Caspase
Les inhibiteurs de caspases sont des composés qui bloquent l'activité des caspases, une famille de protéases qui jouent un rôle central dans l'exécution de l'apoptose. Les caspases clivent des substrats spécifiques dans la cellule pour déclencher le processus apoptotique, conduisant à la mort cellulaire programmée. Les inhibiteurs de caspases sont utilisés pour étudier les mécanismes de l'apoptose, ainsi que pour prévenir la mort cellulaire indésirable dans divers modèles de recherche. Ces inhibiteurs sont également explorés dans des contextes thérapeutiques pour protéger les cellules de l'apoptose dans des maladies telles que les neurodégénérescences. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de caspases de haute qualité pour soutenir vos recherches sur l'apoptose, la mort cellulaire et les domaines connexes.
125 produits trouvés pour "Caspase"
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Aspirin
CAS :<p>Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.</p>Formule :C9H8O4Degré de pureté :99.78% - 99.91%Couleur et forme :White Solid CrystallineMasse moléculaire :180.16Q-VD-OPH
CAS :<p>Q-VD-OPh is an irreversible caspase inhibitor with an IC50 value of 48 nM against caspase-7 and between 25 and 400 nM against caspase-1, 3, 8, 9, 10, 12.</p>Formule :C26H25F2N3O6Degré de pureté :97.8% - 98.95%Couleur et forme :SolidMasse moléculaire :513.5Thiabendazole
CAS :<p>Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.</p>Formule :C10H7N3SDegré de pureté :99.14%Couleur et forme :Light Yellow PowderMasse moléculaire :201.25Fenbufen
CAS :<p>Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis.</p>Formule :C16H14O3Degré de pureté :98.35% - 98.46%Couleur et forme :White SolidMasse moléculaire :254.28Diclofenac sodium
CAS :<p>Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.</p>Formule :C14H10Cl2NNaO2Degré de pureté :98.21% - 99.73%Couleur et forme :White Or Off-White PowderMasse moléculaire :318.13Ac-FLTD-CMK
CAS :<p>Ac-FLTD-CMK, an abscisicin D derivative, selectively inhibits inflammatory caspases-1, -4, and -11 (IC50: 46.7 nM, 1.49 μM, 329 nM) but not caspase-3.</p>Formule :C26H37ClN4O8Degré de pureté :95.17%Couleur et forme :SolidMasse moléculaire :569.05Dehydrocorydaline chloride
CAS :<p>Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.</p>Formule :C22H24ClNO4Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :401.88Ac-YVAD-CMK
CAS :<p>Ac-YVAD-CMK: Irreversible Caspase-1 inhibitor; halts pyroptosis, IL-1β/IL-18; neuroprotective and anti-inflammatory.</p>Formule :C24H33ClN4O8Degré de pureté :97.08% - 99.909%Couleur et forme :SolidMasse moléculaire :540.99Lacidipine
CAS :<p>Lacidipine (SN-305) is a slow-acting, long-duration lipophilic dihydropyridine calcium blocker that prevents reflex tachycardia and lowers blood pressure.</p>Formule :C26H33NO6Degré de pureté :99.98%Couleur et forme :White-To-Off-White Crystalline SolidMasse moléculaire :455.54Diclofenac diethylamine
CAS :<p>Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).</p>Formule :C18H22Cl2N2O2Degré de pureté :99.81% - 99.87%Couleur et forme :SolidMasse moléculaire :369.29Diclofenac
CAS :<p>Diclofenac: a nonsteroidal compound inhibiting COX-1 and COX-2, reducing pro-inflammatory prostaglandins.</p>Formule :C14H11Cl2NO2Degré de pureté :99.69% - 99.97%Couleur et forme :Crystals From Ether-Petroleum Ether SolidMasse moléculaire :296.15Terfenadine
CAS :<p>Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.</p>Formule :C32H41NO2Degré de pureté :98.76% - 99.75%Couleur et forme :SolidMasse moléculaire :471.67ML-9
CAS :<p>ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively.</p>Formule :C15H18Cl2N2O2SDegré de pureté :99.69%Couleur et forme :Crystalline SolidMasse moléculaire :361.29Oxidopamine hydrochloride
CAS :<p>Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.</p>Formule :C8H12ClNO3Degré de pureté :98.34% - 99.85%Couleur et forme :Physical Description Beige Solid (Ntp 1992)Masse moléculaire :205.64Oxidopamine hydrobromide
CAS :<p>Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.</p>Formule :C8H12BrNO3Degré de pureté :98.22% - 99.88%Couleur et forme :Beige To Brown Fine Crystalline PowderMasse moléculaire :250.09Crustecdysone
CAS :<p>Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.</p>Formule :C27H44O7Degré de pureté :99.06% - 99.67%Couleur et forme :Canary Yellow Fine PowderMasse moléculaire :480.63Caspase-3 activator 2
<p>Caspase-3 Activator 2 (Compound 2f) is a caspase 3 activator with cytotoxic effects on HL-60 and K562 cells, exhibiting IC 50 values of 33.52 μM and 76.90 μM,</p>Degré de pureté :98%Couleur et forme :Odour SolidZ-VDVA-(DL-Asp)-FMK
CAS :<p>Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.</p>Formule :C32H46FN5O11Couleur et forme :SolidMasse moléculaire :695.742PQ401
CAS :<p>PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).</p>Formule :C18H16ClN3O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :341.79Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Couleur et forme :Odour SolidBOC-D-FMK
CAS :<p>Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).</p>Formule :C11H18FNO5Degré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :263.26(Iso)-Z-VAD(OMe)-FMK
CAS :<p>(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.</p>Formule :C22H30FN3O7Degré de pureté :97.10%Couleur et forme :SoildMasse moléculaire :467.49Apoptosis Compound Library
<p>A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;</p>Couleur et forme :Odour SolidSanggenon G
CAS :<p>Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.</p>Formule :C40H38O11Couleur et forme :SolidMasse moléculaire :694.72Sarglaroids F
<p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>Formule :C38H44O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :692.75TNF-α-IN-11
<p>TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.</p>Formule :C24H26N2O5Couleur et forme :SolidMasse moléculaire :422.47Ac-VDVAD-CHO TFA
<p>Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.</p>Couleur et forme :Odour SolidAc-Trp-Glu-His-Asp-Aldehyde
CAS :<p>Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].</p>Formule :C28H33N7O9Couleur et forme :SolidMasse moléculaire :611.6IRF1-IN-2
CAS :<p>IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.</p>Formule :C18H20N2O4SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :360.43Ac-LEHD-AMC
CAS :<p>Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.</p>Formule :C33H41N7O11Couleur et forme :SolidMasse moléculaire :711.729Reproxalap
CAS :<p>Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.</p>Formule :C12H13ClN2ODegré de pureté :99.4% - 99.97%Couleur et forme :SolidMasse moléculaire :236.7Ac-LEVD-CHO
CAS :<p>Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].</p>Formule :C22H36N4O9Couleur et forme :SolidMasse moléculaire :500.54Boc-Asp(OBzl)-CMK
CAS :<p>Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].</p>Formule :C17H22ClNO5Couleur et forme :SolidMasse moléculaire :355.81δ-secretase inhibitor 11
CAS :<p>δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.</p>Formule :C10H12N4O2Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :220.23Pralnacasan
CAS :<p>Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).</p>Formule :C26H29N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.54Z-WEHD-FMK
CAS :<p>Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).</p>Formule :C37H42FN7O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :763.78Ac-IEPD-AFC
CAS :<p>Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.</p>Formule :C32H38F3N5O11Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :725.67IRF1-IN-1
CAS :<p>IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor , inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1,protecting against skin inflammatory damage.</p>Formule :C22H24N4O4SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :440.52AKN-028
CAS :<p>AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.</p>Formule :C17H14N6Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :302.33TD1092
<p>TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.</p>Formule :C55H70N8O9Couleur et forme :SolidMasse moléculaire :987.19MX1013
CAS :<p>MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9.</p>Formule :C18H23FN2O6Couleur et forme :SolidMasse moléculaire :382.39Almorexant hydrochloride
CAS :<p>Almorexant hydrochloride (ACT 078573 hydrochloride) is a dual orexin receptor antagonist that induces apoptosis and can be used to study sleep disorders.</p>Formule :C29H32ClF3N2O3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :549.02J22352
CAS :<p>J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in</p>Formule :C24H21N3O4Couleur et forme :SolidMasse moléculaire :415.44EF24
CAS :<p>EF24 treatment boosts caspase 3/9 activity, hinders MEK1/ERK phosphorylation, and exhibits strong anti-tumor effects in OSCC by deactivating MAPK/ERK.</p>Formule :C19H15F2NODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :311.33PAC-1
CAS :<p>PAC-1 (Procaspase activating compound 1) has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer and Thoracic Cancers.</p>Formule :C23H28N4O2Degré de pureté :96.78% - 99.77%Couleur et forme :SolidMasse moléculaire :392.49Ivachtin
CAS :<p>Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining</p>Formule :C20H21N3O7SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :447.46Penicillic acid
CAS :<p>Penicillic acid, a mycotoxin from Aspergillus/Penicillium, blocks Fas ligand apoptosis and is cytotoxic to rat lung macrophages.</p>Formule :C8H10O4Degré de pureté :98%Couleur et forme :Needles From Petroleum Ether Slight Yellow PowderMasse moléculaire :170.16Guggulsterone
CAS :<p>Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.</p>Formule :C21H28O2Degré de pureté :99.4% - 99.8%Couleur et forme :Light Yellow PowderMasse moléculaire :312.455,7,4'-Trimethoxyflavone
CAS :<p>5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.</p>Formule :C18H16O5Degré de pureté :97.53%Couleur et forme :SolidMasse moléculaire :312.32Chelidonic acid
CAS :<p>Chelidonic acid, in Chelidonium majus, acts as an analgesic, antimicrobial, CNS sedative, and has anti-inflammatory properties.</p>Formule :C7H4O6Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :184.1Almorexant
CAS :<p>Almorexant (ACT 078573), a strong dual orexin receptor antagonist, has Ki of 1.3 nM for OX1 and 0.17 nM for OX2.</p>Formule :C29H31F3N2O3Degré de pureté :97.75% - 98.02%Couleur et forme :SolidMasse moléculaire :512.56Asperosaponin VI
CAS :<p>Asperosaponin VI, from Dipsacus asper rhizome, treats back pain, hematoma, and fractures.</p>Formule :C47H76O18Degré de pureté :97.15% - 99.79%Couleur et forme :SolidMasse moléculaire :929.1Z-IETD-FMK
CAS :<p>Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective caspase 8 inhibitor, which has cell permeable.</p>Formule :C30H43FN4O11Degré de pureté :95% - 99.81%Couleur et forme :SolidMasse moléculaire :654.68Ginsenoside Rh2
CAS :<p>Ginsenoside Rh2 (20(S)-Ginsenoside Rh2), an extract of red Panax ginseng, is a potent anti-inflammatory and anticancer drug.</p>Formule :C36H62O8Degré de pureté :99.20% - 99.76%Couleur et forme :White PowderMasse moléculaire :622.872-HBA
CAS :<p>2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.</p>Formule :C17H14O3Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :266.29Ac-DEVD-AMC
CAS :<p>Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .</p>Formule :C30H37N5O13Degré de pureté :98.20%Couleur et forme :White PowderMasse moléculaire :675.64KEA1-97
CAS :<p>Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M).</p>Formule :C15H9Cl2FN4Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :335.16Paris saponin VII
CAS :<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Formule :C51H82O21Degré de pureté :99.51% - 99.63%Couleur et forme :SolidMasse moléculaire :1031.18Z-VAD(OMe)-FMK
CAS :<p>View and buy Z-VAD(OMe)-FMK from TargetMol.Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor.Cited in 10 publications.</p>Formule :C22H30FN3O7Degré de pureté :95.92% - 99.71%Couleur et forme :SolidMasse moléculaire :467.49Ac-DEVD-CHO acetate
<p>Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) is a specific inhibitor of Caspase-3.</p>Formule :C22H34N4O13Degré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :562.52PHYTOSPHINGOSINE
CAS :<p>Phytosphingosine: anticancer phospholipid; triggers apoptosis in cancer cells via caspase 8 activation and Bax translocation.</p>Formule :C18H39NO3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :317.51TC11
CAS :<p>TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis</p>Formule :C20H22N2O2Degré de pureté :97.86%Couleur et forme :SolidMasse moléculaire :322.4Belnacasan
CAS :<p>Belnacasan (VX-765) is an orally active IL-converting enzyme/caspase-1 inhibitor.</p>Formule :C24H33ClN4O6Degré de pureté :96.53% - 99.5%Couleur et forme :SolidMasse moléculaire :508.99Sesamolin
CAS :<p>Sesamolin and sesamin guard nerves, reduce microglia damage by blocking p38 MAPK and caspase-3, and curb nitric oxide in stimulated cells.</p>Formule :C20H18O7Degré de pureté :98.77% - 99.04%Couleur et forme :SolidMasse moléculaire :370.35Wedelolactone
CAS :<p>Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.</p>Formule :C16H10O7Degré de pureté :98.07% - 99.87%Couleur et forme :SolidMasse moléculaire :314.25PI-1840
CAS :<p>PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.</p>Formule :C22H26N4O3Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :394.47Dehydrocorydaline
CAS :<p>1.</p>Formule :C22H24NO4Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :366.43Daphnetin
CAS :<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formule :C9H6O4Degré de pureté :97.47% - 99.8%Couleur et forme :SolidMasse moléculaire :178.14Ac-DEVD-pNA
CAS :<p>Ac-DEVD-pNA is the preferred peptidic substrate for caspase-3.</p>Formule :C26H34N6O13Degré de pureté :>99.99%Couleur et forme :WhiteMasse moléculaire :638.58Z-YVAD-FMK
CAS :<p>AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.</p>Formule :C31H39FN4O9Degré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :630.66Emricasan
CAS :<p>Emricasan (IDN-6556) is a pan-caspase inhibitor with irreversible properties.</p>Formule :C26H27F4N3O7Degré de pureté :98.13% - 99%Couleur et forme :SolidMasse moléculaire :569.5Z-FA-FMK
CAS :<p>Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.</p>Formule :C21H23FN2O4Degré de pureté :98.84% - 99.68%Couleur et forme :SolidMasse moléculaire :386.42Dihydrocapsaicin
CAS :<p>Dihydrocapsaicin, similar to capsaicin, is an irritant found in Capsicum, used in "pure" capsaicin products at about 10%, activates VR1, and is an antioxidant.</p>Formule :C18H29NO3Degré de pureté :99.61% - ≥95%Couleur et forme :White CrystalMasse moléculaire :307.43Aristolactam I
CAS :<p>Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway.</p>Formule :C17H11NO4Degré de pureté :98.98% - 99.63%Couleur et forme :SolidMasse moléculaire :293.27Ossirene
CAS :<p>Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.</p>Formule :C2H4Cl3O2Te·H4NDegré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :312.05Tauroursodeoxycholate
CAS :<p>Tauroursodeoxycholate (UR 906), a hydrophilic bile acid, low in humans, may treat PBC, insulin resistance, and ALS.</p>Formule :C26H45NO6SDegré de pureté :98.77% - 99.93%Couleur et forme :White SolidMasse moléculaire :499.7Senkyunolide I
CAS :<p>1. Senkyunolide I has neuroprotective effect, associated with its anti-oxidation and anti-apoptosis properties.</p>Formule :C12H16O4Degré de pureté :99.73% - 99.88%Couleur et forme :SolidMasse moléculaire :224.25Diclofenac Potassium
CAS :<p>Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.</p>Formule :C14H10Cl2KNO2Degré de pureté :99.51%Couleur et forme :White To Yellowish Crystalline PowderMasse moléculaire :334.24CASP3 Activator 1541
CAS :<p>CASP3 Activator 1541 is an activator of the proenzyme forms of caspase-3, and induces cell death.</p>Formule :C24H17N3O4Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :411.41L67
CAS :<p>L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).</p>Formule :C16H14Br2N4O4Degré de pureté :98.34% - 99.56%Couleur et forme :SolidMasse moléculaire :486.11Phenoxodiol
CAS :<p>Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)</p>Formule :C15H12O3Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :240.25AVN-944
CAS :<p>AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.</p>Formule :C25H27N5O5Degré de pureté :99.07% - ≥95%Couleur et forme :SolidMasse moléculaire :477.51Taurodeoxycholic acid sodium hydrate
CAS :<p>Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.</p>Formule :C26H46NNaO7SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :539.705,7-Dihydroxychromone
CAS :<p>1.</p>Formule :C9H6O4Degré de pureté :99.76% - ≥95%Couleur et forme :SolidMasse moléculaire :178.14Boc-Asp(OMe)-fluoromethyl ketone
CAS :<p>Boc-Asp(OMe)-FMK is a broad-spectrum caspase inhibitor that blocks Fas-mediated processes without affecting IL-8 chemotaxis.</p>Formule :C11H18FNO5Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :263.26Tauroursodeoxycholate sodium
CAS :<p>Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.</p>Formule :C26H44NNaO6SDegré de pureté :97.90%Couleur et forme :SolidMasse moléculaire :521.69Z-VAD-FMK
CAS :<p>Z-VAD-FMK (Caspase Inhibitor VI) is a broad-spectrum inhibitor of caspases.Z-VAD-FMK binds to activated caspases and inhibits apoptosis.Z-VAD-FMK does not</p>Formule :C21H28FN3O7Degré de pureté :98.24% - 99.79%Couleur et forme :SolidMasse moléculaire :453.46(E/Z)-Necrosulfonamide
CAS :<p>(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.</p>Formule :C18H15N5O6S2Degré de pureté :97.62% - 98%Couleur et forme :SolidMasse moléculaire :461.47Lobaplatin
CAS :<p>Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe.</p>Formule :C9H18N2O3PtDegré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :397.33Z-DEVD-FMK
CAS :<p>Z-DEVD-FMK (Caspase-3 Inhibitor) is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7,</p>Formule :C30H41FN4O12Degré de pureté :96.19% - 99.69%Couleur et forme :SolidMasse moléculaire :668.66Arnicolide D
CAS :<p>Arnicolide D is a sesquiterpene lactone.</p>Formule :C19H24O5Degré de pureté :96.66%Couleur et forme :SolidMasse moléculaire :332.39Dehydrocorydaline nitrate
CAS :<p>DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.</p>Formule :C22H24N2O7Degré de pureté :99.79% - 99.92%Couleur et forme :SolidMasse moléculaire :428.44Dehydrotrametenolic acid
CAS :<p>Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in</p>Formule :C31H48O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.71Limonin glucoside
CAS :<p>Limonin glucoside: a citrus compound, blocks HIV/HTLV-1, triggers cancer cell death, kills Aedes larvae.</p>Formule :C32H42O14Couleur et forme :SolidMasse moléculaire :650.674Caspase-3-IN-1
CAS :<p>Caspase-3-IN-1 is a potent inhibitor of Caspase-3 (IC50: 14.5 nM).</p>Formule :C26H25N3O6SCouleur et forme :SolidMasse moléculaire :507.56Tigilanol tiglate
CAS :<p>Tigilanol tiglate (EBC-46) is a PKC/C1 domain activator. Tigilanol tiglate induces immunogenic cell death and tumour regression.</p>Formule :C30H42O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.65Anisperimus
CAS :<p>Anisperimus (LF 15-0195) is an immunosuppressant that prevents CNS autoimmunity by promoting the development of regulatory CD4 T cells expressing Foxp3.</p>Formule :C18H39N7O3Degré de pureté :98.10%Couleur et forme :SolidMasse moléculaire :401.55AD-2646
CAS :<p>AD-2646 has antidepressant activity and inhibits 2-deoxy-D-glucose (2-DG)-induced gastric acid secretion.</p>Formule :C23H40N2O4Couleur et forme :SolidMasse moléculaire :408.57ZYZ-488
CAS :<p>ZYZ-488 is an Apoptosis protease activating factor-1 (Apaf-1) inhibitor, which suppresses the activation of procaspase-9 and procaspase-3.</p>Formule :C20H29N3O11Degré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :487.46Caspase-9 Inhibitor III
CAS :<p>Caspase-9 Inhibitor III (Ac-LEHD-cmk) blocks caspase-9, protects against ischemic heart damage.</p>Formule :C24H35ClN6O9Couleur et forme :SolidMasse moléculaire :587.02p-nitro-Pifithrin-α
CAS :<p>p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor.</p>Formule :C15H16BrN3O3SCouleur et forme :SolidMasse moléculaire :398.27SDZ 224-015
CAS :<p>SDZ 224-015 is an inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1 with anti-COVID-19 and anti-inflammatory activity.</p>Formule :C30H35Cl2N3O9Degré de pureté :95.49% - 95.49%Couleur et forme :SolidMasse moléculaire :652.52VRT-043198
CAS :<p>VRT-043198, a VX-765 metabolite, is a potent ICE/caspase-1 inhibitor, crossing the blood-brain barrier with K i of 0.8/0.6 nM.</p>Formule :C22H29ClN4O6Couleur et forme :SolidMasse moléculaire :480.94QM31
CAS :<p>QM31 is a selective Apaf-1 inhibitor(inbitita formation of the apoptosome with IC50 of 7.9μM).</p>Formule :C39H38Cl4N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :768.56N1,N11-Diethylnorspermine
CAS :<p>DENSPM: potent anticancer, spurs polyamine breakdown, triggers cytochrome c release and caspase 3, kills GBM via SSAT & H2O2.</p>Formule :C13H32N4Couleur et forme :SolidMasse moléculaire :244.42GRI977143
CAS :<p>GRI977143: selective LPA2 agonist (EC50=3.3μM), blocks caspases 3/7/8/9, limits DNA fragmentation.</p>Formule :C22H17NO4SDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :391.44OT-82
CAS :<p>OT-82 is a NAMPT inhibitor with anticancer activity and cytotoxicity and is used in the study of leukemias.</p>Formule :C26H21FN4ODegré de pureté :98.91% - 99.315%Couleur et forme :SolidMasse moléculaire :424.47ML132
CAS :<p>ML132 is an effective and selective inhibitor of caspase 1 (IC50: 0.316 nM).</p>Formule :C22H28ClN5O5Couleur et forme :SolidMasse moléculaire :477.94CZL55
CAS :<p>CZL55 is a potent caspase-1 inhibitor with an IC50 value of 0.024 μM.CZL55 has low cytotoxicity and can be used in the study of febrile seizures (FS).</p>Formule :C20H22N2O6Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :386.4NLRP3 agonist 1
CAS :<p>Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.</p>Formule :C15H16N6Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :280.33M190S
CAS :<p>M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.</p>Formule :C21H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :375.42Ac-YVAD-pNA
CAS :<p>Ac-YVAD-pNA, a specific substrate for Caspase-1, serves to detect Caspase-1 activity, a crucial mediator of inflammatory processes [1] [2].</p>Formule :C29H36N6O10Couleur et forme :SolidMasse moléculaire :628.639GDC-2394
CAS :<p>GDC-2394: Oral, selective NLRP3 inhibitor; blocks IL-1β (human 0.4μM, mouse 0.1μM), spares NLRC4.</p>Formule :C20H25N5O4SCouleur et forme :SolidMasse moléculaire :431.51CIL62
CAS :<p>CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].</p>Formule :C23H26O5Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :382.45EP1013
CAS :<p>EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.</p>Formule :C18H23FN2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :382.38M867
CAS :<p>M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].</p>Formule :C27H43N7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.67Ac-VAD-CHO
CAS :<p>Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release of</p>Formule :C14H23N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.35Z-YVAD-CMK
CAS :<p>Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].</p>Formule :C30H37ClN4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :633.09ZIF-8
CAS :<p>ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.</p>Formule :C4H6N2ZnCouleur et forme :SolidMasse moléculaire :147.513Caspase-3-IN-2
CAS :<p>Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.</p>Formule :C10H6ClNO5Couleur et forme :SolidMasse moléculaire :255.611N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride
CAS :<p>N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that functions by alkylating the histidine residue at the active site, thus inhibiting trypsin and trypsin-like proteases. It effectively inhibits caspase-3, caspase-6, and caspase-7 with IC50 values of 12.0, 54.5, and 19.3 μM, respectively. Additionally, N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in HL-60 cells and prevents the reduction of mitochondrial transmembrane potential during the apoptosis process.</p>Formule :C14H22Cl2N2O3SMasse moléculaire :369.31M826
<p>M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in</p>Formule :C28H45N7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :575.7Ac-DMLD-CMK
CAS :<p>Ac-DMLD-CMK is a peptide designed to target the caspase3-Gsdme signaling pathway in mice. It specifically inhibits the activation of caspase 3 and Gsdme, preventing the cleavage of Gsdme by caspase 3, which reduces pyroptosis. This process helps alleviate damage to renal tubular epithelial cells and decrease the secretion of inflammatory cytokines. Ac-DMLD-CMK can lower serum creatinine and blood urea nitrogen levels in mice induced by Cisplatin, thereby mitigating the progression of renal dysfunction. It holds potential for research into chemotherapy-induced nephrotoxicity.</p>Formule :C22H35ClN4O9SCouleur et forme :SolidMasse moléculaire :567.053(2R,3S)-Emricasan
CAS :<p>(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.</p>Formule :C26H27F4N3O7Couleur et forme :SolidMasse moléculaire :569.5Z-VA-DL-D-FMK
CAS :Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) acts as an inhibitor of caspases. It irreversibly binds to caspases, enhancing the sensitivity to TNF-α and stimulating HIV replication in infected T cells ACH-2.Formule :C21H28FN3O7Couleur et forme :SolidMasse moléculaire :453.46
