Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(145 produits)
- Bcr-Abl(102 produits)
- EGFR(572 produits)
- FAK(72 produits)
- FLT(92 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(170 produits)
- JAK(245 produits)
- PDGFR(126 produits)
- RAAS(86 produits)
- Src(78 produits)
- Syk(38 produits)
- Thrombine(47 produits)
- VDA(2 produits)
- VEGFR(268 produits)
Affichez 6 plus de sous-catégories
1414 produits trouvés pour "Angiogenèse"
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Vandetanib hydrochloride
CAS :<p>Vandetanib hydrochloride is an oral VEGFR2 inhibitor with an IC50 of 40 nM, also targeting VEGFR3 (110 nM) and EGFR (500 nM).</p>Formule :C22H25BrClFN4O2Couleur et forme :SolidMasse moléculaire :511.81(Z)-SU4312
CAS :<p>(Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).</p>Formule :C17H16N2ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :264.321-Naphthyl PP1
CAS :<p>1-Naphthyl PP1 (1-NA-PP 1) is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively)</p>Formule :C19H19N5Degré de pureté :99.85%Couleur et forme :White Cyrstalline SolidMasse moléculaire :317.39Gefitinib dihydrochloride
CAS :<p>Gefitinib dihydrochloride: orally active, selective EGFR inhibitor (IC50: 33-54 nM), hinders tumor growth, induces autophagy and apoptosis in cancer research.</p>Formule :C22H26Cl3FN4O3Couleur et forme :SolidMasse moléculaire :519.82RGB-286638 free base
CAS :<p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>Formule :C29H35N7O4Degré de pureté :98% - 99.91%Couleur et forme :SolidMasse moléculaire :545.63E-4031 dihydrochloride
CAS :<p>E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)</p>Formule :C21H29Cl2N3O3SDegré de pureté :99.31% - 99.87%Couleur et forme :SolidMasse moléculaire :474.44WS6
CAS :<p>WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>Formule :C29H31F3N6O3Degré de pureté :97.65% - 99.95%Couleur et forme :SolidMasse moléculaire :568.59Quizartinib HCl
CAS :<p>Quizartinib (AC220/AC010220) is an oral FLT3/STK1 inhibitor for treating AML, blocking kinase-driven cell proliferation and promoting apoptosis.</p>Formule :C29H34Cl2N6O4SCouleur et forme :SolidMasse moléculaire :633.597BIO
CAS :<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Formule :C16H10BrN3O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :356.17NS309
CAS :<p>NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.</p>Formule :C8H4Cl2N2O2Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :231.04Epidermal Growth Factor
CAS :<p>EGF binds EGFR, promotes cell growth & heals diabetic foot ulcers.</p>Formule :C270H401N73O83S7Degré de pureté :97.17%Couleur et forme :SolidMasse moléculaire :6222Tranilast
CAS :<p>Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of</p>Formule :C18H17NO5Degré de pureté :99.67% - >99.99%Couleur et forme :White With Light Yellow Crystalline PowderMasse moléculaire :327.33Cetuximab
CAS :<p>Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM).</p>Formule :C107H179N35O36S7Degré de pureté :95 - 98.60%Couleur et forme :LiquidMasse moléculaire :152 kDaSB-431542
CAS :<p>SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective.</p>Formule :C22H16N4O3Degré de pureté :99.035% - >99.99%Couleur et forme :SolidMasse moléculaire :384.39GDC-0214
CAS :<p>GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).</p>Formule :C28H28ClF2N9O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :612.03Afatinib
CAS :<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Formule :C24H25ClFN5O3Degré de pureté :98.56% - 99.9%Couleur et forme :Off-White SolidMasse moléculaire :485.94NVP-BSK805 trihydrochloride
CAS :<p>NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.</p>Formule :C27H31Cl3F2N6OCouleur et forme :SolidMasse moléculaire :599.93Zorifertinib
CAS :<p>Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor.</p>Formule :C22H23ClFN5O3Degré de pureté :98.20% - 99.36%Couleur et forme :White To Off-White SolidMasse moléculaire :459.9Semaxinib
CAS :<p>Semaxinib (SU5416): potent VEGFR2 inhibitor, 20x more selective over PDGFRβ, not active on InsR/EGFR/FGFR, blocks ATP on VEGFR2, may reduce tumor vessels.</p>Formule :C15H14N2ODegré de pureté :99.84%Couleur et forme :Yellow To Yellow OrangeMasse moléculaire :238.28SKLB4771
CAS :<p>SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.</p>Formule :C25H27N7O3S2Degré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :537.66AG1557
CAS :<p>AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).</p>Formule :C16H14IN3O2Degré de pureté :98.61% - 99.23%Couleur et forme :SolidMasse moléculaire :407.21Canertinib
CAS :<p>Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.</p>Formule :C24H25ClFN5O3Degré de pureté :98% - >99.99%Couleur et forme :White Or Similar To White Crystalline PowderMasse moléculaire :485.94Theliatinib tartrate
CAS :<p>Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.</p>Formule :C29H32N6O8Couleur et forme :SolidMasse moléculaire :592.6PF-06651600 malonate
CAS :<p>PF-06651600 is a potent and selective JAK3 inhibitor.</p>Formule :C18H23N5O5Couleur et forme :SolidMasse moléculaire :389.41SU 4313
CAS :<p>SU 4313 is a bioactive chemical.</p>Formule :C18H17NODegré de pureté :99.51% - 99.89%Couleur et forme :SolidMasse moléculaire :263.33EBE-A22
CAS :<p>EBE-A22 (PD153035 Analog 63) is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.</p>Formule :C17H16BrN3O2Degré de pureté :99.087% - 99.88%Couleur et forme :SolidMasse moléculaire :374.23BAY 61-3606 HCl
CAS :<p>BAY 61-3606 HCl: a reversible Syk inhibitor, halts mast cell degranulation, cytokines, and sensitizes MCF-7 cells to TRAIL-induced apoptosis.</p>Formule :C20H19ClN6O3Couleur et forme :SolidMasse moléculaire :426.86ZM39923 hydrochloride
CAS :<p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>Formule :C23H25NO·HClDegré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :367.91AMG 925 HCl
CAS :<p>AMG 925 HCl is a selective and potent dual inhibitor of FLT3 (IC50: 2±1 nM) and CDK4 (IC50: 3±1 nM).</p>Formule :C26H30ClN7O2Couleur et forme :SolidMasse moléculaire :508.02Seralutinib
CAS :<p>Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.</p>Formule :C27H27N5O3Degré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :469.54Verteporfin
CAS :<p>Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions.</p>Formule :C41H42N4O8Degré de pureté :95.37% - 99.82%Couleur et forme :Dark Green To Black SolidMasse moléculaire :718.79DGY-06-116
CAS :<p>DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.</p>Formule :C32H33ClN8O2Degré de pureté :97.65%Couleur et forme :SolidMasse moléculaire :597.11Vactosertib Hydrochloride
CAS :<p>Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.</p>Formule :C22H19ClFN7Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :435.89Pacritinib hydrochloride
CAS :<p>Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.</p>Formule :C28H32N4O3·xClHCouleur et forme :SolidWS3
CAS :<p>WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>Formule :C28H30F3N7O3Degré de pureté :97.93% - 99.94%Couleur et forme :SolidMasse moléculaire :569.58Endoxifen (Z-isomer)
CAS :<p>Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.</p>Formule :C25H27NO2Degré de pureté :99.19% - 99.81%Couleur et forme :SolidMasse moléculaire :373.49Fostamatinib
CAS :<p>Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.</p>Formule :C23H26FN6O9PDegré de pureté :93.08% - 99.38%Couleur et forme :SolidMasse moléculaire :580.46(Z)-Semaxinib
CAS :<p>(Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition for</p>Formule :C15H14N2ODegré de pureté :98.82% - ≥95%Couleur et forme :SolidMasse moléculaire :238.28Ensartinib
CAS :<p>Ensartinib (X-396) is a potent and orally active dual ALK/MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).</p>Formule :C26H27Cl2FN6O3Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :561.44Avitinib maleate
CAS :<p>Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.</p>Formule :C30H30FN7O6Degré de pureté :98% - 99.74%Couleur et forme :SolidMasse moléculaire :603.61FGFR2-IN-3 hydrochloride
CAS :<p>FGFR2-IN-3 hydrochloride is a selective, orally active FGFR2 inhibitor.</p>Formule :C28H25ClFN7O2Couleur et forme :SolidMasse moléculaire :546.0Radotinib
CAS :<p>Radotinib (IY-5511), and sometimes referred to by its investigational name IY5511, is a drug for the treatment of different types of Y, most notably</p>Formule :C27H21F3N8ODegré de pureté :99.13% - 99.97%Couleur et forme :SolidMasse moléculaire :530.5AG-1557 hydrochloride (189290-58-2(free base))
<p>AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).</p>Formule :C16H15ClIN3O2Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :443.66Protein kinase inhibitor 6
CAS :<p>Protein kinase inhibitor 6 is a protein kinase inhibitor.</p>Formule :C13H9FN2SDegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :244.29Nastorazepide
CAS :<p>Nastorazepide is a selective, orally available antagonist of gastrin/cholecystokinin 2 (CCK-2) receptor with potential antineoplastic activity.</p>Formule :C29H36N4O5Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :520.62Lificiguat
CAS :<p>Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha</p>Formule :C19H16N2O2Degré de pureté :98.85% - 99.92%Couleur et forme :SolidMasse moléculaire :304.34Naluzotan
CAS :<p>Naluzotan（PRX 00023） is a novel and potent 5-HT1A agonist with IC50 and Ki values of approximately 20 nM and 5.1 nM, respectively.Naluzotan is a potent hERG K+</p>Formule :C23H38N4O3SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :450.64ASP3026
CAS :<p>ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies,and Positive for Anaplastic Lymphoma Kinase.</p>Formule :C29H40N8O3SDegré de pureté :98.78% - 99.81%Couleur et forme :SolidMasse moléculaire :580.742,4-DPD
CAS :<p>2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)</p>Formule :C11H13NO4Degré de pureté :99.74%Couleur et forme :Yellow Solid CrystallineMasse moléculaire :223.232-(1,8-naphthyridin-2-yl)phenol
CAS :<p>2-NP is a STAT1 enhancer.</p>Formule :C14H10N2ODegré de pureté :99.33% - 99.82%Couleur et forme :SolidMasse moléculaire :222.24AG 1406
CAS :<p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>Formule :C16H18N2ODegré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :254.33Bafetinib
CAS :<p>Bafetinib (INNO-406): Dual Bcr-Abl/Lyn inhibitor; IC50: 5.8/19 nM; ineffective against T315I mutant, less on c-Kit/PDGFR.</p>Formule :C30H31F3N8ODegré de pureté :94.16% - 99.68%Couleur et forme :SolidMasse moléculaire :576.62PRT062607 hydrochloride
CAS :<p>PRT062607 hydrochloride (P505-15 Hydrochloride) is a selective inhibitor of Syk. PRT062607 displays at least 80-fold selectivity for Syk over other kinases.</p>Formule :C19H23N9O·HClDegré de pureté :97.7% - 99.81%Couleur et forme :SolidMasse moléculaire :429.91Tropisetron
CAS :<p>Tropisetron (ICS 205-930) is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.</p>Formule :C17H20N2O2Degré de pureté :99.68%Couleur et forme :White SolidMasse moléculaire :284.35EHop-016
CAS :<p>EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.</p>Formule :C25H30N6ODegré de pureté :98.99% - >99.99%Couleur et forme :SolidMasse moléculaire :430.55Filgotinib maleate
CAS :<p>Filgotinib maleate, a selective oral JAK1 inhibitor, treats RA and Crohn's. IC50s: JAK1-10nM, JAK2-28nM, JAK3-810nM, TYK2-116nM.</p>Formule :C25H27N5O7SCouleur et forme :SolidMasse moléculaire :541.58BMS 599626 2HCl
CAS :<p>BMS 599626 2HCl (873837-23-1(HCl)) (AC480 dihydrochloride) is a selective inhibitor of HER1 and HER2 (IC50s: 20 nM and 30 nM), ~8-fold less potent to HER4, >100</p>Formule :C27H29FN8O3Cl2Degré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :603.48Regorafenib
CAS :<p>Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally</p>Formule :C21H15ClF4N4O3Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :482.82KRCA-0008
CAS :<p>KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.</p>Formule :C30H37ClN8O4Degré de pureté :96.19%Couleur et forme :SolidMasse moléculaire :609.12N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
CAS :<p>Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.</p>Formule :C22H18BrN7Degré de pureté :99.935%Couleur et forme :SolidMasse moléculaire :460.33NRC-2694 hydrochloride
CAS :<p>NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.</p>Formule :C24H27ClN4O3Couleur et forme :SolidMasse moléculaire :454.95Epitinib
CAS :<p>Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).</p>Formule :C24H26N6O2Couleur et forme :SolidMasse moléculaire :430.5(E/Z)-Zotiraciclib citrate
<p>(E/Z)-Zotiraciclib ((E/Z)-TG02) citrate is a potent inhibitor of CDK2, JAK2 and FLT3 and can be used in cancer research.</p>Formule :C29H32N4O8Couleur et forme :SolidMasse moléculaire :564.59PKI-166 hydrochloride
CAS :<p>EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.</p>Formule :C20H19ClN4OCouleur et forme :SolidMasse moléculaire :366.85Treprostinil Sodium
CAS :<p>Treprostinil Sodium (UT-15) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).</p>Formule :C23H33NaO5Degré de pureté :99.67% - >99.99%Couleur et forme :SolidMasse moléculaire :412.5Ritlecitinib tosylate
CAS :<p>Ritlecitinib (PF-06651600) is a potent, selective JAK3 inhibitor with proven in vivo efficacy, low clearance, and has undergone clinical trials.</p>Formule :C22H27N5O4SCouleur et forme :SolidMasse moléculaire :457.549ALK kinase inhibitor-1
CAS :<p>SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.</p>Formule :C28H32FN5O3SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :537.65Afatinib Dimaleate
CAS :<p>Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.</p>Formule :C32H33ClFN5O11Degré de pureté :98.11% - 99.87%Couleur et forme :SolidMasse moléculaire :718.08Atopaxar hydrochloride
CAS :<p>Atopaxar hydrochloride is used in the Treatment of Cardiovascular Disorders.</p>Formule :C29H39ClFN3O5Couleur et forme :SolidMasse moléculaire :564.1Vandetanib trifluoroacetate
CAS :<p>Vandetanib trifluoroacetate: oral VEGFR2/KDR inhibitor, IC50=40nM, also blocks VEGFR3/FLT4 (110nM) and EGFR/HER1 (500nM).</p>Formule :C24H25BrF4N4O4Couleur et forme :SolidMasse moléculaire :589.386Cevidoplenib dimesylate hydrochloride
CAS :<p>Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory properties.</p>Formule :C90H132Cl5N27O12Degré de pureté :97.52%Couleur et forme :SolidMasse moléculaire :1957.9Dapagliflozin
CAS :<p>Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.</p>Formule :C21H25ClO6Degré de pureté :99.5% - 99.93%Couleur et forme :SolidMasse moléculaire :408.87MGCD-265 analog
CAS :<p>Glesatinib, an oral tyrosine kinase inhibitor, targets c-Met and VEGFR2 with IC50s of 29 nM and 10 nM, may treat cancer.</p>Formule :C26H20FN5O2S2Degré de pureté :98.06% - 98.68%Couleur et forme :SolidMasse moléculaire :517.6Cabozantinib hydrochloride
CAS :<p>Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6</p>Formule :C28H25ClFN3O5Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :537.96Derazantinib dihydrochloride
CAS :<p>Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.</p>Formule :C29H31Cl2FN4OCouleur et forme :SolidMasse moléculaire :541.49Tandutinib hydrochloride
CAS :<p>Tandutinib hydrochloride: FLT3 inhibitor (IC50 0.22 μM), targets c-Kit, PDGFR, treats AML, crosses blood-brain barrier.</p>Formule :C31H43ClN6O4Couleur et forme :SolidMasse moléculaire :599.16(S)-Sunvozertinib
CAS :<p>(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.</p>Formule :C29H35ClFN7O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :584.08ZM323881
CAS :<p>ZM323881 is a potent and selective inhibitor of VEGFR2 with an IC 50 of less than 2 nM.</p>Formule :C22H18FN3O2Couleur et forme :SolidMasse moléculaire :375.4Saracatinib difumarate
CAS :<p>Saracatinib difumarate is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities.</p>Formule :C35H40ClN5O13Couleur et forme :SolidMasse moléculaire :774.18TG 100801
CAS :<p>TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).</p>Formule :C33H30ClN5O3Degré de pureté :99.28% - 99.61%Couleur et forme :SolidMasse moléculaire :580.08AZ 5104
CAS :Produit contrôlé<p>Applications AZ 5104 is a derivative of AZD 9291 (A808075) is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).<br>References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);<br></p>Formule :C27H31N7O2Couleur et forme :Off-WhiteMasse moléculaire :485.58N-Acryloyl Osimertinib (>85%)
CAS :<p>Applications N-Acryloyl Osimertinib is used in the preparation of pyrimidinyl indole derivative as EGFR inhibitor for targeted therapy of cancer<br>References Rao, Y., et al.: Faming Zhuanli Shenqing (2016), CN 105777716 A 20160720<br></p>Formule :C31H35N7O3Degré de pureté :>85%Couleur et forme :Off White SolidMasse moléculaire :553.65SB 203580 hydrochloride
CAS :<p>SB 203580 hydrochloride (Adezmapimod hydrochloride) is a p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy.</p>Formule :C21H17ClFN3OSDegré de pureté :97.79%Couleur et forme :SolidMasse moléculaire :413.9CCT241161
CAS :<p>CCT241161: oral pan-RAF inhibitor; IC50s: LCK (3 nM), CRAF (6), SRC (10), V600E-BRAF (15), BRAF (30); fights BRAF/NRAS melanomas, anti-proliferative.</p>Formule :C28H27N7O3SDegré de pureté :99.76% - 99.77%Couleur et forme :SolidMasse moléculaire :541.62rac-Clopidogrel Hydrochloride
CAS :<p>Impurity Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B<br>Applications Clopidogrel Related Compound B (Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B) is a tetrahydrothienopyridine as inhibitor of angiogenesis.<br>References Maffrand, J. P., et al.: Eur. J. Med. Chem., 9, 483 (1974), Thebault, J.J., et al.: Clin. Pharmacol. Ther., 18, 485 (1975),<br></p>Formule :C16H16ClNO2S·ClHCouleur et forme :NeatMasse moléculaire :358.28rac trans-3-Hydroxy Apatinib Dihydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Dihydrochloride salt of trans-3-Hydroxy Apatinib, a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br>References Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>Formule :C24H25Cl2N5O2Couleur et forme :NeatMasse moléculaire :486.39Glycerol 1-Monobutyrate (Technical Grade)
CAS :<p>Applications Glycerol 1-Monobutyrate functions as a key regulatory molecule in angiogenic process.<br>References Dobson, D. E., et al.: Cell (Cambridge, MA, U. S.), 61, 223 (1990)<br></p>Formule :C7H14O4Couleur et forme :NeatMasse moléculaire :162.18Dapolsertib
CAS :<p>Dapolsertib (SEL24-B489) is an orally active and efficient PIM and FLT3-ITD inhibitor, reducing PIM-specific substrate phosphorylation.</p>Formule :C15H18Br2N4O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :446.14Itacnosertib
CAS :<p>Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells,antitumor and antileukemic.</p>Formule :C26H28N8ODegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :468.55Seribantumab
CAS :<p>Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting cancer cell proliferation.</p>Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :143.2 (kDa)Amivantamab
CAS :<p>Amivantamab (JNJ-61186372) is an antibody that recognizes EGFR and MET and has anticancer and antitumor activities.</p>Degré de pureté :97.24% (SEC-HPLC) - 99.74%Couleur et forme :LiquidMasse moléculaire :145.88 kDaTirabrutinib
CAS :<p>Tirabrutinib, an oral Btk inhibitor (IC50=6.8 nM), crosses the BBB and halts B cell signaling for autoimmune and hematologic studies.</p>Formule :C25H22N6O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :454.48α-Eudesmol
CAS :<p>Applications α-Eudesmol is an isomer of β-Eudesmol (E938600), a sesquiterpenoid known to induce neurite outgrowth. β-Eudesmol exhibits antiangiogenic activity.<br>References Obara, Y. et al.: J. Pharmacol. Exp . Ther., 30, 803 (2011); Tsuneki, H. et al.: Eur. J. Pharmacol., 512, 105 (2005);<br></p>Formule :C15H26OCouleur et forme :White To Off-WhiteMasse moléculaire :222.37Cpd27
CAS :<p>Cpd27 (TIE-2/VEGFR-2 kinase-IN-2) is a TIE-2 and VEGFR-2 inhibitor that inhibits RIPK1 and can be used to study glaucoma.</p>Formule :C20H13F4N5O2Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :431.34SB-505124 hydrochloride
CAS :<p>SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.</p>Formule :C20H22ClN3O2Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :371.863,3-Azo-1-butanol
CAS :Produit contrôléFormule :C4H8N2OCouleur et forme :NeatMasse moléculaire :100.12Cavutilide
CAS :<p>Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.</p>Formule :C22H26FN3O3Degré de pureté :99.82% - 99.85%Couleur et forme :SolidMasse moléculaire :399.458Donafenib
CAS :<p>Donafenib(Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3,</p>Formule :C21H13ClD3F3N4O3Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :467.84AZ 12799734
CAS :<p>AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.</p>Formule :C18H18N4O3SDegré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :370.43Behenamide
CAS :Produit contrôlé<p>Applications Behenamide is a fatty acid amide as an angiogenic. The mechanism of angiogenic activity is unknown and this lipid does not promote proliferation of endothelial cells or induce inflammatory effects.<br>References Wakamatsu, K., et al.: Biochem. Biophysical Res. Comm., 168, 423 (1990),<br></p>Formule :C22H45NOCouleur et forme :White To Off-WhiteMasse moléculaire :339.6
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