Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(166 produits)
- Bcr-Abl(117 produits)
- EGFR(580 produits)
- FAK(72 produits)
- FLT(86 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(180 produits)
- JAK(243 produits)
- PDGFR(129 produits)
- RAAS(89 produits)
- Src(82 produits)
- Syk(37 produits)
- Thrombine(57 produits)
- VDA(2 produits)
- VEGFR(242 produits)
Affichez 6 plus de sous-catégories
2375 produits trouvés pour "Angiogenèse"
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Simotinib hydrochloride
CAS :Simotinib hydrochloride: selective oral EGFR inhibitor, IC50 19.9 nM, potent anticancer agent.Formule :C25H27Cl2FN4O4Couleur et forme :SolidMasse moléculaire :537.41Glaziovine
CAS :Glaziovine is an agent of anti-ulcerogenic natural alkaloid.Formule :C18H19NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :297.35WAY-270250
CAS :WAY-270250 is an IGF-1R/SRC inhibitor.Formule :C18H16N2O2Degré de pureté :99.97%Couleur et forme :SoildMasse moléculaire :292.33Secretin, canine
CAS :Secretin: endocrine hormone, increases bicarbonate-rich pancreatic fluid, regulates canine gastric functions via Src kinase pathway.Formule :C131H222N44O41Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3069.43DBt-10
DBt-10 is a potent Bruton's tyrosine kinase (BTK) degrader [1].Formule :C68H86ClFN16O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1277.96KRAS G12D inhibitor 25
CAS :KRAS G12D inhibitor 25 (Compound 148) acts as an inhibitor for KRAS G12C and HSP90α, displaying IC50 values of <0.1 μM and 0.1-1 μM respectively. Additionally, it suppresses the proliferation of MIA PaCa-2 and NCI-H358 cell lines, with EC50 values of <0.1 μM and 0.1-1 μM correspondingly. This compound also promotes the degradation of ERBB2, exhibiting a DC50 of 0.1-1 μM.Formule :C56H62ClN11O6Couleur et forme :SolidMasse moléculaire :1020.62Bevasiranib
CAS :Bevasiranib is a siRNA targeting VEGF production, key in choroidal neo-vascularization and wet AMD.Couleur et forme :SolidWu-5
CAS :Wu-5 is a potent USP10 inhibitor that inhibits FLT3 and AMPK pathways, promoting the breakdown of FLT3-ITD and inducing apoptosis.Formule :C15H13NO7SDegré de pureté :99.65%Couleur et forme :SoildMasse moléculaire :351.33CN009543V
CAS :CN009543V is an enhancer of tyrosine phosphorylation of EGFR via downstream signaling pathways.Formule :C12H12N4O6SCouleur et forme :SolidMasse moléculaire :340.31Lyn peptide inhibitor
CAS :Inhibits Lyn kinase, blocks IL-5 receptor, prevents eosinophil differentiation and reduces asthma-related inflammation in mice.Formule :C115H184N30O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2370.91EGFR T790M/L858R-IN-2
EGFRT790M/L858R-IN-2: selective inhibitor, IC50: 3.5 nM (mutant), 1290 nM (WT); reduces p-EGFR/AKT/ERK1/2, triggers apoptosis, G1 arrest, anti-cancer.Formule :C28H28FN7OCouleur et forme :SolidMasse moléculaire :497.57PD-149163 hydrochloride
PD-149163 hydrochloride is a neurokinin B agonist with antipsychotic activity, used for research on neurological diseases.Formule :C42H72ClN9O6Couleur et forme :SolidMasse moléculaire :834.53AT-533
CAS :AT-533 inhibits Hsp90, HSV, hinders HIF-1α/VEGF/VEGFR-2, Erk1/2, FAK, Akt/mTOR/p70S6K, and blocks tumor growth, angiogenesis, and HUVEC activities.Formule :C23H30N4O3Degré de pureté :99.67%Couleur et forme :SoildMasse moléculaire :410.51Ref: TM-T67836
1mg37,00€5mg82,00€10mg116,00€25mg207,00€50mg309,00€100mg447,00€200mg600,00€1mL*10mM (DMSO)86,00€BCR-ABL-IN-3
CAS :BCR-ABL-IN-3 irreversibly inhibits Bcr-Abl with <100 nM IC50, showing significant anti-cancer effects.Formule :C20H17ClF2N4O3SCouleur et forme :SolidMasse moléculaire :466.89SJ10542
CAS :SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formule :C41H46N12O5SCouleur et forme :SolidMasse moléculaire :818.95JAK 3 inhibitor IV
CAS :JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found toFormule :C16H19NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :241.33JBJ-09-063 TFA
JBJ-09-063 TFA, an EGFR inhibitor selective for EGFR mutations, IC50s: 0.147-0.396 nM, blocks EGFR/Akt/ERK signaling, for EGFR-mutant lung cancer research.Formule :C33H30F4N4O5SCouleur et forme :SolidMasse moléculaire :670.67EGFR/PI3Kα-IN-1
EGFR/PI3Kα-IN-1 (compound 30k), a dual EGFR/PI3Kα inhibitor, exhibits potent activity with IC 50 values of 3.6 nM (EGFRL858R/T790M) and 30 nM (PI3Kα). It effectively inhibits tumor cell proliferation and demonstrates significant anticancer activity.Formule :C50H49N11O5SCouleur et forme :SolidMasse moléculaire :916.06Emirodatamab
CAS :Emirodatamab (AMG-427) is an anti-FLT3/CD3 bispecific T-cell engager with an extended half-life. It can induce high cytotoxicity in primary AML progenitor cells and enhance FLT-3 expression. Combining Emirodatamab with anti-PD-1 antibodies increases T-cell dependent cytotoxicity (TDCC). This compound is under investigation for use in relapsed or refractory AML.SA-PA
SA-PA, a self-assembled intracellular PROTAC leveraging azide-alkyne click chemistry, selectively degrades VEGFR-2, PDGFR-β, and EphB4 proteins within U87 cellsFormule :C40H32ClF3N10O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :873.19FGFR-IN-14
FGFR-IN-14 (compound 10h) is a pan-FGFR inhibitor. It effectively inhibits FGFR1, FGFR2, FGFR3, and the FGFR2V564F gatekeeper mutant, with IC50 values of 46, 41, 99, and 62 nM, respectively. Additionally, FGFR-IN-14 demonstrates strong antiproliferative effects on NCI-H520 lung cancer cells and SNU-16 and KATO III gastric cancer cells, with IC50 values of 19, 59, and 73 nM, respectively.Formule :C24H19F2N7O2Masse moléculaire :475.15683SJF 1521
CAS :SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.Formule :C57H61ClFN7O9SDegré de pureté :99.20%Couleur et forme :SolidMasse moléculaire :1074.65VEGFR-2-IN-36
VEGFR-2-IN-36 (compound 15) serves as a potent VEGFR-2 inhibitor, exhibiting an IC50 value of 0.067 μM, and acts as an apoptosis inducer with demonstratedFormule :C24H23N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :489.48VEGFR2/HDAC1-IN-1
VEGFR2/HDAC1-IN-1 (compound 13) is a potent dual inhibitor of VEGFR-2 and HDAC, with IC50 values of 57.83 nM for VEGFR-2 and 9.82 nM for HDAC.Degré de pureté :98%Couleur et forme :Odour SolidEmodic acid
CAS :Emodic acid is a useful organic compound for research related to life sciences. The catalog number is T124807 and the CAS number is 478-45-5.Formule :C15H8O7Couleur et forme :SolidMasse moléculaire :300.222FAK-IN-14
CAS :FAK-IN-14 is a FAK inhibitor that induces apoptosis and cell cycle arrest. FAK-IN-14 has a more significant inhibitory effect on FAK, FGFR1 and Pyk2.Formule :C21H24BrN7OSDegré de pureté :99.7%Couleur et forme :SoildMasse moléculaire :502.43PROTAC TYK2 degradation agent1
CAS :PROTAC TYK2 Agent1 selectively degrades TYK2, with a 14 nM DC50, for autoimmune research.Formule :C55H69N13O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1056.28JAK-IN-15
CAS :JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).Formule :C22H23FN4O3SCouleur et forme :SolidMasse moléculaire :442.51PROTAC BTK Degrader-1
CAS :Potent, selective oral PROTAC BTK Degrader-1; IC50: 34.51 nM (WT), 64.56 nM (BTK-481S); reduces BTK protein, inhibits tumors.Formule :C43H43N9O4Couleur et forme :SolidMasse moléculaire :749.86GW297361
CAS :GW297361 is a potent inhibitor of the cell cycle protein-dependent kinase Cdk1 and also inhibits the Pho85 signaling pathway.The IC50s of GW297361 on yeast Cdk1Formule :C16H12N4O3S2Degré de pureté :98.30%Couleur et forme :SolidMasse moléculaire :372.42AS2553627
CAS :AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.Formule :C18H19N5OCouleur et forme :SolidMasse moléculaire :321.38Anticancer agent 133
Compound Rh2 (Anticancer agent 133) is a cytotoxic and antimetastatic agent that induces cell cycle arrest, apoptosis, and autophagy.Formule :C24H19Cl3N5ORhDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.71M4K2234
CAS :M4K2234 (26b) inhibits ALK2/ALK5 (IC50: 5/2144 nM), used as a probe for ALK1/2 kinases in cancer research.Formule :C27H31FN4O2Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :462.56ALK/ROS1-IN-5
ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.
Formule :C32H28F2N4O3Couleur et forme :SolidMasse moléculaire :554.586GSK143
CAS :GSK143: Oral SYK inhibitor, pIC50=7.5, curbs pErk, anti-inflammatory, hinders immune cells in mice.Formule :C17H22N6O2Couleur et forme :SolidMasse moléculaire :342.403FDU73
FDU73 is a potent and selective BTK PROTAC degrader with a DC50 of 2.9 nM in JeKo-1 cells. It inhibits tumor cell proliferation and exhibits antitumor activity.Couleur et forme :Odour SolidSNIPER(ABL)-047
SNIPER(ABL)-047, a compound that links HG-7-85-01 (an ABL inhibitor) to MV-1 (an IAP ligand) via a linker, effectively decreases the BCR-ABL protein levels,Formule :C67H82F3N11O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1274.5Tyrosinase-IN-16
CAS :Tyrosinase-IN-16 inhibited tyrosinase.Formule :C8H6BrN3SDegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :256.12CNX-500
CAS :CNX-500: covalent Btk inhibitor linked to biotin, IC50 0.5 nM, low effect on EGFR and Src kinases.Formule :C48H68N10O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :961.18TL13-112
CAS :TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).Formule :C49H60ClN9O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1002.57LAE-102
LAE-102 is a monoclonal antibody that acts as an antagonist of activin receptor II-A (ACTRIIA/ACVR2). It shows potential for research in the fields of endocrine and metabolic disorders, oncology, and respiratory diseases.Couleur et forme :Odour LiquidEGFR-IN-42
EGFR-IN-42 (17b) is a potent EGFR inhibitor with nanomolar efficacy, merging tamoxifen/endoxifen and gefitinib, exhibiting enhanced anti-cancer action.Formule :C49H53ClFN5O5Couleur et forme :SolidMasse moléculaire :846.433-Hydroxy Midostaurin
CAS :3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of roughly 132 nM inFormule :C35H30N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.648KN1022
CAS :KN1022 is an inhibitor of phosphorylation of platelet-derived growth factor (PDGF) receptor with IC50 of 0.26 μM.Formule :C21H22N6O5Degré de pureté :99.68%Couleur et forme :SoildMasse moléculaire :438.44SC209
CAS :SC209, a STRO-002 metabolite from patent WO2021247798, synthesizes anti-EGFR ADCs.Formule :C27H44N4O4Couleur et forme :SolidMasse moléculaire :488.66HDS 029
CAS :HDS 029 has a wide range of applications in life science related research.Formule :C17H11ClFN5OCouleur et forme :SolidMasse moléculaire :355.76Os30
Os30 is a potent fourth-generation EGFR inhibitor, specifically targeting the EGFRC797S-TK mutation with IC50 values of 18 nM for EGFRDel19/T790M/C797S TK andDegré de pureté :98%Couleur et forme :Odour SolidFLT3-IN-20
FLT3-IN-20 (compound 34f) is a potent FLT3 inhibitor, demonstrating IC50 values of 1 nM for FLT3-D835Y and 4 nM for FLT3-ITD.Formule :C28H33N7O2SCouleur et forme :SolidMasse moléculaire :531.67SPP-037
SPP-037 is an orally active selective inhibitor of ST6GAL1, with an IC50 of 3.59 μM. It exhibits anti-migration activity against MDA-MB-231 cells by inhibiting integrin α2,6-sialylation and the integrin-FAK-paxillin pathway. In MDA-MB-231 xenograft mouse models, SPP-037 demonstrates antitumor properties. This compound is applicable in breast cancer research.Formule :C36H50ClN3O9SCouleur et forme :SolidMasse moléculaire :735.29563SOS1/EGFR-IN-2
SOS1/EGFR-IN-2 (Compound 4) functions as a dual inhibitor of SOS1 and EGFR, exhibiting IC50 values of 8.3 and 14.6 nM, respectively. It demonstrates significant antiproliferative effects on cancer cells harboring various KRAS mutations.Formule :C25H29F3N4O3Couleur et forme :SolidMasse moléculaire :490.52Multi-kinase-IN-4
Multi-kinase-IN-4 (compound 5d) is a multi-targeted kinase inhibitor active against VEGFR2, EGFR, HER2, and CDK2, with respective IC50 values of 0.33, 0.22, 0.Formule :C21H20ClFN2OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.91VSLRGDTRG acetate
VSLRGDTRG acetate is a synthetic peptide of the RGD motif from cadherin17 (CDH17), capable of binding to α2β1 integrin and activating its signaling pathways. It facilitates the high-affinity conformational change of β1 integrin via the RGD motif, enhancing cell adhesion and phosphorylation of FAK and ERK1/2, thereby promoting tumor proliferation and metastasis. VSLRGDTRG acetate is applicable in research on cancers expressing CDH17, such as colon and pancreatic cancers.Couleur et forme :Odour SolidEGFR-IN-140
EGFR-IN-140 (Compound 31) is an inhibitor of EGFR, effectively targeting both wild-type EGFR and the EGFRL858R/T790M/C797S mutant, with Ki values of 0.95 nM and 2.1 nM, respectively. Additionally, it inhibits EGFRdel19/T790M/C797S in Ba/F3 cells with an IC50 of 56.9 nM and demonstrates antitumor activity in mouse models.Formule :C27H37FN8O2Couleur et forme :SolidMasse moléculaire :524.633SJF620 hydrochloride
CAS :SJF620 hydrochloride is a PROTAC that utilizes a lenalidomide analog to recruit CRBN and ligands to target Btk, exhibiting a DC50 of 7.9 nM [1].Formule :C41H45ClN8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :797.3MS9449
CAS :MS9449 is a powerful EGFR PROTAC; Kd: 17 nM (WT), 10 nM (L858R); targets mutant EGFRs via UPS and autophagy; hinders NSCLC cell growth.Formule :C60H76ClFN10O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1151.82PF15
CAS :PF15, a PROTAC for FLT3-ITD, degrades FLT3 kinase. DC50: 76.7 nM; hinders FLT3-ITD+ cell growth; potential in leukemia.Formule :C44H49N13O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :855.94QL-X-138 HCl
QL-X-138 HCl is a BTK/MNK dual kinase inhibitor with anticancer activity and anti-dengue virus 2 activity that inhibits BTK, MNK1, and MNK2 kinases.Formule :C25H20ClN5O2Degré de pureté :99.25%Couleur et forme :SoildMasse moléculaire :457.91DSPE-PEG2000-A7R
DSPE-PEG2000-A7R is a PEG compound consisting of DSPE and a tumor vasculature-targeting peptide (A7R). A7R exhibits high affinity and specificity for VEGFR-2, a receptor that is overexpressed in various tumors.Couleur et forme :Odour SolidDSPE-PEG5000-GE11
DSPE-PEG5000-GE11 is a PEG compound composed of DSPE and the EGFR-targeting peptide (GE11). GE11 is applicable for cancer cells with EGFR overexpression. DSPE-PEG5000-GE11 is utilized in drug delivery.Couleur et forme :Odour SolidEGFR-IN-43
EGFR-IN-43 (17c) is a potent EGFR inhibitor with ER antagonist action, tamoxifen/endoxifen+gefitinib linkage, and strong anticancer activity.Formule :C50H55ClFN5O5Couleur et forme :SolidMasse moléculaire :860.45AZ12672857
CAS :AZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM.
Formule :C26H30N8O2Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :486.57WYE-687
CAS :WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Formule :C28H32N8O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :528.61PACAP-38 (31-38), human, mouse, rat
CAS :PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine productionFormule :C47H83N17O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1062.27FLT3/IRAK4-IN-1
FLT3/IRAK4-IN-1 is a selective inhibitor of FLT3 and IRAK4, exhibiting significant activity against FLT3-WT (IC50= 1.95 nM), FLT3-D835Y (IC50= 3.22 nM), and IRAK4 (IC50= 53.72 nM). It demonstrates low cytotoxicity towards normal bone marrow cells, effectively promotes apoptosis, and has potential to overcome resistance. FLT3/IRAK4-IN-1 can be utilized in studies of acute myeloid leukemia (AML).Couleur et forme :Odour SolidK882
K882 (Compound 4e) is an Src inhibitor with a KD of 0.315 μM. It induces apoptosis and inhibits XIAP and Survivin. Additionally, K882 blocks the activation of the PI3K/Akt/mTOR, Jak1/Stat3, and Ras/MAPK signaling pathways. K882 exhibits antitumor activity against non-small cell lung cancer.Formule :C18H16N2O2Couleur et forme :SolidMasse moléculaire :292.33SNIPER(ABL)-044
SNIPER(ABL)-044, a compound that links HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, achieving aFormule :C51H64F3N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1020.17LH168
LH168 is a potent and selective probe for WDR5, with a SPR Kd value of 13 nM.Formule :C29H31F3N6O2SCouleur et forme :SolidMasse moléculaire :584.66FLT3-IN-21
FLT3-IN-21 (compound LC-3), a potent FLT3 inhibitor with an IC50 value of 8.4 nM, induces apoptosis and arrests the cell cycle in the G1 phase.Formule :C20H22FN5O2Couleur et forme :SolidMasse moléculaire :383.42PROTAC BTK Degrader-2
CAS :PROTAC BTK Degrader-2, a potent degrader of BTK through the PROTAC mechanism, effectively diminishes BTK protein levels [1].Formule :C47H54F2N8O13Couleur et forme :SolidMasse moléculaire :976.97dALK-3
dALK-3 is a degrader of anaplastic lymphoma kinase (ALK) that effectively induces the degradation of EML4-ALK with a DC50 of 0.182 μM. It exhibits significant antiproliferative activity against H3122 cells and is applicable for tumor research.Formule :C39H45ClN7O5PCouleur et forme :SolidMasse moléculaire :758.245FAK-IN-24
CAS :FAK-IN-24 (Compound 9f) is a potent FAK inhibitor with an IC50 of 0.815 nM. It induces DNA damage and apoptosis, and exhibits activity against glioblastoma. FAK-IN-24 effectively inhibits proliferation of glioblastoma cell lines U87-MG (IC50= 15 nM) and U251 (IC50= 20 nM), and suppresses tumor growth in U87-MG xenograft models.Formule :C39H45Cl2F3N8O3Couleur et forme :SolidMasse moléculaire :801.728HAT-SIL-TG-1&AT
HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.Formule :C60H69N17O11SCouleur et forme :SolidMasse moléculaire :1236.36FLT3/VEGFR2-IN-1
FLT3/VEGFR2-IN-1 (Compound 26) is a potent inhibitor of FLT3, VEGFR2, and HDAC, exhibiting IC50 values of 14.5 nM, 3.9 nM, and 30.8 nM against FLT3, VEGFR2, and HDAC1, respectively. It effectively inhibits the phosphorylation of STAT3 and ERK1/2, as well as the proliferation of leukemia cells. FLT3/VEGFR2-IN-1 demonstrates antitumor activity and is applicable in research on acute myeloid leukemia.Formule :C29H35N7O5Couleur et forme :SolidMasse moléculaire :561.63hCA/VEGFR-2-IN-1
hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual inhibitor targeting both Carbonic Anhydrase (CA) IX/XII and Vascular Endothelial Growth Factor Receptor 2 (Formule :C21H17FN6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.46FAK PROTAC B5
CAS :FAK PROTAC B5: a degrader with 14.9 nM IC50, strong degradation, anti-growth, good plasma stability, and fair permeability.Formule :C41H43ClN10O7Couleur et forme :SolidMasse moléculaire :823.3EGFR-IN-131
EGFR-IN-131 (compound 3a) is an efficacious EGFR inhibitor capable of crossing the blood-brain barrier, with an IC50 value of 272.9 nM. This compound exhibits anti-proliferative activity, induces cellular apoptosis (apoptosis), and causes cell cycle arrest in the G0/G1 phase. Additionally, EGFR-IN-131 reduces the protein expression of p-EGFR.Formule :C26H23FN4O2SCouleur et forme :SolidMasse moléculaire :474.55LC-SF-14
LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR, with IC50 values of 71.6 nM and 8.9 nM, respectively. It blocks FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation, and also inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM). Furthermore, LC-SF-14 exhibits antitumor activity in SNU-16 xenograft mouse models, making it suitable for research on FGFR2-driven gastric cancer.Formule :C44H50Cl3N13O5SCouleur et forme :SolidMasse moléculaire :977.28442PROTAC FLT3/CDK9 degrader-1
Potent PROTAC degrader for FLT3/CDK9, induces apoptosis, and shows promise for FLT3-ITD mutated AML research.Formule :C48H62N12O7Couleur et forme :SolidMasse moléculaire :919.08BIIB091
CAS :BIIB091 is a highly selective, reversible BTK inhibitor for treating autoimmune diseases.Formule :C28H34N10O2Couleur et forme :SolidMasse moléculaire :542.648FLT3-IN-23
FLT3-IN-23 (compound 15), a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3), exhibits an IC 50 value of 7.42 nM and demonstrates antiproliferative effectsCouleur et forme :Odour SolidFGFR1 inhibitor-2
CAS :FGFR1 inhibitor-2, potent at 4.55 μM IC50 in MDA-MB-231, targets triple-negative breast cancer.Formule :C25H22F5N3O3Couleur et forme :SolidMasse moléculaire :507.461Sotiburafusp alfa
CAS :Sotiburafusp alfa is a humanized bispecific fusion protein comprising a VEGFR-1 extracellular domain fragment (129-228, 1-100 in the current sequence) connectedDegré de pureté :98%Couleur et forme :SolidBefotertinib
CAS :Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer.Formule :C29H32F3N7O2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :567.61Ref: TM-T39275
1mg84,00€5mg177,00€10mg281,00€25mg497,00€50mg708,00€100mg973,00€1mL*10mM (DMSO)222,00€Ibrutinib-biotin
CAS :Ibrutinib-biotin probe links Ibrutinib to biotin, with IC50 0.755-1.02 nM for BTK (patent WO2014059368A1).Formule :C56H80N12O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1097.39VEGFR/PARP-IN-1
VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively.Formule :C29H27N9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.58VEGFR-2-IN-61
VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with an IC50 of 2.83 µM. It effectively inhibits the proliferation of various cancer cells, including MCF-7 cells, with an IC50 of 2.12 µM. Additionally, VEGFR-2-IN-61 suppresses cell migration and induces oxidative stress and apoptosis in MCF-7 cells.Formule :C27H25N5OCouleur et forme :SolidMasse moléculaire :435.52Adenosine receptor modulator 1
Adenosine receptor modulator 1 acts as an inducer of collagen VII (C7). It enhances the expression of COL7A1 mRNA in donor-derived keratinocytes and, in synergy with Gentamicin, increases the overall levels of C7.Formule :C25H28N6O3Couleur et forme :SolidMasse moléculaire :460.53AKN-028
CAS :AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
Formule :C17H14N6Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :302.33TLT8
TLT8 is a ByeTAC protein degrader that targets BTK. It induces BTK degradation by non-covalently binding to Rpn-13 and BTK. TLT8 is applicable in research on chronic lymphocytic leukemia.Couleur et forme :Odour SolidCS-VIP 8 TFA
CS-VIP 8 TFA is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 μM). It induces a conformational change in the MLL1 complex, leading to the dissociation of MLL1 from the complex, thereby inhibiting the MLL1 histone methyltransferase activity and modulating HOX gene expression. CS-VIP 8 TFA shows potential for research in hematological disorders such as leukemia.Formule :C45H53F7N12O9Couleur et forme :SolidMasse moléculaire :1038.39467EGFR-TK-IN-5
EGFR-TK-IN-5 (Compound NCE 2) is a thiazolyl pyrazoline derivative with significant inhibitory activity and stability against EGFR. It is applicable in tumor research.Formule :C26H20ClFN4OSCouleur et forme :SolidMasse moléculaire :490.98LCB 03-0110
CAS :LCB 03-0110 (3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol) is a potent inhibitor of discoidin domain receptor family tyrosine kinasesFormule :C24H23N3O2SDegré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :417.52Ref: TM-T9659
1mg115,00€5mg249,00€10mg368,00€25mg562,00€50mg787,00€100mg1.054,00€1mL*10mM (DMSO)280,00€SNIPER(ABL)-020
SNIPER(ABL)-020, a Dasatinib-Bestatin conjugate via linker, inhibits ABL and targets IAP, reducing BCR-ABL protein.Formule :C44H59ClN10O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :923.52EGFR-IN-83
EGFR-IN-83 (Compound 9), an EGFR inhibitor with an IC50 of 2.53 nM, exhibits antiproliferative effects on MCF-7 and MDA-MB-231 cell lines, with respective IC50Formule :C22H17F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :410.39DSPE-PEG5000-A7R
DSPE-PEG5000-A7R is a PEG compound composed of DSPE and the tumor vascular targeting peptide (A7R). The peptide A7R exhibits high affinity and specificity for VEGFR-2, which is overexpressed in various tumors.Couleur et forme :Odour SolidFAK-IN-9
CAS :FAK-IN-9 (8f) is a potent oral FAK inhibitor, IC50 of 27.44 nM; induces TNBC cell apoptosis.Formule :C36H38ClN7O8SCouleur et forme :SolidMasse moléculaire :764.25GC1118
GC1118 (GC-1118A) is a fully human anti-EGFR monoclonal antibody with a KD value of 0.16 nM against EGFR. It potently inhibits signal transduction triggered by both high-affinity and low-affinity EGFR ligands. GC1118 exhibits strong antiproliferative activity in both KRAS wild-type and KRAS mutant cells. It can penetrate the blood-brain barrier (BBB) and blood-tumor barrier (BTB) to reach tumor sites and demonstrates excellent antitumor effects in various mouse xenograft models. GC1118 is applicable for cancer studies, including colorectal cancer.Couleur et forme :Odour LiquidRR-src
CAS :Tyrosine kinase substrate peptideFormule :C64H106N22O21Degré de pureté :98%Couleur et forme :Lyophilized PowderMasse moléculaire :1519.663-Methylthienyl-carbonyl-JNJ-7706621
CAS :Potent CDK inhibitor 3-Methylthienyl-carbonyl-JNJ-7706621, IC50: CDK1=6.4nM, CDK2=2nM, GSK-3=0.041μM; moderate on CDK4/VEGF-R2/FGF-R2.Formule :C14H14N6O3S2Couleur et forme :SolidMasse moléculaire :378.43PROTAC EGFR degrader 5
CAS :PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.Formule :C57H72FN13O5SCouleur et forme :SolidMasse moléculaire :1070.33
