Ferroptose
La ferroptose est une forme de mort cellulaire régulée caractérisée par l'accumulation de peroxydes lipidiques et par le stress oxydatif dépendant du fer. Contrairement à l'apoptose, la ferroptose n'est pas entraînée par les caspases, mais plutôt par l'échec des défenses antioxydantes cellulaires, conduisant à la mort cellulaire. Les inhibiteurs et inducteurs de la ferroptose sont essentiels pour étudier cette voie unique de mort cellulaire, impliquée dans diverses maladies, notamment le cancer, la neurodégénérescence et les lésions d'ischémie-reperfusion. Chez CymitQuimica, nous offrons une large gamme de modulateurs de la ferroptose de haute qualité pour soutenir vos recherches sur les mécanismes de mort cellulaire, le stress oxydatif et la pathologie des maladies.
215 produits trouvés pour "Ferroptose"
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Ferroptosis-IN-16
<p>Ferroptosis-IN-16 (Compound 13l) acts as a specific inhibitor of ferroptosis, demonstrating EC50 values of 0.7 nM in ES-2 cells and 0.9 nM in LX-2 cells. It effectively alleviates acute liver injury induced by Acetaminophen in mouse models and shows excellent metabolic stability in mouse liver microsomes.</p>Formule :C26H23N5OCouleur et forme :SolidMasse moléculaire :421.49W1131 TFA
<p>W1131 TFA is a STAT3 inhibitor and ferroptosis inducer that regulates the IL6-JAK-STAT3 and ferroptosis pathways,gastric cancer.</p>Formule :C25H20F3N5O6Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :543.45PRLX-93936 HCL
CAS :<p>PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.</p>Formule :C21H26Cl2N4O2Degré de pureté :98.4% - 99.94%Couleur et forme :SolidMasse moléculaire :437.3784-B10
CAS :<p>84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.</p>Formule :C25H22F3NO5Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :473.44CuATSM
CAS :<p>Cu/Zn-SOD1 enzyme scavenges radicals; mutations cause ALS. Cu-ATSM, crossing blood-brain barrier, targets hypoxic tissue, may aid ALS mice.</p>Formule :C8H14CuN6S2Couleur et forme :SolidMasse moléculaire :321.92Idebenone
CAS :Formule :C19H30O5Degré de pureté :>98.0%(T)(HPLC)Couleur et forme :Light yellow to Brown powder to crystalMasse moléculaire :338.44CuATSP
CAS :<p>CuATSP is a potent free radical trapping antioxidant (RTA) and ferroptosis inhibitor inhibit lipid peroxidation, for (ALS) and Parkinson's disease.</p>Formule :C18H18CuN6S2Degré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :446.05Cerivastatin sodium
CAS :<p>Cerivastatin sodium (BAY W 6228 sodium) is an HMG-CoA reductase inhibitor with lipid-lowering activity that reduces LDL cholesterol levels.</p>Formule :C26H33FNNaO5Degré de pureté :98.50% - 99.67%Couleur et forme :SolidMasse moléculaire :481.53CCW16
CAS :<p>CCW16 is a covalent E3 ubiquitin ligase RNF4 ligand, cysteine reactivity, inducing ferroptosis in AML cells by activating ROS signalling.</p>Formule :C22H20ClNO3Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :381.85Chrysosplenetin
CAS :<p>Chrysosplenetin is a metabolic inhibitor of artemisinin.</p>Formule :C19H18O8Degré de pureté :97.43% - 98.4%Couleur et forme :SolidMasse moléculaire :374.34L-Glutamic acid monosodium salt
CAS :<p>L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.</p>Formule :C5H8NO4·NaDegré de pureté :99.93%Couleur et forme :White Solid CrystallineMasse moléculaire :169.11Piperlongumine
CAS :<p>Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.</p>Formule :C17H19NO5Degré de pureté :97.03% - 99.90%Couleur et forme :SolidMasse moléculaire :317.34NADPH tetracyclohexanamine
CAS :<p>NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.</p>Formule :C45H82N11O17P3Degré de pureté :98.73% - 99.05%Couleur et forme :SolidMasse moléculaire :1142.12L-BUTHIONINE-(S,R)-SULFOXIMINE
CAS :<p>L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase that induces oxidative stress by depleting GSH.</p>Formule :C8H18N2O3SDegré de pureté :97.07% - ≥98%Couleur et forme :White Fine PowderMasse moléculaire :222.31ML-210
CAS :<p>ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor. ML-210 has antitumor activity and induces ferroptosis. Cost-effective and quality-assured.</p>Formule :C22H20Cl2N4O4Degré de pureté :97% - 99.03%Couleur et forme :SolidMasse moléculaire :475.32Piperazine Erastin
CAS :<p>Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.</p>Formule :C35H41ClN6O4Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :645.19RSL3
CAS :<p>View and buy RSL3 from TargetMol.RSL3 is a VDAC-independent ferroptosis activator.Cited in 10 publications.</p>Formule :C23H21ClN2O5Degré de pureté :98% - 99.96%Couleur et forme :SolidMasse moléculaire :440.88TBHQ
CAS :TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Formule :C10H14O2Degré de pureté :99.17% - 99.53%Couleur et forme :White Solid PowderMasse moléculaire :166.22Trolox
CAS :<p>Trolox is a vitamin E analogue, used in reducing oxidative stress or damage.</p>Formule :C14H18O4Degré de pureté :98.90% - 99.90%Couleur et forme :White To Fainly Beige Crystalline PowderMasse moléculaire :250.29Alogliptin
CAS :<p>Alogliptin (SYR-322)(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9</p>Formule :C18H21N5O2Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :339.39Alogliptin Benzoate
CAS :<p>Alogliptin Benzoate, a potent DPP-4 inhibitor with >10,000-fold selectivity over DPP-8/9, may also curb TLR-4-induced inflammation.</p>Formule :C25H27N5O4Degré de pureté :99.94% - >99.99%Couleur et forme :White PowderMasse moléculaire :461.51WITHAFERIN A
CAS :<p>WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/</p>Formule :C28H38O6Degré de pureté :97.41% - 99.99%Couleur et forme :SolidMasse moléculaire :470.6Bardoxolone Methyl
CAS :<p>Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-</p>Formule :C32H43NO4Degré de pureté :97.81% - 99.09%Couleur et forme :SolidMasse moléculaire :505.69Siramesine hydrochloride
CAS :<p>Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit</p>Formule :C30H32ClFN2ODegré de pureté :99.72% - >99.99%Couleur et forme :SolidMasse moléculaire :491.04Necrostatin-1
CAS :<p>Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity.</p>Formule :C13H13N3OSDegré de pureté :99.25% - >99.99%Couleur et forme :SolidMasse moléculaire :259.33JKE-1674
CAS :<p>JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210.Cost-effective and quality-assured.</p>Formule :C20H20Cl2N4O4Degré de pureté :98.02% - 98.4%Couleur et forme :SolidMasse moléculaire :451.3Bay 11-7085
CAS :<p>Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).</p>Formule :C13H15NO2SDegré de pureté :99.76% - 99.94%Couleur et forme :White SolidMasse moléculaire :249.33DL-Buthionine-(S,R)-sulfoximine
CAS :<p>DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is an inhibitor of γ-glutamylcysteine synthetase for the treatment of solid tumors.</p>Formule :C8H18N2O3SDegré de pureté :98% - 99.64%Couleur et forme :White Fine PowderMasse moléculaire :222.31Coenzyme Q10
CAS :<p>Coenzyme Q10 (CoQ10) (ubiquinone) is a naturally occurring compound, acting as the electron carrier in the mitochondrial respiratory chain.</p>Formule :C59H90O4Degré de pureté :99.14% - 99.88%Couleur et forme :DrypowderMasse moléculaire :863.34ML162
CAS :<p>ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces ferroptosis. ML162 has antitumor activity. Cost-effective and quality-assured.</p>Formule :C23H22Cl2N2O3SDegré de pureté :98.42% - 99.55%Couleur et forme :SolidMasse moléculaire :477.4(E)-Ferulic acid
CAS :<p>(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of</p>Formule :C10H10O4Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :194.18D-glutamine
CAS :<p>D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.</p>Formule :C5H10N2O3Degré de pureté :99.99%Couleur et forme :White Or Off-White PowderMasse moléculaire :146.14BAY 87-2243
CAS :<p>BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).</p>Formule :C26H26F3N7O2Degré de pureté :98% - 99.95%Couleur et forme :SolidMasse moléculaire :525.53L-Buthionine-(S,R)-sulfoximine hydrochloride
<p>L-Buthionine-(S,R)-sulfoximine hydrochloride is a fast, irreversible γ-GCS inhibitor that depletes glutathione. IC50: 1.9-29 μM in various tumors.</p>Formule :C8H19ClN2O3SCouleur et forme :SolidMasse moléculaire :258.77Liproxstatin-1 hydrochloride
CAS :<p>Liproxstatin-1 hydrochloride is a high-potency ferroptosis inhibitor capable of effectively preventing ferroptotic cell death, with an IC50 value of 22 nM [1].</p>Formule :C19H22Cl2N4Couleur et forme :SolidMasse moléculaire :377.31Pioglitazone potassium
CAS :<p>Pioglitazone potassium is an oral PPARγ agonist with EC50 of 0.93 μM (human) and 0.99 μM (mouse), used in diabetes research.</p>Formule :C19H19KN2O3SCouleur et forme :SolidMasse moléculaire :394.53CDDO-Im
CAS :CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).Formule :C34H43N3O3Degré de pureté :98.3% - 99.61%Couleur et forme :SolidMasse moléculaire :541.72(-)-Epicatechin
CAS :<p>(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization</p>Formule :C15H14O6Degré de pureté :98.55% - 98.80%Couleur et forme :SolidMasse moléculaire :290.27UAMC-3203 hydrochloride
CAS :<p>UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.</p>Formule :C25H38ClN5O2SDegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :508.12Baicalein monohydrate
CAS :<p>Baicalein monohydrate blocks 12-lipoxygenase, curbs leukotrienes, lysosomal enzymes, Ca2+ dynamics, and fights arthritis.</p>Formule :C15H12O6Couleur et forme :SolidMasse moléculaire :288.25Ferrostatin-1
CAS :<p>Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death, potently inhibits Erastin-induced iron death in HT-1080 cells. High-Quality, Low-Cost!</p>Formule :C15H22N2O2Degré de pureté :96.1% - 99.68%Couleur et forme :SolidMasse moléculaire :262.35CIL56
CAS :<p>CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS).</p>Formule :C23H27N3O5S2Degré de pureté :99.46% - 99.91%Couleur et forme :SolidMasse moléculaire :489.61Hemin
CAS :<p>Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer.</p>Formule :C34H32ClFeN4O4Degré de pureté :97.169% - 99.59%Couleur et forme :Dark Purple Crystalline PowderMasse moléculaire :651.94DihydroarteMisinic acid
CAS :<p>DihydroarteMisinic acid (Dihydro-Artmisinic Acid) is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal</p>Formule :C15H24O2Degré de pureté :99.06% - 99.17%Couleur et forme :SolidMasse moléculaire :236.35Arteannuin B
CAS :<p>1. Arteannuin B has potent antimalarial activity.</p>Formule :C15H20O3Degré de pureté :98% - 99.8%Couleur et forme :SolidMasse moléculaire :248.32Eprenetapopt
CAS :<p>Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells.</p>Formule :C10H17NO3Degré de pureté :98.75% - 99.57%Couleur et forme :SolidMasse moléculaire :199.25DL-α-Tocopherol
CAS :<p>DL-alpha-Tocopherol (Ephanyl) is a synthetic vitamin E that protects skin fibroblasts from the cytotoxic effects of UV light and has antioxidant properties.</p>Formule :C29H50O2Degré de pureté :99.61% - 99.90%Couleur et forme :Light Yellow Liquid ViscousMasse moléculaire :430.71SRS11-92
CAS :<p>SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1</p>Formule :C22H28N2O2Degré de pureté :98.58%Couleur et forme :SolidMasse moléculaire :352.47Deferitrin
CAS :<p>Deferitrin (GT-56-252) is an iron chelator. It potentially for the treatment of thalassemia and iron overload.</p>Formule :C11H11NO4SDegré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :253.271R,3S-RSL 3
CAS :<p>1R,3S-RSL 3 is a harmala alkaloid.</p>Formule :C23H21ClN2O5Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :440.88
