Endocrinologie/Hormones

<p>Alvimopan is a potent opioid antagonist targeting gut receptors to reverse opioid effects on motility.</p>

<p>(R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.</p>

<p>LY2940094 (LY-2940094) decreases ethanol self-administration in animal models.</p>

<p>Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.</p>

SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.

<p>BI-671800 (AP-761) is a DP2/CRTH2 antagonist with IC50 values of 4.5 nM and 3.7 nM, potential for treating asthma.</p>

<p>Betamethasone valerate (Luxiq) is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions.</p>

<p>Mestranol (Devocin), a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.</p>

<p>Loteprednol etabonate (Lotemax) is an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity.</p>

<p>Ethynodiol diacetate (Ethynodiol acetate) is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.</p>

<p>GW-870086 is an effective anti-inflammatory agent.</p>

<p>Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM).</p>

<p>Hydrocortisone acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive</p>

<p>Betamethasone Dipropionate, a synthetic glucocorticoid, modulates gene expression to manage inflammation and autoimmune activity.</p>

<p>Altrenogest (Allyltrenbolone)(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone.</p>

<p>Halcinonide (Halciderm), a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations.</p>

<p>Canrenone (SC14266) is an aldosterone antagonist with potassium-sparing diuretic activity.</p>

Clomiphene citrate (NSC 35770) is a selective estrogen receptor modulator.

Hydrocortisone 17-butyrate (Cortisol 17-butyrate) is a glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects.

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Human ACVA protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ACVA. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human ACVA in the samples is then determined by comparing the OD of the samples to the standard curve.</p>