Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(167 produits)
- Bcr-Abl(118 produits)
- EGFR(581 produits)
- FAK(72 produits)
- FLT(86 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(180 produits)
- JAK(243 produits)
- PDGFR(129 produits)
- RAAS(89 produits)
- Src(82 produits)
- Syk(37 produits)
- Thrombine(57 produits)
- VDA(2 produits)
- VEGFR(242 produits)
Affichez 6 plus de sous-catégories
2386 produits trouvés pour "Angiogenèse"
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JAK3-IN-12
CAS :JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.Formule :C19H19N5O4SCouleur et forme :SolidMasse moléculaire :413.45FGFR-IN-13
CAS :FGFR-IN-13 (compound III-30), an irreversible covalent inhibitor of the fibroblast growth factor receptor (FGFR), effectively modulates signaling through FGFR1 (IC 50 = 0.20 ± 0.02 nM) and FGFR4 (IC 50 = 0.40 ± 0.03 nM). It suppresses the expression of crucial proteins such as total-PARP and Bcl-2, while enhancing the expression of Cleaved-PARP and Bax in a dose-dependent manner. Notably, FGFR-IN-13 demonstrates considerable antitumor and oral activity [1].Formule :C23H21N5O3Masse moléculaire :415.44Zotiraciclib HCl
CAS :Zotiraciclib (TG02/SB1317) is a CDK/JAK2/FLT3 inhibitor potentially treating Myc-overexpressing cancers, including glioblastoma.Formule :C23H26Cl2N4OCouleur et forme :SolidMasse moléculaire :445.388AMG-Tie2-1
CAS :AMG-Tie2-1 is a Tie2 and VEGFR2 inhibitor with anticancer and antitumor activity for the study of cardiovascular disease and cancer.Formule :C25H20F3N5O2Degré de pureté :98.9%Couleur et forme :SolidMasse moléculaire :479.45EGFR-IN-56
CAS :EGFR-IN-56 (13a) inhibits EGFR, EGFRT790M (IC50: 541.7nM), EGFRT790M/L858R (IC50: 132.1nM), blocks G2/M phase, and triggers apoptosis.Formule :C23H22N4O3SCouleur et forme :SolidMasse moléculaire :434.51Infigratinib phosphate
CAS :Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, andFormule :C26H34Cl2N7O7PDegré de pureté :99.24% - 99.6%Couleur et forme :SolidMasse moléculaire :658.47TM-233
CAS :TM-233 is an inhibitor of both JAK/STAT and proteasome activities that acts by inducing cell death in myeloma cells.Formule :C25H20O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :384.42JAK-IN-11
CAS :JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.Formule :C23H22FN5O4SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :483.52PD180970
CAS :PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit.Formule :C21H15Cl2FN4ODegré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :429.27BLK-IN-2
CAS :BLK-IN-2为一种高效、选择性且不可逆的B-淋巴酪氨酸激酶(BLK)抑制剂，具有5.9 nM的IC50值。该化合物亦能抑制BTK，其IC50值为202.0 nM。BLK-IN-2在多种淋巴瘤细胞中展现出显著的抗增殖作用。Formule :C39H41N9O3Couleur et forme :SolidMasse moléculaire :683.8Depatuxizumab mafodotin
CAS :Depatuxizumab mafodotin, an antibody-drug conjugate (ADC) targeting the epidermal growth factor receptor (EGFR), is utilized in cancer research [1].Couleur et forme :LiquidBCR-ABL-IN-2
CAS :BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor (IC50s: 57 nM, 773 nM for ABL1 native and ABL1 T315I).Formule :C24H25Cl2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :502.39MAX-40279 hemifumarate
CAS :MAX-40279 hemifumarate inhibits FLT3 and FGFR kinases, showing promise for AML treatment.Formule :C48H50F2N12O6S2Couleur et forme :SolidMasse moléculaire :993.12TG 100801 Hydrochloride
CAS :TG 100801: prodrug for macular degeneration. TG 100572: inhibits kinases (VEGFRs, FGFRs, PDGFRβ, Src family), with varying IC50s.Formule :C33H31Cl2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :616.54Atopaxar Hydrobromide
CAS :Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.Formule :C29H39BrFN3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.54DB07107
CAS :DB07107 is a potent inhibitor of drug resistant T315I mutant Bcr-Abl tyrosine kinase and a potent Akt1 inhibitor (IC50: 360 nM).Formule :C23H22N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :370.45EGFR-IN-64
CAS :EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.Formule :C20H21N3O3Couleur et forme :SolidMasse moléculaire :351.4AC430
CAS :AC430, a specific JAK2 inhibitor for cancer and autoimmune therapy, excels in preclinical trials with low doses. Developed by Ambit.Formule :C19H16FN5OCouleur et forme :SolidMasse moléculaire :349.36Aminoquinuride
CAS :Surfen, or Aminoquinuride, reduces inflammation but blocks remyelination in MS mouse models and regulates murine T cell activation.Formule :C21H20N6OCouleur et forme :SolidMasse moléculaire :372.42HKI-357 dimaleate
CAS :HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.Formule :C39H37ClFN5O11Couleur et forme :SolidMasse moléculaire :806.2KL-1156
CAS :KL-1156 is an NF-κB inhibitor. It is also a lipopolysaccharide (LPS)-induced nitric oxide production inhibitor.Formule :C17H17NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :299.32Rogaratinib
CAS :Rogaratinib (BAY1163877) is an aberrant inhibitor of fibroblast growth factor receptor (FGFR).Formule :C23H26N6O3SDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :466.56FN-1501
CAS :FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).Formule :C22H25N9ODegré de pureté :97.4%Couleur et forme :SolidMasse moléculaire :431.49Ref: TM-T15335
1mg87,00€5mg177,00€1mL*10mM (DMSO)203,00€10mg295,00€25mg537,00€50mg807,00€100mg1.099,00€Spebrutinib besylate
CAS :Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s).Formule :C28H28FN5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.62Sch 13835
CAS :Sch 13835 is an inhibitor of platelet derived growth factor.Formule :C15H10ClNO4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :335.76EGFR T790M/L858R-IN-5
CAS :EGFR T790M/L858R-IN-5 (example 52) functions as a potent EGFR T790M/L858R inhibitor, demonstrating a 92.9% inhibition rate at a concentration of 0.05 μM [1].Formule :C28H31N9OMasse moléculaire :509.61EL-102
CAS :EL-102 is a HIF1α inhibitor with anticancer activity that inhibits microtubule protein polymerization and can be used to study prostate cancer.Formule :C19H16N2O3S2Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :384.47Ref: TM-T15205
1mg93,00€1mL*10mM (DMSO)173,00€5mg205,00€10mg331,00€25mg515,00€50mg700,00€100mg1.044,00€FGFR2-IN-2
CAS :FGFR2-IN-2 is a specific FGFR2 inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used in the study of cancer and cardiovascular disease.Formule :C23H22N4ODegré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :370.45HS-438
CAS :HS-438 inhibits imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia.Formule :C17H17N3O3SCouleur et forme :SolidMasse moléculaire :343.4FLT3/ITD-IN-2
CAS :FLT3/ITD-IN-2: Powerful FLT3/ITD, FLT3D835Y, and FLT3 inhibitor; hinders AML cell growth. IC50s: 0.3-1.0 nM.Formule :C23H26F3N7O2Couleur et forme :SolidMasse moléculaire :489.49Tarlox-TKI
CAS :Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.Formule :C19H18BrClN6ODegré de pureté :97.03%Couleur et forme :SolidMasse moléculaire :461.74TK4b
CAS :TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) & 19.40 nM (JAK2).Formule :C21H22N2O2Couleur et forme :SolidMasse moléculaire :334.41TX-1918
CAS :TX-1918, a tyrphostin, blocks eEF-2K to hinder HepG2, HCT116 cell growth.Formule :C14H12O3Couleur et forme :SolidMasse moléculaire :228.24Nuvenzepine
CAS :Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment.Formule :C19H20N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.39JAK-IN-20
CAS :JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.Formule :C28H30FN7O2Couleur et forme :SolidMasse moléculaire :515.58Peficitinib hydrochloride
CAS :Peficitinib HCl (ASP015K) is an oral JAK inhibitor with IC50s: JAK1 (3.9 nM), JAK2 (5.0 nM), JAK3 (0.7 nM), Tyk2 (4.8 nM).Formule :C18H23ClN4O2Couleur et forme :SolidMasse moléculaire :362.86pan-HER-IN-1
CAS :Compound C5: Irreversible, oral pan-HER inhibitor with low IC50s for EGFR/HERs; induces apoptosis and has antitumor effects.Formule :C19H14BrN5OCouleur et forme :SolidMasse moléculaire :408.25AAE871
CAS :AAE871 is a type I FLT3 inhibitor.Formule :C24H34N8O2SCouleur et forme :SolidMasse moléculaire :498.64AG-13958 monohydrochloride
CAS :AG-13958 monohydrochloride, a VEGFA inhibitor, may treat neovascular AMD to prevent rapid vision loss.Formule :C26H23ClFN7OCouleur et forme :SolidMasse moléculaire :503.96c-ABL-IN-4
CAS :c-ABL-IN-4 is a potent inhibitor of c-Abl.Formule :C18H11ClF3N3O3Couleur et forme :SolidMasse moléculaire :409.75c-ABL-IN-3
CAS :c-ABL-IN-3, from patent WO2021048567A1, is a potent c-Abl inhibitor for researching ALS, PD, and cancer.Formule :C17H11F3N4O3Couleur et forme :SolidMasse moléculaire :376.29BTK inhibitor 10
CAS :BTK inhibitor 10, an oral drug from patent WO2018145525, may treat rheumatoid arthritis.Formule :C25H23N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.48J-1048
CAS :J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/Formule :C23H17FN6S2Couleur et forme :SolidMasse moléculaire :460.55Flonoltinib
CAS :Flonoltinib (JAK2/FLT3-IN-1) is an orally active and efficient JAK2/FLT3 inhibitor with anti-cancer properties.Formule :C25H34FN7ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :467.58UNC-CA359
CAS :UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.Formule :C18H14ClN3O2Couleur et forme :SolidMasse moléculaire :339.78NSC 33994
CAS :NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). It also shows no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.Formule :C28H42N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.65JAK3/BTK-IN-6
CAS :JAK3/BTK-IN-6: potent BTK (0.6 nM) & JAK3 (0.4 nM) inhibitor, stable in human liver, for blood/immune research.Formule :C21H17BF3N5O3Couleur et forme :SolidMasse moléculaire :455.2EGFR-IN-21
CAS :EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.Formule :C36H44BrN10O2PCouleur et forme :SolidMasse moléculaire :759.68BCR-ABL-IN-6
CAS :BCR-ABL-IN-6, an imatinib derivative, inhibits Bcr-AblWT (4.6 nM IC50) and T315I (277 nM), for chronic myeloid leukemia study.Formule :C27H22F3N5O2Couleur et forme :SolidMasse moléculaire :505.49VS 8
CAS :VS 8: potent oral VEGFR-2 inhibitor, anti-angiogenic, induces cancer cell apoptosis & migration, acts on CSCs.Formule :C26H20F3N3O3Couleur et forme :SolidMasse moléculaire :479.45EGFR/HER2-IN-2
CAS :EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual EGFR and HER2 inhibitor that acts on both EGFR (IC50: 5.02 μM) and HER2 (IC50: 0.83 μM).Formule :C26H23N5O3Couleur et forme :SolidMasse moléculaire :453.49JBJ-09-063 hydrochloride
JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.Formule :C31H30ClFN4O3SCouleur et forme :SolidMasse moléculaire :593.11EGFR-IN-25
CAS :EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.Formule :C34H43N9O2Couleur et forme :SolidMasse moléculaire :609.76EGFR-IN-54
CAS :EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.Formule :C17H14N4O4S3Couleur et forme :SolidMasse moléculaire :434.51NSC114792
CAS :NSC114792 is a selective JAK3 inhibitor.Formule :C26H32N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.62EGFR-IN-52
CAS :EGFR-IN-52, a potent EGFR inhibitor, has IC50s: 0.358 μM (wild-type), 86.02 μM (L858R-TK), 432.67 μM (T790M-TK); induces cancer cell apoptosis.Formule :C19H18N4O3SCouleur et forme :SolidMasse moléculaire :382.44EGFR/HER2/CDK9-IN-3
CAS :EGFR/HER2/CDK9-IN-3 inhibits EGFR (191.08 nM IC50), HER2 (132.65 nM), CDK9 (113.98 nM); shows anti-tumor effects.Formule :C24H21N3O4S2Couleur et forme :SolidMasse moléculaire :479.57SUN13837
CAS :SUN13837, an oral FGFR modulator, crosses the BBB and shows neuroprotective promise.Formule :C21H29N5O2Couleur et forme :SolidMasse moléculaire :383.49TYK2-IN-11
CAS :TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.Formule :C18H17N5O3SCouleur et forme :SolidMasse moléculaire :383.42EGFR/HER2-IN-3
CAS :EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.Formule :C26H23N5O3Couleur et forme :SolidMasse moléculaire :453.49FLT3-IN-18
CAS :FLT3-IN-18: potent, selective FLT3 inhibitor, IC50 0.003 μM, induces apoptosis, G1 arrest, blocks FLT3/STAT5, potential in AML research.Formule :C26H36N8OCouleur et forme :SolidMasse moléculaire :476.62(R)-Elsubrutinib
CAS :(R)-Elsubrutinib ((R)-ABBV-105) is a Btk inhibitor and an isomer of Elsubrutinib, suitable for inflammation research.Formule :C17H19N3O2Degré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :297.35Ref: TM-T72653
1mg145,00€5mg250,00€10mg340,00€1mL*10mM (DMSO)462,00€25mg573,00€50mg879,00€100mg1.314,00€SJF620
CAS :SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).Formule :C41H44N8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :760.84EGFR-IN-69
CAS :EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.Formule :C31H37Cl2N7O3SCouleur et forme :SolidMasse moléculaire :658.64VEGFR2 Kinase Inhibitor II
CAS :VEGFR2 kinase inhibitor II: Reversible, cell-permeable, targets VEGFR2 (IC50=70nM), less effective on PDGFRβ (IC50=920nM). Blocks VEGF/PDGF-stimulated growth.Formule :C17H15BrN2OCouleur et forme :SolidMasse moléculaire :343.22BLK-IN-1
CAS :BLK-IN-1 selectively blocks BLK and BTK with IC50s of 18.8 and 20.5 nM, used in cancer research.Formule :C29H23F3N6O3Couleur et forme :SolidMasse moléculaire :560.53CPL304110
CAS :CPL304110: oral, selective FGFR 1-3 inhibitor; IC50 - FGFR1: 0.75nM, FGFR2: 0.5nM, FGFR3: 3.05nM.Formule :C25H30N6O2Couleur et forme :SolidMasse moléculaire :446.54EGFR-IN-31
CAS :EGFR-IN-31: Potent EGFR inhibitor, targets mutations & overexpression in NSCLC; potential cancer research compound. (WO2021185298A1, 2)Formule :C32H36FN7O2Couleur et forme :SolidMasse moléculaire :569.67FLT3/D835Y-IN-1
CAS :FLT3/D835Y-IN-1, an oral FLT3 inhibitor (IC50: FLT3 - 0.26 nM, D835Y - 0.18 nM), shows anticancer potential in AML research.Formule :C22H21N5O3Couleur et forme :SolidMasse moléculaire :403.43EGFR-IN-57
CAS :EGFR-IN-57: potent EGFR-TK blocker, IC50 0.054 μM, oral. Halts VEGFR-2, CK2α, topo IIβ, tubulin. Causes G2/M, pre-G1 arrest, cancer cell death.Formule :C22H15N3O2SCouleur et forme :SolidMasse moléculaire :385.44EGFR-IN-60
CAS :EGFR-IN-60: oral anticancer drug, inhibits EGFR/JAK3, effective on H1975/A431 cells, promotes apoptosis.Formule :C28H28Cl2N6OCouleur et forme :SolidMasse moléculaire :535.47ProMMP-9 inhibitor-3c
CAS :ProMMP-9 inhibitor-3c hinders MMP-9 homodimers, blocks proMMP-9/α4β1 integrin/CD44 binding, and detaches EGFR.Formule :C18H20FN3O2SCouleur et forme :SolidMasse moléculaire :361.43ZT55
CAS :ZT55: Oral JAK2 inhibitor, IC50: 0.031 μM, hinders JAK2 V617F HEL cell growth, induces apoptosis, arrests cell cycle, effective in mice HEL tumor studies.Formule :C17H16N2O3Couleur et forme :SolidMasse moléculaire :296.32VEGFR-2-IN-24
CAS :VEGFR-2-IN-24 is a potent inhibitor of VEGFR-2 (IC50: 0.22 μM) and can be used to study tumors.Formule :C28H23N3O6SCouleur et forme :SolidMasse moléculaire :529.56FGFR4-IN-11
CAS :FGFR4-IN-11: selective, covalent FGFR4 inhibitor; IC50=2.1 nM; blocks FGF19 pathway; anticancer.Formule :C29H29N5O5Couleur et forme :SolidMasse moléculaire :527.57c-Met-IN-14
CAS :c-Met-IN-14: selective c-Met kinase inhibitor, IC50 2.89 nM, anticancer, stops G2/M phase, induces A549 cell apoptosis.Formule :C34H38ClFN4O7SCouleur et forme :SolidMasse moléculaire :701.2BI-1622
CAS :BI-1622, an oral HER2 inhibitor, IC50: 7 nM, >25x selectivity over EGFR, shows effective in vivo antitumor activity.Formule :C26H24N10O2Couleur et forme :SolidMasse moléculaire :508.53EGFR-IN-26
CAS :EGFR-IN-26 is an EGFR inhibitor that can be used in cancer research.Formule :C29H34N6O3Couleur et forme :SolidMasse moléculaire :514.62TRK/ALK-IN-1
TRK/ALK-IN-1: Potent dual TRK & ALK inhibitor; IC50s: 2.2nM (TRKA), 9.3nM (ALK WT), 38nM (ALK L1196M); cancer research potential.Formule :C31H35ClF2N8O2SCouleur et forme :SolidMasse moléculaire :657.18FGFR3-IN-1
CAS :FGFR3-IN-1 (compound 1) is a fibroblast growth factor receptor (FGFR) inhibitor that inhibits FGFR1 (IC50: 40 nM), FGFR2 (IC50: 5.1 nM) and FGFR3 (IC50: 12 nM).Formule :C28H39N9O3SCouleur et forme :SolidMasse moléculaire :581.73PHM16
CAS :PHM16 is an ATP competitive FAK and FGFR2 inhibitor.Formule :C20H22N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :410.43EGFR-IN-49
CAS :EGFR-IN-49 selectively inhibits EGFR mutations T790M (IC50: 65 nM) & T790M/L858R (IC50: 13.6 nM), triggering apoptosis dose-dependently.Formule :C22H15N5O2SCouleur et forme :SolidMasse moléculaire :413.45TIE-2/VEGFR-2 kinase-IN-1
CAS :TIE-2/VEGFR-2 kinase-IN-1 synthesizes inhibitors for angiogenesis-related disease research.Formule :C13H11N3O2Couleur et forme :SolidMasse moléculaire :241.25Erbstatin
CAS :Erbstatin is a tyrosine-protein kinase inhibitor. When combined with foroxymithine, it has antineoplastic activity against L-1210 leukemia.Formule :C9H9NO3Couleur et forme :SolidMasse moléculaire :179.17PD-173956
CAS :PD-173956 is an inhibitor of the Src family tyrosine kinases.Formule :C20H13Cl2FN4OCouleur et forme :SolidMasse moléculaire :415.25EGFR-IN-55
CAS :"EGFR-IN-55 targets EGFRWT (70 nM IC50) & EGFRL858R/T790M (3.9 nM IC50), halts NCI-H1975 cell cycle in G0/G1, showing anticancer properties."Formule :C25H25Cl2N7O2Couleur et forme :SolidMasse moléculaire :526.42CP-690550A
CAS :Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.Formule :C15H21N5O2Couleur et forme :SolidMasse moléculaire :303.36Ficonalkib
CAS :Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.Formule :C29H39N7O3SCouleur et forme :SolidMasse moléculaire :565.73EGFR/CDK2-IN-1
CAS :EGFR/CDK2-IN-1, an inhibitor of both EGFR and CDK2, demonstrates effective cytotoxicity towards MCF7 and HepG2 cells, suggesting its potential application inFormule :C19H12BrClO2Couleur et forme :SolidMasse moléculaire :387.65Nazartinib mesylate
CAS :Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).Formule :C27H35ClN6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.12MDK5466
CAS :MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death.Formule :C21H23N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.49HIV-IN-6
CAS :HIV-IN-6, an anti-HIV agent, blocks replication by targeting SFKs like Hck involved with Nef protein.Formule :C20H16N4O3SDegré de pureté :97.78%Couleur et forme :SolidMasse moléculaire :392.43Lavendustin C6
CAS :Lavendustin C6 is a effective tyrosine kinase inhibitor.Formule :C20H25NO5Couleur et forme :SolidMasse moléculaire :359.42TRK II-IN-1
CAS :TRK II-IN-1: potent type II TRK inhibitor; IC50s: TRKA (3.3 nM), TRKB (6.4 nM), TRKC (4.3 nM), TRKA G667C (9.4 nM); also targets FLT3, RET, VEGFR2.Formule :C29H31F3N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.6BTK-IN-23
CAS :BTK-IN-23: BTK inhibitor, IC50=12.8 nM; also blocks BLX (35.6 nM), BMX (5.7 nM); better selectivity than Ibrutinib.Formule :C27H28N6O2Couleur et forme :SolidMasse moléculaire :468.55SMU-B
CAS :SMU-B is a well-tolerated c-Met/ALK dual inhibitor.Formule :C26H25Cl2FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.41EGFR-IN-88
CAS :EGFR-IN-88 (Compound 4i), an EGFR inhibitor with an IC50 of 87 nM, exhibits cytotoxic effects on A549 cells at an IC50 of 3.902 μM and can induce cell apoptosisFormule :C22H18Cl2N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.37BAY 2476568
CAS :BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).Formule :C24H27FN4O4Couleur et forme :SolidMasse moléculaire :454.49FGFR4-IN-5
CAS :FGFR4-IN-5: potent, selective FGFR4 inhibitor, IC50 6.5 nM, strong in vivo anti-tumor effect, for liver cancer research.Formule :C23H23Cl2N5O5Couleur et forme :SolidMasse moléculaire :520.37DPPY
CAS :DPPY inhibits EGFR, BTK, JAK3 (IC50<10 nM), curbs B-cell lymphoma growth, and may be studied for IPF treatment.Formule :C25H26ClN7O3Couleur et forme :SolidMasse moléculaire :507.97
