Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(167 produits)
- Bcr-Abl(118 produits)
- EGFR(583 produits)
- FAK(72 produits)
- FLT(86 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(180 produits)
- JAK(243 produits)
- PDGFR(129 produits)
- RAAS(89 produits)
- Src(82 produits)
- Syk(37 produits)
- Thrombine(57 produits)
- VDA(2 produits)
- VEGFR(242 produits)
Affichez 6 plus de sous-catégories
2393 produits trouvés pour "Angiogenèse"
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EGFR-IN-11
CAS :EGFR-IN-11 selectively blocks EGFR-tyrosine kinase and promotes apoptosis; targets EGFRL858R/T790M/C797S, IC50=18 nM; halts cell cycle at G0/G1.Formule :C29H35N9O2SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :573.71Epitinib succinate
CAS :Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.Formule :C28H32N6O6Degré de pureté :98.02% - 99.79%Couleur et forme :SolidMasse moléculaire :548.59Ref: TM-T35914
1mg72,00€2mg92,00€5mg161,00€10mg258,00€25mg425,00€50mg583,00€100mg800,00€500mg1.603,00€GTP-14564
CAS :GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3.Formule :C15H10N2ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :234.25EMI1
CAS :EMI1 targets mutated EGFR in drug-resistant NSCLC research.Formule :C20H18N2O3Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :334.37A-935142
CAS :A-935142 enhances hERG (Kv 11.1) channels, slows inactivation, promotes activation, and shortens repolarization.Formule :C18H19F3N2O2Degré de pureté :98.97% - 99.91%Couleur et forme :SolidMasse moléculaire :352.35PP58
CAS :PP58 is an inhibitor of PDGFR, FGFR and Src family.Formule :C22H19Cl2N5O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :456.32TP0427736 hydrochloride
CAS :TP0427736 hydrochloride is a novel and selective ALK5 inhibitor, capable of inhibiting Smad2/3 phosphorylation in A549 cells.Formule :C14H11ClN4S2Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :334.85(±)-Zanubrutinib
CAS :(±)-Zanubrutinib ((±)-BGB-3111) is a potent and orally available Bruton's tyrosine kinase (Btk) inhibitor that demonstrates superior oral bioavailability,Formule :C27H29N5O3Degré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :471.55Ref: TM-TQ0039
1mg47,00€5mg92,00€1mL*10mM (DMSO)101,00€10mg145,00€25mg256,00€50mg409,00€100mg587,00€500mg1.215,00€Chiauranib
CAS :Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Formule :C27H21N3O3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :435.47Ref: TM-T35570
1mg66,00€5mg144,00€1mL*10mM (DMSO)157,00€10mg245,00€25mg492,00€50mg710,00€100mg973,00€Vamotinib
CAS :Vamotinib (PF-114) is a tyrosine kinase inhibitor with antiproliferative and antitumor activity.Vamotinib is used in the study of Alzheimer's disease.Formule :C29H27F3N6ODegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :532.56Ref: TM-T63746
1mg101,00€5mg245,00€1mL*10mM (DMSO)288,00€10mg401,00€25mg717,00€50mg982,00€100mg1.341,00€200mg1.783,00€CGP77675
CAS :CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates andFormule :C26H29N5O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :443.54Conteltinib
CAS :Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.Formule :C32H45N9O3SDegré de pureté :98.12% - 99.54%Couleur et forme :SolidMasse moléculaire :635.82Ref: TM-T14997
1mg70,00€5mg150,00€1mL*10mM (DMSO)205,00€10mg216,00€25mg369,00€50mg517,00€100mg722,00€Sunvozertinib
CAS :Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2.Cost-effective and quality-assured.Formule :C29H35ClFN7O3Degré de pureté :98.11% - 99.63%Couleur et forme :SolidMasse moléculaire :584.08Ref: TM-T64124
1mg34,00€5mg60,00€10mg85,00€25mg124,00€1mL*10mM (DMSO)150,00€50mg200,00€100mg353,00€500mg1.314,00€FM-479
CAS :FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.
Formule :C25H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.523TIE-2/VEGFR-2 kinase-IN-5
CAS :TIE-2/VEGFR-2 kinase-IN-5 is a TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor commonly used in biomedical research related to angiogenesis.Formule :C21H13F6N5O2Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :481.35FC 11
CAS :FC 11 is a reversible FAK PROTAC Degrader with DC50 of 40-370 pM and degrades pFAKtyr397 in TM3 cells within 3 hours at 100 nM.Formule :C41H42F3N13O9SCouleur et forme :SolidMasse moléculaire :949.91BTK-IN-17
BTK-IN-17: selective, oral BTK inhibitor, IC50=13.7 nM, reduces p-BTK Y223/p-PLCγ2 Y1217, anti-inflammatory.Formule :C26H23N7O2Couleur et forme :SolidMasse moléculaire :465.51HER2-IN-5
CAS :HER2-IN-5 is an effective inhibitor of orally active HER-2.Formule :C27H33N7O3Couleur et forme :SolidMasse moléculaire :503.6Nazartinib S-enantiomer
CAS :Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.Formule :C26H31ClN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :495.02EGFR-IN-30
CAS :EGFR-IN-30 is an EGFR inhibitor (IC50: 1-10 nM, <1 nM WT/mutants) with potential in cancer research.Formule :C28H33BrN7O2PCouleur et forme :SolidMasse moléculaire :610.49FGFR-IN-2
CAS :FGFR-IN-2 (compound 1) is a potent inhibitor of FGFR, acting on FGFR1 (IC50: 7.3 nM), FGFR2 (IC50: 4.3 nM), FGFR3 (IC50: 7.6 nM) and FGFR4 (IC50: 11 nM).Formule :C25H30N6O2Couleur et forme :SolidMasse moléculaire :446.54JAK-IN-17
"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."Formule :C33H38F2N6O8Couleur et forme :SolidMasse moléculaire :684.69EGFR-IN-36
CAS :EGFR-IN-36 inhibits EGFR, HER2, & mutants with IC50s: 19.09 nM (EGFR WT), 120.01 nM (HER2 WT), 2.35 nM (HER2 mutant).Formule :C26H25ClN6O2Couleur et forme :SolidMasse moléculaire :488.97BPIQ-I
CAS :BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.Formule :C16H12BrN5Couleur et forme :SolidMasse moléculaire :354.2ALK/EGFR-IN-3
CAS :ALK/EGFR-IN-3 is a dual ALK and EGFR inhibitor that demonstrates potent anti-proliferative effects on various cancer cell lines, including H1975, PC9, and Baf3-Formule :C27H34ClN7O3SCouleur et forme :SolidMasse moléculaire :572.12BMX-IN-1
CAS :BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosineFormule :C29H24N4O4SDegré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :524.59CCT365623 hydrochloride
CAS :CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF.Formule :C18H18ClNO4S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.99DW10075
CAS :DW10075, a novel potent and highly selective inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo.Formule :C29H23N5O3Couleur et forme :SolidMasse moléculaire :489.52DZD1516
CAS :DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in bothFormule :C28H27F2N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :547.56SG3-179
CAS :SG3-179 is a BET inhibitor.Formule :C28H35ClFN7O3SCouleur et forme :SolidMasse moléculaire :604.14Infigratinib-Boc
CAS :Infigratinib-Boc, a derivative of the ATP-competitive pan-FGFR inhibitor Infigratinib, incorporates a Boc (t-Butyloxy carbonyl) group [1].Formule :C29H35Cl2N7O5Couleur et forme :SolidMasse moléculaire :632.54AKB-6899
CAS :AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treatedFormule :C14H11FN2O4Degré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :290.25Simotinib
CAS :Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.Formule :C25H26ClFN4O4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :500.95TIE-2/VEGFR-2 kinase-IN-4
CAS :TIE-2/VEGFR-2 kinase-IN-4, a benzimidazole derivative, serves as a potent inhibitor of the tyrosine kinase receptors TIE-2 and VEGFR-2, exhibiting inhibitoryFormule :C26H17F4N5O4Couleur et forme :SolidMasse moléculaire :539.4410Z-Hymenialdisine
CAS :Pan kinase inhibitorFormule :C11H10BrN5O2Degré de pureté :98%Couleur et forme :Light Yellow SolidMasse moléculaire :324.13FGFR3-IN-7
CAS :FGFR3-IN-7 is a potent, selective inhibitor of FGFR 3, demonstrating an IC50 value of less than 350 nM , and is utilized in cancer research [1].Formule :C25H24FN9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.52HDAC-IN-63
CAS :HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor with IC50 values of 0.844 nM for FLT3 and 30.0 nM for HDAC1.Formule :C25H26Cl2N6O3Couleur et forme :SolidMasse moléculaire :529.42Henatinib
CAS :Henatinib: orally active multi-kinase inhibitor targeting VEGFR-2, c-kit, PDGFR with antitumor effects.Formule :C25H29FN4O4Couleur et forme :SolidMasse moléculaire :468.52DosatiLink-1
CAS :DosatiLink-1 acts as an inhibitor of the Abelson murine leukemia (ABL) enzyme [1].Formule :C69H93Cl2F2N13O17SCouleur et forme :SolidMasse moléculaire :1517.52NMS-P953
CAS :NMS-P953: JAK2 inhibitor, reduces tumor growth in SET-2 model, confirmed in vivo action, good pharmacokinetics and safety.Formule :C16H11ClF3N5OCouleur et forme :SolidMasse moléculaire :381.74ALK/EGFR-IN-2
CAS :ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells.Formule :C27H34ClN7O3SCouleur et forme :SolidMasse moléculaire :572.12EGFR-IN-71
CAS :EGFR-IN-71 is a potent inhibitor of epidermal growth factor receptor (EGFR) (IC50= 3.7 μM). EGFR-IN-71 has research value in chordoma.Formule :C16H9ClIN3Couleur et forme :SolidMasse moléculaire :405.62PI3K/VEGFR2-IN-1
CAS :PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting both PI3K and VEGFR2 with IC50 values of 2.21 μM for PI3K and 68 μM for VEGFR2, respectively.Formule :C17H14ClN3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :343.83Cinsebrutinib
CAS :Cinsebrutinib, a Bruton's tyrosine kinase inhibitor, holds potential for research in cancer treatment.Formule :C22H26FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :383.462′-Thioadenosine
CAS :2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM againstFormule :C10H13N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :283.31JAK-IN-24
CAS :JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.Formule :C20H25N5O2Couleur et forme :SolidMasse moléculaire :367.44Tyrphostin AG1433
CAS :Tyrphostin AG1433 (AG1433) is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).Formule :C16H14N2O2Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :266.29HKI-357
CAS :HKI-357 irreversibly inhibits EGFR/ERBB2 (IC50: 34/33 nM), blocks EGFR Y1068 autophosphorylation, and AKT/MAPK phosphorylation.Formule :C31H29ClFN5O3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :574.05Ref: TM-T11569
2mgÀ demander1mg62,00€5mg125,00€1mL*10mM (DMSO)159,00€10mg188,00€25mg373,00€50mg540,00€100mg787,00€200mg1.035,00€TG 100572 Hydrochloride
CAS :TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.Formule :C26H27Cl2N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.43SNIPER(TACC3)-11
CAS :SNIPER(TACC3)-11 is a powerful FGFR3-TACC3 protein degrader, reducing its amount and hindering FGFR3-TACC3+ cancer cell growth.Formule :C51H66N10O7S2Couleur et forme :SolidMasse moléculaire :995.26SD 1008
CAS :SD 1008 is a JAK2/STAT3 signaling pathway inhibitor. SD 1008 inhibits activation of STAT3, JAK2, and Src.Formule :C18H19NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.35JAK-IN-25
CAS :JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.Formule :C19H17N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :379.37BTK-IN-11
CAS :BTK-IN-11: potent BTK inhibitor; may research autoimmune, inflammatory diseases, cancer. (Patent WO2022063101A1, Z2)Formule :C26H22ClN5O3Couleur et forme :SolidMasse moléculaire :487.94N-desmethyl Regorafenib N-oxide
CAS :N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.Formule :C20H13ClF4N4O4Couleur et forme :SolidMasse moléculaire :484.79JND3229
CAS :JND3229 inhibits EGFRC797S; IC50: 5.8-30.5 nM; halts cell growth; effective in non-small cell lung cancer study.Formule :C33H41ClN8O2Degré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :617.18DDa-1
CAS :DDa-1 is a potent (kinase degrader) [1].Formule :C60H77Cl2N13O3SCouleur et forme :SoildMasse moléculaire :1131.31FLT3/ITD-IN-5
CAS :FLT3/ITD-IN-5 (Example 6) is an orally active inhibitor of both FLT3 and FLT3-ITD, exhibiting IC50 values of 0.088 nM and 0.348 nM, respectively. This compound is utilized in cancer research.Formule :C23H25N7O2Couleur et forme :SolidMasse moléculaire :431.49Risvodetinib
CAS :Risvodetinib: potent inhibitor of protein tyrosine kinases c-Abl1, c-Abl2, and c-kit.Formule :C33H34N8O2Couleur et forme :SolidMasse moléculaire :574.68TIE-2/VEGFR-2 kinase-IN-3
CAS :TIE-2/VEGFR-2 kinase-IN-3, a benzimidazole derivative, serves as a potent inhibitor of the tyrosine kinase receptors TIE-2 and VEGFR-2, exhibiting IC50 valuesFormule :C23H17F4N5O3SCouleur et forme :SolidMasse moléculaire :519.47FGFR3-IN-6
CAS :FGFR3-IN-6 is a potent, selective inhibitor of FGFR 3, exhibiting an IC50 value of less than 350 nM , and is utilized in cancer research [1].Formule :C25H23FN8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.5JAK-IN-26
CAS :JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFormule :C22H24N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.46FGFR4-IN-16
CAS :FGFR4-IN-16 (CY-15-2) is a covalent inhibitor targeting FGFR-4, utilized in cancer research [1].Formule :C35H30Cl2N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :685.56EGFR/HER2-IN-13
CAS :EGFR/HER2-IN-13 (Compd 38) serves as an inhibitor targeting mutant EGFR/HER2s that show resistance to existing drugs. It is primarily utilized in cancer research.Formule :C27H36N8O3Couleur et forme :SolidMasse moléculaire :520.63TAK-659
CAS :TAK-659 is a spleen tyrosine kinase (SYK) inhibitor.Formule :C17H21FN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :344.39AT-9283 L-lactate
CAS :AT-9283 L-lactate is an inhibitor of aurora kinase.Formule :C22H29N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.52JAK-IN-31
CAS :JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,Formule :C21H19N7O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.55HIF-2α-IN-1
CAS :HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.Formule :C16H8F5NO4SDegré de pureté :97.99%Couleur et forme :SolidMasse moléculaire :405.3FGFR-IN-11
CAS :FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (Formule :C28H29ClN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.01BT424
CAS :BT424, a specific HCK inhibitor, modulates macrophage activation and autophagy in vitro, and mitigates inflammation and renal fibrosis in the UUO model [1].Formule :C22H15BCl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.08JAK kinase-IN-1
CAS :JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32Formule :C17H19F2N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.44Pivanex
CAS :Pivanex, an oral HDAC inhibitor, targets metastasis, angiogenesis, reduces Bcr-Abl protein, and promotes apoptosis.Formule :C10H18O4Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :202.25Atiprimod dimaleate
CAS :Atiprimod Dimaleate is a JAK2 inhibitor.Formule :C30H52N2O8Couleur et forme :SolidMasse moléculaire :568.74JGK-068S
CAS :Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].Formule :C22H23BrFN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :488.35Labuxtinib
CAS :Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].Formule :C20H16FN5O2Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :377.37Ref: TM-T79851
1mg132,00€5mg319,00€1mL*10mM (DMSO)354,00€10mg512,00€25mg1.018,00€50mg1.468,00€100mg1.972,00€200mg2.655,00€JAK2-IN-4
CAS :JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.Formule :C23H27N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.56Atiprimod dihydrochloride
CAS :JAK2 inhibitor; IC50=397 nM; hampers STAT3/5 phosphorylation; curbs growth and triggers apoptosis in JAK2V617F+ cells.Formule :C22H46Cl2N2Couleur et forme :SolidMasse moléculaire :409.52Lifirafenib
CAS :Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinantFormule :C25H17F3N4O3Degré de pureté :97.99% - 98%Couleur et forme :SolidMasse moléculaire :478.42Ref: TM-T22272
50mgÀ demander100mgÀ demander1mg34,00€5mg65,00€10mg92,00€1mL*10mM (DMSO)94,00€25mg180,00€Edralbrutinib
CAS :Edralbrutinib (TG-1701) is a potent BTK inhibitor with anticancer activity and is used in the treatment of tumors, immune system disorders, and blood andFormule :C26H21F2N5O3Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :489.47QL-1200186
CAS :QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production followingFormule :C26H27N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :485.54TL02-59
CAS :TL02-59: Fgr inhibitor (IC50=0.03nM), also targets Lyn (0.1nM), Hck (160nM), halts acute myelogenous leukemia growth.Formule :C32H34F3N5O4Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :609.64Ref: TM-T13186
1mg49,00€2mg62,00€5mg93,00€1mL*10mM (DMSO)111,00€10mg133,00€25mg260,00€50mg401,00€100mg557,00€200mg790,00€Cremastranone
CAS :Cremastranone: natural homoisoflavanone that hinders human retinal cell proliferation, migration, and tube creation.Formule :C18H18O7Couleur et forme :SolidMasse moléculaire :346.33JAK-IN-5
CAS :JAK-IN-5 is a JAK inhibitor.Formule :C27H31FN6ODegré de pureté :98.1% - 99.37%Couleur et forme :SolidMasse moléculaire :474.57Ref: TM-T11710
1mg177,00€5mg370,00€1mL*10mM (DMSO)537,00€10mg552,00€25mg879,00€50mg1.189,00€100mg1.603,00€500mg3.205,00€Nezulcitinib
CAS :Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.Formule :C30H37N7O2Couleur et forme :SolidMasse moléculaire :527.66PonatiLink-1-24
CAS :Ponatinib, also known as PonatiLink-1-24, is a selective inhibitor of the Abelson murine leukemia (ABL) enzyme [1].Formule :C101H144ClF5N12O29Couleur et forme :SolidMasse moléculaire :2120.73PF-06250112
CAS :PF-06250112 is an effective and highly selective BTK inhibitor (IC50: 0.5 nM.Formule :C22H20F2N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.43Atiprimod (free base)
CAS :Atiprimod: an oral azaspirane inhibiting STAT3, blocking IL-6/VEGF pathways, and promoting apoptosis by downregulating Bcl-2 and Mcl-1.Formule :C22H44N2Couleur et forme :SolidMasse moléculaire :336.6MTP
CAS :MTP, a PKM2 inhibitor, promotes apoptosis in cancer cells via caspase-3 activation while also inducing autophagy and enhancing ROS generation.Formule :C29H23F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.51BCR-ABL-IN-4
CAS :BCR-ABL-IN-4: Anticancer BCR-ABL inhibitor; stops K562 cells (IC50: 0.67 nM), targets T315I Ba/F3 cells (IC50: 16 nM).Formule :C27H24ClF2N5O4Couleur et forme :SolidMasse moléculaire :555.96Brepocitinib
CAS :Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).Formule :C18H21F2N7ODegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :389.4Ref: TM-TQ0010
1mg34,00€2mg46,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg99,00€25mg205,00€50mg371,00€100mg595,00€200mg833,00€T338C Src-IN-1
CAS :T338C Src-IN-1 is a potent mutant-Src T338C inhibitor(T338C,IC50=111 nM relative to WT c-Src (10-fold increase)).Formule :C17H20N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.4415-deoxy-Δ12,14-Prostaglandin D2
CAS :15-deoxy-Δ12,14-Prostaglandin D2 (15-deoxy-Δ12,14-PGD2) is a PGD2 metabolite functioning as an agonist for the PGD2 receptor 2 (DP2), with a binding affinity (Ki) of 50 nM for the mouse DP2 receptor expressed in HEK293 cell membranes. It activates eosinophils with an EC50 of 8 nM and enhances the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), initiating PPARγ-mediated transcription at 5 µM concentration. Furthermore, it exhibits cytotoxicity towards L1210 murine leukemia cells with an IC50 of 0.3 µg/ml and displays weaker inhibition of ADP-induced platelet aggregation than PGD2, with an IC50 of 320 ng/ml.Formule :C20H30O4Couleur et forme :SolidMasse moléculaire :334.456DosatiLink-2
CAS :DosatiLink-2 is an inhibitor of the Abelson murine leukemia (ABL) enzyme [1].Formule :C65H85Cl2F2N13O15SCouleur et forme :SolidMasse moléculaire :1429.42UNC5293
CAS :UNC5293: potent oral MERTK inhibitor, Ki=190 pM, IC50=0.9 nM; selective vs Axl/Tyro3/Flt3; good mouse PK; used in leukemia research.Formule :C30H42N6O2Couleur et forme :SolidMasse moléculaire :518.69BEBT-109
CAS :BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.Formule :C27H32N8O3Degré de pureté :97.26%Couleur et forme :SolidMasse moléculaire :516.6EGFR-IN-61
CAS :EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 & H1975 cell growth (IC50: 2.14 & 1.82 μM).Formule :C33H37ClN8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :629.15FGFR4-IN-8
CAS :FGFR4-IN-8 is a selective, ATP-competitive FGFR4 inhibitor with IC50s as low as 0.25 nM, halting growth of Hep3B cells at 29 nM and showing in vivo efficacy.Formule :C32H34Cl2FN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.56EGFR kinase inhibitor 1
CAS :Potent EGFR blocker; acts on WT, L858R/T790M (IC50: 1.7 nM), less on T790M/C797S; stalls cell cycle, induces apoptosis, deters metastasis.Formule :C30H31N7O2Couleur et forme :SolidMasse moléculaire :521.61EGFR-IN-85
CAS :EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFRFormule :C26H30N8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.57BMS-599626 Hydrochloride
CAS :BMS-599626 HCl (AC480 HCl) is an oral inhibitor of HER1, HER2, HER4 kinases, potentially blocking tumor growth. IC50: 22/32/190 nM.Formule :C27H28ClFN8O3Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :567.01SIM010603
CAS :SIM010603, an oral RTK inhibitor, targets Kit, VEGFR-2, PDGFR-β, RET, FLT3 (IC50: 5.0-68.1 nmol/l), inhibits cell proliferation and angiogenesis.Formule :C22H25FN4O2Couleur et forme :SolidMasse moléculaire :396.46
