Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(167 produits)
- Bcr-Abl(118 produits)
- EGFR(581 produits)
- FAK(72 produits)
- FLT(86 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(180 produits)
- JAK(243 produits)
- PDGFR(129 produits)
- RAAS(89 produits)
- Src(82 produits)
- Syk(37 produits)
- Thrombine(57 produits)
- VDA(2 produits)
- VEGFR(242 produits)
Affichez 6 plus de sous-catégories
2387 produits trouvés pour "Angiogenèse"
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JBJ-04-125-02
CAS :JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.Formule :C29H26FN5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :543.61GW 583340 dihydrochloride
CAS :GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.Formule :C28H27Cl3FN5O3S2Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :671.03JAK3i
CAS :JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.Formule :C18H15FN4O3Degré de pureté :98.61% - 99.81%Couleur et forme :SolidMasse moléculaire :354.34MAX-40279
CAS :MAX-40279 is a potent, dual FLT3 kinase and FGFR kinase inhibitor. MAX-40279 has potential for acute myeloid leukemia (AML) studies.Formule :C22H23FN6OSCouleur et forme :SolidMasse moléculaire :438.52EGFR/HER2/TS-IN-1
CAS :EGFR/HER2/TS-IN-1 inhibits EGFR (0.203 μM), HER2 (0.088 μM), TS (0.168 μM), and induces apoptosis in MCF7 cells.Formule :C24H15N5O4S2Couleur et forme :SolidMasse moléculaire :501.54Tyk2-IN-5
CAS :Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).Formule :C21H19FN8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.43Limertinib
CAS :Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.Formule :C29H32ClN7O2Degré de pureté :97.44%Couleur et forme :SolidMasse moléculaire :546.06Ref: TM-T35897
1mg60,00€5mg130,00€1mL*10mM (DMSO)156,00€10mg187,00€25mg341,00€50mg512,00€100mg770,00€200mg1.035,00€LDC0496
CAS :LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.Formule :C32H35N5O3Couleur et forme :SolidMasse moléculaire :537.65T338C Src-IN-2
CAS :T338C Src-IN-2: Potent c-Src T338C kinase inhibitor; IC50: 317 nM, T338C/V323A: 57 nM, T338C/V323S: 19 nM.Formule :C17H18FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :327.36AFG210
CAS :AFG210 is a novel first-generation “type II” FLT3 inhibitor.Formule :C19H14F3N3O2Couleur et forme :SolidMasse moléculaire :373.33M1002
CAS :M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.Formule :C15H8F6N2O2SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :394.29Ref: TM-T61822
1mg49,00€5mg92,00€1mL*10mM (DMSO)108,00€10mg144,00€25mg235,00€50mg350,00€100mg515,00€500mg1.071,00€EGFR-IN-2
CAS :EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.Formule :C26H33N9O3SDegré de pureté :98.52% - 99.79%Couleur et forme :SolidMasse moléculaire :551.66JNJ-64264681
CAS :JNJ-64264681 is a potent, orally active, selective, and irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK).Formule :C27H30N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :518.63VI 16832
CAS :VI 16832 is a broad-spectrum Type I kinase inhibitor used to quantify relative kinase abundance and study signaling across SILAC-encoded cancer cell lines.Formule :C22H25N5O2Degré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :391.47AP 24149
CAS :AP 24149, a potent dual inhibitor targeting Src and Abl, exhibits IC50 values of 9.1 nM for Src and 3.6 nM for Abl, respectively.Formule :C23H24N5OPCouleur et forme :SolidMasse moléculaire :417.44RET-IN-19
CAS :RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.Formule :C28H28N6O4SCouleur et forme :SolidMasse moléculaire :544.62VEGFR-2-IN-23
CAS :VEGFR-2-IN-23 (11b) is a potent VEGFR-2 inhibitor with an IC50 of 0.34 nM, exhibits antitumor effects, and causes G1 cell cycle arrest.Formule :C22H15N5O2Couleur et forme :SolidMasse moléculaire :381.39HSP90-IN-13
CAS :HSP90-IN-13 (5k): potent HSP90 inhibitor, IC50 25.07 nM, targets EGFR/VEGFR-2/Topo-2, blocks MCF-7 G2/M cycle, induces apoptosis.Formule :C26H21N5O3SCouleur et forme :SolidMasse moléculaire :483.54KRN383
CAS :KRN383 inhibits ITD cell growth at ≤2.9 nM, erases ITD tumors in mice at 80 mg/kg dose, and may suit various treatment plans.Formule :C17H17N3O4Couleur et forme :SolidMasse moléculaire :327.33Rac-ZINC4085554
CAS :Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620
Formule :C20H19N3O7Degré de pureté :90%Couleur et forme :SolidMasse moléculaire :413.38Ilorasertib hydrochloride
CAS :Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Formule :C25H22ClFN6O2SDegré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :525FLT3-IN-6
CAS :FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC50 of 1.336 nM.Formule :C23H25N5O3Couleur et forme :SolidMasse moléculaire :419.48DBPR112
CAS :DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.Formule :C32H31N5O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :533.62PF-06651481-00
CAS :PF-06651481-00 (Bosutinib Isomer I) is a Bosutinib analog and a Bcr-Abl inhibitor.
Formule :C26H29Cl2N5O3Degré de pureté :97.01%Couleur et forme :SolidMasse moléculaire :530.45JNJ28871063 hydrochloride
CAS :ErbB receptor family inhibitorFormule :C24H28Cl2N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :519.42Antiproliferative agent-34
CAS :Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.Formule :C27H27N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.55Lck-IN-1
CAS :Lck-IN-1 is a potent inhibitor of lymphocyte protein tyrosine kinase (Lck) [1].Formule :C14H15N5Couleur et forme :SolidMasse moléculaire :253.3JAK3/BTK-IN-1
CAS :JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two importantFormule :C25H28N8ODegré de pureté :97.89%Couleur et forme :SolidMasse moléculaire :456.54AGL 2043
CAS :AGL 2043 is a potent, reversible, ATP-competitive inhibitor of type III receptor tyrosine kinases.Formule :C15H12N4SCouleur et forme :SolidMasse moléculaire :280.35α7 nAchR-JAK2-STAT3 agonist 1
CAS :α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM).Formule :C25H30O6Couleur et forme :SolidMasse moléculaire :426.5JAK3-IN-12
CAS :JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.Formule :C19H19N5O4SCouleur et forme :SolidMasse moléculaire :413.45GZD856
CAS :GZD856 is an orally bioavailable PDGFRα/β inhibitor (IC50s: 68.6 and 136.6 nM) with anti-lung cancer activities.Formule :C29H27F3N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.56FGFR-IN-13
CAS :FGFR-IN-13 (compound III-30), an irreversible covalent inhibitor of the fibroblast growth factor receptor (FGFR), effectively modulates signaling through FGFR1 (IC 50 = 0.20 ± 0.02 nM) and FGFR4 (IC 50 = 0.40 ± 0.03 nM). It suppresses the expression of crucial proteins such as total-PARP and Bcl-2, while enhancing the expression of Cleaved-PARP and Bax in a dose-dependent manner. Notably, FGFR-IN-13 demonstrates considerable antitumor and oral activity [1].Formule :C23H21N5O3Masse moléculaire :415.44CGI560
CAS :CGI560 is a potent BTK inhibitor with IC50 = 400 nM for BTK.Formule :C29H27N5OCouleur et forme :SolidMasse moléculaire :461.56MBM-55S
CAS :MBM-55S, a Nek2 inhibitor with 1 nM IC50, induces cell cycle arrest and apoptosis, suppressing tumor growth.Formule :C36H39FN6O10Degré de pureté :99.37% - 99.89%Couleur et forme :SolidMasse moléculaire :734.73Ref: TM-T11961
1mg185,00€2mg279,00€5mg426,00€10mg627,00€1mL*10mM (DMSO)630,00€25mg938,00€50mg1.320,00€100mg1.786,00€500mg3.591,00€Zotiraciclib HCl
CAS :Zotiraciclib (TG02/SB1317) is a CDK/JAK2/FLT3 inhibitor potentially treating Myc-overexpressing cancers, including glioblastoma.Formule :C23H26Cl2N4OCouleur et forme :SolidMasse moléculaire :445.388AMG-Tie2-1
CAS :AMG-Tie2-1 is a Tie2 and VEGFR2 inhibitor with anticancer and antitumor activity for the study of cardiovascular disease and cancer.Formule :C25H20F3N5O2Degré de pureté :98.9%Couleur et forme :SolidMasse moléculaire :479.45EGFR-IN-56
CAS :EGFR-IN-56 (13a) inhibits EGFR, EGFRT790M (IC50: 541.7nM), EGFRT790M/L858R (IC50: 132.1nM), blocks G2/M phase, and triggers apoptosis.Formule :C23H22N4O3SCouleur et forme :SolidMasse moléculaire :434.51Infigratinib phosphate
CAS :Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, andFormule :C26H34Cl2N7O7PDegré de pureté :99.24% - 99.6%Couleur et forme :SolidMasse moléculaire :658.47JAK-IN-28
CAS :JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].Formule :C20H18ClN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.86BCR-ABL-IN-5
CAS :BCR-ABL-IN-5: Bcr-Abl kinase inhibitor, IC50: Bcr-AblWT 0.014 μM, Bcr-AblT315I 0.45 μM; anti-leukemia cell growth.Formule :C25H21Cl2N5O2Couleur et forme :SolidMasse moléculaire :494.37ALK5-IN-30
CAS :ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM).Formule :C24H25FN8Couleur et forme :SolidMasse moléculaire :444.51FGFR-IN-9
FGFR-IN-9: oral FGFR inhibitor, IC50: 17.1 nM (FGFR4 WT), 29.6 (FGFR3), 30.7 (V550L), 46.7 (FGFR2), 64.3 nM (FGFR1).Formule :C25H28N6O3SCouleur et forme :SolidMasse moléculaire :492.59Luxeptinib
CAS :Luxeptinib (CG-806) is an oral, non-covalent pan-FLT3/BTK inhibitor for acute myeloid leukemia.Formule :C25H17F4N5O2Couleur et forme :SolidMasse moléculaire :495.43Falnidamol
CAS :Falnidamol (BIBX 1382), an oral selective EGFR inhibitor, IC50 3 nM, weak on ErbB2 and others, anti-cancer pyrimido-pyrimidine.Formule :C18H19ClFN7Degré de pureté :98.816%Couleur et forme :SolidMasse moléculaire :387.84Ref: TM-TQ0271
2mg39,00€5mg60,00€1mL*10mM (DMSO)60,00€10mg96,00€25mg182,00€50mg318,00€100mg439,00€200mg612,00€TC-S 7009
CAS :TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization & gene expression.Formule :C12H6ClFN4O3Degré de pureté :99.46% - 99.71%Couleur et forme :SolidMasse moléculaire :308.65VEGFR-3-IN-1
CAS :VEGFR-3-IN-1, a potent VEGFR3 inhibitor (IC50=110.4 nM), hinders tumor growth and VEGFR3 signaling, affecting HDLEC and MDA-MB cell proliferation/migration.Formule :C29H29ClF3N7OSDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :616.1JNJ-49095397
CAS :JNJ-49095397 (RV568) is a p38 MAPK-α and p38 MAPK-γ kinase inhibitor for the study of respiratory syncytial virus infection.Formule :C34H36N6O4Degré de pureté :98.33% - 99.04%Couleur et forme :SolidMasse moléculaire :592.69Sunvozertinib
CAS :Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2.Cost-effective and quality-assured.Formule :C29H35ClFN7O3Degré de pureté :98.11% - 99.63%Couleur et forme :SolidMasse moléculaire :584.08Ref: TM-T64124
1mg34,00€5mg60,00€10mg85,00€25mg124,00€1mL*10mM (DMSO)150,00€50mg200,00€100mg353,00€500mg1.314,00€SI-2 hydrochloride
CAS :SI-2 hydrochloride, an SRC-3 inhibitor, induces breast cancer cell death (IC50: 3-20 nM) with good oral bioavailability.Formule :C15H16ClN5Degré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :301.77Butyzamide
CAS :Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.Formule :C29H32Cl2N2O5SDegré de pureté :99.39% - 99.83%Couleur et forme :SoildMasse moléculaire :591.55Ref: TM-T67894
1mg149,00€5mg253,00€1mL*10mM (DMSO)329,00€10mg371,00€25mg573,00€50mg862,00€100mg1.305,00€200mg1.755,00€PPY A
CAS :PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinase and inhibits the growth of Bcr-Abl T315l mutant or wild-type Bcr-Abl gene-transformed cellsFormule :C22H20N4O2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :372.42Pz-1
CAS :Pz-1 is an inhibitor of VEGFR2 and RET (rearranged during transfection) tyrosine kinase that blocks the blood supply required for RET-stimulated growth.Formule :C26H26N6O2Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :454.52PD 174265
CAS :PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.Formule :C17H15BrN4ODegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :371.23Dasatinib hydrochloride
CAS :Dasatinib hydrochloride is an oral Src/Bcr-Abl inhibitor with potent antitumor effects, Ki values of 16 pM (Src) and 30 pM (Bcr-Abl).Formule :C22H27Cl2N7O2SDegré de pureté :99.88% - 99.98%Couleur et forme :SolidMasse moléculaire :524.47Epitinib succinate
CAS :Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.Formule :C28H32N6O6Degré de pureté :98.02% - 99.79%Couleur et forme :SolidMasse moléculaire :548.59Ref: TM-T35914
1mg72,00€2mg92,00€5mg161,00€10mg258,00€25mg425,00€50mg583,00€100mg800,00€500mg1.603,00€AMPK-IN-3
CAS :AMPK-IN-3: potent, selective AMPK (α2/α1) & KDR inhibitor; IC50: 60.7/107/3820 nM; anticancer in K562 cells.Formule :C25H33N5O3Degré de pureté :97.25%Couleur et forme :SolidMasse moléculaire :451.56PKI-166
CAS :PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth & spread of many human cancers, including pancreatic.Formule :C20H18N4ODegré de pureté :99.2%Couleur et forme :SolidMasse moléculaire :330.38Ref: TM-T16549
2mg39,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg111,00€25mg215,00€50mg358,00€100mg572,00€200mg767,00€EMI1
CAS :EMI1 targets mutated EGFR in drug-resistant NSCLC research.Formule :C20H18N2O3Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :334.37EGFR-IN-9
CAS :EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).Formule :C29H24N4O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :476.53SKLB 1028
CAS :SKLB 1028, an oral EGFR/FLT3/Abl inhibitor, excels in AML and CML with Abl mutations.Formule :C24H29N9Degré de pureté :99.99% - >99.99%Couleur et forme :SolidMasse moléculaire :443.55Ref: TM-T34656
1mg52,00€5mg113,00€1mL*10mM (DMSO)126,00€10mg177,00€25mg358,00€50mg530,00€100mg758,00€500mg1.558,00€c-Fms-IN-3
CAS :c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.Formule :C23H30N6ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :406.52Ref: TM-T10649
1mg52,00€5mg105,00€1mL*10mM (DMSO)110,00€10mg161,00€25mg264,00€50mg358,00€100mg522,00€A-935142
CAS :A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.Formule :C18H19F3N2O2Degré de pureté :98.97% - 99.91%Couleur et forme :SolidMasse moléculaire :352.35Fenlean
CAS :"Fenlean (FLZ) in phase I trial at Chinese Academy's Institute of Pharmacy for Parkinson's treatment."Formule :C26H27NO6Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :449.5Ref: TM-T31773
1mg73,00€2mg98,00€5mg165,00€10mg295,00€25mg532,00€50mg800,00€100mg954,00€200mg1.288,00€JH-VIII-157-02
CAS :JH-VIII-157-02 inhibits ALK, specifically EML4-ALK variants, with IC50s of 2 nM.Formule :C28H27N5O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :465.55Ref: TM-T15612
1mg110,00€5mg227,00€1mL*10mM (DMSO)234,00€10mg339,00€25mg530,00€50mg713,00€100mg982,00€HIF-2α-IN-3
CAS :HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.Formule :C12H6ClN5O5Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :335.66Ref: TM-T11562
1mg73,00€2mg92,00€5mg161,00€1mL*10mM (DMSO)172,00€10mg245,00€25mg480,00€50mg735,00€100mg999,00€200mg1.333,00€Tyrphostin A25
CAS :Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.Formule :C10H6N2O3Degré de pureté :98.98%Couleur et forme :Yellow Green Powder /Off-White SolidMasse moléculaire :202.17Izencitinib
CAS :Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.Formule :C22H26N8Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :402.50Ref: TM-T35898
1mg84,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg281,00€25mg567,00€50mg888,00€100mg1.431,00€200mg1.963,00€MBM-55
CAS :MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM.Formule :C28H27FN6O2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :498.55Ref: TM-T11960
1mg168,00€5mg281,00€1mL*10mM (DMSO)309,00€10mg409,00€25mg627,00€50mg822,00€100mg1.108,00€500mg2.242,00€A 419259 trihydrochloride
CAS :A 419259 trihydrochloride (RK 20449 trihydrochloride) is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn).Formule :C29H37Cl3N6ODegré de pureté :99.75% - 99.96%Couleur et forme :SolidMasse moléculaire :592(R)-Zanubrutinib
CAS :(R)-Zanubrutinib ((R)-BGB-3111) is a selective inhibitor of Bruton tyrosine kinase (BTK).Formule :C27H29N5O3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :471.55Ref: TM-T13447
1mg37,00€5mg80,00€1mL*10mM (DMSO)85,00€10mg133,00€25mg215,00€50mg323,00€100mg442,00€200mg615,00€Chiauranib
CAS :Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Formule :C27H21N3O3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :435.47Ref: TM-T35570
1mg66,00€5mg144,00€1mL*10mM (DMSO)157,00€10mg245,00€25mg492,00€50mg710,00€100mg973,00€ARN25068
CAS :ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.Formule :C19H18N6SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :362.45TP0427736 hydrochloride
CAS :TP0427736 hydrochloride is a novel and selective ALK5 inhibitor, capable of inhibiting Smad2/3 phosphorylation in A549 cells.Formule :C14H11ClN4S2Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :334.85Cloperastine fendizoate
CAS :Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).Formule :C40H38ClNO5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :648.19(Z)-FeCP-oxindole
CAS :(Z)-FeCP-oxindole is a selective inhibitor of VEGFR2 with an IC50 of 200 nM for human. (Z)-FeCP-oxindole shows anticancer activity.Formule :C19H15FeNODegré de pureté :99.63% - 99.84%Couleur et forme :SolidMasse moléculaire :329.17BRD7389
CAS :BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.Formule :C24H18N2O2Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :366.41H-9 dihydrochloride
CAS :H-9 dihydrochloride: Strong PKA inhibitor, curbs 5-HT response and EGF signaling, affects pharyngeal function.Formule :C11H15Cl2N3O2SDegré de pureté :97.3%Couleur et forme :SolidMasse moléculaire :324.23Tilfrinib
CAS :Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities.Formule :C17H13N3ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :275.3Ref: TM-T17098
1mg43,00€2mg56,00€5mg93,00€1mL*10mM (DMSO)93,00€10mg130,00€25mg243,00€50mg439,00€100mg645,00€500mg1.333,00€Rezivertinib
CAS :Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.Formule :C27H30N6O3Degré de pureté :99.26% - 99.98%Couleur et forme :SolidMasse moléculaire :486.57Ref: TM-T36644
1mL*10mM (DMSO)42,00€1mg60,00€5mg130,00€10mg177,00€25mg326,00€50mg467,00€100mg670,00€200mg888,00€CTA 056
CAS :CTA 056 is an ITK inhibitor that inhibits the growth of MOLT-4 xenograft tumors in mice and can be used to study autoimmune disorders.Formule :C35H34N6ODegré de pureté :97.22% - 97.76%Couleur et forme :SolidMasse moléculaire :554.68LY 456236 hydrochloride
CAS :LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM.Formule :C16H16ClN3O2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :317.77Larotinib
CAS :Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.Formule :C24H26ClFN4O4Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :488.94(±)-Zanubrutinib
CAS :(±)-Zanubrutinib ((±)-BGB-3111) is a potent and orally available Bruton's tyrosine kinase (Btk) inhibitor that demonstrates superior oral bioavailability,Formule :C27H29N5O3Degré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :471.55Ref: TM-TQ0039
1mg47,00€5mg92,00€1mL*10mM (DMSO)101,00€10mg145,00€25mg256,00€50mg409,00€100mg587,00€500mg1.215,00€SRX3207
CAS :SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.Formule :C29H29N7O3SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :555.65Nilotinib hydrochloride
CAS :Nilotinib HCl (AMN-107 HCl), an oral Bcr-Abl inhibitor, targets neuroinflammation, cognitive issues, and chronic myelogenous leukemia.Formule :C28H23ClF3N7ODegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :565.98Pimicotinib
CAS :Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.Formule :C22H24N6O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :420.46Ref: TM-T79157
1mg52,00€5mg111,00€1mL*10mM (DMSO)156,00€10mg170,00€25mg329,00€50mg528,00€100mg843,00€PP58
CAS :PP58 is an inhibitor of PDGFR, FGFR and Src family.Formule :C22H19Cl2N5O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :456.32WDR5-0102
CAS :WDR5-0102 inhibits WDR5-MLL1 (Kd=4 μM), blocks MLL1 HMT activity, but doesn't affect SETD7 and 6 other HMTs.
Formule :C18H19ClN4O3Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :374.82EGFR-IN-11
CAS :EGFR-IN-11 selectively blocks EGFR-tyrosine kinase and promotes apoptosis; targets EGFRL858R/T790M/C797S, IC50=18 nM; halts cell cycle at G0/G1.Formule :C29H35N9O2SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :573.71Defactinib hydrochloride
CAS :Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.Formule :C20H22ClF3N8O3SDegré de pureté :98.06% - 98.78%Couleur et forme :SolidMasse moléculaire :546.95MY10
CAS :MY10, a potent and orally active inhibitor of the receptor protein tyrosine phosphatase (RPTPβ/ζ), effectively reduces binge-like ethanol consumption andFormule :C15H10F6OS2Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :384.36Ref: TM-T61678
1mg58,00€5mg126,00€1mL*10mM (DMSO)167,00€10mg197,00€25mg394,00€50mg628,00€100mg982,00€200mg1.314,00€NX-2127
CAS :NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferativeFormule :C39H45N9O5Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :719.83CHMFL-EGFR-202
CAS :CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases).Formule :C25H24ClN7O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :489.96Ref: TM-T10802
1mg109,00€2mg163,00€5mg241,00€1mL*10mM (DMSO)289,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€TG-89
CAS :TG-89 is an inhibitor of JAK2, JAK3, RET and FLT3, and has an IC50 value of 11.2 μM against JAK2, showing anticancer activity in the treatment of ovarian andFormule :C26H34N6O3SDegré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :510.65CGP77675
CAS :CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates andFormule :C26H29N5O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :443.54Vamotinib
CAS :Vamotinib (PF-114) is a tyrosine kinase inhibitor with antiproliferative and antitumor activity.Vamotinib is used in the study of Alzheimer's disease.Formule :C29H27F3N6ODegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :532.56Ref: TM-T63746
1mg101,00€5mg245,00€1mL*10mM (DMSO)288,00€10mg401,00€25mg717,00€50mg982,00€100mg1.341,00€200mg1.783,00€SU16f
CAS :SU16f, a 3-substituted indolin-2-one, is a selective PDGFRβ inhibitor; IC50: 10 nM (PDGFRβ), 140 nM (PDGFR1), 2.29 μM (PDGFR2), halts GC cell growth.Formule :C24H22N2O3Degré de pureté :97.69%Couleur et forme :SolidMasse moléculaire :386.44P505-15 Acetate
CAS :P505-15 Acetate inhibits spleen tyrosine kinase, reduces immune response and inflammation, and lowers arthritis severity.
Formule :C21H27N9O3Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :453.5JAK-STAT-IN-1
CAS :JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.Formule :C21H21N5O2Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :375.42
