Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(167 produits)
- Bcr-Abl(118 produits)
- EGFR(581 produits)
- FAK(72 produits)
- FLT(86 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(180 produits)
- JAK(243 produits)
- PDGFR(129 produits)
- RAAS(89 produits)
- Src(82 produits)
- Syk(37 produits)
- Thrombine(57 produits)
- VDA(2 produits)
- VEGFR(242 produits)
Affichez 6 plus de sous-catégories
2385 produits trouvés pour "Angiogenèse"
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Pazopanib-d6
CAS :Pazopanib-d6 is a deuterated compound of Pazopanib.Formule :C21H17D6N7O2SCouleur et forme :SolidMasse moléculaire :443.56Iruplinalkib
CAS :Iruplinalkib (WX-0593) is an orally active, selective and potent ALK and ROS1 tyrosine kinase inhibitor with anticancer activity for use in the study of non-small cell lung cancer.Formule :C29H38ClN6O2PDegré de pureté :97.38% - 99.29%Couleur et forme :SolidMasse moléculaire :569.08Momelotinib sulfate
CAS :Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.Formule :C23H26N6O10S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :610.62Rociletinib hydrobromide
CAS :Rociletinib hydrobromide is an orally delivered inhibitor of the mutant form of EGFR kinase (Kis: 21.5 nM and 303.3 nM for EGFR L858R/T790M and EGFR WT).Formule :C27H29BrF3N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :636.46(3S,4S)-PF-06459988
CAS :(3S, 4S)-PF-06459988, a less active S enantiomer, specifically inhibits T790M mutant EGFR with high selectivity.Formule :C19H22ClN7O3Couleur et forme :SolidMasse moléculaire :431.88Elsubrutinib
CAS :Elsubrutinib (ABBV-105) is an orally active, selective, and irreversible BTK inhibitor with an IC50 of 0.18 μM for the catalytic domain of BTK.Formule :C17H19N3O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :297.36Ref: TM-T39130
1mg145,00€5mg250,00€10mg340,00€25mg573,00€50mg879,00€100mg1.314,00€1mL*10mM (DMSO)356,00€Trichilinin D
CAS :Trichilinin D is a natural product that can be used in related research in the field of life sciences. Its product number is TN8637.Formule :C37H44O8Masse moléculaire :616.74iHCK-37
CAS :iHCK-37 (ASN05260065) is an Hck inhibitor with antitumor activity and blocks HIV-1 replication, used in chronic myelogenous leukemia (CML) research.Formule :C30H32N4O2S2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :544.73Rilematovir
CAS :Rilematovir (JNJ-678) inhibits fusion protein, has antiviral properties, low toxicity, and targets RSV treatment.Formule :C21H20ClF3N4O3SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :500.92Bleximenib oxalate
CAS :Bleximenib oxalate (Menin-MLL inhibitor 24 oxalate) is a menin-MLL inhibitor that blocks the binding of the menin-KMT2A complex to chromatin at gene promoters.Formule :C34H52FN7O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :689.82FLT3-IN-16
CAS :FLT3-IN-16 is a potent FLT3 inhibitor (IC50 = 1.1 μM) for acute myeloid leukemia research.Formule :C15H15N3O2SDegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :301.36Ref: TM-T9843
2mg34,00€5mg52,00€10mg86,00€25mg172,00€50mg260,00€100mg369,00€200mg487,00€1mL*10mM (DMSO)58,00€Tirbanibulin dihydrochloride
CAS :Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).Formule :C26H31Cl2N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.45Afatinib D6
CAS :Afatinib D6 (BIBW 2992 D6) is a deuterium-labeled Afatinib. Afatinib is an irreversible EGFR family inhibitor.Formule :C24H25ClFN5O3Couleur et forme :SolidMasse moléculaire :491.98GDC-0834
CAS :GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC50 of 1.1 and 5.6 μM in mouse andFormule :C33H36N6O3SCouleur et forme :SolidMasse moléculaire :596.74AP23846
CAS :AP23846 is an Src family kinase inhibitor that reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines.Formule :C24H34N5OPDegré de pureté :97.83%Couleur et forme :SolidMasse moléculaire :439.53Conteltinib tetrahydrochloride
Conteltinibtetrahydrochloride (CT-707 tetrahydrochloride) is the tetrahydrochloride form of Conteltinib. It acts as an inhibitor for FAK (IC50=1.6 nM), ALK, and Pyk2. When used in combination with Cabozantinib, Conteltinib tetrahydrochloride exhibits a synergistic antitumor effect.Formule :C32H49Cl4N9O3SCouleur et forme :SolidMasse moléculaire :781.667EW-7195
CAS :EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.
Formule :C23H18N8Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :406.44SU14813 maleate
CAS :SU14813 maleate is an inhibitor of multi-targeted receptor tyrosine kinases (IC50s: 2, 50, 4, 15 nM for VEGFR1, VEGFR2, PDGFRβ, and KIT).Formule :C27H31FN4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.56AV-412 free base
CAS :AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).Formule :C27H28ClFN6OCouleur et forme :SolidMasse moléculaire :507Imatinib D4
CAS :Imatinib D4 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.Formule :C29H31N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :497.63Pentagamavunon-1
CAS :PGV-1, an oral Curcumin analog, induces apoptosis by inhibiting COX-2, VEGF, and NF-κB activation.Formule :C23H24O3Couleur et forme :SolidMasse moléculaire :348.43N-Desethyl Sunitinib
CAS :N-Desethyl Sunitinib (SU012662) is inhibitor of tyrosine kinases tumor proliferation and angiogenesis, including VEGFR, PDGFR, KIT, and FLT3,Formule :C20H23FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :370.42Cevidoplenib dimesylate hydrochloride
CAS :Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory properties.Formule :C90H132Cl5N27O12Degré de pureté :97.52%Couleur et forme :SolidMasse moléculaire :1957.9(S)-Sunvozertinib
CAS :(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.Formule :C29H35ClFN7O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :584.08Onatasertib
CAS :Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity.Formule :C21H27N5O3Degré de pureté :99.14% - 99.93%Couleur et forme :SolidMasse moléculaire :397.47Ibrutinib deacryloylpiperidine
CAS :Ibrutinib deacryloylpiperidine (IBT4A) is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 of 0.5 nM.Formule :C17H13N5ODegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :303.32Derazantinib dihydrochloride
CAS :Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.Formule :C29H31Cl2FN4OCouleur et forme :SolidMasse moléculaire :541.49R-268712
CAS :R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Formule :C20H18FN5ODegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :363.39Ref: TM-T16708
1mg44,00€5mg93,00€10mg130,00€25mg250,00€50mg378,00€100mg537,00€200mg762,00€1mL*10mM (DMSO)92,00€TX1-85-1
CAS :TX1-85-1: irreversible Her3 inhibitor (IC50: 23 nM), degrades Her3 protein, disrupts signaling, binds Cys721 covalently.Formule :C32H36N8O3Degré de pureté :97.16% - 98.12%Couleur et forme :SolidMasse moléculaire :580.68JCN037
CAS :JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).Formule :C16H11BrFN3O2Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :376.18Nastorazepide
CAS :Nastorazepide is a selective, orally available antagonist of gastrin/cholecystokinin 2 (CCK-2) receptor with potential antineoplastic activity.Formule :C29H36N4O5Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :520.62Tolimidone
CAS :Tolimidone (NSC 314335) is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.
Formule :C11H10N2O2Degré de pureté :99.85% - 99.85%Couleur et forme :SolidMasse moléculaire :202.21CP-673451
CAS :CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than otherFormule :C24H27N5O2Degré de pureté :99.62% - 99.88%Couleur et forme :SolidMasse moléculaire :417.5Ref: TM-T6091
1mg49,00€2mg63,00€5mg90,00€10mg170,00€25mg334,00€50mg512,00€100mg737,00€500mg1.521,00€1mL*10mM (DMSO)108,00€Vadimezan
CAS :Vadimezan (NSC 640488) is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity.Formule :C17H14O4Degré de pureté :97.38% - 99.8%Couleur et forme :SolidMasse moléculaire :282.29Ref: TM-T6273
2mg39,00€5mg58,00€10mg93,00€25mg172,00€50mg268,00€100mg401,00€200mg580,00€1mL*10mM (DMSO)89,00€CNX-774
CAS :CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).Formule :C26H22FN7O3Degré de pureté :97.35% - 99.11%Couleur et forme :SolidMasse moléculaire :499.5Ref: TM-T2302
1mg38,00€2mg50,00€5mg84,00€10mg119,00€25mg222,00€50mg369,00€100mg537,00€500mg1.161,00€1mL*10mM (DMSO)88,00€Pelitinib
CAS :Pelitinib (EKB-569) (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).Formule :C24H23ClFN5O2Degré de pureté :98.37% - 99.84%Couleur et forme :Off-White SolidMasse moléculaire :467.92Altiratinib
CAS :Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Formule :C26H21F3N4O4Degré de pureté :99.67% - 99.75%Couleur et forme :SolidMasse moléculaire :510.46PF 477736
CAS :PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Formule :C22H25N7O2Degré de pureté :97.58% - 99.94%Couleur et forme :SolidMasse moléculaire :419.48N-piperidine Ibrutinib
CAS :N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively.Formule :C22H22N6ODegré de pureté :96.65%Couleur et forme :SolidMasse moléculaire :386.45GMB-475
CAS :GMB-475, a PROTAC-based BCR-ABL1 inhibitor, tackles drug resistance by promoting VHL-mediated degradation.Formule :C43H46F3N7O7SDegré de pureté :98.78% - >99.99%Couleur et forme :SolidMasse moléculaire :861.93Ref: TM-T8488
1mg50,00€2mg66,00€5mg99,00€10mg160,00€25mg281,00€50mg416,00€100mg600,00€200mg835,00€1mL*10mM (DMSO)152,00€Neratinib
CAS :Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.Formule :C30H29ClN6O3Degré de pureté :96.17% - 99.85%Couleur et forme :SolidMasse moléculaire :557.04PF-562271 besylate
CAS :PF-562271 besylate: potent, ATP-competitive FAK inhibitor, IC50 1.5 nM, 10x less effective on Pyk2, highly selective vs other kinases.Formule :C21H20F3N7O3S·C6H6O3SDegré de pureté :97.65% - 99.01%Couleur et forme :SolidMasse moléculaire :665.66Ref: TM-T6177
1mg35,00€5mg74,00€10mg94,00€25mg138,00€50mg198,00€100mg296,00€200mg427,00€1mL*10mM (DMSO)89,00€1-NM-PP1
CAS :1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.Formule :C20H21N5Degré de pureté :98% - 98.93%Couleur et forme :White Cyrstalline SolidMasse moléculaire :331.41Ref: TM-T2153
1mg48,00€2mg63,00€5mg84,00€10mg132,00€25mg271,00€50mg505,00€100mg668,00€1mL*10mM (DMSO)90,00€Tandutinib
CAS :Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3Formule :C31H42N6O4Degré de pureté :99.45% - ≥98%Couleur et forme :White SolidMasse moléculaire :562.7Coumarin-3-carboxylic acid
CAS :The combination of Valproic acid with Coumarin-3-carboxylic acid (3-Carboxycoumarin) suppresses the proliferation and migration of lung cancer cells via EGFR/Formule :C10H6O4Degré de pureté :99.88%Couleur et forme :Light Brown Crystalline PowderMasse moléculaire :190.15(Rac)-JBJ-04-125-02
CAS :(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.Formule :C29H26FN5O3SDegré de pureté :97.57%Couleur et forme :SolidMasse moléculaire :543.61Ref: TM-T8872
1mg100,00€5mg205,00€10mg334,00€25mg567,00€50mg807,00€100mg1.099,00€1mL*10mM (DMSO)249,00€Acriflavine Hydrochloride
CAS :Acriflavine HCl is a HIF-1α inhibitor reducing PGK1, VEGF, and HIF-1α levels both in vitro and in vivo.Formule :C14H14ClN3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :259.73WHI-P180
CAS :WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.Formule :C16H15N3O3Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :297.31Vactosertib
CAS :Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.Formule :C22H18FN7Degré de pureté :98.85% - 99.81%Couleur et forme :SolidMasse moléculaire :399.42Tirbanibulin
CAS :Tirbanibulin (KX2-391) is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of a variety of cancers.Formule :C26H29N3O3Degré de pureté :99.43% - 99.67%Couleur et forme :SolidMasse moléculaire :431.53Ref: TM-T6345
1mg34,00€5mg60,00€10mg73,00€25mg142,00€50mg253,00€100mg424,00€200mg605,00€1mL*10mM (DMSO)63,00€
