Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(145 produits)
- Bcr-Abl(102 produits)
- EGFR(572 produits)
- FAK(72 produits)
- FLT(92 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(170 produits)
- JAK(245 produits)
- PDGFR(126 produits)
- RAAS(86 produits)
- Src(78 produits)
- Syk(38 produits)
- Thrombine(47 produits)
- VDA(2 produits)
- VEGFR(268 produits)
Affichez 6 plus de sous-catégories
1414 produits trouvés pour "Angiogenèse"
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EW-7195
CAS :<p>EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.</p>Formule :C23H18N8Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :406.44Imatinib D4
CAS :<p>Imatinib D4 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.</p>Formule :C29H31N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :497.63Poseltinib
CAS :<p>Poseltinib is an oral, irreversible BTK inhibitor (IC50 1.95 nM) with higher selectivity over BMX, TEC, and TXK, blocking BCR, FcR, and TLR signaling.</p>Formule :C26H26N6O3Couleur et forme :SolidMasse moléculaire :470.52Bleximenib oxalate
CAS :<p>Bleximenib oxalate (Menin-MLL inhibitor 24 oxalate) is a menin-MLL inhibitor that blocks the binding of the menin-KMT2A complex to chromatin at gene promoters.</p>Formule :C34H52FN7O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :689.82Itacitinib adipate
CAS :<p>Itacitinib adipate: oral JAK1 inhibitor, tested in phase II myelofibrosis trial.</p>Formule :C32H33F4N9O5Couleur et forme :SolidMasse moléculaire :699.66Iruplinalkib
CAS :<p>Iruplinalkib (WX-0593) is an orally active, selective and potent ALK and ROS1 tyrosine kinase inhibitor with anticancer activity for use in the study of non-small cell lung cancer.</p>Formule :C29H38ClN6O2PDegré de pureté :97.38%Couleur et forme :SolidMasse moléculaire :569.08BI-3663
CAS :<p>BI-3663 is a selective PTK2/FAK PROTAC with cereblon ligands, degrading PTK2 (IC50: 18 nM), and shows anti-cancer properties.</p>Formule :C44H42F3N7O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :917.84Aflibercept
CAS :<p>Aflibercept has a wide range of applications in life science related research.</p>Couleur et forme :LiquidLestaurtinib
CAS :<p>Lestaurtinib (CEP 701) is a FLT3 inhibitor that inhibits the phosphorylation of RPTKs and can be used to study leukemia.</p>Formule :C26H21N3O4Degré de pureté :99.17%Couleur et forme :Off-White SolidMasse moléculaire :439.46GMB-475
CAS :<p>GMB-475, a PROTAC-based BCR-ABL1 inhibitor, tackles drug resistance by promoting VHL-mediated degradation.</p>Formule :C43H46F3N7O7SDegré de pureté :98.78% - >99.99%Couleur et forme :SolidMasse moléculaire :861.93Gefitinib-based PROTAC 3
CAS :<p>Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).</p>Formule :C47H57ClFN7O8SDegré de pureté :97.29% - 98.25%Couleur et forme :SolidMasse moléculaire :934.51N-piperidine Ibrutinib
CAS :<p>N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively.</p>Formule :C22H22N6ODegré de pureté :96.65%Couleur et forme :SolidMasse moléculaire :386.45Syk Inhibitor II dihydrochloride
CAS :<p>Syk inhibitor II selectively blocks Syk (IC50 = 41 nM), impacting platelet function and inflammation, with lower potency against other kinases.</p>Formule :C14H17Cl2F3N6ODegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :413.22Merestinib dihydrochloride
CAS :<p>Merestinib dihydrochloride (LY2801653 dihydrochloride) is a kinase inhibitor with antitumor activity that inhibits MET and MKNK1/2.</p>Formule :C30H24Cl2F2N6O3Couleur et forme :SolidMasse moléculaire :625.45Xanthinol Nicotinate
CAS :<p>Xanthinol Nicotinate (Complamin) is a potent vasodilator that can easily enter the cell and causes an increase in glucose metabolism resulting in an increased</p>Formule :C13H21N5O4·C6H5NO2Degré de pureté :99.91%Couleur et forme :White Crystalline PowderMasse moléculaire :434.45Dasatinib N-oxide
CAS :<p>Dasatinib N-oxide is a key metabolite and potential impurity of the kinase inhibitor dasatinib.</p>Formule :C22H26ClN7O3SDegré de pureté :98.54% - 99.94%Couleur et forme :SolidMasse moléculaire :504UF010
CAS :<p>UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively.</p>Formule :C11H15BrN2ODegré de pureté :98.03% - 99.68%Couleur et forme :SolidMasse moléculaire :271.15AMG-47a
CAS :<p>AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.</p>Formule :C29H28F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :535.56Vandetanib hydrochloride
CAS :<p>Vandetanib hydrochloride is an oral VEGFR2 inhibitor with an IC50 of 40 nM, also targeting VEGFR3 (110 nM) and EGFR (500 nM).</p>Formule :C22H25BrClFN4O2Couleur et forme :SolidMasse moléculaire :511.81NVP-BAW2881
CAS :<p>NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor with activity to inhibit chronic and acute skin inflammation.</p>Formule :C22H15F3N4O2Degré de pureté :98.19% - 99.97%Couleur et forme :SolidMasse moléculaire :424.38Arnebin 1
CAS :<p>(Rac)-Arnebin 1 (beta, beta-dimethylacrylshikonin) has anti-tumor, anti-inflammatory, anti-immune deficiency and protecting liver.</p>Formule :C21H22O6Degré de pureté :98.76% - 99.81%Couleur et forme :SolidMasse moléculaire :370.396OICR-9429
CAS :<p>OICR-9429 blocks WDR5 binding to MLL/Histone 3, hindering acute myeloid leukemia cell growth in vitro.</p>Formule :C29H32F3N5O3Degré de pureté :97.07% - 99.93%Couleur et forme :SolidMasse moléculaire :555.59A 83-01
CAS :<p>A 83-01 (ALK5 Inhibitor IV) is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7.</p>Formule :C25H19N5SDegré de pureté :97% - 98.2%Couleur et forme :SolidMasse moléculaire :421.52PX-478
CAS :<p>PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.</p>Formule :C13H20Cl4N2O3Degré de pureté :97% - 99.79%Couleur et forme :SolidMasse moléculaire :394.12Pantoprazole sodium
CAS :<p>Pantoprazole sodium is a proton pump inhibitor that irreversibly blocks gastric acid secretion by bonding with H+/K+-ATPase.</p>Formule :C16H14F2N3NaO4SDegré de pureté :96.92% - 99.81%Couleur et forme :White To Off-White SolidMasse moléculaire :405.35Avitinib
CAS :<p>Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,</p>Formule :C26H26FN7O2Degré de pureté :99.81% - >99.99%Couleur et forme :SolidMasse moléculaire :487.53Cetuximab
CAS :<p>Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM).</p>Formule :C107H179N35O36S7Degré de pureté :95 - 98.60%Couleur et forme :LiquidMasse moléculaire :152 kDaBisindolylmaleimide I
CAS :<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Formule :C25H24N4O2Degré de pureté :98.19% - 98.75%Couleur et forme :Orange SolidMasse moléculaire :412.48A 83-01 sodium salt
CAS :<p>A 83-01 sodium salt inhibits ALK5, ALK4, and ALK7 kinases with IC50s: 12, 45, 7.5 nM.</p>Formule :C25H19N5NaSCouleur et forme :SolidMasse moléculaire :444.51NCGC00262650
CAS :<p>NCGC00262650 is an inhibitor of AMA1-RON2 interaction and c-Src tyrosine kinase activity.</p>Formule :C18H20N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :308.38Midostaurin
CAS :<p>PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.</p>Formule :C35H30N4O4Degré de pureté :97.61% - >99.99%Couleur et forme :SolidMasse moléculaire :570.64MCB-613
CAS :<p>MCB-613 is an effective steroid receptor coactivator (SRC) stimulator.</p>Formule :C20H20N2ODegré de pureté :98.17% - 99.754%Couleur et forme :SolidMasse moléculaire :304.39Takeda-6d
CAS :<p>Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.</p>Formule :C27H19ClFN5O3SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :547.99Vorolanib
CAS :<p>Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.</p>Formule :C23H26FN5O3Degré de pureté :97.35%Couleur et forme :SolidMasse moléculaire :439.48Tranilast
CAS :<p>Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of</p>Formule :C18H17NO5Degré de pureté :99.67% - >99.99%Couleur et forme :White With Light Yellow Crystalline PowderMasse moléculaire :327.33Regorafenib mesylate
CAS :<p>Regorafenib mesylate is an oral multi-kinase inhibitor targeting VEGFR, PDGFRβ, Kit, RET, Raf-1 with strong anti-tumor and anti-angiogenic effects.</p>Formule :C22H19ClF4N4O6SCouleur et forme :SolidMasse moléculaire :578.92GluR6 antagonist-1
CAS :<p>GluR6 antagonist-1 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.</p>Formule :C15H11ClN2OSDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :302.78BMS817378
CAS :<p>BMS817378 is a potent and selective inhibitor of MET(IC50 : 1.7 nM).</p>Formule :C24H18ClF2N4O7PDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :578.85VH-298
CAS :<p>VH-298 blocks VHL:HIF-α interaction, stabilizes HIF-α, and triggers hypoxic response differently by inhibiting VHL post-HIF-α PHD hydroxylation.</p>Formule :C27H33N5O4SDegré de pureté :99.17% - >99.99%Couleur et forme :SolidMasse moléculaire :523.65SPHINX31
CAS :<p>SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50: 5.9 nM).</p>Formule :C27H24F3N5O2Degré de pureté :98.81% - 99.3%Couleur et forme :SolidMasse moléculaire :507.51Ibuprofen Lysine
CAS :<p>Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.</p>Formule :C19H32N2O4Degré de pureté :99.26%Couleur et forme :CoaMasse moléculaire :352.47Gefitinib dihydrochloride
CAS :<p>Gefitinib dihydrochloride: orally active, selective EGFR inhibitor (IC50: 33-54 nM), hinders tumor growth, induces autophagy and apoptosis in cancer research.</p>Formule :C22H26Cl3FN4O3Couleur et forme :SolidMasse moléculaire :519.82Benidipine hydrochloride
CAS :<p>Benidipine hydrochloride (Coniel) , a hydrochloride salt form of benidipine, is used as a blocker of dihydropyridine calcium channel.</p>Formule :C28H32ClN3O6Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :542.03Regorafenib monohydrate
CAS :<p>Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine</p>Formule :C21H17ClF4N4O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :500.83AZD3759 hydrochloride
CAS :<p>AZD3759 hydrochloride is an oral, CNS-penetrant EGFR inhibitor with IC50s of 0.2/0.3/0.2 nM.</p>Formule :C22H24Cl2FN5O3Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :496.361-Naphthyl PP1
CAS :<p>1-Naphthyl PP1 (1-NA-PP 1) is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively)</p>Formule :C19H19N5Degré de pureté :99.85%Couleur et forme :White Cyrstalline SolidMasse moléculaire :317.39CEP-28122 mesylate salt
<p>CEP-28122 mesylate, a diaminopyrimidine, selectively inhibits ALK with IC50 of 1.9 nM and exhibits antitumor effects.</p>Formule :C29H39ClN6O6SCouleur et forme :SolidMasse moléculaire :635.17JK-P3
CAS :<p>JK-P3: a pyrazole inhibitor of VEGFR-2 (IC50: 7.8 μM), stalls FGFR 1/3 in vitro, halts HUVEC wound healing/tube formation, not cell growth.</p>Formule :C18H17N3O3Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :323.35KX2-361
CAS :<p>KX2-361 is a orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma</p>Formule :C24H24FN3O2Degré de pureté :99.64% - 99.68%Couleur et forme :SolidMasse moléculaire :405.46Blu-782
CAS :<p>Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)</p>Formule :C31H42N6O4Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :562.7Vatalanib succinate
CAS :<p>Vatalanib succinate is a VEGFR, PDGFR-β, c-Kit, c-Fms, and aromatase inhibitor.</p>Formule :C24H21ClN4O4Couleur et forme :SolidMasse moléculaire :464.91Filgotinib
CAS :<p>Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.</p>Formule :C21H23N5O3SDegré de pureté :98.03% - ≥95%Couleur et forme :SolidMasse moléculaire :425.5Trastuzumab
CAS :<p>Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.</p>Degré de pureté :98% - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%Couleur et forme :LiquidMasse moléculaire :Approximately 145.53 kDaGusacitinib HCl
CAS :<p>Gusacitinib (ASN-002/EN-3351), a potent SYK/JAK inhibitor, has strong antitumor activity in various cancers.</p>Formule :C24H29ClN8O2Couleur et forme :SolidMasse moléculaire :497HG-14-10-04
CAS :<p>HG-14-10-04 is a potent and specific ALK inhibitor.</p>Formule :C29H34ClN7ODegré de pureté :99.75% - >99.99%Couleur et forme :SolidMasse moléculaire :532.08Brigatinib
CAS :<p>Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.</p>Formule :C29H39ClN7O2PDegré de pureté :97.18% - >99.99%Couleur et forme :SolidMasse moléculaire :584.09CZC-8004
CAS :<p>CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.</p>Formule :C17H16FN5Degré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :309.34DGY-06-116
CAS :<p>DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.</p>Formule :C32H33ClN8O2Degré de pureté :97.65%Couleur et forme :SolidMasse moléculaire :597.11Dovitinib
CAS :<p>Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.</p>Formule :C21H21FN6ODegré de pureté :99.35% - 99.92%Couleur et forme :SolidMasse moléculaire :392.43Acriflavine Hydrochloride
CAS :<p>Acriflavine HCl is a HIF-1α inhibitor reducing PGK1, VEGF, and HIF-1α levels both in vitro and in vivo.</p>Formule :C14H14ClN3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :259.73VEGFR2-IN-2
CAS :<p>VEGFR2-IN-2 has anti-inflammatory and analgesic activities.</p>Formule :C15H11BrN2ODegré de pureté :99.504%Couleur et forme :SolidMasse moléculaire :315.16Radotinib
CAS :<p>Radotinib (IY-5511), and sometimes referred to by its investigational name IY5511, is a drug for the treatment of different types of Y, most notably</p>Formule :C27H21F3N8ODegré de pureté :99.13% - 99.97%Couleur et forme :SolidMasse moléculaire :530.5Tropisetron
CAS :<p>Tropisetron (ICS 205-930) is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.</p>Formule :C17H20N2O2Degré de pureté :99.68%Couleur et forme :White SolidMasse moléculaire :284.35CA-4948
CAS :<p>CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.</p>Formule :C24H25N7O5Degré de pureté :99.35% - 99.88%Couleur et forme :SolidMasse moléculaire :491.5Tivozanib
CAS :<p>Tivozanib (KRN951) is an oral VEGFRs 1-3 inhibitor with potential antiangiogenic and cancer-fighting properties.</p>Formule :C22H19ClN4O5Degré de pureté :98.08% - 99.67%Couleur et forme :SolidMasse moléculaire :454.862,4-DPD
CAS :<p>2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)</p>Formule :C11H13NO4Degré de pureté :99.74%Couleur et forme :Yellow Solid CrystallineMasse moléculaire :223.23Quizartinib HCl
CAS :<p>Quizartinib (AC220/AC010220) is an oral FLT3/STK1 inhibitor for treating AML, blocking kinase-driven cell proliferation and promoting apoptosis.</p>Formule :C29H34Cl2N6O4SCouleur et forme :SolidMasse moléculaire :633.59(S)-Afatinib
CAS :<p>(S)-Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, L858R, L858R/T790M, HER2, and HER4, respectively.</p>Formule :C24H25ClFN5O3Degré de pureté :99.22% - >99.99%Couleur et forme :Off-White SolidMasse moléculaire :485.942-(1,8-naphthyridin-2-yl)phenol
CAS :<p>2-NP is a STAT1 enhancer.</p>Formule :C14H10N2ODegré de pureté :99.33% - 99.82%Couleur et forme :SolidMasse moléculaire :222.24MELK-8a
CAS :<p>MELK-8a inhibits MELK kinase crucial for cancer cell mitosis (IC50: 2 nM).</p>Formule :C25H32N6OCouleur et forme :SolidMasse moléculaire :432.567BIO
CAS :<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Formule :C16H10BrN3O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :356.17Protein kinase inhibitor 6
CAS :<p>Protein kinase inhibitor 6 is a protein kinase inhibitor.</p>Formule :C13H9FN2SDegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :244.29Silymarin
CAS :<p>Silymarin, a liver-aiding polyphenolic flavonoid, is extracted from milk thistle seeds.</p>Formule :C25H22O10Degré de pureté :98%Couleur et forme :Yellow And Brown PowderMasse moléculaire :482.44PD-161570
CAS :<p>PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.</p>Formule :C26H35Cl2N7ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :532.514SC-203
CAS :<p>4SC-203 is a multi-kinase inhibitor with potential anti-tumor activity.Cost-effective and quality-assured.</p>Formule :C33H38N8O4SDegré de pureté :96.4% - 99.67%Couleur et forme :SolidMasse moléculaire :642.775-phenylthieno[2,3-d]pyrimidin-4-amine
CAS :<p>5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.</p>Formule :C12H9N3SDegré de pureté :97%Couleur et forme :SolidMasse moléculaire :227.29CGP77675 hydrate
<p>CGP77675 hydrate: Oral Src family kinase inhibitor with IC50s of 5-20/40 nM (Src auto/phosphorylation) and has anticancer properties.</p>Couleur et forme :SolidAC1NS4RE
CAS :<p>It is a tyrosine kinase inhibitor.</p>Formule :C15H13ClN2ODegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :272.73Momelotinib HCl
CAS :<p>Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.</p>Formule :C23H24Cl2N6O2Couleur et forme :SolidMasse moléculaire :487.38Nastorazepide
CAS :<p>Nastorazepide is a selective, orally available antagonist of gastrin/cholecystokinin 2 (CCK-2) receptor with potential antineoplastic activity.</p>Formule :C29H36N4O5Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :520.62GDC-0214
CAS :<p>GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).</p>Formule :C28H28ClF2N9O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :612.03SB-431542
CAS :<p>SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective.</p>Formule :C22H16N4O3Degré de pureté :99.035% - >99.99%Couleur et forme :SolidMasse moléculaire :384.39Adaphostin
CAS :<p>Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.</p>Formule :C24H27NO4Degré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :393.48(Z)-SU4312
CAS :<p>(Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).</p>Formule :C17H16N2ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :264.32Zorifertinib
CAS :<p>Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor.</p>Formule :C22H23ClFN5O3Degré de pureté :98.20% - 99.36%Couleur et forme :White To Off-White SolidMasse moléculaire :459.9NVP-BSK805 trihydrochloride
CAS :<p>NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.</p>Formule :C27H31Cl3F2N6OCouleur et forme :SolidMasse moléculaire :599.93E-4031 dihydrochloride
CAS :<p>E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)</p>Formule :C21H29Cl2N3O3SDegré de pureté :99.31% - 99.87%Couleur et forme :SolidMasse moléculaire :474.44WS6
CAS :<p>WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>Formule :C29H31F3N6O3Degré de pureté :97.65% - 99.95%Couleur et forme :SolidMasse moléculaire :568.59NRC-2694 hydrochloride
CAS :<p>NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.</p>Formule :C24H27ClN4O3Couleur et forme :SolidMasse moléculaire :454.95NS309
CAS :<p>NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.</p>Formule :C8H4Cl2N2O2Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :231.04SKLB4771
CAS :<p>SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.</p>Formule :C25H27N7O3S2Degré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :537.66Ritlecitinib tosylate
CAS :<p>Ritlecitinib (PF-06651600) is a potent, selective JAK3 inhibitor with proven in vivo efficacy, low clearance, and has undergone clinical trials.</p>Formule :C22H27N5O4SCouleur et forme :SolidMasse moléculaire :457.549Afatinib
CAS :<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Formule :C24H25ClFN5O3Degré de pureté :98.56% - 99.9%Couleur et forme :Off-White SolidMasse moléculaire :485.94EHop-016
CAS :<p>EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.</p>Formule :C25H30N6ODegré de pureté :98.99% - >99.99%Couleur et forme :SolidMasse moléculaire :430.55(E/Z)-Zotiraciclib citrate
<p>(E/Z)-Zotiraciclib ((E/Z)-TG02) citrate is a potent inhibitor of CDK2, JAK2 and FLT3 and can be used in cancer research.</p>Formule :C29H32N4O8Couleur et forme :SolidMasse moléculaire :564.59N-Desethylsunitinib hydrochloride
CAS :<p>N-Desethylsunitinib HCl, active sunitinib metabolite, inhibits VEGFR, PDGFRβ, KIT.</p>Formule :C20H24ClFN4O2Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :406.88AG1557
CAS :<p>AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).</p>Formule :C16H14IN3O2Degré de pureté :98.61% - 99.23%Couleur et forme :SolidMasse moléculaire :407.21Canertinib
CAS :<p>Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.</p>Formule :C24H25ClFN5O3Degré de pureté :98% - >99.99%Couleur et forme :White Or Similar To White Crystalline PowderMasse moléculaire :485.94PF-06651600 malonate
CAS :<p>PF-06651600 is a potent and selective JAK3 inhibitor.</p>Formule :C18H23N5O5Couleur et forme :SolidMasse moléculaire :389.41EBE-A22
CAS :<p>EBE-A22 (PD153035 Analog 63) is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.</p>Formule :C17H16BrN3O2Degré de pureté :99.087% - 99.88%Couleur et forme :SolidMasse moléculaire :374.23
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