Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(145 produits)
- Bcr-Abl(102 produits)
- EGFR(572 produits)
- FAK(72 produits)
- FLT(92 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(170 produits)
- JAK(245 produits)
- PDGFR(126 produits)
- RAAS(86 produits)
- Src(78 produits)
- Syk(38 produits)
- Thrombine(47 produits)
- VDA(2 produits)
- VEGFR(268 produits)
Affichez 6 plus de sous-catégories
1414 produits trouvés pour "Angiogenèse"
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Ensartinib
CAS :<p>Ensartinib (X-396) is a potent and orally active dual ALK/MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).</p>Formule :C26H27Cl2FN6O3Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :561.44Nastorazepide
CAS :<p>Nastorazepide is a selective, orally available antagonist of gastrin/cholecystokinin 2 (CCK-2) receptor with potential antineoplastic activity.</p>Formule :C29H36N4O5Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :520.62Filgotinib maleate
CAS :<p>Filgotinib maleate, a selective oral JAK1 inhibitor, treats RA and Crohn's. IC50s: JAK1-10nM, JAK2-28nM, JAK3-810nM, TYK2-116nM.</p>Formule :C25H27N5O7SCouleur et forme :SolidMasse moléculaire :541.58Epidermal Growth Factor
CAS :<p>EGF binds EGFR, promotes cell growth & heals diabetic foot ulcers.</p>Formule :C270H401N73O83S7Degré de pureté :97.17%Couleur et forme :SolidMasse moléculaire :6222Regorafenib
CAS :<p>Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally</p>Formule :C21H15ClF4N4O3Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :482.82KRCA-0008
CAS :<p>KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.</p>Formule :C30H37ClN8O4Degré de pureté :96.19%Couleur et forme :SolidMasse moléculaire :609.12Lificiguat
CAS :<p>Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha</p>Formule :C19H16N2O2Degré de pureté :98.85% - 99.92%Couleur et forme :SolidMasse moléculaire :304.34N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
CAS :<p>Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.</p>Formule :C22H18BrN7Degré de pureté :99.935%Couleur et forme :SolidMasse moléculaire :460.33(E/Z)-Zotiraciclib citrate
<p>(E/Z)-Zotiraciclib ((E/Z)-TG02) citrate is a potent inhibitor of CDK2, JAK2 and FLT3 and can be used in cancer research.</p>Formule :C29H32N4O8Couleur et forme :SolidMasse moléculaire :564.59Epitinib
CAS :<p>Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).</p>Formule :C24H26N6O2Couleur et forme :SolidMasse moléculaire :430.5NRC-2694 hydrochloride
CAS :<p>NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.</p>Formule :C24H27ClN4O3Couleur et forme :SolidMasse moléculaire :454.95PKI-166 hydrochloride
CAS :<p>EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.</p>Formule :C20H19ClN4OCouleur et forme :SolidMasse moléculaire :366.85Ritlecitinib tosylate
CAS :<p>Ritlecitinib (PF-06651600) is a potent, selective JAK3 inhibitor with proven in vivo efficacy, low clearance, and has undergone clinical trials.</p>Formule :C22H27N5O4SCouleur et forme :SolidMasse moléculaire :457.549ALK kinase inhibitor-1
CAS :<p>SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.</p>Formule :C28H32FN5O3SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :537.65Afatinib Dimaleate
CAS :<p>Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.</p>Formule :C32H33ClFN5O11Degré de pureté :98.11% - 99.87%Couleur et forme :SolidMasse moléculaire :718.08Atopaxar hydrochloride
CAS :<p>Atopaxar hydrochloride is used in the Treatment of Cardiovascular Disorders.</p>Formule :C29H39ClFN3O5Couleur et forme :SolidMasse moléculaire :564.1HA 155
CAS :<p>HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.</p>Formule :C24H19BFNO5SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :463.29Vandetanib trifluoroacetate
CAS :<p>Vandetanib trifluoroacetate: oral VEGFR2/KDR inhibitor, IC50=40nM, also blocks VEGFR3/FLT4 (110nM) and EGFR/HER1 (500nM).</p>Formule :C24H25BrF4N4O4Couleur et forme :SolidMasse moléculaire :589.386Dapagliflozin
CAS :<p>Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.</p>Formule :C21H25ClO6Degré de pureté :99.5% - 99.93%Couleur et forme :SolidMasse moléculaire :408.87Cevidoplenib dimesylate hydrochloride
CAS :<p>Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory properties.</p>Formule :C90H132Cl5N27O12Degré de pureté :97.52%Couleur et forme :SolidMasse moléculaire :1957.9Semaxinib
CAS :<p>Semaxinib (SU5416): potent VEGFR2 inhibitor, 20x more selective over PDGFRβ, not active on InsR/EGFR/FGFR, blocks ATP on VEGFR2, may reduce tumor vessels.</p>Formule :C15H14N2ODegré de pureté :99.84%Couleur et forme :Yellow To Yellow OrangeMasse moléculaire :238.28Tandutinib hydrochloride
CAS :<p>Tandutinib hydrochloride: FLT3 inhibitor (IC50 0.22 μM), targets c-Kit, PDGFR, treats AML, crosses blood-brain barrier.</p>Formule :C31H43ClN6O4Couleur et forme :SolidMasse moléculaire :599.16Derazantinib dihydrochloride
CAS :<p>Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.</p>Formule :C29H31Cl2FN4OCouleur et forme :SolidMasse moléculaire :541.49(S)-Sunvozertinib
CAS :<p>(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.</p>Formule :C29H35ClFN7O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :584.08Saracatinib difumarate
CAS :<p>Saracatinib difumarate is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities.</p>Formule :C35H40ClN5O13Couleur et forme :SolidMasse moléculaire :774.18FGFR2-IN-3 hydrochloride
CAS :<p>FGFR2-IN-3 hydrochloride is a selective, orally active FGFR2 inhibitor.</p>Formule :C28H25ClFN7O2Couleur et forme :SolidMasse moléculaire :546.0CGP77675 hydrate
<p>CGP77675 hydrate: Oral Src family kinase inhibitor with IC50s of 5-20/40 nM (Src auto/phosphorylation) and has anticancer properties.</p>Couleur et forme :SolidZM323881
CAS :<p>ZM323881 is a potent and selective inhibitor of VEGFR2 with an IC 50 of less than 2 nM.</p>Formule :C22H18FN3O2Couleur et forme :SolidMasse moléculaire :375.4AZ 5104
CAS :Produit contrôlé<p>Applications AZ 5104 is a derivative of AZD 9291 (A808075) is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).<br>References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);<br></p>Formule :C27H31N7O2Couleur et forme :Off-WhiteMasse moléculaire :485.58TG 100801
CAS :<p>TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).</p>Formule :C33H30ClN5O3Degré de pureté :99.28% - 99.61%Couleur et forme :SolidMasse moléculaire :580.08N-Acryloyl Osimertinib (>85%)
CAS :<p>Applications N-Acryloyl Osimertinib is used in the preparation of pyrimidinyl indole derivative as EGFR inhibitor for targeted therapy of cancer<br>References Rao, Y., et al.: Faming Zhuanli Shenqing (2016), CN 105777716 A 20160720<br></p>Formule :C31H35N7O3Degré de pureté :>85%Couleur et forme :Off White SolidMasse moléculaire :553.65SB 203580 hydrochloride
CAS :<p>SB 203580 hydrochloride (Adezmapimod hydrochloride) is a p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy.</p>Formule :C21H17ClFN3OSDegré de pureté :97.79%Couleur et forme :SolidMasse moléculaire :413.93,3-Azo-1-butanol
CAS :Produit contrôléFormule :C4H8N2OCouleur et forme :NeatMasse moléculaire :100.12rac trans-3-Hydroxy Apatinib Dihydrochloride
CAS :Produit contrôlé<p>Stability Hygroscopic<br>Applications Dihydrochloride salt of trans-3-Hydroxy Apatinib, a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br>References Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>Formule :C24H25Cl2N5O2Couleur et forme :NeatMasse moléculaire :486.39CCT241161
CAS :<p>CCT241161: oral pan-RAF inhibitor; IC50s: LCK (3 nM), CRAF (6), SRC (10), V600E-BRAF (15), BRAF (30); fights BRAF/NRAS melanomas, anti-proliferative.</p>Formule :C28H27N7O3SDegré de pureté :99.76% - 99.77%Couleur et forme :SolidMasse moléculaire :541.62AZ 12799734
CAS :<p>AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.</p>Formule :C18H18N4O3SDegré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :370.43rac-Clopidogrel Hydrochloride
CAS :<p>Impurity Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B<br>Applications Clopidogrel Related Compound B (Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B) is a tetrahydrothienopyridine as inhibitor of angiogenesis.<br>References Maffrand, J. P., et al.: Eur. J. Med. Chem., 9, 483 (1974), Thebault, J.J., et al.: Clin. Pharmacol. Ther., 18, 485 (1975),<br></p>Formule :C16H16ClNO2S·ClHCouleur et forme :NeatMasse moléculaire :358.28Glycerol 1-Monobutyrate (Technical Grade)
CAS :<p>Applications Glycerol 1-Monobutyrate functions as a key regulatory molecule in angiogenic process.<br>References Dobson, D. E., et al.: Cell (Cambridge, MA, U. S.), 61, 223 (1990)<br></p>Formule :C7H14O4Couleur et forme :NeatMasse moléculaire :162.18Dapolsertib
CAS :<p>Dapolsertib (SEL24-B489) is an orally active and efficient PIM and FLT3-ITD inhibitor, reducing PIM-specific substrate phosphorylation.</p>Formule :C15H18Br2N4O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :446.14Itacnosertib
CAS :<p>Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells,antitumor and antileukemic.</p>Formule :C26H28N8ODegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :468.55Seribantumab
CAS :<p>Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting cancer cell proliferation.</p>Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :143.2 (kDa)Amivantamab
CAS :<p>Amivantamab (JNJ-61186372) is an antibody that recognizes EGFR and MET and has anticancer and antitumor activities.</p>Degré de pureté :97.24% (SEC-HPLC) - 99.74%Couleur et forme :LiquidMasse moléculaire :145.88 kDaTirabrutinib
CAS :<p>Tirabrutinib, an oral Btk inhibitor (IC50=6.8 nM), crosses the BBB and halts B cell signaling for autoimmune and hematologic studies.</p>Formule :C25H22N6O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :454.48α-Eudesmol
CAS :<p>Applications α-Eudesmol is an isomer of β-Eudesmol (E938600), a sesquiterpenoid known to induce neurite outgrowth. β-Eudesmol exhibits antiangiogenic activity.<br>References Obara, Y. et al.: J. Pharmacol. Exp . Ther., 30, 803 (2011); Tsuneki, H. et al.: Eur. J. Pharmacol., 512, 105 (2005);<br></p>Formule :C15H26OCouleur et forme :White To Off-WhiteMasse moléculaire :222.37Cpd27
CAS :<p>Cpd27 (TIE-2/VEGFR-2 kinase-IN-2) is a TIE-2 and VEGFR-2 inhibitor that inhibits RIPK1 and can be used to study glaucoma.</p>Formule :C20H13F4N5O2Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :431.34SB-505124 hydrochloride
CAS :<p>SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.</p>Formule :C20H22ClN3O2Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :371.86Cavutilide
CAS :<p>Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.</p>Formule :C22H26FN3O3Degré de pureté :99.82% - 99.85%Couleur et forme :SolidMasse moléculaire :399.458Donafenib
CAS :<p>Donafenib(Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3,</p>Formule :C21H13ClD3F3N4O3Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :467.84Behenamide
CAS :Produit contrôlé<p>Applications Behenamide is a fatty acid amide as an angiogenic. The mechanism of angiogenic activity is unknown and this lipid does not promote proliferation of endothelial cells or induce inflammatory effects.<br>References Wakamatsu, K., et al.: Biochem. Biophysical Res. Comm., 168, 423 (1990),<br></p>Formule :C22H45NOCouleur et forme :White To Off-WhiteMasse moléculaire :339.6Syk Inhibitor II
CAS :<p>Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).</p>Formule :C14H15F3N6ODegré de pureté :97.63%Couleur et forme :SolidMasse moléculaire :340.3
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