PKC
Les inhibiteurs de la protéine kinase C (PKC) ciblent la famille des kinases PKC, qui sont impliquées dans un large éventail de processus cellulaires, notamment la régulation du cycle cellulaire, l'apoptose et la différenciation. La PKC joue un rôle clé dans les voies de transduction du signal qui influencent la prolifération et la survie des cellules. L'inhibition de la PKC peut entraîner des changements dans la progression du cycle cellulaire, ce qui rend ces inhibiteurs précieux dans la recherche sur le cancer, la neurobiologie et les maladies cardiovasculaires. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de PKC de haute qualité pour soutenir vos recherches en transduction du signal, régulation du cycle cellulaire et développement thérapeutique.
102 produits trouvés pour "PKC"
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Midostaurin
CAS :<p>PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.</p>Formule :C35H30N4O4Degré de pureté :97.61% - >99.99%Couleur et forme :SolidMasse moléculaire :570.64Daphnetin
CAS :<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formule :C9H6O4Degré de pureté :97.47% - 99.8%Couleur et forme :SolidMasse moléculaire :178.14Chelerythrine
CAS :<p>1.</p>Formule :C21H18NO4Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :348.37Sotrastaurin
CAS :<p>Sotrastaurin (AEB071) is a potent pan-PKC inhibitor (Kis: 0.95/0.64/2.1/3.2/1.8/0.22 nM for PKCα/βI/δ/ε/η/θ).</p>Formule :C25H22N6O2Degré de pureté :98% - 99.70%Couleur et forme :SolidMasse moléculaire :438.48Decursin
CAS :<p>Decursin: potential antiepileptic, hepatoprotective, anti-cancer, anti-amnesic; affects NOX activation, PKCα/MAPK/NF-κB pathways, AChE.</p>Formule :C19H20O5Degré de pureté :97.22% - 99.84%Couleur et forme :SolidMasse moléculaire :328.36Ζ-Stat
CAS :<p>ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis in</p>Formule :C10H8O10S3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :384.36Chelerythrine chloride
CAS :<p>Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to</p>Formule :C21H18ClNO4Degré de pureté :95% - 99.19%Couleur et forme :Yellow To Orange SolidMasse moléculaire :383.83R59949
CAS :<p>R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.</p>Formule :C28H25F2N3OSDegré de pureté :97.04%Couleur et forme :SolidMasse moléculaire :489.58Taurolithocholic acid sodium salt
CAS :<p>Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but</p>Formule :C26H44NNaO5SDegré de pureté :99.79% - 99.93%Couleur et forme :SolidMasse moléculaire :505.69Desmethylglycitein
CAS :<p>Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has</p>Formule :C15H10O5Degré de pureté :97.93%Couleur et forme :SolidMasse moléculaire :270.24Hypocrellin A
CAS :<p>Hypocrellin A is a natural PKC inhibitor with light-induced antitumor, antifungal and antiviral activities.Cost-effective and quality-assured.</p>Formule :C30H26O10Degré de pureté :98% - 99.81%Couleur et forme :SolidMasse moléculaire :546.52Bisindolylmaleimide V
CAS :<p>Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor.</p>Formule :C21H15N3O2Degré de pureté :90%Couleur et forme :Red SolidMasse moléculaire :341.36Staurosporine
CAS :<p>Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr</p>Formule :C28H26N4O3Degré de pureté :99.24% - 99.82%Couleur et forme :Off-White PowderMasse moléculaire :466.531,2-Dimyristoyl-sn-glycerol
CAS :<p>1,2-Dimyristoyl-sn-glycerol (1,2-DMG) is able to increase AChE activity by 35-40% at concentrations of 25 micrograms/ml in the parasite S. mansoni..</p>Formule :C31H60O5Degré de pureté :99.96%Couleur et forme :White Powder With LumpsMasse moléculaire :512.81HA-100
CAS :<p>HA-100 is an inhibitor of protein kinase</p>Formule :C13H15N3O2SDegré de pureté :99.44%Couleur et forme :Pale Yellow Crystalline SolidMasse moléculaire :277.34Bisindolylmaleimide I
CAS :<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Formule :C25H24N4O2Degré de pureté :98.19% - 98.75%Couleur et forme :Orange SolidMasse moléculaire :412.48Mitoxantrone
CAS :<p>Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.</p>Formule :C22H28N4O6Degré de pureté :96.29% - 98.74%Couleur et forme :Blue PowderMasse moléculaire :444.48PKC-θ inhibitor hcl
CAS :<p>PKC-theta inhibitor hcl is a selective PKC-θinhibitor(IC50:12 nM).</p>Formule :C20H26ClF3N6O3Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :490.91Aurothiomalate sodium
CAS :<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Formule :C4H3AuNa2O4SDegré de pureté :99.66%Couleur et forme :SoildMasse moléculaire :390.07Decursinol angelate
CAS :<p>Decursinol angelate is anti-tumor, anti-inflammatory, anti-oxidant, hepatoprotective, and inhibits VEGF and cancer cell invasion.</p>Formule :C19H20O5Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :328.36Rottlerin
CAS :<p>Rottlerin (NSC-56346), a Mallotus Philippinensis extract, inhibits PKC (3-100 μM IC50); triggers apoptosis by activating caspase 3.</p>Formule :C30H28O8Degré de pureté :97.41% - 99.44%Couleur et forme :Orange To Brown PowderMasse moléculaire :516.54D-ERYTHRO-SPHINGOSINE
CAS :<p>D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator</p>Formule :C18H37NO2Degré de pureté :98% - 99.85%Couleur et forme :SolidMasse moléculaire :299.49Procyanidin A1
CAS :<p>Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+.</p>Formule :C30H24O12Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :576.5Afuresertib
CAS :<p>Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic</p>Formule :C18H17Cl2FN4OSDegré de pureté :97.51% - 99.51%Couleur et forme :SolidMasse moléculaire :427.32Bisindolylmaleimide IV
CAS :<p>Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)</p>Formule :C20H13N3O2Degré de pureté :98.83%Couleur et forme :Dark Red SolidMasse moléculaire :327.34Daphnoretin
CAS :<p>1.</p>Formule :C19H12O7Degré de pureté :98% - 99.85%Couleur et forme :SolidMasse moléculaire :352.29TPPB
CAS :<p>TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).</p>Formule :C27H30F3N3O3Degré de pureté :97.71% - 98.00%Couleur et forme :SolidMasse moléculaire :501.54Ro 31-8220 Mesylate
CAS :<p>Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.</p>Formule :C25H23N5O2S·CH4O3SDegré de pureté :98.79% - 99.02%Couleur et forme :SolidMasse moléculaire :553.65Ingenol
CAS :<p>Ingenol mebutate treats actinic keratosis, has anticancer properties, and may reactivate latent HIV.</p>Formule :C20H28O5Degré de pureté :99.78% - 99.87%Couleur et forme :SolidMasse moléculaire :348.43PKCβ inhibitor 1
CAS :<p>PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,</p>Formule :C24H21N5O2Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :411.46Protein Kinase C 19-31 acetate
<p>PKC 19-31 acetate, a serine-altered PKCa-derived PKC inhibitor, tests PKC activity.</p>Formule :C69H122N26O18Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :1603.9Hypericin
CAS :<p>Hypericin (Cyclosan) is a natural anthraquinone compound. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant effects. Cost-effective and quality-assured.</p>Formule :C30H16O8Degré de pureté :99.05% - ≥98%Couleur et forme :Red-Coloured Anthraquinone-DerivativeMasse moléculaire :504.44Enzastaurin
CAS :<p>Enzastaurin (LY317615) (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.</p>Formule :C32H29N5O2Degré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :515.6Ruboxistaurin hydrochloride
CAS :<p>Ruboxistaurin HCl (LY 333531) selectively inhibits PKCβI/II with IC50 of 4.7/5.9 nM; much less effective on other PKC types and ATP-kinases.</p>Formule :C28H28N4O3·HClDegré de pureté :98.44% - 99.22%Couleur et forme :SolidMasse moléculaire :505.01Ionomycin calcium
CAS :<p>Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.</p>Formule :C41H70CaO9Degré de pureté :98% - 98.11%Couleur et forme :SolidMasse moléculaire :747.07Phorbol 12,13-dibutyrate
CAS :<p>Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.</p>Formule :C28H40O8Degré de pureté :99.32% - 99.37%Couleur et forme :SolidMasse moléculaire :504.61CGP60474
CAS :<p>CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.</p>Formule :C18H18ClN5ODegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :355.82PS315
CAS :<p>PS315, a PS48 derivative, allosterically inhibits PKCζ/η (IC50: 10/30 μM), targeting aPKC's PIF-pocket, with anti-cancer properties.</p>Formule :C23H19ClO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.85SC-10
CAS :<p>SC-10 is a direct activator of PKC with potential antiproliferative activity, useful in leukemia research.</p>Formule :C17H22ClNO2SDegré de pureté :99.24% - 99.58%Couleur et forme :SolidMasse moléculaire :339.88AJH-836
CAS :<p>AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) of 4.5 nM for PKCα, and facilitates the translocation of</p>Formule :C22H38O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :382.53NSC668394
CAS :<p>NSC668394 is an ezrin phosphorylation inhibitor.NSC668394 has antitumor activity and increases ezrin cleavage.NSC668394 can be used to study tumor metastasis.</p>Formule :C17H12Br2N2O3Degré de pureté :99.29% - 99.29%Couleur et forme :SolidMasse moléculaire :452.1DCPLA-ME
CAS :<p>DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be used to treat neurodegenerative</p>Formule :C21H38O2Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :322.53TCS 21311
CAS :<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Formule :C27H25F3N4O4Degré de pureté :99.39% - ≥98%Couleur et forme :SolidMasse moléculaire :526.51(-)-Indolactam V
CAS :<p>(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for C1 domains.</p>Formule :C17H23N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :301.38VTX-27
CAS :<p>VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).</p>Formule :C20H24ClFN6ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :418.9PKC-θ inhibitor 1
CAS :<p>PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)</p>Formule :C17H15F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.32PKC-IN-1
CAS :<p>PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,</p>Formule :C25H37FN8O2Degré de pureté :98% - 98.79%Couleur et forme :SolidMasse moléculaire :500.61PKCTheta-IN-2
CAS :<p>PKCTheta-IN-2 (compound 14) is a potent and selective inhibitor of PKCθ, with an IC50 value of 0.25 nM. It demonstrates good selectivity across a broad range of kinases, including the PKC subfamily (30 kinases). Additionally, PKCTheta-IN-2 effectively inhibits the production of IL-2 in mice, where it exhibits an IC50 of 682 nM.</p>Formule :C24H23N5O2Couleur et forme :SolidMasse moléculaire :413.47Dioleyl phosphatidylserine
CAS :<p>Dioleyl phosphatidylserine is a phospholipid that can activate PKC-γ (Protein Kinase C-gamma) when the Ca2+ concentration is below 0.5 μM, specifically at a concentration of 100 μM.</p>Formule :C42H78NO10PCouleur et forme :SolidMasse moléculaire :788.04AS2521780
CAS :<p>AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).</p>Formule :C30H41N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :547.76
