Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(166 produits)
- Bcr-Abl(117 produits)
- EGFR(553 produits)
- FAK(72 produits)
- FLT(88 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(176 produits)
- JAK(243 produits)
- PDGFR(127 produits)
- RAAS(86 produits)
- Src(82 produits)
- Syk(37 produits)
- Thrombine(51 produits)
- VDA(2 produits)
- VEGFR(236 produits)
Affichez 6 plus de sous-catégories
2277 produits trouvés pour "Angiogenèse"
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I194496
CAS :I194496 is an effective inhibitor of cystathionine γ-lyase (CSE) with an IC50 value of 0.79 mM. It inhibits the growth of human TNBC cells by dual targeting the PI3K/Akt and Ras/Raf/ERK pathways. Additionally, I194496 suppresses the metastasis of human TNBC cells by downregulating the Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways.Formule :C28H23F2N5O5SCouleur et forme :SolidMasse moléculaire :579.58TYK2 ligand 2
CAS :TYK2ligand 2 is the TYK2 ligand of PROTACTYD-68. TYD-68 is a highly potent and selective CRBN-recruiting TYK2 PROTAC degrader with a DC50 value of 0.42 nM.Formule :C24H20FN7O4Couleur et forme :SolidMasse moléculaire :489.458VEGFR-2-IN-10
VEGFR-2-IN-10 has enhanced antiangiogenic potency against VEGFR2 phosphorylation induced by VEGF with an IC50 value of 0.7 μM and no cytotoxic effects.Formule :C20H21N3O2Couleur et forme :SolidMasse moléculaire :335.4Tyrphostin 63
CAS :Tyrphostin 63 (compound 13) is an epidermal growth factor receptor (EGFR) inhibitor, with an IC50 of 375 μM and a Ki of 123 μM.Formule :C10H8N2OCouleur et forme :SolidMasse moléculaire :172.183EGFR-IN-23
CAS :EGFR-IN-23, identified as compound 8 in WO2021244502A1, is a potent EGFR tyrosine kinase inhibitor (TKI) demonstrating an inhibitory concentration (IC50) of 8.Formule :C36H44BrN10O3PCouleur et forme :SolidMasse moléculaire :775.68Londamocitinib
CAS :Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.Formule :C28H31F2N7O4SDegré de pureté :98.64% - 99.56%Couleur et forme :SolidMasse moléculaire :599.65Ref: TM-T11706
1mg170,00€5mg416,00€10mg567,00€25mg858,00€50mg1.108,00€100mg1.485,00€1mL*10mM (DMSO)537,00€Oxamic acid
CAS :Oxamic acid is an LDHA inhibitor, antitumor, induces apoptosis, downregulates EGFR expression, and inhibits cancer stem cell properties and EMT.Formule :C2H3NO3Couleur et forme :SolidMasse moléculaire :89.05JAK-2/3-IN-3
JAK-2-/3-IN-3 (ST4j) is a potent JAK2/3 inhibitor for leukemia research, with IC50s: JAK2, 13 nM; JAK3, 14.86 nM; induces apoptosis.Formule :C13H10Cl2N4O2Couleur et forme :SolidMasse moléculaire :325.15YLIU-4-105-1
CAS :YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.Formule :C32H34F3N7O2Couleur et forme :SolidMasse moléculaire :605.65FGFR-IN-15
FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.Formule :C22H23N5O5SCouleur et forme :SolidMasse moléculaire :469.51EGFR-IN-47
EGFR-IN-47: strong oral EGFRL858R/T790M/C797S blocker, induces cell death; promising for NSCLC research. IC50: 0.01 μM.Formule :C29H35N7Couleur et forme :SolidMasse moléculaire :481.64FGFR1 inhibitor-15
CAS :FGFR1inhibitor-15 (Compound 23) is an FGFR1 inhibitor with an IC50 value of 27 μM, useful for tumor research.Formule :C17H13FN4OCouleur et forme :SolidMasse moléculaire :308.31Tandutinib sulfate
CAS :Tandutinib (MLN518) sulfate is an effective and selective inhibitor of FLT3, with an IC50 value of 0.22 μM. It also inhibits c-Kit and PDGFR, displaying IC50 values of 0.17 μM and 0.20 μM respectively. This compound can be utilized in the treatment of acute myeloid leukemia and has the capability to cross the blood-brain barrier.Formule :C31H44N6O8SCouleur et forme :SolidMasse moléculaire :660.78Andamertinib
CAS :Andamertinib is an EGFR inhibitor with antitumor activity.Formule :C31H36N8O3Couleur et forme :SolidMasse moléculaire :568.669SYHA1815
CAS :SYHA1815, an orally active RET inhibitor (IC50=0.9 nmol/L), demonstrates antitumor activity. It exhibits greater selectivity for RET over KDR (IC50=15.9 nmol/L). SYHA1815 operates by downregulating c-Myc, arresting the G1 cell cycle, and inhibiting RET-driven cell proliferation.Formule :C27H26ClF4N5OCouleur et forme :SolidMasse moléculaire :547.98BPI-15086
CAS :BPI-15086 is an orally active, effective, irreversible inhibitor selective for mutations, targeting both EGFR and the T790M resistance mutation tyrosine kinase. It can be utilized in the study of non-small cell lung cancer.Formule :C29H33ClN8O4Couleur et forme :SolidMasse moléculaire :593.08Cernuumolide J
CAS :Cernuumolide J (TMJ-105) functions as a JAK2/STAT3 inhibitor and exhibits potent activity against HEL leukemia cells by inhibiting their growth in both time-dependent and concentration-dependent manners, with an IC 50 value of 1.79 μM. This compound effectively induces G2/M phase arrest and apoptosis by downregulating the phosphorylation of JAK2, STAT3, and Erk, while simultaneously upregulating the phosphorylation of JNK and p38 MAPK. Cernuumolide J holds potential for research applications in anti-cancer therapy.Formule :C24H34O8Couleur et forme :SolidMasse moléculaire :450.52EGFR/VEGFR2-IN-3
CAS :EGFR/VEGFR2-IN-3 (compound 9) is an effective inhibitor of EGFR and VEGFR-2, demonstrating IC50 values of 0.129 µM for EGFR, 0.142 µM for VEGFR-2, and 3.428 µM for COX-2. This compound exhibits cytotoxic properties and induces cell apoptosis (apoptosis) as well as cell cycle arrest at the G2/M phase.Formule :C24H20ClN5O2S2Couleur et forme :SolidMasse moléculaire :510.03HER2-IN-12
HER2-IN-12 is an HER2 inhibitor with an IC50 value of 121 nM and can be used to study cancers such as breast cancer.Formule :C17H18BrN5O2SCouleur et forme :SolidMasse moléculaire :436.33VEGFR-IN-3
CAS :VEGFR-IN-3 inhibits cancer cell growth (OVCAR-4, MDA-MB-468) with IC50s: 0.29, 0.35μM. Used in cancer research.Formule :C27H28N2O6Couleur et forme :SolidMasse moléculaire :476.52
