IN-8 (compound 5h), a FAK inhibitor with an IC50 of 5.32 μM, exhibits potent anti-proliferative activity, making it suitable for use in cancer research [1].Formule :C15H9Cl2N3O2SCouleur et forme :SolidMasse moléculaire :366.22TK4g
CAS :TK4g, a potent JAK inhibitor, has IC50s of 12.61 nM (JAK2) & 15.80 nM (JAK3); promising for lymphoid diseases & leukemia research.Formule :C19H19N3O4SCouleur et forme :SolidMasse moléculaire :385.44EGFR-IN-5
CAS :EGFR-IN-5 inhibits EGFR & mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.Formule :C31H38FN9ODegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :571.69Cenisertib benzoate
CAS :Cenisertib benzoate is an orally bioavailable, synthetic, small-molecule multi-Aurora kinase inhibitor with potential antineoplastic activity.Formule :C31H36FN7O3Couleur et forme :SolidMasse moléculaire :573.66DMH4
CAS :DMH4 is a potent and selective inhibitor of VEGFR2 with an IC50 of 0.16 µM.Formule :C24H24N4O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :400.47RG 14921
CAS :RG 14921 is a pyridone analog of erbstatin, epidermal growth factor (EGF) receptor tyrosine kinase, and cAMP-dependent kinase.Formule :C11H9NO3Couleur et forme :SolidMasse moléculaire :203.19PF-06658607
CAS :PF-06658607 is an alkynylated irreversible Brutons tyrosine kinase (BTK) inhibitor.Formule :C27H24N6O2Couleur et forme :SolidMasse moléculaire :464.52THS-044
CAS :THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activityFormule :C11H12F3N3O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :291.23OXSI-2
CAS :OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM.Formule :C18H15N3O3SDegré de pureté :98%Couleur et forme :Dark Orange SolidMasse moléculaire :353.39BPTQ
CAS :BPTQ: DNA intercalator, halts cancer cell growth by blocking S/G2/M phases.Formule :C17H16N4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :308.4VEGFR-2-IN-19
CAS :VEGFR-2-IN-19 (15b) effectively inhibits VEGFR2, induces apoptosis, and increases oxidative stress, showing potential as an anticancer drug.Formule :C21H19N3O2Couleur et forme :SolidMasse moléculaire :345.39TOP1210
CAS :TOP1210, a narrow spectrum kinase inhibitor, potently inhibits P38α, Src, and Syk kinase activities.Formule :C45H48N8O6Couleur et forme :SolidMasse moléculaire :796.91JBJ-04-125-02
CAS :JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.Formule :C29H26FN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :543.61GW 583340 dihydrochloride
CAS :GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.Formule :C28H27Cl3FN5O3S2Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :671.03JAK3i
CAS :JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.Formule :C18H15FN4O3Degré de pureté :98.61% - 99.81%Couleur et forme :SolidMasse moléculaire :354.34Tyk2-IN-5
CAS :Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).Formule :C21H19FN8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.43M1002
CAS :M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.Formule :C15H8F6N2O2SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :394.29Ref: TM-T61822
1mg49,00€5mg92,00€1mL*10mM (DMSO)108,00€10mg144,00€25mg235,00€50mg350,00€100mg515,00€500mg1.071,00€T338C Src-IN-2
CAS :T338C Src-IN-2: Potent c-Src T338C kinase inhibitor; IC50: 317 nM, T338C/V323A: 57 nM, T338C/V323S: 19 nM.Formule :C17H18FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :327.36HSP90-IN-13
CAS :HSP90-IN-13 (5k): potent HSP90 inhibitor, IC50 25.07 nM, targets EGFR/VEGFR-2/Topo-2, blocks MCF-7 G2/M cycle, induces apoptosis.Formule :C26H21N5O3SCouleur et forme :SolidMasse moléculaire :483.54Ilorasertib hydrochloride
CAS :Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Formule :C25H22ClFN6O2SDegré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :525DBPR112
CAS :DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.Formule :C32H31N5O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :533.62Antiproliferative agent-34
CAS :Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.Formule :C27H27N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.55
