Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
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PKC β pseudosubstrate TFA
PKC β pseudosubstrate TFA is a selective cell-permeable inhibitor of PKC [1] .Formule :C179H295F3N62O40S3Couleur et forme :SolidMasse moléculaire :4108.84CPI-268456
CAS :CPI-268456 is a compound which has bioactive.Formule :C20H15Cl2N3O2Couleur et forme :SolidMasse moléculaire :400.26LSQ-28
LSQ-28 is an orally active HDAC3 inhibitor with an IC50 of 42 nM, demonstrating significant anticancer, antiproliferative, anti-migration, anti-invasion, and anti-wound healing activities. LSQ-28 is suitable for cancer research.Formule :C31H27N5OCouleur et forme :SolidMasse moléculaire :485.579HDAC6-IN-49
HDAC6-IN-49 (Compound 3) is an inhibitor of HDAC, with IC50 values of 0.012 and 0.735 µM against HDAC6 and HDAC1, respectively. Additionally, it inhibits MAO-B, cholinesterase (ChE), histamine receptor (H3R), and serotonin 6 receptor (5-HT6R). HDAC6-IN-49 exhibits neuroprotective effects in SH-SY5Y cells and enhances cognitive functions and motor abilities in fruit fly models of Parkinson's disease and C. elegans models of Alzheimer's disease.Couleur et forme :Odour SolidBRD7-IN-2
BRD7-IN-2 (compound 2-77) is a potent selective inhibitor of bromodomain-containing protein 7 (BRD7), exhibiting significant anti-proliferative activity inFormule :C18H18N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :310.35Pulrodemstat HCl
CAS :Pulrodemstat HCl is an LSD1 inhibitor and a KDM1A inhibitor with anticancer anti, proliferative activity.Formule :C24H24ClF2N5O2Degré de pureté :97.87% - 99.16%Couleur et forme :SoildMasse moléculaire :487.93P3FI-63
CAS :P3FI-63 is a selective KDM3B inhibitor (IC50: 7 μM) with antitumor activity for the study of fusion-positive rhabdomyosarcoma and other transcriptionally addictive cancers.Formule :C15H15N3O2Degré de pureté :99.16%Couleur et forme :SoildMasse moléculaire :269.3TNKS-2-IN-2
CAS :TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.Formule :C26H23N3O6Degré de pureté :99.45%Couleur et forme :SoildMasse moléculaire :473.48PBRM1-BD2-IN-5
CAS :PBRM1-BD2-IN-5 is a potent inhibitor of the PBRM1 Bromodomain, demonstrating dissociation constant (Kd) values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5Formule :C15H13ClN2ODegré de pureté :99.51%Couleur et forme :SoildMasse moléculaire :272.73Ref: TM-T60159
1mg84,00€5mg177,00€10mg260,00€25mg429,00€50mg572,00€100mg793,00€200mg1.063,00€1mL*10mM (DMSO)170,00€PCAF-IN-1
CAS :PCAF-IN-1 is a highly selective PCAF inhibitor with potential anti-tumor, anti-inflammatory, and anti-heart disease effects.Formule :C15H11ClN6Couleur et forme :SolidMasse moléculaire :310.74MC4171
MC4171 is a selective KAT8 inhibitor with antiproliferative activity and can be used to study cancer.Formule :C21H15N3O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :357.36AS-85
CAS :AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.Formule :C26H28F3N5O3S2Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :579.66I-BET567
CAS :I-BET567: potent, oral pan-BET inhibitor; pIC50s: 6.9 (BRD4 BD1), 7.2 (BD2); effective in mouse cancer and inflammation models.Formule :C17H18ClN5O2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :359.81Ref: TM-T9619
1mg89,00€5mg187,00€10mg286,00€25mg575,00€50mg863,00€100mg1.269,00€1mL*10mM (DMSO)205,00€DTP3
CAS :DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Formule :C26H35N7O5Couleur et forme :SolidMasse moléculaire :525.6AZ505 ditrifluoroacetate
CAS :AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).Formule :C33H40Cl2F6N4O8Couleur et forme :SolidMasse moléculaire :805.59GSK778
CAS :GSK778 selectively inhibits BD1 bromodomains (BRD2, BRD3, BRD4, BRDT) and impedes cell growth, causing arrest and apoptosis.Formule :C30H33N5O3Degré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :511.61Ref: TM-T9703
1mg152,00€5mg295,00€10mg477,00€25mg954,00€50mg1.513,00€100mg2.097,00€1mL*10mM (DMSO)44,00€SGC-iMLLT
CAS :SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular targetFormule :C22H24N6ODegré de pureté :99.21% - 99.92%Couleur et forme :SolidMasse moléculaire :388.47TPOP146
CAS :TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).Formule :C27H35N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.58(2R)-Octyl-α-hydroxyglutarate
CAS :(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.Formule :C13H24O5Couleur et forme :SolidMasse moléculaire :260.33KDM4C-IN-1
CAS :KDM4C-IN-1 is aKDM4C inhibitor withial anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia.Formule :C15H14N4O3Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :298.3Eicosapentaenoic Acid (Standard)
CAS :Eicosapentaenoic Acid (Standard) is the standard substance of Eicosapentaenoic Acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Eicosapentaenoic Acid is an ω-3 fatty acid and an inhibitor of fatty acid synthase (FASN). Eicosapentaenoic Acid promotes DNA demethylation in the reexpression of the tumor suppressor gene CCAAT/ enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates the RAS/ERK/C/EBPβ pathway in U937 leukemia cells through demethylation of the CpG island of H-RAS intron 1. Eicosapentaenoic Acid promotes the relaxation of vascular smooth muscle cells and vasodilation.Formule :C20H30O2Couleur et forme :LiquidMasse moléculaire :302.45EHMT2-IN-1
CAS :EHMT2-IN-1: potent EHMT inhibitor, for blood disorders/cancer research; IC50s <100 nM for EHMT1/2 peptides and cellular EHMT2.Formule :C18H23N7OCouleur et forme :SolidMasse moléculaire :353.42PROTAC EZH2 Degrader-1
CAS :PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.Formule :C54H67N7O8Couleur et forme :SolidMasse moléculaire :942.15PR5-LL-CM01
CAS :PR5-LL-CM01 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor in colorectal and pancreatic cancers.Formule :C23H27N7Couleur et forme :SolidMasse moléculaire :401.51Itacitinib adipate
CAS :Itacitinib adipate: oral JAK1 inhibitor, tested in phase II myelofibrosis trial.Formule :C32H33F4N9O5Couleur et forme :SolidMasse moléculaire :699.66Ifidancitinib
CAS :Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.Formule :C20H18FN5O3Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :395.39GSK9311
CAS :GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively).Formule :C24H31N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.53GSK2879552
CAS :GSK2879552: oral, irreversible LSD1 inhibitor with potential cancer-fighting properties.Formule :C23H28N2O2Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :364.48Boc-Lys(Ac)-AMC
CAS :Boc-Lys(Ac)-AMC (Boc-L-Lys(Ac)-AMC) is a synthetic substrate coupled to an HDAC-specific fluorophore (Ex/Em = 355 nm/460 nm).Formule :C23H31N3O6Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :445.51Ref: TM-T36578
5mg51,00€10mg77,00€25mg129,00€50mg182,00€100mg268,00€200mg387,00€1mL*10mM (DMSO)52,00€ADTL-SA1215
CAS :ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.Formule :C26H29I2NO3Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :657.32PROTAC PARP1 degrader
CAS :PROTAC PARP1 degrader suppresses MDA-MB-231 cells at 10 μM, IC50: 6.12 μM in 24h.Formule :C58H63Cl2N11O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1145.1T-448
CAS :T-448 is a lysine-specific demethylase 1 inhibitor (IC50: 22 nM) that improves learning function in mice.T-448 can be used to study memory deficits.Formule :C19H22N4O3SDegré de pureté :97% - 98.63%Couleur et forme :SolidMasse moléculaire :386.47JET-209
JET-209 is a potent proteolysis-targeting chimera (PROTAC) that effectively degrades CBP/p300, exhibiting half-maximal degradation concentration (DC50) valuesFormule :C46H47N9O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :821.92Atinvicitinib
CAS :Atinvicitinib, a selective JAK1 inhibitor, blocks cytokine signaling, modulating itch, allergy, and inflammatory responses, immune and therapeutic studies.Formule :C16H17FN6O3Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :360.35Ref: TM-T39646
1mg138,00€5mg334,00€10mg550,00€25mg1.063,00€50mg1.738,00€100mg2.547,00€1mL*10mM (DMSO)264,00€2'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS :2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.Formule :C9H13ClFN3O4Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :281.67Pim-1/2 kinase inhibitor 1
CAS :Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Formule :C11H9NO3SDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :235.26PKC-θ inhibitor
CAS :PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.Formule :C20H25F3N6O3Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :454.45Ref: TM-T5423
1mg101,00€5mg236,00€10mg313,00€25mg442,00€50mg580,00€100mg893,00€200mg1.198,00€1mL*10mM (DMSO)259,00€HDAC-IN-4
CAS :HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.Formule :C20H21N3O2Couleur et forme :SolidMasse moléculaire :335.4Protein kinase inhibitor H-7 dihydrochloride
CAS :Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor.Formule :C14H19Cl2N3O2SDegré de pureté :99.81%Couleur et forme :White Crystalline SolidMasse moléculaire :364.29SIRT5 inhibitor 3
CAS :SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .Formule :C22H12FN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.35MS8511 hydrochloride
CAS :MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.Formule :C28H42ClN5O3Couleur et forme :SolidMasse moléculaire :532.12(±)-1,2-Diolein
CAS :(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.Formule :C39H72O5Couleur et forme :SolidMasse moléculaire :620.99O6BTG-octylglucoside
CAS :O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).Formule :C24H34BrN5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :616.531,4-DPCA ethyl ester
CAS :1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.Formule :C15H12N2O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :268.27Ref: TM-T36796
2mg37,00€5mg54,00€10mg90,00€25mg157,00€50mg256,00€100mg434,00€200mg623,00€1mL*10mM (DMSO)59,00€Ilunocitinib
CAS :Ilunocitinib is a non-selective and orally active Janus kinase (JAK) inhibitor for pruritus and atopic dermatitis caused by atopic dermatitis in dogs.Formule :C17H17N7O2SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :383.43Ref: TM-T38571
1mg92,00€5mg230,00€10mg356,00€25mg713,00€50mg1.189,00€100mg1.791,00€200mg2.412,00€1mL*10mM (DMSO)251,00€GSK-J2
CAS :GSK-J2 is an inactive enantiomer of GSK-J1 that is lipophilic and serves as an inactive control for GSK-J21.Formule :C22H23N5O2Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :389.45Ref: TM-T11476
1mg34,00€5mg71,00€10mg92,00€25mg157,00€50mg222,00€100mg329,00€200mg487,00€1mL*10mM (DMSO)101,00€DA-3003-1
CAS :DA-3003-1 (NSC 663284) is a Cdc25 dual specificity phosphatase inhibitor with antitumor activity and inhibits Cdc25B2, Cdc25A, Cdc25B2, and Cdc25C.Formule :C15H16ClN3O3Degré de pureté :99.27% - 99.79%Couleur et forme :SolidMasse moléculaire :321.76CHZ868
CAS :CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.Formule :C22H19F2N5O2Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :423.42BAY-850
CAS :BAY-850 is ainhibitor of adenosine triphosphatase family protein 2 that inhibits ovarian cancer growth and metastasis in in vitro and in vivo models.Formule :C38H44ClN5O3Degré de pureté :98% - 98%Couleur et forme :SolidMasse moléculaire :654.24SIRT-IN-3
CAS :SIRT-IN-3: potent SIRT1 inhibitor (IC50=17μM), 4x selective over SIRT2, 14x over SIRT3 (IC50s: 74μM & 235μM).Formule :C13H12N2OCouleur et forme :SolidMasse moléculaire :212.25
