Endocrinologie/Hormones

Premarin (Estrone 3-sulfate) is an an estrogen sulfate with neuroprotective actions during traumatic brain injury.

Benazeprilat(CGS 14831) is an orally active active metabolite of Benazepril.Benazeprilat has potent antihypertensive activity and can be used in combination

Norethynodrel, a synthetic hormone, mimics progesterone, treats uterine bleeding/endometriosis, and is used with mestranol as a contraceptive.

Estetrol (Donesta), a fetal liver-synthesized estrogen, selectively modulates estrogen receptors and may ease menopausal symptoms.

ARD-266 is a PROTAC degrader based on the von Hippel-Lindau E3 ligase that induces the degradation of AR proteins and is useful in prostate cancer research.

4,4'-(Cyclohexylidenemethylene)diphenol (Compound 2) is a symmetrical cyclic non-steroidal estrogen. It exhibits high binding affinity to estrogen receptors ERα and ERβ.

ERα/ERβ antagonist-1 (Compound 10) functions as a partial antagonist of both ERα and ERβ. It reduces the activity of ERα and ERβ in HepG2 liver cells in a dose-dependent manner.

TLB 150 Benzoate (RAD150) is a modulator of the androgen receptor with an IC50 value of 0.13 μM.

R4K1 is a cell-permeable stapled peptide that binds with high affinity to estrogen receptor (ER) α, inhibiting its interaction with coactivators. It penetrates breast cancer cells, regulating gene transcription and suppressing cell proliferation. R4K1 is applicable for tumor research.

AR antagonist 9 is an orally active, selective androgen receptor (AR) antagonist that inhibits cancer by disrupting the formation of AR ligand-binding domain dimers, showing potential in overcoming drug resistance in prostate cancer (PCa). Its antagonistic activity against AR has an IC50 of 0.051 μM, comparable to Enzalutamide (IC50= 0.060 μM). This compound demonstrates superior inhibitory effects on ARF876L/T877A and ARW741C mutants compared to Enzalutamide. Additionally, AR antagonist 9 possesses favorable pharmacokinetic properties, with an oral bioavailability (F) of 66.24% in rats, and significantly inhibits tumor growth in LNCaP xenograft mouse models upon oral administration. AR antagonist 9 holds promise for research in overcoming PCa resistance.

CGP-42112 acetate is a potent angiotensin receptor AT2 agonist that inhibits the increase in protein kinase A activity produced by LPS.

ERα degrader 6 (Compound 31q) is an ERα degrader with a K I of 75 nM and also inhibits ARO with an IC50 value of 37.7 nM.

ET Receptor Antagonist 2 (Compound 16j) is an orally active ET receptor antagonist with an IC50 of 0.22 nM, suitable for pulmonary arterial hypertension (PAH)

ERD-3111 (Compound 44), an orally active PROTAC ERα degrader (DC50: 0.5 nM), exhibits efficacy in inhibiting tumor growth in both the parental MCF-7 xenograft

Compound 181, also known as 14-3-3σ/ERα Stabilizer-1, is a covalent stabilizer targeting the 14-3-3σ/ERα proteins.

WCA-814, an androgen receptor (AR) antagonist-Hsp90 inhibitor conjugate, induces degradation of both full-length and AR-V7, exhibiting cytotoxic effects in

Androgen Receptor Antagonist 9 (compound 28) serves as an antagonist to the androgen receptor [1].

Anticancer agent 135 (compound 26h) acts as a potent androgen receptor (AR) antagonist, effectively blocking AR nuclear translocation and inhibiting AR/AR-V7

ET Receptor Antagonist 1 (compound 16h), with an IC50 value of 0.18 nM, is an orally active agent that can be utilized for pulmonary arterial hypertension (PAH

"ET receptor antagonist 3 (compound 17d) is an orally active ET receptor antagonist with an IC50 of 0.26 nM, utilized for pulmonary arterial hypertension (PAH)

Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the

MK-0773 FA (MK-0773 FA (606101-58-0 Free base)) is an androgen receptor modulator used for the prevention and treatment of cancer-related muscle wasting.

Parathyroid Hormone (1-34), bovine is a PTH receptor agonist used to study osteoporosis and hypoparathyroidism.

(Rac)-PF-998425: nonsteroidal AR antagonist, potent & selective, IC50: 26 nM (binding), 90 nM (cellular), potential for androgenetic alopecia study.

(R,S)-Ivosidenib is the less active enantiomer of Ivosidenib .

TA 0910 acid-type is a metabolite of TA 0910. TA-0910 is a metabolically stable analog of thyrotropin-releasing hormone.

BAN ORL 24 dihydrochloride is a highly potent nociceptin/orphan FQ (N/OFQ) receptor (NOP) antagonist that can be used to study neurological diseases.

Enalaprilat (Enalapril acid) is an ACE inhibitor used in the study of cardiovascular disease.

Monomethyl fumarate D3 is a deuterium labeled Monomethyl fumarate.

ZQ-16 is a potent GPR84 agonist (EC50=0.213 μM) activating multiple signaling pathways.

GDC-0927 is a novel,non-steroidal, potent, orally bioavailable, selective estrogen receptor antagonist.

AC-186 is an ERβ agonist with neuroprotective activity for the study of Parkinson's disease.

GPR40 agonist 6 (Compound 7a) is a potent and selective agonist of free fatty acid receptor 1 ( FFAR1 or GPR40 ) with an EC 50 of 0.058 μM against GPR40 [1].

D4-abiraterone is the active metabolite of abiraterone.Δ4-Abiraterone is a inhibitor of CYP17A1, 3β-HSD and SRD5A, and an antagonist of the androgen receptor.

Atosiban (RW22164), an oxytocin/vasopressin inhibitor, halts premature labor as an intravenous tocolytic, reducing uterine contractions rapidly.

Azilsartan (TAK-536) D5 is the deuterium-labeled Azilsartan. Azilsartan is a specific antagonist of the angiotensin II type 1 receptor.

Angiogenin (108-122) peptide treats cancer, infectious, fibrotic, inflammatory, neurodegenerative, autoimmune, and heart diseases.

TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1).

Losartan D4 Carboxylic Acid is the deuterium labeled Losartan, which is an angiotensin II receptor antagonist.

YE 120 is a GPR35 agonist.

Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor.

DOCP, a mineralocorticoid, treats dogs with adrenal insufficiency.

ARD-1676 is an orally administered androgen receptor (AR) PROTAC degrader that combines an AR ligand with a cereblon ligand.

5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2It is formed from progesterone by 5β-reductase.25β-DHP

Olmesartan lactone impurity, a cyclic ester from Olmesartan, aids in hypertension research as an AT1R blocker.

It is an inhibitor of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)

Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.

Fenarimol, a pyrimidine-type fungicide, exhibits potent inhibitory activity against BR biosynthesis.

Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains.

Trans-Diethyl-1,1,1',1'-Stilbestrol-3,3',5,5'-d8 is a deuterated compound of Trans-Diethyl-Stilbestrol. Trans-Diethyl-Stilbestrol has a CAS number of 56-53-1. Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders.

DL-Cystine is a cysteine derivative that inhibits endothelial cell proliferation by regulating TGFβ1. a GPR inhibitor and nAChR agonist .

VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases. IC50 value: Target: Renin

Olmesartan D4 is the deuterium labeled Olmesartan. Olmesartan is an antagonist of angiotensin II receptor (AT1R) used to treat high blood pressure.

ERα degrader-2 is an estrogen receptor (SERD) degrader with anticancer activity that inhibits ERα for the prevention and treatment of HER-positive breast canc

MK-0773 (PF-05314882) is a selective androgen receptor modulator that binds to AR (IC50: 6.6 nM) for the study of diseases caused by endocrine abnormalities.

Porcine dynorphin A (1-13) is a potent κ opioid receptor agonist; it's antinociceptive and raises [Ca2+]i in neurons like NMDA.

GPR30 agonist-1 is a compound that acts as an agonist for G protein-coupled receptor 30 (GPR30), inducing vasorelaxation.

Dehydroepiandrosterone-d2 is a deuterated compound of Dehydroepiandrosterone.

Hydrocortisone cypionate is a corticosteroid ester and synthetic glucocorticoid corticosteroid.

AZD1979 is a highly potent MCHR1 (Melanin-concentrating hormone receptor 1) antagonist , CNS exposure and insulin sensitivity in steady-state model assessments,

AVE 0991, a nonpeptide, oral Mas agonist, binds [125I]-Ang-(1-7) with IC50 of 21±35 nM.

(E)-4-Hydroxytamoxifen is a less active isomer of (Z)-4-hydroxytamoxifen and also is an estrogen receptor modulator.

Leelamine hydrochloride, a pine bark extract, inhibits androgen receptor and CB1, reducing lipid synthesis in prostate cancer.

17β-Estradiol-2,4-d2 is a deuterated compound of 17β-Estradiol. 17β-Estradiol has a CAS number of 50-28-2. Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.

Diflorasone Diacetate, a topical glucocorticoid, has immunosuppressive and anti-inflammatory properties.

Corticosterone-d8 is a deuterium-labeled corticosterone, a corticosteroid with both mineralocorticoid and glucocorticoid activity.

Loperamide phenyl, an impurity detected in Loperamide, is an opioid receptor agonist.

Dienestrol diacetate, a derivative of the synthetic non-steroid phenolic compound, DIENESTROL, exhibits estrogenic activities.

ZK 216348 is a selective glucocorticoid receptor agonist with an IC50 of 20.3 nM. also binds to progesterone receptors and mineralocorticoid receptors.

Hydrocortisone buteprate is a medium-potent, non-halogenated double-ester of hydrocortisone with a highly favorable benefit-to-risk ratio for inflammatory skin disorders.

Apalutamide-13C-d3 is a 13C and 2H labeled Apalutamide. Apalutamide is an androgen receptor (AR) antagonist, used in research on prostate diseases.

Alvimopan dihydrate is a potent, oral μ-opioid receptor blocker (IC50 1.7 nM, Ki 0.47 nM) used in postoperative ileus research.

Prednisolone valerate acetate is a prodrug anti-inflammatory and immunosuppressive,converted to the active form of Prednisolone and glucocorticoid receptor.

Bazedoxifene is an orally active SERM against ERα and ERβ and inhibits IL-6/GP130, applied in postmenopausal osteoporosis and pancreatic cancer research.

MS 15203 is a GPR171 agonist that reduces chronic neuropathic and inflammatory pain in male mice.

Dienestrol (Standard) is the standard substance of Dienestrol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Dienestrol (Restrol) is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and make the vulva and urethra healthy.

Hydrocortisone hemisuccinate (Standard) is the standard substance of Hydrocortisone hemisuccinate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) is a corticosteroid used as an analytical and chromatography reagent.

Pamoic acid disodium is a GPR35 agonist.

2-Bromoestradiol, an estrogen 2-hydroxylase inhibitor, reduces the irreversible binding of radiolabeled estradiol metabolite(s) to microsomal proteins [1].

NQO1 substrate is a highly potent NQO1 substrate with potential antitumor activity for leukemia research.

BMS-986121 is a selective positive allosteric modulator (PAM) of the μ opioid receptor with analgesic effects.

Candesartan D4 is the deuterium labeled Candesartan. Candesartan is an antagonist of angiotensin II receptor.

GPR41 agonist-1 is a GPR41 agonist, used for studying metabolic diseases such as diabetes and obesity.

PD 123319 ditrifluoroacetate is a selective non-peptide AT2 receptor antagonist with IC50 of 34 nM.

Vanillylpyruvic acid is a phenylpyruvic acid derivative applicable in biochemical experiments and drug synthesis research.

Endomorphin 2 TFA, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM.

Valsartan D9: deuterium-labeled, angiotensin II receptor antagonist, treats hypertension & heart failure.

Beclomethasone 17-propionate is the active metabolite of BDP. As a GR agonist, 17-BMP inhibits the production of pro-inflammatory cytokines.

Betamethasone acetate, the 21-acetate ester of betamethasone, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester.

Azilsartan mepixetil: potent, long-acting angiotensin II blocker, safely lowers blood pressure, protects heart and kidneys.

Betamethasone Acetate (Standard) is the standard substance of Betamethasone Acetate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Betamethasone acetate, the 21-acetate ester of betamethasone, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester.

SCO-267 is a full agonist of GPR40/FFAR1， stimulating insulin secretion and GLP-1 release in diabetic rats, improving glucose tolerance,type 2 diabetes.