Endocrinologie/Hormones
Les inhibiteurs en endocrinologie/hormonaux sont des composés qui bloquent l'action des hormones ou interfèrent avec les voies de signalisation hormonales. Ces inhibiteurs sont essentiels pour étudier la régulation des systèmes endocriniens et pour développer des traitements pour les maladies liées aux hormones, telles que le diabète, les troubles de la thyroïde et les cancers hormonodépendants. En modulant l'activité hormonale, ces inhibiteurs peuvent aider à élucider les interactions complexes au sein du système endocrinien. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité en endocrinologie/hormonaux pour soutenir vos recherches en endocrinologie, pharmacologie et sciences médicales.
Sous-catégories appartenant à la catégorie "Endocrinologie/Hormones"
- Récepteur des androgènes(209 produits)
- Annexine A(11 produits)
- Aromatase(20 produits)
- Récepteur d'œstrogène/progestatif(49 produits)
- GPR(1 produits)
- Récepteur des glucocorticoïdes(153 produits)
- LHRH(1 produits)
- Récepteur opioïde(297 produits)
- Récepteur de prostaglandine(120 produits)
- RAAS(87 produits)
- Réductase(52 produits)
- Somatostatine(49 produits)
- Récepteur des hormones thyroïdiennes (THR)(26 produits)
- Récepteur de la vasopressine(44 produits)
Affichez 6 plus de sous-catégories
3183 produits trouvés pour "Endocrinologie/Hormones"
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4',2-Dihydroxy-4,6-dimethoxydihydrochalcone
CAS :<p>4',2-Dihydroxy-4,6-dimethoxydihydrochalcone, an estrogen-like compound, binds to bovine estrogen receptors, IC50 15 μM.</p>Formule :C17H18O5Couleur et forme :SolidMasse moléculaire :302.32(Rac)-Finerenone
CAS :<p>Rac-Finerenone, or (Rac)-BAY 94-8862, is an oral nonsteroidal MR antagonist with high selectivity and an IC50 of 18 nM.</p>Formule :C21H22N4O3Couleur et forme :SolidMasse moléculaire :378.432D3R/MOR antagonist 1
<p>Compound 114 (D3R/MOR antagonist 1) exhibits dual antagonistic activity at dopamine D3 receptors (D3R) and mu-opioid receptors (MOR), with K i values of 46.5 nM</p>Formule :C22H27Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.38BAM-22P
CAS :<p>Bovine adrenal medulla docosapeptide (BAM-22P) is a potent opioid agonist, derived from the proenkephalin A gene, which is present in the adrenal medulla.</p>Formule :C130H184N38O31S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2839.22Adrenorphin
CAS :<p>Adrenorphin (Metorphamide)(3TFA) is an agonist of μ-opioid receptor(Ki :12 nM).</p>Formule :C44H69N15O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :984.18TAN67
CAS :<p>TAN67 is the first effective selective non-peptide delta1 opioid receptor.</p>Formule :C23H26Br2N2OCouleur et forme :SolidMasse moléculaire :506.282OT antagonist 1 demethyl derivative
<p>OT antagonist 1 demethyl derivative is the demethyl derivative of OT antagonist 1. OT antagonist 1 is a selective Oxytocin antagonist (Ki of 50 nM. )</p>Formule :C21H20N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.41Ludaterone
CAS :<p>Ludaterone is an antiandrogen agent, with potent antiandrogenic activity.</p>Formule :C20H25ClO5Couleur et forme :SolidMasse moléculaire :380.86DPP-4/GPR119 modulator 1
CAS :<p>Orally active DPP-4 inhibitor/GPR119 agonist, Compound 22 lowers glucose, moderate hERG inhibition, IC50 4.9 µM, for diabetes research.</p>Formule :C30H39ClN10O3Couleur et forme :SolidMasse moléculaire :623.15Vasopressin Dimer (anti-parallel) (TFA)
<p>Vasopressin Dimer (anti-parallel) TFA, an anti-parallel dimer form of vasopressin, has the capability to activate four G protein-coupled receptors: V1aR, V1bR,</p>Formule :C94H131F3N30O26S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2282.49AH 8529
CAS :<p>AH 8529 is an orally active opioid compound with analgesic properties.</p>Formule :C16H23ClN2OCouleur et forme :SolidMasse moléculaire :294.82β-Endorphin, equine
CAS :<p>Endorphin Beta is A substance produced in the brain, especially in the pituitary gland, Endorphin Beta blocks the sensation of pain.</p>Formule :C154H248N42O44SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3423.94β-Endorphin, equine TFA
<p>β-Endorphin, equine TFA, an endogenous opioid peptide, demonstrates high affinity binding to μ/δ opioid receptors and possesses analgesic properties [1] [2] [3</p>Formule :C156H249F3N42O46SCouleur et forme :SolidMasse moléculaire :3537.96Frakefamide TFA
<p>Frakefamide TFA: potent, peripherally active μ-opioid agonist; doesn't cross blood-brain barrier.</p>Formule :C32H35F4N5O7Couleur et forme :SolidMasse moléculaire :677.64ET receptor antagonist 2
<p>ET Receptor Antagonist 2 (Compound 16j) is an orally active ET receptor antagonist with an IC50 of 0.22 nM, suitable for pulmonary arterial hypertension (PAH)</p>Formule :C22H25N5O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.53ERα degrader 6
<p>ERα degrader 6 (Compound 31q) is an ERα degrader with a K I of 75 nM and also inhibits ARO with an IC50 value of 37.7 nM.</p>Formule :C28H23F3N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :568.57ERD-3111
CAS :<p>ERD-3111 (Compound 44), an orally active PROTAC ERα degrader (DC50: 0.5 nM), exhibits efficacy in inhibiting tumor growth in both the parental MCF-7 xenograft</p>Formule :C45H46F4N8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :854.89Inocoterone acetate
CAS :<p>Inocoterone acetate is a nonsteroidal antiandrogen that binds to the androgen receptor and possesses antiandrogenic activity in animal models.</p>Formule :C18H26O3Couleur et forme :SolidMasse moléculaire :290.40Ganoderic acid Df
CAS :<p>Ganoderic acid Df, a lanostane triterpenoid from Ganoderma lucidum, inhibits aldose reductase with IC50 of 22.8 μM.</p>Formule :C30H44O7Couleur et forme :SolidMasse moléculaire :516.67rac-1,2-bis-Palmitoyl-3-chloropropanediol
CAS :<p>3-MCPD ester found in edible oils, highest in olive pomace; toxic to mouse kidneys and spermatids.</p>Formule :C35H67ClO4Couleur et forme :SolidMasse moléculaire :587.3715,26-Dihydroxylanosta-7,9(11),24-trien-3-one
CAS :<p>15,26-Dihydroxylanosta-7,9(11),24-trien-3-one is a natural product that can be used as a reference standard. The CAS number of 15,26-Dihydroxylanosta-7,9(11),24-trien-3-one is 420781-85-7.</p>Formule :C30H46O3Couleur et forme :SolidMasse moléculaire :454.7D3R/MOR antagonist 2
<p>Compound 121, a D3R/MOR antagonist with K i values of 361 nM and 85.2 nM for D3R and MOR respectively, has the potential for analgesic effects through MOR</p>Formule :C25H31ClN2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :410.98ER degrader 4
CAS :<p>ER degrader 4, a selective and orally active compound, effectively degrades estrogen receptors and exhibits anti-tumor activity [1].</p>Formule :C26H19FO4SCouleur et forme :SolidMasse moléculaire :446.49Urotensin II, mouse TFA (9047-55-6 free base)
<p>Urotensin II, mouse TFA is an endogenous ligand for the orphan GPR14 or SENR. It is a potent vasoconstrictor.</p>Formule :C78H101N18F3O21S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1747.88PTP1B/AKR1B1-IN-1
<p>PTP1B/AKR1B1-IN-1 is a dual inhibitor targeting protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), exhibiting inhibitory potency with IC50s</p>Formule :C22H21NO4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :427.54SNC 80
CAS :<p>SNC 80, a non-peptide δ-opioid agonist (Ki=1.78 nM, IC50=2.73 nM), also targets μ-δ heteromers (EC50=52.8 nM), with analgesic and antidepressant potential.</p>Formule :C28H39N3O2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :449.63Axelopran
CAS :<p>Axelopran (TD-1211) treats opioid constipation; it's a potent, selective peripheral opioid blocker.</p>Formule :C26H39N3O4Couleur et forme :SolidMasse moléculaire :457.61PU-WS13 hydrobromide
<p>PU-WS13 hydrobromide is a GRP94 inhibitor with anti-inflammatory activity and inhibits the proliferation of M2-like macrophages in mouse TNBC tumors.</p>Formule :C17H21BrCl2N6SDegré de pureté :98.63%Couleur et forme :SoildMasse moléculaire :492.26CTAP
CAS :<p>Potent μ opioid antagonist, IC50 3.5 nM, 1200x selectivity over δ and somatostatin, brain-penetrant, active in vivo.</p>Formule :C51H69N13O11S2Degré de pureté :98%Couleur et forme :White Solid/PowderMasse moléculaire :1104.32ICI 174,864
CAS :<p>Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.</p>Formule :C38H53N5O7Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :691.87CGP-42112 acetate
<p>CGP-42112 acetate is a potent angiotensin receptor AT2 agonist that inhibits the increase in protein kinase A activity produced by LPS.</p>Formule :C54H73N13O13Degré de pureté :99.06% - 99.92%Couleur et forme :SoildMasse moléculaire :1112.24OT-R antagonist 1
CAS :<p>OT-R antagonist 1: Nonpeptide, selective, low-weight blocker of oxytocin; IC50 = 8 nM for Ca2+ disruption.</p>Formule :C28H29N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.55Nurr1 agonist 12
<p>Nurr1 agonist 12 (Compound 37) acts as an agonist of the nuclear receptor-related protein 1 (Nurr1), enhancing its transcriptional activity with an EC50 of 0.06 μM. It stimulates human response elements NBRE, NurRE, and DR5 with EC50 values of 0.07 μM, 0.027 μM, and 0.014 μM, respectively. Additionally, Nurr1 agonist 12 induces the expression of neurotrophic genes regulated by Nurr1, such as tyrosine hydroxylase (TH), SOD1/2, BDNF, Sestrin 3, and BIRC5 (Survivin). The compound also demonstrates neuroprotective effects against neurotoxicity caused by Paraquat.</p>Formule :C18H12ClN3OCouleur et forme :SolidMasse moléculaire :321.76Antidiabetic agent 15
<p>Antidiabetic agent 15 (compound 1B15) acts as a dual inhibitor of AT1R and NEP, reducing oxidative stress and restoring mitochondrial membrane potential.</p>Formule :C26H23NO5Couleur et forme :SolidMasse moléculaire :429.1576214-3-3σ/ERα stabilizer-1
<p>Compound 181, also known as 14-3-3σ/ERα Stabilizer-1, is a covalent stabilizer targeting the 14-3-3σ/ERα proteins.</p>Formule :C25H35Cl2N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :496.479,10-Dihydrophenanthrene
CAS :<p>9,10-Dihydrophenanthrene has inhibitory activity against the androgen receptor and can be used in related research in the field of life sciences.</p>Formule :C14H12Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :180.25Dermorphin Analog
<p>Dermorphin Analog, a heptapeptide from amphibian skin, binds μ-opioid receptors selectively and strongly.</p>Formule :C44H59N11O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :901.43Galloylalbiflorin
CAS :<p>Galloylalbiflorin, an AR antagonist with IC50 53.3μM, is sourced from Paeonia lactiflora roots, exhibiting anti-androgenic properties.</p>Formule :C30H32O15Couleur et forme :SolidMasse moléculaire :632.57Methylprednisolone Acetate
<p>Methylprednisolone Acetate(Depo-Medrate) has the ability to inhibit oxygen free radicals and can be used to treat acute spinal cord injuries.</p>Formule :C24H32O6Degré de pureté :99.74%Couleur et forme :Off-White SolidMasse moléculaire :416.51TrxR1 prodrug-1
<p>TrxR1 prodrug-1 (compound 5u) is a potent inhibitor of TrxR1, demonstrating significant antitumor activity in nude mice and NSCLC organoids.</p>Formule :C22H30N2O6S2Couleur et forme :SolidMasse moléculaire :482.613Epi-Cryptoacetalide
<p>Epi-Cryptoacetalide is a useful organic compound for research related to life sciences and the catalog number is T126054.</p>Formule :C18H22O3Couleur et forme :SolidMasse moléculaire :286.371Neuropeptide EI, rat
CAS :<p>Displays functional MCH-antagonist and MSH-agonist activity in different behavioral paradigms.</p>Formule :C63H98N16O23Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1447.55DDHF20
<p>DDHF20 is an inhibitor of Staphylococcus aureus, specifically targeting and inhibiting its thioredoxin reductase (TrxR) by acting as a competitive inhibitor at the NADPH binding site. DDHF20 shows potential for research in combating infections related to Staphylococcus aureus.</p>Formule :C34H28O4Couleur et forme :SolidMasse moléculaire :500.58ODM-204
CAS :<p>ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme(IC50s of 80 nM and 22 nM, respectively).</p>Formule :C20H21F3N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :374.40MT-7716 hydrochloride
CAS :<p>MT-7716 hydrochloride is a selective agonist of non-peptide nociceptin receptor (NOP)</p>Formule :C27H29ClN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :477WAY267464 HCl
CAS :<p>WAY267464: nonpeptide OT agonist, anxiolytic, modulates selectivity, improves CNS entry and oral uptake.</p>Formule :C32H37Cl2N7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.59Antihypertensive agent 3
<p>Antihypertensive agent 3 (compound 4a), an angiotensin II receptor 1 antagonist, demonstrates antihypertensive activity in spontaneously hypertensive rats (SHRs</p>Formule :C16H13NO4SCouleur et forme :SolidMasse moléculaire :315.34OBHSA
CAS :<p>OBHSA（Oxabicycloheptane sulfonamide） is a novel selective estrogen receptor depressant (SERD) that can be used to study breast cancer.</p>Formule :C27H24F3NO6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :547.54DuP 747 HCl
CAS :<p>DuP 747 HCl is a selective kappa agonist with analgesic activity.DuP 747 consists of two conformations.</p>Formule :C24H29Cl3N2O2Degré de pureté :99.85%Couleur et forme :SoildMasse moléculaire :483.86GNE-274
CAS :<p>GNE-274, akin to GDC-0927 but non-degrading, is a partial ER agonist in breast cancer, enhancing chromatin at ER sites, inhibiting ER-LBD.</p>Formule :C29H31NO4Couleur et forme :SolidMasse moléculaire :457.57(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin
CAS :<p>'(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin blocks oxytocin receptors, stopping oxytocin effects on CA1 neuron currents.'</p>Formule :C45H69N9O12S2Couleur et forme :SolidMasse moléculaire :992.21GNE-502
CAS :<p>GNE-502 is an orally active and potent estrogen receptor (ER) degrader, specifically designed for research on breast cancer.</p>Formule :C25H30FN3O3SCouleur et forme :SolidMasse moléculaire :471.59Eprosartan
CAS :<p>Eprosartan is a selective AT1 receptor blocker with IC50s of 9.2 nM (rat) and 3.9 nM (human), used for hypertension.</p>Formule :C23H24N2O4SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :424.51Olmesartan medoxomil impurity C
CAS :<p>Impurity C of Olmesartan medoxomil is a selective AT1 inhibitor with an IC50 of 66.2 μM.</p>Formule :C29H28N6O5Couleur et forme :SolidMasse moléculaire :540.57Naldemedine
CAS :<p>Naldemedine (S 297995), developed by Shionogi, is a drug for opioid side effects like constipation. It's well tolerated with minor GI issues.</p>Formule :C32H34N4O6Couleur et forme :SolidMasse moléculaire :570.64Urotensin II, mouse
CAS :<p>UTS2 is a human gene, alias U-II, on chromosome 1p36.23, codes for Urotensin-II, a potent vasoconstrictor. Formula: C64H85N13O18S2, Molar mass: 1388.6 g/mol.</p>Formule :C76H100N18O19S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1633.86DPC-AJ1951
CAS :<p>Potent 14 amino acid peptide agonist of the parathyroid hormone (PTH) receptor (EC50 = 26 nM).</p>Formule :C76H127N23O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1666.98Neuropeptide AF (human)
CAS :<p>Neuropeptide AF (93-110), Human is an endogenous antiopioid peptide.</p>Formule :C90H132N26O25Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1978.17NPFF1-R antagonist 1
<p>NPFF1-R antagonist 1 (compound 8b) is a piperidine analog and an effective neuropeptide FF (NPFF) receptor antagonist. It exhibits 15-fold selectivity for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively.</p>Formule :C37H44N4OMasse moléculaire :560.35151WCA-814
<p>WCA-814, an androgen receptor (AR) antagonist-Hsp90 inhibitor conjugate, induces degradation of both full-length and AR-V7, exhibiting cytotoxic effects in</p>Formule :C46H53ClN10O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :861.43[Ala17]-MCH TFA
<p>'[Ala17]-MCH TFA is an MCH analogue, a selective MCHR1 ligand (Ki=0.16 nM) with high affinity (Kd=0.37 nM), and low MCHR2 affinity (Ki=34 nM).</p>Formule :C99H156F3N29O28S4Couleur et forme :SolidMasse moléculaire :2385.73[Nphe1]Nociceptin(1-13)NH2 TFA
<p>[Nphe1]Nociceptin(1-13)NH2 is a selective nociceptin receptor antagonist with potential analgesic properties, pKi=8.4, pA2=6.0.</p>Formule :C63H101F3N22O17Couleur et forme :SolidMasse moléculaire :1495.61OX04528
CAS :<p>OX04528 is an orally active and potent GPR84 biased agonist.OX04528 inhibits cAMP signaling and may be useful in cancer research.</p>Formule :C16H13F6NO2Degré de pureté :99.74%Couleur et forme :SoildMasse moléculaire :365.27Aclerastide
CAS :<p>Aclerastide, an angiotensin receptor agonist, decreases fibrosis in wounds; effect increases with use duration, blocked by AT antagonist.</p>Formule :C42H64N12O11Couleur et forme :SolidMasse moléculaire :913.03PROTAC ERα Degrader-8
CAS :<p>PROTAC ERα Degrader-8 (compound ii-56), a highly potent degrader of Erα, achieves a DC50 of just 0.000006 μM in MCF7 cells [1].</p>Formule :C47H51N5O4Couleur et forme :SolidMasse moléculaire :749.94Angiotensin II (1-4), human
CAS :<p>Angiotensin II constricts blood vessels and boosts blood pressure by escalating norepinephrine release.</p>Formule :C24H37N7O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :551.59ER ligand-9
CAS :<p>ER ligand-9 is a conjugate of an estrogen receptor (Estrogen Receptor/ERR) ligand and a linker, utilized in the synthesis of PROTACs ERD-1233.</p>Formule :C31H33NO3Couleur et forme :SolidMasse moléculaire :467.599RS 21314
CAS :<p>RS 21314 is a thiol ester corticosteroid that is topical.</p>Formule :C24H30F2O5SCouleur et forme :SolidMasse moléculaire :468.55Cgp 44099
CAS :<p>Cgp 44099 is a potent plasma renin inhibitor from all subprimate species.</p>Formule :C69H104N14O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1337.676MCH(human, mouse, rat) TFA
<p>MCH TFA, a peptide, selectively binds MCH1R and MCH2R with IC50 of 0.3nM, 1.5nM; EC50s are 3.9nM (MCH1R) and 0.1nM (MCH2R) in CHO cells.</p>Formule :C107H161F3N30O28S4Couleur et forme :SolidMasse moléculaire :2500.86CTOP acetate
<p>CTOP acetate is a somatostatin analogue and a μ-opioid receptor antagonist.</p>Formule :C52H71N11O13S2Degré de pureté :99.87%Couleur et forme :SoildMasse moléculaire :1122.32Abaloparatide
CAS :<p>Abaloparatide (BA 058) is a selective PTHR1 analog that promotes bone growth and may be researched for osteoporosis.</p>Formule :C174H300N56O49Couleur et forme :SolidMasse moléculaire :3960.59UFP-101 acetate
<p>UFP-101 acetate is a selective and competitive antagonist of the NOP receptor (pKi = 10.24) with >3000-fold selectivity over δ, μ, and κ opioid receptors.</p>Formule :C84H142N32O23Degré de pureté :95.92%Couleur et forme :SolidMasse moléculaire :1968.23difelikefalin acetate(1024828-77-0 Free base)
CAS :<p>is a ketone and a building block.</p>Formule :C38H57N7O8Degré de pureté :96.94%Couleur et forme :SolidMasse moléculaire :739.9Imlunestrant tosylate
CAS :<p>Imlunestrant (LY-3484356) tosylate, an oral SERD, targets ER+ aBC/EEC by blocking estrogen receptors and gene transcription.</p>Formule :C36H32F4N2O6SCouleur et forme :SolidMasse moléculaire :696.71Melanin Concentrating Hormone, salmon
CAS :Melanin Concentrating Hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus.Formule :C89H139N27O24S4Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :2099.48Prepro-TRH-(160-169)
CAS :<p>Prepro-TRH-(160-169), a pro-TRH peptide, enhances TRH-stimulated TSH secretion.</p>Formule :C54H75N11O18SCouleur et forme :SolidMasse moléculaire :1198.3PROTAC ER Degrader-3
CAS :<p>PROTAC ER Degrader-3 from patent WO2017201449A1 is a PAC synthesis intermediate for ADC/PROTAC antibody conjugates, boosting ERα degradation.</p>Formule :C71H77N7O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1220.434PROTAC ERα Degrader-7
CAS :<p>PROTAC ERα Degrader-7 (Compound i-320) is a powerful PROTAC degrader targeting the estrogen receptor alpha (ERα), exhibiting a DC50 of 0.000006 µM. This compound consists of a cereblon-binding segment, LBM, connected to ERBM, an ERα-binding ligand that includes a benzofused partially saturated 6-membered carbocyclic or heterocyclic ring [1].</p>Formule :C46H49F2N5O4Couleur et forme :SolidMasse moléculaire :773.91BMS-903452
CAS :<p>BMS-903452: potent GPR119 agonist, EC50 = 14 nM, treats rodent diabetes, no P450 inhibition, safe for liver cells.</p>Formule :C21H19Cl2FN4O4SDegré de pureté :99.76% - >99.99%Couleur et forme :SolidMasse moléculaire :513.37R4K1
<p>R4K1 is a cell-permeable stapled peptide that binds with high affinity to estrogen receptor (ER) α, inhibiting its interaction with coactivators. It penetrates breast cancer cells, regulating gene transcription and suppressing cell proliferation. R4K1 is applicable for tumor research.</p>Formule :C82H146N34O19Couleur et forme :SolidMasse moléculaire :1912.25Kylo-0603
CAS :<p>KYLO-0603 is an orally active and selective THR-β agonist with an EC50 of 31.07 nM. It effectively reduces serum cholesterol and low-density lipoprotein cholesterol levels. By activating THR-β receptors, KYLO-0603 enhances the expression of THR-regulated genes like iodothyronine deiodinase 1 (Dio1), malic enzyme 1 (Me1), and thyroid hormone-responsive (Thrsp) gene, while it inhibits the expression of inflammatory and fibrosis-related genes, including low-density lipoprotein receptor (LDL-R) gene. This compound is applicable for the study of metabolic associated steatohepatitis (MASH) and liver fibrosis.</p>Formule :C81H134N8O28Couleur et forme :SolidMasse moléculaire :1667.97β-Endorphin (rat)
CAS :<p>β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities.</p>Formule :C157H254N42O44SCouleur et forme :SolidMasse moléculaire :3466.07(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8)
CAS :<p>E-2078, known chemically as (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8), is a stable analog of Dynorphin A (1–8) and functions as a kappa opioid</p>Formule :C50H81N15O9Couleur et forme :SolidMasse moléculaire :1036.2718-Oxocortisol
CAS :<p>18-Oxocortisol, a naturally occurring mineralocorticoid and adrenal biomarker, is produced by CYP11B2.</p>Formule :C21H28O6Couleur et forme :SolidMasse moléculaire :376.449Koreanoside E
CAS :<p>Koreanoside E is a useful organic compound for research related to life sciences. The catalog number is T125538 and the CAS number is 1804014-67-2.</p>Formule :C27H30O11Couleur et forme :SolidMasse moléculaire :530.526DP32
CAS :<p>DP32 is a dual-function compound incorporating an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. It is applicable in analgesia-related research.</p>Formule :C57H77N13O7Couleur et forme :SolidMasse moléculaire :1056.30U-54494A hydrochloride
CAS :<p>U-54494A hydrochloride is a benzamide derivative related to kappa opioid receptor agonists. U-54494A hydrochloride has anticonvulsant activity.</p>Formule :C18H25Cl3N2OCouleur et forme :SolidMasse moléculaire :391.76[DAla2, DArg6] Dynorphin A, (1-13) (porcine)
CAS :'[DAla2, DArg6] Dynorphin A (1-13) porcine is a potent opioid peptide resistant to enzymatic degradation.'Formule :C76H128N24O15Couleur et forme :SolidMasse moléculaire :1617.98PROTAC ER Degrader-14
CAS :<p>PROTAC ER Degrader-14 (compound 86) is a PROTAC-type estrogen receptor/ERR degrader. It comprises an E3 ubiquitin ligase ligand (blue part) (S)-Deoxy-thalidomide, a PROTAC linker (black part) N-Boc-piperazine, and a target protein ligand (red part) ER ligand-6. The combination of the E3 ligase and linker forms tert-Butyl (S)-4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazine-1-carboxylate.</p>Formule :C44H46FN5O5Couleur et forme :SolidMasse moléculaire :743.865ERα/ERβ antagonist-1
CAS :<p>ERα/ERβ antagonist-1 (Compound 10) functions as a partial antagonist of both ERα and ERβ. It reduces the activity of ERα and ERβ in HepG2 liver cells in a dose-dependent manner.</p>Formule :C22H24O3Couleur et forme :SolidMasse moléculaire :336.42PRL 3195
CAS :<p>PRL 3195: Somatostatin antagonist, Ki: 6 nM (sst5), 17 nM (sst2), 66 nM (sst3), 1 μM (sst1/4).</p>Formule :C58H69ClN12O9S2Couleur et forme :SolidMasse moléculaire :1177.83SNIPER(ER)-87
CAS :<p>SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (</p>Formule :C59H73N5O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1044.32KOR agonist 5
<p>KOR agonist 5 (Compound 10a) is both a KOR/MOR modulator, exhibiting agonistic effects on KOR and antagonistic effects on MOR. It effectively blocks morphine-induced antinociception and gastrointestinal motility inhibition. KOR agonist 5 is applicable in research related to substance use disorder (SUD).</p>Formule :C38H38N2O5Couleur et forme :SolidMasse moléculaire :602.72Helianorphin-19
<p>Helianorphin-19: Potent KOR agonist (Ki=25 nM; EC50=45 nM), 200x selective over μ/δ receptors, effective in mouse pain model, non-sedative.</p>Couleur et forme :LiquidhFSH-β-(33-53) (TFA)
<p>hFSH-β-(33-53) TFA, a thiol-containing peptide representing the second follicle-stimulating hormone receptor (FSHR) binding domain, acts as an FSHR antagonist.</p>Formule :C115H183N31O32SxC2HF3O2Couleur et forme :SolidMasse moléculaire :2657.96ZINC05925939
<p>ZINC05925939 is an estrogen receptor β (ESR2) inhibitor used in breast cancer research.</p>Formule :C17H17NO2Couleur et forme :SolidMasse moléculaire :267.32SNIPER(ER)-110
<p>SNIPER(ER)-110 links cIAP1 and estrogen ligands. SNIPER(ER)-51 degrades ER protein; DC50 <3 nM at 4h, 7.7 nM at 48h.</p>Formule :C66H83N5O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1122.39PROTAC ERα Y537S degrader-1
CAS :<p>PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group.</p>Formule :C46H49N5O6Couleur et forme :SolidMasse moléculaire :767.91Retosiban
CAS :<p>Retosiban is an effective and selective oxytocin antagonist (Ki: 0.65 nM).</p>Formule :C27H34N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.58Norleual
CAS :<p>Angiotensin IV analog, potent HGF/c-MET inhibitor (IC50=3 pM), halts MDCK cell growth and invasion, AT4 antagonist, impairs LTP, antiangiogenic.</p>Formule :C41H58N8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :774.95Nurr1 agonist 5
<p>Compound 5o, a Nurr1 agonist, exhibits neuroprotective properties as a transcription factor Nurr1 agonist, possessing a dissociation constant (Kd) of 0.5 μM and</p>Couleur et forme :Odour Solid[Sar1, Ile8]-Angiotensin II TFA
<p>[Sar1,Ile8]-Angiotensin II (TFA) contracts arteries and affects cell growth in vascular muscle.</p>Formule :C48H74F3N13O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1082.18Saralasin
CAS :Competitive non-selective angiotensin II antagonist.Formule :C42H65N13O10Degré de pureté :98%Couleur et forme :PowderMasse moléculaire :912Faznolutamide
CAS :<p>Faznolutamide is an antiandrogen agent [1] [2] .</p>Formule :C19H17FN4O2SCouleur et forme :SolidMasse moléculaire :384.43Orphanin FQ(1-11)
CAS :<p>Nociceptin peptide fragment (1-11) with potent ORL1/KOR-3 receptor agonism (Ki = 55 nM), no opioid receptor affinity, and analgesic in mice.</p>Formule :C49H75N15O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1098.2TRV056
CAS :<p>TRV056 is a Gq-biased AT1R agonist effective in Gq-mediated signaling and a basis for similar drug development.</p>Formule :C52H74N14O13Couleur et forme :SolidMasse moléculaire :1103.2494,4'-(Cyclohexylidenemethylene)diphenol
CAS :<p>4,4'-(Cyclohexylidenemethylene)diphenol (Compound 2) is a symmetrical cyclic non-steroidal estrogen. It exhibits high binding affinity to estrogen receptors ERα and ERβ.</p>Formule :C19H20O2Couleur et forme :SolidMasse moléculaire :280.36TLB 150 Benzoate
CAS :<p>TLB 150 Benzoate (RAD150) is a modulator of the androgen receptor with an IC50 value of 0.13 μM.</p>Formule :C27H20ClN5O3Couleur et forme :SolidMasse moléculaire :497.93Methylpiperidino pyrazole
CAS :<p>Methylpiperidino pyrazole is an ERα inhibitor and can prevent the BPS-induced Rb phosphorylation and cell cycle progression.</p>Formule :C29H31N3O3Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :469.57AR antagonist 9
<p>AR antagonist 9 is an orally active, selective androgen receptor (AR) antagonist that inhibits cancer by disrupting the formation of AR ligand-binding domain dimers, showing potential in overcoming drug resistance in prostate cancer (PCa). Its antagonistic activity against AR has an IC50 of 0.051 μM, comparable to Enzalutamide (IC50= 0.060 μM). This compound demonstrates superior inhibitory effects on ARF876L/T877A and ARW741C mutants compared to Enzalutamide. Additionally, AR antagonist 9 possesses favorable pharmacokinetic properties, with an oral bioavailability (F) of 66.24% in rats, and significantly inhibits tumor growth in LNCaP xenograft mouse models upon oral administration. AR antagonist 9 holds promise for research in overcoming PCa resistance.</p>Formule :C18H13F4NO2Couleur et forme :SolidMasse moléculaire :351.2917-Epiestriol
CAS :<p>17-Epiestriol, metabolite of estrone, forms via 16α-hydroxy intermediate and binds ERα and ERβ with affinity less than 17β-estradiol.</p>Formule :C18H24O3Couleur et forme :SolidMasse moléculaire :288.38RLA-4842
<p>RLA-4842: iron-based anti-androgen; inhibits mCRPC cell proliferation.</p>Formule :C42H46F3N5O8SCouleur et forme :SolidMasse moléculaire :837.9Emd 55068
CAS :<p>Emd 55068 is a synthetic antagonist of renin.</p>Formule :C41H65N9O6Couleur et forme :SolidMasse moléculaire :780.01A 779
CAS :<p>A 779 is a potent antagonist of the G-protein-coupled receptor Mas, the Ang1-7 receptor, which is distinct from conventional AngII.</p>Formule :C39H60N12O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :872.97TRV055 acetate
<p>TRV055 acetate is a ligand of angiotensin II type 1 receptor and stimulates cellular Gq-mediated signaling.</p>Formule :C44H61N9O11Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :892.01Alclometasone
CAS :<p>Alclometasone is a glucocorticoid that reduces inflammation and treats various skin conditions like eczema and psoriasis.</p>Formule :C22H29ClO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :408.92ARD-266
CAS :<p>ARD-266 is a PROTAC degrader based on the von Hippel-Lindau E3 ligase that induces the degradation of AR proteins and is useful in prostate cancer research.</p>Formule :C52H59ClN6O7Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :915.51AKR1Cs-IN-1
<p>AKR1Cs-IN-1 (Compound 29) is an effective and broad-spectrum inhibitor of the Aldo-Keto Reductase 1C family (AKR1C1-1C4). It achieves subtype inhibition by simultaneously binding to the SP2 and SP3 pockets, thereby blocking metabolic pathways related to drug resistance. In enzyme assays, AKR1Cs-IN-1 exhibits significant inhibitory activity with IC50 values of 0.09, 0.28, 0.05, and 0.51 µM for AKR1C1, AKR1C2, AKR1C3, and AKR1C4, respectively. The compound shows excellent resensitizing effects in doxorubicin (DOX)-resistant breast cancer cell line MCF-7/ADR, effectively enhancing the cytotoxicity of DOX. AKR1Cs-IN-1 holds promise for research on breast cancer resistance.</p>Couleur et forme :Odour SolidUFP-101
CAS :<p>Strong, selective NOP receptor antagonist with pKi=10.24; >3000x selectivity over δ, μ, κ receptors; blocks nociceptin effects.</p>Formule :C82H138N32O21Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1908.19Latanoprost acid
CAS :<p>Latanoprost acid is a prostanoid receptor agonist that blocks RANKL and can be used to reduce intraocular pressure.</p>Formule :C23H34O5Degré de pureté :97.96%Couleur et forme :Pale Yellow OilMasse moléculaire :390.51Neuropeptide AF (human) acetate
<p>Neuropeptide AF (human) acetate (Neuropeptide AF (human) acetate (192387-38-5 Free base)) is an anti-opioid neuropeptide, a Neuropeptide AF (human) derivative,</p>Degré de pureté :99.89%Couleur et forme :SoildNorethindrone acetate
CAS :<p>Norethindrone acetate (19-Norethindroneacetate) is an oestrogen with inhibitory effects on adolescent menstruation and hepatic adenomas and is often used in</p>Formule :C22H28O3Degré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :340.46Cgp 29287
CAS :<p>Cgp 29287 is a primate-specific renin inhibitor. It also has a prolonged duration of action.</p>Formule :C72H110N20O15Couleur et forme :SolidMasse moléculaire :1495.77Gridegalutamide
CAS :<p>Gridegalutamide exhibits anti-androgen and anti-tumor activities.</p>Formule :C41H45F3N8O5SCouleur et forme :SolidMasse moléculaire :818.91Enclomiphene-d4
<p>Enclomiphene-d4 is the deuterium-labeled analog of Enclomiphene. Enclomiphene functions as a potent and orally active estrogen receptor antagonist, exhibiting antiestrogenic properties.</p>Couleur et forme :Odour SolidUFP-803
CAS :<p>UT receptor ligand acts mainly as silent antagonist with slight agonist effects; blocks U-II in rat aorta, pIC50 = 7.46, & inhibits plasma leakage in mice.</p>Formule :C50H64N10O12S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1061.24(S)-CVN424
CAS :<p>(S)-CVN424 modulates GPR6, key for neurological/psychiatric research, including Parkinson's.</p>Formule :C24H29F2N5O3Couleur et forme :SolidMasse moléculaire :473.525BI 653048 phosphate
CAS :<p>BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM).</p>Formule :C23H28F4N3O8PSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :613.52BIBS 39
CAS :<p>BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist.</p>Formule :C32H36N4O3Degré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :524.65ST-CY14
<p>ST-CY14 is an inhibitor of the Nur77-PPARγ interaction with an EC50 of 3.15 μM. It binds to Nur77 (Kd=32 nM) to prevent its ubiquitination and degradation by PPARγ, reducing fatty acid uptake and mitochondrial respiration, and inhibiting the transcription of CD36 and FABP4. ST-CY14 suppresses proliferation and migration of MCF7 and MDA-MB-231 cancer cells and impedes tumor growth and bone metastasis in mouse models.</p>Formule :C139H237N57O31S2Couleur et forme :SolidMasse moléculaire :3266.86RLA-5331
<p>RLA-5331: iron activator with anti-androgen properties; inhibits mCRPC cell proliferation.</p>Formule :C40H43F3N6O7SCouleur et forme :SolidMasse moléculaire :808.87Estrogen receptor modulator 6
CAS :<p>ER modulator 6 (3a) is a potent ERβ agonist with a K i of 0.44 nM; 19x more selective for ERβ than ERα.</p>Formule :C18H16F2O3Couleur et forme :SolidMasse moléculaire :318.32PD 123177
CAS :<p>PD 123177 is an inhibitor of Nonpeptide angiotensin AII-2.</p>Formule :C29H28N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.56C-Type Natriuretic Peptide (1-53), human
CAS :<p>CNP, from natriuretic family, first in pigs, now in other species, processes into CNP-22/CNP-53, similar to ANP/BNP, with varying potencies.</p>Formule :C251H417N81O71S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5801.77AKR1B10-IN-1
CAS :<p>AKR1B10-IN-1: potent AKR1B10 inhibitor, IC50 3.5 nM; hinders lung cancer cell growth, spread, and Cisplatin resistance.</p>Formule :C19H16FNO4Couleur et forme :SolidMasse moléculaire :341.338Yp537
CAS :<p>Yp537 acts as an estrogen receptor (ER) inhibitor, specifically preventing the dimerization of the human estrogen receptor [1].</p>Formule :C64H104N13O22PSCouleur et forme :SolidMasse moléculaire :1470.62Dipropyl phthalate
CAS :<p>Dipropyl phthalate is a weak androgen receptor inhibitor, and can be used in biochemical experiments and drug synthesis.</p>Formule :C14H18O4Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :250.29PROTAC AR-V7 degrader-1
CAS :<p>Potent, oral AR-V7 degrader (Compound 6); DC50: 0.32µM; targets AR-DBD via VHL E3; EC50: 0.88µM in 22Rv1 cells.</p>Formule :C41H52N6O6S2Couleur et forme :SolidMasse moléculaire :789.024A7C-301
<p>4A7C-301, a Nurr1 agonist, exhibits potent neuroprotective effects in vitro and markedly mitigates neuropathological abnormalities while enhancing motor and</p>Couleur et forme :Odour SolidRo 64-6198
CAS :<p>Ro 64-6198: Nonpeptide, selective NOP agonist, high brain uptake, EC50=25.6 nM, 100x NOP>opioid affinity.</p>Formule :C26H31N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.54[Orn8]-Urotensin II
CAS :<p>[Orn8]-Urotensin II is a Urotensin receptor ligand and a partial agonist at Urotensin receptors.</p>Formule :C63H83N13O18S2Couleur et forme :SolidMasse moléculaire :1374.55ARCC-4
CAS :<p>ARCC-4: A VHL-recruiting, low-nanomolar (DC50=5nM) AR degrader; outshines enzalutamide; degrades AR mutants resistant to therapy.</p>Formule :C53H56F3N7O7S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1024.18Parathyroid hormone (1-34) (rat)
CAS :<p>Parathyroid hormone (PTH) receptor agonist. Increases serum PTH levels and bone mass in rats.</p>Formule :C180H291N55O48S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4057.74Biphalin TFA
CAS :<p>Biphalin TFA is an opioid peptide analog that penetrates the blood-brain barrier (BBB) and encompasses two active enkephalin pharmacophores.</p>Formule :C46H56N10O10·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :909.00 (free base)PL-017
CAS :<p>μ opioid receptor agonist; IC50: 5.5 nM (μ), >10,000 nM (δ). Induces reversible analgesia, catalepsy, hyperthermia in rats.</p>Formule :C29H37N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :535.64Betamethasone acibutate
CAS :<p>Betamethasone acibutate, a glucocorticoid, is derived from Betamethasone.</p>Formule :C28H37FO7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.59Remikiren
CAS :<p>Remikiren is a highly specific renin inhibitor with oral activity for the treatment of hypertensio.</p>Formule :C33H50N4O6SCouleur et forme :SolidMasse moléculaire :630.84Nocistatin
CAS :<p>Nocistatin, a neuropeptide, blocks Nociceptin effects and inhibits 5-HT release, acting on an opioid-related receptor.</p>Formule :C32H56N10O12Couleur et forme :SolidMasse moléculaire :772.852-Ethylhexyl trans-4-methoxycinnamate
CAS :<p>2-Ethylhexyl trans-4-methoxycinnamate is a sunscreen agent.</p>Formule :C18H26O3Degré de pureté :98.92%Couleur et forme :Pale Yellow LiquidMasse moléculaire :290.4Hydrocortisone sodium succinate
CAS :<p>Hydrocortisone sodium succinate is a glucocorticoid which is used to alleviate allergic reactions, particularly those of the skin and gums.</p>Formule :C25H34NaO8Couleur et forme :SolidMasse moléculaire :485.529Aliskiren D6 Hydrochloride
CAS :<p>Aliskiren (CGP 60536) D6 Hydrochloride is a deuterium-labeled Aliskiren. Aliskiren hemifumarate is a direct and orally active renin inhibitor (IC50: 1.5 nM).</p>Formule :C30H54ClN3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :594.26Angiotensin amide
CAS :<p>Angiotensin amide, an octapeptide amide, can be used to increase blood pressure by vasoconstriction.</p>Formule :C49H70N14O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1031.17β-Lipotropin (60-65)
CAS :<p>β-Lipotropin (60-65) (β-LPH (60-65)), an opioid agonist, is a significant [1] opioid peptide.</p>Formule :C33H47N9O8SCouleur et forme :SolidMasse moléculaire :729.85T4-ATA (S-isomer)
<p>T4-ATA S-isomer, the active form of the thyroid hormone, represents the S-isomer of T4-ATA.</p>Formule :C19H15I4NO6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :893.014'-hydroxy Tamoxifen
CAS :<p>It is a metabolite of tamoxifen and an estrogen receptor modulator.</p>Formule :C26H29NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.511α-Hydroxy-3-epi-vitamin D3
CAS :<p>1α-Hydroxy-3-epi-vitamin D3, a natural metabolite derived from 1alpha,25-dihydroxyvitamin D3, effectively suppresses parathyroid hormone (PTH) secretion[1].</p>Formule :C27H44O2Couleur et forme :SolidMasse moléculaire :400.647Dynorphin B (1-13) (TFA)
<p>Dynorphin B (1-13) TFA acts as an agonist on opioid κ-receptor .</p>Formule :C76H116N21F3O19Couleur et forme :SolidMasse moléculaire :1684.86PROTAC ERRα Degrader-3
CAS :<p>PROTAC ERRα Degrader-3 is a highly effective and selective von Hippel-Lindau-based ligand that efficiently degrades the ERRα protein.</p>Formule :C47H50F6N6O7SCouleur et forme :SolidMasse moléculaire :957.0Herkinorin
CAS :<p>Herkinorin: μ-opioid agonist with 100x μ-affinity, 50x less κ-affinity than Salvinorin A, from Salvia divinorum. Semi-synthetic from Salvinorin B.</p>Formule :C28H30O8Couleur et forme :SolidMasse moléculaire :494.53Ac-RYYRIK-NH2
CAS :<p>NOP site high affinity ligand (Ki=1.5 nM); blocks nociceptin effects in rat brain/heart; agonist in vivo, reduces mouse movement.</p>Formule :C44H70N14O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :939.12ALR2-IN-6
<p>ALR2-IN-6 (compound 9) is a potent competitive inhibitor of ALR2, with a Ki value of 0.064 μM. It is applicable in research related to neuropathy, retinopathy, and nephropathy.</p>Formule :C21H19BrFN3OCouleur et forme :SolidMasse moléculaire :427.06955Ac-RYYRWK-NH2 TFA
CAS :<p>Ac-RYYRWK-NH2: potent, specific NOP receptor partial agonist with 0.071 nM affinity; no affinity for μ/κ/δ-opioid receptors.</p>Formule :C51H70F3N15O11Couleur et forme :SolidMasse moléculaire :1126.21Antitumor agent-195
<p>Antitumor agent-195 (compound 16c) is a dual-targeting agent that simultaneously targets STAT3 and NQO1. At a concentration of 1 μM, it significantly inhibits the phosphorylation of STAT3 at the Tyr705 site and effectively induces apoptosis in MDA-MB-231 and MDA-MB-468 breast cancer cells. As a substrate of NQO1, Antitumor agent-195 markedly increases ROS production, causing severe DNA damage in a dose-dependent manner. It also demonstrates strong antitumor properties in MDA-MB-231 xenograft models.</p>Formule :C22H22N2O4Couleur et forme :SolidMasse moléculaire :378.42THR-β agonist 2 diacetate
<p>THR-β agonist 2 diacetate (Compound 3) is a potent THR-β agonist with potential applications in researching metabolic disorders such as obesity, hyperlipidemia, hypercholesterolemia, and diabetes, as well as other conditions like steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis, and other related diseases and conditions.</p>Couleur et forme :Odour SolidPTP1B/AKR1B1-IN-2
<p>PTP1B/AKR1B1-IN-2 (Compound 7f) is a potent inhibitor targeting both PTP1B and AKR1B1 with IC50 values of 3.2 and 2.1 μM, respectively, and K i values of 4.0</p>Formule :C23H23NO4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.56[Sar1, Ile8]-Angiotensin II acetate
<p>'[Sar1, Ile8]-Angiotensin II acetate triggers oxidases and prompts superoxide in muscles; has varied vascular impacts.</p>Formule :C48H77N13O12Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :1028.2L 363564
CAS :<p>L 363564 is a kidney renin inhibitor.</p>Formule :C54H76N12O10Couleur et forme :SolidMasse moléculaire :1053.276Melanin Concentrating Hormone, salmon TFA
<p>MCH (salmon) TFA is a 19-amino-acid neuropeptide affecting appetite, energy, sleep, and heart health via GPCR SLC-1/GPR24 and MCHR2.</p>Formule :C91H140F3N27O26S4Couleur et forme :SolidMasse moléculaire :2213.5BigLEN(mouse)
CAS :<p>GPR171 agonist from ProSAAS controls mouse appetite, reduces glutamate in paraventricular neurons via G protein.</p>Formule :C78H130N24O22Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1756.03(rel)-PROTAC ERRα Degrader-1
<p>(rel)-PROTAC ERRα Degrader-1 is a relative configuration of PROTAC ERRα Degrader-1, which is an estrogen-related receptor alpha (ERRa) degrader.</p>Formule :C54H49Cl2F6N7O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1108.91PROTAC ERRα Degrader-2
CAS :<p>PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group.</p>Formule :C57H55Cl2F6N7O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1150.99PROTAC ER Degrader-4
CAS :<p>PROTAC ER Degrader-4 is a PROATC degrader of estrogen receptor (ER)(IC50 of 0.8 nM).</p>Formule :C53H67F3N6O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1005.2Floramanoside C
CAS :<p>Floramanoside C exhibits 2,2-diphenyl-1-picrylhydrazyl scavenging and aldose reductase inhibitory activities [1].</p>Formule :C21H18O15Couleur et forme :SolidMasse moléculaire :510.36Nociceptin (1-13), amide
CAS :<p>Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain</p>Formule :C61H100N22O15Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1381.59HINT1-IN-1
<p>HINT1-IN-1 (compound 8) is an inhibitor of histidine triad nucleotide-binding protein 1 (HINT1) with a Ki of 1.14 μM. It influences the cross-regulation between μ-opioid receptors (MOR) and NMDA receptors (NMDAR).</p>Formule :C23H24N8O5Couleur et forme :SolidMasse moléculaire :492.49DAMGO (TFA)
CAS :<p>DAMGO is a selective peptide agonist of the µ-opioid receptor .</p>Formule :C28H36F3N5O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :627.61OT-R antagonist 2
CAS :<p>OT-R antagonist 2 is a nonpeptide low molecular weight antagonist of OT-R .</p>Formule :C28H29N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.55BI 653048
CAS :<p>BI 653048 is a selective and orally active agonist of nonsteroidal glucocorticoid (IC50: 55 nM). BI 653048 is also an HCV NS3 protease inhibitor.</p>Formule :C23H25F4N3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.523-epi-25-hydroxy Vitamin D3
CAS :<p>3-epi-25-hydroxy Vitamin D3 lowers serum PTH in male weanling rats at 0.5 and 1 IU/g doses; doesn't affect females.</p>Formule :C27H44O2Couleur et forme :SolidMasse moléculaire :400.64KOR agonist 4
<p>KOR agonist 4 (compound 39) is an agonist targeting the κ opioid receptor (Kappa Opioid Receptor) and activates G protein signaling. It has an EC50 of 14 nM and an Emax of 83% for binding to GTPγS. This compound demonstrates moderate to high intrinsic clearance in human liver cells and shows selectivity for the κ opioid receptor over the μ (MOR) and δ (DOR) opioid receptors by factors of 60 and 810, respectively. KOR agonist 4 is useful for research into central nervous system (CNS) disorders.</p>Formule :C21H25N3Couleur et forme :SolidMasse moléculaire :319.44Alunacedase alfa
CAS :<p>Alunacedase alfa (APN-01) is an angiotensin-converting enzyme 2 with antiviral activity.</p>Degré de pureté :99.1% (SDS-PAGE); 99.9% (SEC-HPLC) - 99.1% (SDS-PAGE); 99.9% (SEC-HPLC)Couleur et forme :LiquidPerindoprilat
CAS :<p>Perindoprilat (Perindoprilate) is an angiotensin-converting enzyme inhibitor.</p>Formule :C17H28N2O5Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :340.41PROTAC AR Degrader-4 TFA
<p>PROTAC AR Degrader-4: IAP ligand, linker, AR binder; it's a SNIPER that degrades AR non-genetically.</p>Formule :C45H68F3N3O11Couleur et forme :SolidMasse moléculaire :884.03Cgp 38560
CAS :<p>CGP 38560 is a potent renin inhibitor.</p>Formule :C40H67N5O9S2Couleur et forme :SolidMasse moléculaire :826.12Nurr1 agonist 2
CAS :<p>Nurr1 agonist 2 with EC50 of 0.07 μM, boosts TH & VMAT2 mRNA, binds Nurr1 LBD at Kd 0.14 μM, for parkinsonism study.</p>Formule :C18H14O3SDegré de pureté :98.78%Couleur et forme :SoildMasse moléculaire :310.37Dynorphin A (1-8)
CAS :<p>Dynorphin (1-8) is an opioid octapeptide from the porcine hypothalamus. It comprises the N-terminal eight residues of dynorphin.</p>Formule :C46H72N14O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :981.15Dynorphin B (1-13)
CAS :Dynorphin B (1-13) acts as an agonist on opioid κ-receptor.Formule :C74H115N21O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1570.84Ac-RYYRWK-NH2
CAS :<p>Selective NOP receptor partial agonist peptide; Ki=0.71 nM; >4000 nM for μ, δ, κ receptors; boosts food intake in vivo.</p>Formule :C49H69N15O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1012.17Brain Natriuretic Peptide (1-32), rat
CAS :<p>Rat Brain Natriuretic Peptide (1-32) is a 32-amino-acid peptide from heart, released when ventricles stretch excessively.</p>Formule :C146H239N47O44S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3452.94Azilsartan Medoxomil Potassium
CAS :<p>Azilsartan Medoxomil Potassium (TAK-491 Potassium) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.</p>Formule :C30H23N4O8·KDegré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :606.62Zavacorilant
CAS :<p>Zavacorilant is capable of modulating glucocorticoid receptor (GR).</p>Formule :C25H26FN7O3S2Couleur et forme :SolidMasse moléculaire :555.65AZ 1729
CAS :<p>FFA2 modulator; inhibits cAMP, enhances 35SGTPγS binding (pEC50: 6.9, 7.23); alters Gi/Gq signaling; affects lipolysis, neutrophil migration.</p>Formule :C18H16FN5OSCouleur et forme :SolidMasse moléculaire :369.42Raloxifene 6-glucuronide
CAS :<p>Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8.</p>Formule :C34H35NO10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :649.71CP-472555
CAS :<p>CP-472555 is a selective nonsteroidal glucocorticoid receptor antagonist with anti-GR and anti-obesity activity in animal models.</p>Formule :C31H32N2O2Couleur et forme :SolidMasse moléculaire :464.60NH-3
CAS :<p>NH-3, an orally active THR antagonist with a 55 nM IC50, blocks thyroid hormone binding and cofactor recruitment.</p>Formule :C28H27NO6Degré de pureté :97.79% - 99.40%Couleur et forme :SolidMasse moléculaire :473.523-Cl-Pyridine-amide-acrylaldehyde-piperazine
<p>3-Cl-Pyridine-amide-acrylaldehyde-piperazine serves as a synthetic intermediate for LO-4-25. LO-4-25 is a ligand for the androgen receptor (AR) DNA binding domain and is linked to a truncated fumaramide handle via a connector. In 22Rv1 cells, LO-4-25 demonstrates potent degradation of both AR and AR-V7.</p>Couleur et forme :Odour SolidAntihypertensive agent 2
<p>Antihypertensive agent 2 (Compound 4g) exhibits effective antagonistic activities against angiotensin II receptor 1 and reduces blood pressure with equal or</p>Formule :C22H15NO3Couleur et forme :SolidMasse moléculaire :341.36BigLEN(rat)
CAS :<p>Potent GPR171 agonist (EC50 = 1.6 nM). ProSAAS-derived peptide. Regulates body weight in mice and promotes the outgrowth of neurites in Neuro2A cells.</p>Formule :C76H128N24O23Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1746PF-06478939 TFA
<p>PF-06478939 TFA is a peptide that acts as a non-brain-penetrating agonist at the oxytocin (OT) and vasopressin receptors, exhibiting EC50 values of 0.01 nM and</p>Formule :C78H134N14O22S2·xC2HF3O2Degré de pureté :98%Couleur et forme :Solid
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