Angiogenèse
Les inhibiteurs de l'angiogenèse sont des composés qui interfèrent avec la formation de nouveaux vaisseaux sanguins, un processus crucial dans la croissance et la métastase des cancers. En inhibant l'angiogenèse, ces composés peuvent restreindre l'apport sanguin aux tumeurs, ralentissant ou arrêtant leur croissance. Les inhibiteurs de l'angiogenèse sont essentiels dans la recherche sur le cancer et le développement thérapeutique, offrant des informations sur les mécanismes de progression tumorale et proposant des traitements potentiels pour le cancer et d'autres maladies liées à l'angiogenèse. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'angiogenèse de haute qualité pour soutenir vos recherches en oncologie et biologie vasculaire.
Sous-catégories appartenant à la catégorie "Angiogenèse"
- BTK(146 produits)
- Bcr-Abl(102 produits)
- EGFR(572 produits)
- FAK(72 produits)
- FLT(93 produits)
- Récepteur du facteur de croissance des fibroblastes (FGFR)(169 produits)
- JAK(245 produits)
- PDGFR(126 produits)
- RAAS(87 produits)
- Src(79 produits)
- Syk(37 produits)
- Thrombine(47 produits)
- VDA(2 produits)
- VEGFR(268 produits)
Affichez 6 plus de sous-catégories
1424 produits trouvés pour "Angiogenèse"
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EMI56
CAS :<p>EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].</p>Formule :C21H20N2O3Couleur et forme :SolidMasse moléculaire :348.4TK4b
CAS :<p>TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) & 19.40 nM (JAK2).</p>Formule :C21H22N2O2Couleur et forme :SolidMasse moléculaire :334.41EGFR-IN-39
CAS :<p>EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.</p>Formule :C24H25ClN6O3Couleur et forme :SolidMasse moléculaire :480.95FLT3/ITD-IN-2
CAS :<p>FLT3/ITD-IN-2: Powerful FLT3/ITD, FLT3D835Y, and FLT3 inhibitor; hinders AML cell growth. IC50s: 0.3-1.0 nM.</p>Formule :C23H26F3N7O2Couleur et forme :SolidMasse moléculaire :489.49EMI48
CAS :<p>EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].</p>Formule :C21H20N2O3Couleur et forme :SolidMasse moléculaire :348.4KL-1156
CAS :<p>KL-1156 is an NF-κB inhibitor. It is also a lipopolysaccharide (LPS)-induced nitric oxide production inhibitor.</p>Formule :C17H17NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :299.32Lck Inhibitor III
CAS :<p>Lck Inhibitor III, a potent inhibitor of Lck, exhibits an IC50 value of 867 nM.</p>Formule :C25H30N6O4Couleur et forme :SolidMasse moléculaire :478.54K 00546
CAS :<p>K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).</p>Formule :C15H13F2N7O2S2Degré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :425.44EGFR/BRAFV600E-IN-1
CAS :<p>EGFR/BRAFV600E-IN-1 inhibits EGFR (0.08 μM) & BRAFV600E (0.15 μM), affects A-549, MCF-7, Panc-1 & HT-29 (IC50: 0.79-1.3 μM).</p>Formule :C24H24ClN3O3Couleur et forme :SolidMasse moléculaire :437.92PF-00956980
CAS :<p>PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.</p>Formule :C18H26N6OCouleur et forme :SolidMasse moléculaire :342.44DB07107
CAS :<p>DB07107 is a potent inhibitor of drug resistant T315I mutant Bcr-Abl tyrosine kinase and a potent Akt1 inhibitor (IC50: 360 nM).</p>Formule :C23H22N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :370.45PD180970
CAS :<p>PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit.</p>Formule :C21H15Cl2FN4ODegré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :429.27Debio 0617B
CAS :<p>Debio 0617B inhibits kinases for AML stem cell treatment, targeting JAK, ABL, SRC, and STAT3-related tumours.</p>Formule :C28H23ClF3N7O2Couleur et forme :SolidMasse moléculaire :581.98T338C Src-IN-2
CAS :<p>T338C Src-IN-2: Potent c-Src T338C kinase inhibitor; IC50: 317 nM, T338C/V323A: 57 nM, T338C/V323S: 19 nM.</p>Formule :C17H18FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :327.36TK4g
CAS :<p>TK4g, a potent JAK inhibitor, has IC50s of 12.61 nM (JAK2) & 15.80 nM (JAK3); promising for lymphoid diseases & leukemia research.</p>Formule :C19H19N3O4SCouleur et forme :SolidMasse moléculaire :385.44EGFR-IN-67
CAS :<p>EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].</p>Formule :C18H17N3SCouleur et forme :SolidMasse moléculaire :307.41Squarunkin A hydrochloride
CAS :<p>Squarunkin A HCl inhibits UNC119-cargo binding, specifically blocks Src kinase activation, IC50=10 nm.</p>Formule :C25H33ClF3N5O4Couleur et forme :SoildMasse moléculaire :560.02JAK-2/3-IN-2
CAS :<p>JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).</p>Formule :C19H19ClN2OSCouleur et forme :SolidMasse moléculaire :358.89JNJ-47117096 hydrochloride
CAS :<p>JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.</p>Formule :C21H23ClN4O2Couleur et forme :SolidMasse moléculaire :398.89MS 154N
CAS :<p>MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.</p>Formule :C47H56ClFN8O8Couleur et forme :SolidMasse moléculaire :915.45Esuberaprost Sodium
CAS :<p>Famitinib (SHR1020), an oral drug, inhibits c-kit, VEGFR-2, and PDGFRβ (IC50: 2.3/4.7/6.6 nM) and triggers apoptosis in gastric cancer.</p>Formule :C23H27FN4O2Couleur et forme :SolidMasse moléculaire :410.48OD36 hydrochloride
CAS :<p>OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently</p>Formule :C16H16Cl2N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :367.23TYK2-IN-12
CAS :<p>TYK2-IN-12: selective oral TYK2 inhibitor (Ki: 0.51 nM), blocks IL-12-induced IFNγ; IC50: human 2.7 µM, mouse 7.0 µM, used for psoriasis research.</p>Formule :C24H20F2N4O2Couleur et forme :SolidMasse moléculaire :434.44PDE5-IN-3
CAS :<p>PDE5-IN-3: Inhibits PDE5 (1.57 nM), EGFR (5.827 μM), Wnt pathway (1286.96 ng/mL), induces apoptosis, and has antitumor effects.</p>Formule :C21H14BrN5O2Couleur et forme :SolidMasse moléculaire :448.27PDGFR-IN-1
CAS :<p>PDGFR-IN-1 is a platelet-derived growth factor receptor (PDGFR) inhibitor, strongly inhibiting PDGFRα and PDGFRβ, useful for studying solid tumors.</p>Formule :C25H30N8ODegré de pureté :99.13% - 99.49%Couleur et forme :SolidMasse moléculaire :458.56FAK/aurora kinase-IN-1
CAS :<p>FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].</p>Formule :C23H24ClN7O3Couleur et forme :SolidMasse moléculaire :481.93IHMT-TRK-284
CAS :<p>IHMT-TRK-284: Oral type II TRK inhibitor; targets TRKA, TRKB, TRKC (IC50s: 10.5, 0.7, 2.6 nM); selective and anti-tumor effective.</p>Formule :C25H27N7OSCouleur et forme :SolidMasse moléculaire :473.59FGFR3-IN-2
CAS :<p>FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor that inhibits FGFR3 (IC50: 4.1 nM) and VEGFR2 (IC50: 570 nM).</p>Formule :C28H39N9O4SCouleur et forme :SolidMasse moléculaire :597.73CpCDPK1/TgCDPK1-IN-1
CAS :<p>CpCDPK1/TgCDPK1-IN-1 is a inhibitor of CpCDPK1 and TgCDPK1, inhibits Abl and Src, and has antiparasitic activity for the study of Toxoplasma infections.</p>Formule :C18H17N5Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :303.36AG-370
CAS :<p>AG 370, an indole tyrphostin, functions as a powerful inhibitor of PDGF-induced mitogenesis, demonstrating an IC50 of 20 μM.</p>Formule :C15H9N5Couleur et forme :SolidMasse moléculaire :259.27GW694590A
CAS :<p>GW694590A (UNC10112731) functions as a MYC protein stabilizer that enhances the levels of endogenous MYC protein. It also acts on receptor tyrosine kinases, inhibiting DDR2, KIT, and PDGFRα by 81%, 68%, and 67% at a concentration of 1 μM, respectively. As a protein kinase inhibitor, GW694590A affects both ATP-dependent and ATP-independent luciferases, potentially influencing the Fluc reporter gene [1].</p>Formule :C22H19N5O4Couleur et forme :SolidMasse moléculaire :417.42ALK-IN-22
CAS :<p>ALK-IN-22 suppresses ALK and mutants (IC50: 2.3-3.7 nM), hinders phosphorylation, and induces apoptosis in tumor studies.</p>Formule :C24H24ClN7O2Couleur et forme :SolidMasse moléculaire :477.95RIPK2-IN-1
CAS :<p>RIPK2-IN-1 (compound 18f) is a potent inhibitor of RIPK2 (IC50: 51 nM) and also inhibits ALK2 (IC50: 5 nM).</p>Formule :C23H27N5O3SCouleur et forme :SolidMasse moléculaire :453.56EGFR-IN-59
CAS :<p>EGFR-IN-59: EGFR inhibitor, IC50 = 190 nM, induces apoptosis, cytotoxic to A549 cells (IC50 = 8.62 μM) and WI38 cells (IC50 = 52.6 μM). Use: Various cancers.</p>Formule :C27H23N5O4SCouleur et forme :SolidMasse moléculaire :513.57EGFR mutant-IN-2
CAS :<p>EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].</p>Formule :C27H27F3N6O2SCouleur et forme :SolidMasse moléculaire :556.6TC-S 7003
CAS :TC-S 7003 (Lck Inhibitor) is a Lck inhibitor with anti-inflammatory activity that inhibits T-cell proliferation and can be used to study arthritis.Formule :C31H30N8ODegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :530.62RET-IN-19
CAS :<p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>Formule :C28H28N6O4SCouleur et forme :SolidMasse moléculaire :544.62TyK2-IN-2
CAS :<p>TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).</p>Formule :C16H18N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :310.35VA5 TG2 inhibitor
CAS :<p>VA5 inhibits transamidase and GTP-binding by locking protein in an open state, disabling GTPase.</p>Formule :C31H34N4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :590.62ARQ 069
CAS :<p>ARQ 069 inhibits FGFR2 phosphorylation concentration-dependently (IC50: 9.7 µM), without affecting β-actin. Preferentially binds inactive FGFR1/2.</p>Formule :C18H15N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :273.33JTV-519 free base
CAS :<p>JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmic</p>Formule :C25H32N2O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :424.6EGFR-IN-46
CAS :<p>EGFR-IN-46: Potent EGFR/FAK inhibitor (IC50: 20.17 & 14.25 nM), curbs cancer cell growth, triggers apoptosis.</p>Formule :C27H32F3N3O3Couleur et forme :SolidMasse moléculaire :503.56Y 11
CAS :<p>focal adhesion kinase (FAK) inhibitor</p>Formule :C8H17BrN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :265.15FLT3-IN-6
CAS :<p>FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC50 of 1.336 nM.</p>Formule :C23H25N5O3Couleur et forme :SolidMasse moléculaire :419.48KBP-7018
CAS :<p>KBP-7018: potent tyrosine kinase inhibitor targeting c-KIT, RET, PDGFR with IC50s of 10, 7.6, 25nM.</p>Formule :C31H30N4O5Couleur et forme :SolidMasse moléculaire :538.59CGI560
CAS :<p>CGI560 is a potent BTK inhibitor with IC50 = 400 nM for BTK.</p>Formule :C29H27N5OCouleur et forme :SolidMasse moléculaire :461.56MBM-55S
CAS :<p>MBM-55S, a Nek2 inhibitor with 1 nM IC50, induces cell cycle arrest and apoptosis, suppressing tumor growth.</p>Formule :C36H39FN6O10Degré de pureté :99.37% - 99.89%Couleur et forme :SolidMasse moléculaire :734.73BMS-243117
CAS :<p>BMS-243117: Selective LCK inhibitor, IC50=1.1µM, inhibits T cell growth, promising for immunosuppression, arthritis, asthma treatment.</p>Formule :C20H21ClN4O2SCouleur et forme :SolidMasse moléculaire :416.92BTK-IN-9
CAS :<p>BTK-IN-9 reversibly inhibits BTK, disrupts mitochondria, boosts ROS, and triggers apoptosis in Z138 cells, impeding condyloma cell growth.</p>Formule :C25H19N7O4Couleur et forme :SolidMasse moléculaire :481.46JAK-IN-14
CAS :<p>JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.</p>Formule :C19H15FN4ODegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :334.35
