Topoisomérase
Les topoisomérases sont des enzymes qui régulent la topologie de l'ADN lors de processus tels que la réplication, la transcription et la ségrégation des chromosomes en introduisant des cassures transitoires dans les brins d'ADN pour soulager le stress torsionnel. Les inhibiteurs de topoisomérase interfèrent avec ce processus, entraînant l'accumulation de cassures dans l'ADN et l'induction de la mort cellulaire, en particulier dans les cellules à division rapide. Ces inhibiteurs sont largement utilisés comme agents chimiothérapeutiques dans le traitement du cancer. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de topoisomérase de haute qualité pour soutenir vos recherches sur la réplication de l'ADN, la thérapie contre le cancer et la régulation du cycle cellulaire.
141 produits trouvés pour "Topoisomérase"
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9-Methoxycamptothecin
CAS :9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.Formule :C21H18N2O5Degré de pureté :98.49% - 99.56%Couleur et forme :SolidMasse moléculaire :378.38Mitoxantrone
CAS :<p>Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.</p>Formule :C22H28N4O6Degré de pureté :96.29% - 98.74%Couleur et forme :Blue PowderMasse moléculaire :444.48(±)-10-Hydroxycamptothecin
CAS :<p>(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata.</p>Formule :C20H16N2O5Degré de pureté :98% - 99.06%Couleur et forme :SolidMasse moléculaire :364.35IndiMitecan
CAS :<p>IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].</p>Formule :C25H21N3O6Degré de pureté :98.53%Couleur et forme :SoildMasse moléculaire :459.45Doxorubicin
CAS :Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.Formule :C27H29NO11Degré de pureté :99.31%Couleur et forme :Red Crystalline Solid SolidMasse moléculaire :543.52Exatecan
CAS :Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL).Exatecan has antitumor activity and may be used inFormule :C24H22FN3O4Degré de pureté :99.69% - 99.96%Couleur et forme :SolidMasse moléculaire :435.45PNU-159682
CAS :PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.Formule :C32H35NO13Degré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :641.62Ref: TM-T16557
1mg92,00€5mg188,00€10mg344,00€25mg567,00€50mg775,00€100mg1.017,00€1mL*10mM (DMSO)278,00€Camptothecin
CAS :Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.Formule :C20H16N2O4Degré de pureté :99.52% - 99.88%Couleur et forme :Solid PowderMasse moléculaire :348.35Ellipticine
CAS :Ellipticine is a powerful cancer drug with different actions, IC50: 0.27-1.48 μM for leukemia, breast cancer, neuroblastoma, glioblastoma.Formule :C17H14N2Degré de pureté :97.26% - 99.88%Couleur et forme :SolidMasse moléculaire :246.31IID432
IID432 is a TopoII (topoisomerase II) inhibitor against Trypanosoma cruzi with an EC50 of 8 nM, achieving recurrence-free parasite clearance in chronic Chagas disease mouse models.Formule :C19H19N7OMasse moléculaire :361.4T638
CAS :T638 is an inhibitor of topoisomerase II (TOP2). It specifically inhibits the activity of TOP2A with an IC50 of 0.7 uM and effectively suppresses the growth of cancer cells.Formule :C18H16N4OSCouleur et forme :SolidMasse moléculaire :336.41BNS-22
CAS :BNS-22 is a DNA topoisomerase II (Topo II) inhibitor, induces mitotic abnormalities and exhibits antiproliferative activity against human cancer cells.Formule :C24H25NO5Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :407.46Exatecan mesylate dihydrate
CAS :Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].Formule :C25H30FN3O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :567.58PluriSIn #2
CAS :PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.Formule :C11H8FN3O3Degré de pureté :98% - 99.79%Couleur et forme :SolidMasse moléculaire :249.2Daniquidone
CAS :Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity for neoplasmsFormule :C15H11N3ODegré de pureté :98.39% - 99.52%Couleur et forme :SolidMasse moléculaire :249.27Amsacrine
CAS :Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.Formule :C21H19N3O3SDegré de pureté :99.2% - 99.34%Couleur et forme :Yellow Crystalline Powder SolidMasse moléculaire :393.46Aldoxorubicin
CAS :Aldoxorubicin, an albumin-binding prodrug of Doxorubicin, exhibits potent antitumor effects in cancer lines and mouse models.Formule :C37H42N4O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :750.75Pyrazoloacridine
CAS :Pyrazoloacridine (PD 115934) binds DNA, inhibits topo I/II, has 1.25 μM IC50 in K562 cells, and exhibits anti-cancer effects.Formule :C19H21N5O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :367.4Pegamotecan
CAS :Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cellFormule :C52H48N6O14Degré de pureté :96.40% - 97.83%Couleur et forme :SolidMasse moléculaire :980.984LMP744 hydrochloride
CAS :<p>LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. </p>Formule :C24H25ClN2O7Degré de pureté :99.59% - 99.85%Couleur et forme :SolidMasse moléculaire :488.92SDOX
CAS :SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.Formule :C69H97NO20S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1324.63ARN-21934
CAS :ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.Formule :C21H24N6Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :360.46Ref: TM-T36968
1mg62,00€2mg89,00€5mg135,00€10mg212,00€25mg373,00€50mg509,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)149,00€Anticancer agent 216
CAS :Anticanceragent 216 (34A) is a camptothecin compound with IC50 values of 9.6 nM for MCF-7 cells and 11.6 nM for MDA-MB-231 cells.Formule :C23H21N3O6Couleur et forme :SolidMasse moléculaire :435.43Ac-Exatecan
CAS :Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.Formule :C26H24FN3O5Degré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :477.48Pradofloxacin
CAS :Pradofloxacin is a fluoroquinolone antibioticthat exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV.Formule :C21H21FN4O3Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :396.41Topoisomerase inhibitor 2
CAS :Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].Formule :C23H23N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.46Topoisomerase I inhibitor 9
CAS :Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 valueFormule :C23H15Br2FN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.19NH2-methylpropanamide-Exatecan TFA
CAS :Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.Formule :C30H30F4N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :634.58Trovafloxacin mesylate
CAS :Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formule :C21H19F3N4O6SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :512.469-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS :9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potentialFormule :C22H18ClFN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.84Intoplicine
CAS :Intoplicine is an inhibitor of DNA topoisomerase I and II.Formule :C21H24N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.44Topotecan acetate
CAS :Topotecan acetate is an inhibitor of topoisomerase.Formule :C25H27N3O7Couleur et forme :SolidMasse moléculaire :481.498Anticancer agent 215
CAS :Anticanceragent 215 (1) is a camptothecin derivative with IC50 values of 5.2 nM and 8.2 nM against MCF-7 and MDA-MB-231 cells, respectively.Formule :C23H22FN3O4Couleur et forme :SolidMasse moléculaire :423.44Topoisomerase I/II inhibitor 7
CAS :Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.Formule :C18H13ClN2O3Couleur et forme :SolidMasse moléculaire :340.76Gimatecan
CAS :Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formule :C25H25N3O5Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :447.48TH1338
CAS :<p>TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.</p>Formule :C22H21N3O4Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :391.42Topoisomerase II inhibitor 18
CAS :Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].Formule :C20H21N3OSCouleur et forme :SolidMasse moléculaire :351.47Karenitecin
CAS :<p>Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.</p>Formule :C25H28N2O4SiDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.59LMP517
CAS :LMP517 (NSC 781517), an indenoisoquinoline, is a potent dual TOP1 and TOP2 inhibitor that shows better antitumor activity than its parent compound LMP744 against H82 (Small Cell Lung Cancer) xenografts, inducing TOP1 cleavage complexes (TOP1ccs) and TOP2ccs [1].Formule :C22H19FN2O5Couleur et forme :SolidMasse moléculaire :410.4Edotecarin
CAS :Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).Formule :C29H28N4O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.55Saintopin
CAS :Saintopin is an antitumor antibiotic and an inhibitor of DNA topoisomerases I and II, which induces DNA cleavage [1] [2].Formule :C18H10O7Couleur et forme :SolidMasse moléculaire :338.27
