NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
445 produits trouvés pour "NF-κB"
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Dihydroartemisinin
CAS :<p>Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!</p>Formule :C15H24O5Degré de pureté :98% - 99.41%Couleur et forme :White SolidMasse moléculaire :284.35GLPG2534
CAS :<p>GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 can be used in psoriasis and atopic dermatitis.</p>Formule :C21H24N6O4Degré de pureté :99.51% - 99.61%Couleur et forme :SolidMasse moléculaire :424.45CDDO-dhTFEA
CAS :<p>CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.</p>Formule :C33H45F3N2O3Degré de pureté :95.61% - 99.59%Couleur et forme :SolidMasse moléculaire :574.72Mangiferin
CAS :<p>Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.</p>Formule :C19H18O11Degré de pureté :99.78% - 99.86%Couleur et forme :Light Yellow PowderMasse moléculaire :422.34Nimbolide
CAS :<p>Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.</p>Formule :C27H30O7Degré de pureté :95.84% - 99.4%Couleur et forme :SolidMasse moléculaire :466.52TBK1/IKKε-IN-2
CAS :<p>TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.</p>Formule :C26H27N5O3Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :457.52α-Lipoic Acid
CAS :<p>α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.</p>Formule :C8H14O2S2Degré de pureté :98.39% - 99.73%Couleur et forme :Forms Yellowish Flakes Light Yellow To Yellow PowderMasse moléculaire :206.33GSK3145095
CAS :<p>GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.</p>Formule :C20H17F2N5O2Degré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :397.38Sulfasalazine
CAS :<p>Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative. Sulfasalazine induces ferroptosis and inhibits NF-κB. Cost effective and quality assured.</p>Formule :C18H14N4O5SDegré de pureté :98.00% - 99.28%Couleur et forme :Minute Brownish-Yellow CrystalsMasse moléculaire :398.39Sinomenine hydrochloride
CAS :<p>Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.</p>Formule :C19H24ClNO4Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :365.851Aspirin
CAS :<p>Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.</p>Formule :C9H8O4Degré de pureté :99.78% - 99.91%Couleur et forme :White Solid CrystallineMasse moléculaire :180.16RIPK1-IN-7
CAS :<p>RIPK1-IN-7: Strong, selective RIPK1 inhibitor (Kd=4 nM, IC50=11 nM) with great antimetastasis effects in B16 melanoma.</p>Formule :C25H22F3N5O2Degré de pureté :98.02% - 98.18%Couleur et forme :SolidMasse moléculaire :481.47IRAK4-IN-4
CAS :<p>IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4)</p>Formule :C22H16N2O2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :340.37Urolithin B
CAS :<p>Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical</p>Formule :C13H8O3Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :212.2Guaiacol
CAS :<p>Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.</p>Formule :C7H8O2Degré de pureté :99.95%Couleur et forme :Colourless To Pale Yellow Solid CrystallineMasse moléculaire :124.14Methylthiouracil
CAS :<p>Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.</p>Formule :C5H6N2OSDegré de pureté :99.89% - >99.99%Couleur et forme :Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Masse moléculaire :142.18AZ1495
CAS :<p>AZ1495: oral IRAK4 inhibitor (IC50: 5 nM), IRAK1 (23 nM), treats MYD88L265P DLBCL.</p>Formule :C21H31N5O2Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :385.5Theophylline
CAS :<p>Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central</p>Formule :C7H8N4O2Degré de pureté :99.65% - 99.98%Couleur et forme :White Solid PowderMasse moléculaire :180.16BAY-985
CAS :<p>BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.</p>Formule :C27H30F3N9ODegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :553.584-Hydroxychalcone
CAS :<p>4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.</p>Formule :C15H12O2Degré de pureté :99.75%Couleur et forme :Yellow PowderMasse moléculaire :224.25Sodium salicylate
CAS :<p>Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.</p>Formule :C7H5NaO3Degré de pureté :99.36% - 99.92%Couleur et forme :White Solid AmorphousMasse moléculaire :160.11Asatone
CAS :<p>Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).</p>Formule :C24H32O8Degré de pureté :99.84% - 99.92%Couleur et forme :SolidMasse moléculaire :448.51DCZ0415
CAS :<p>DCZ0415: Potent TRIP13 inhibitor; combats myeloma in vitro, in vivo, and in drug-resistant patients; hinders DNA repair and NF-κB activity.</p>Formule :C23H20N2O2Degré de pureté :99.34% - 99.95%Couleur et forme :SolidMasse moléculaire :356.42Lidocaine hydrochloride
CAS :<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Formule :C14H23ClN2ODegré de pureté :99.81% - 99.92%Couleur et forme :White Crystal PowderMasse moléculaire :270.798Sulindac
CAS :<p>Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity.</p>Formule :C20H17FO3SDegré de pureté :99.09% - 99.15%Couleur et forme :Yellow SolidMasse moléculaire :356.41Theophylline monohydrate
CAS :<p>Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium</p>Formule :C7H8N4O2·H2ODegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :198.185-Aminosalicylic Acid
CAS :<p>5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1 (PAK1) and NF-Κb. High-Quality, Low-Cost!</p>Formule :C7H7NO3Degré de pureté :98.88% - 99.49%Couleur et forme :Purplish-Tan Solid PowderMasse moléculaire :153.14NIK SMI1
CAS :<p>NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).</p>Formule :C20H19N3O4Degré de pureté :99.04% - 99.99%Couleur et forme :SolidMasse moléculaire :365.38Erdosteine
CAS :<p>Erdosteine (RV 144), a mucolytic thiol, modulates mucus and aids expectoration, reduces cough, and protects lungs from smoke damage.</p>Formule :C8H11NO4S2Degré de pureté :99.43% - 99.94%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :249.31Oxaprozin
CAS :<p>Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.</p>Formule :C18H15NO3Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :293.32(E/Z)-BCI
CAS :<p>(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS</p>Formule :C22H23NODegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :317.42DMAPT
CAS :<p>DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.</p>Formule :C17H27NO3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :293.4Mevastatin
CAS :<p>Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.</p>Formule :C23H34O5Degré de pureté :99.12%Couleur et forme :White-Yellowish To Yellow Powder Solid PowderMasse moléculaire :390.51Metaxalone
CAS :<p>Metaxalone, sold as Skelaxin by King Pharmaceuticals, is a muscle relaxant for pain from strains and sprains.</p>Formule :C12H15NO3Degré de pureté :98.84% - 99.94%Couleur et forme :White To Almost White Crystalline Powder SolidMasse moléculaire :221.25Articaine hydrochloride
CAS :<p>Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.</p>Formule :C13H21ClN2O3SDegré de pureté :99.76%Couleur et forme :White Crystalline PowderMasse moléculaire :320.84DRI-C21045
CAS :<p>Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).</p>Formule :C32H24N2O7SDegré de pureté :97.20%Couleur et forme :SolidMasse moléculaire :580.61IMD-0560
CAS :<p>IMD-0560 is a novel inhibitor of IκB kinase β.</p>Formule :C15H8BrF6NO2Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :428.12Ergolide
CAS :<p>Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.</p>Formule :C17H22O5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :306.35Baicalin
CAS :<p>Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV</p>Formule :C21H18O11Degré de pureté :90.08% - 99.32%Couleur et forme :Yellow PowderMasse moléculaire :446.36Naringin dihydrochalcone
CAS :<p>Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.</p>Formule :C27H34O14Degré de pureté :99.07% - 99.73%Couleur et forme :Solid PowderMasse moléculaire :582.55Indacaterol maleate
CAS :<p>Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.</p>Formule :C28H32N2O7Degré de pureté :99.03% - 99.67%Couleur et forme :SolidMasse moléculaire :508.56SN50 acetate (213546-53-3 free base)
<p>SN50 acetate is a cell permeable inhibitor of NF-κB translocation.</p>Formule :C131H234N36O31SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :2841.55Lidocaine
CAS :<p>Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.</p>Formule :C14H22N2ODegré de pureté :99.95% - >99.99%Couleur et forme :Needles From Benzene Or Alcohol SolidMasse moléculaire :234.34Lidocaine Hydrochloride hydrate
CAS :<p>Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.</p>Formule :C14H22N2O·HCl·H2ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :288.82TH023
<p>TH023 is an inhibitor of the TLR4 signaling pathway, specifically targeting the formation of TLR4 homodimers. In HEK-Blue hTLR4 cells, TH023 suppresses the secretion of embryonic alkaline phosphatase with an IC50 of 0.354 μM and inhibits NO expression in RAW264.7 cells, with an IC50 of 1.61 μM. Additionally, TH023 inhibits the activation of NF-κB and reduces the nuclear translocation of NF-κB p65. The compound demonstrates anti-inflammatory effects in a mouse model of LPS-induced acute sepsis and improves lung injury in mice.</p>Formule :C22H21ClF2N4OCouleur et forme :SolidMasse moléculaire :430.88Helenalin
CAS :<p>Helenalin: anti-inflammatory sesquiterpene, inhibits NF-κB by alkylating p65 cysteine groups, blocks DNA binding.</p>Formule :C15H18O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :262.3PROTAC IRAK4 ligand-4
CAS :<p>PROTAC IRAK4 ligand-4, a Ligand for Target Protein for PROTAC (Ligand for Target Protein for PROTAC), exhibits anti-tumor activity and is utilized in synthesizing PROTAC IRAK4 degrader-12. This compound serves as a targeted ligand with specific applications in the development of cancer therapeutics.</p>Formule :C24H26F2N6O3Couleur et forme :SolidMasse moléculaire :484.5IKK-IN-3
CAS :<p>IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).</p>Formule :C17H17N5SCouleur et forme :SolidMasse moléculaire :323.42HS-243
CAS :<p>HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.</p>Formule :C17H16N4O3Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :324.33NF-κΒ activator 1
CAS :<p>NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.</p>Formule :C16H11FN2O2SDegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :314.33Coronalolic acid
CAS :<p>Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.</p>Formule :C30H46O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :470.68CIB-1476
<p>CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.</p>Formule :C28H28N2O6SCouleur et forme :SolidMasse moléculaire :520.6Cyclo(L-Pro-L-Val)
CAS :<p>Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.</p>Formule :C10H16N2O2Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :196.25(R)-(-)-Ibuprofen
CAS :<p>(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation.</p>Formule :C13H18O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :206.28EN450
CAS :<p>EN450 is a targeted cysteine degrader of NF-κB with antiproliferative activity and potential anticancer activity for the study of leukemia.</p>Formule :C11H13ClN2O3SDegré de pureté :99.72%Couleur et forme :SoildMasse moléculaire :288.75PROTAC IRAK4 degrader-12
CAS :<p>PROTAC IRAK4 degrader-12, a Cereblon ligand-based PROTAC, induces a maximum degradation of IRAK4 in K562 cells at 108.46% with an IC50 value of 4.87 nM. (Structure Note: Pink, IRAK4 Inhibitor; Blue, E3; Black, linker.)</p>Formule :C46H50ClF2N11O6Couleur et forme :SolidMasse moléculaire :926.41RIPK1-IN-27
<p>RIPK1-IN-27 (compound 19) is an inhibitor of RIPK1.</p>Formule :C27H28N4O3Couleur et forme :SolidMasse moléculaire :456.54Gliotoxin
CAS :<p>Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.</p>Formule :C13H14N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.39PROTAC STING degrader-3
<p>PROTACSTING degrader-3 (Compound ST9) is a STINGPROTAC-type degrader with a DC50 of 0.62 μM. It induces STING degradation via the ubiquitin-proteasome pathway. This compound exerts anti-inflammatory effects by inhibiting the STING/TBK1/NF-κB signaling. Additionally, it offers renal protection and can be used in research on acute kidney injury.</p>Couleur et forme :Odour SolidAnti-inflammatory agent 51
CAS :<p>Anti-inflammatory agent 51 amide/sulfonamide anti-inflammatory and anti-tumor activity inhibition of NF-κB activation acute lung injury and ulcerative colitis.</p>Formule :C22H22N6O6SDegré de pureté :99.46%Couleur et forme :SoildMasse moléculaire :498.51Antidesmone
CAS :<p>Antidesmone from Ajuga decumbens inhibits acute lung injury by modulating MAPK and NF-κB.</p>Formule :C19H29NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.44SjDX5-271
CAS :<p>SjDX5-271 is a 3 kDa peptide that inhibits the TLR4/MyD88/NF-κB signaling pathway. It induces cell polarization, alleviates liver inflammation, and protects mice from liver ischemia-reperfusion injury.</p>Formule :C137H215N47O49SCouleur et forme :SolidMasse moléculaire :3336.52Aloenin aglycone
CAS :<p>Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate.</p>Formule :C13H12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.23NBD peptide
CAS :<p>NBD peptide inhibits the NF-κB signaling pathway by preventing the binding of the NEMO-IKK complex. It exhibits anti-inflammatory activity by blocking the production of pro-inflammatory cytokines. Additionally, NBD peptide demonstrates immunosuppressive effects through the regulation of immune cells. It enhances transmembrane capacity by conjugating with the cell-penetrating peptide HIV-TAT.</p>Formule :C62H88N14O20Couleur et forme :SolidMasse moléculaire :1349.44SU1261
<p>SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.</p>Couleur et forme :Odour SolidPS 1145 dihydrochloride
CAS :<p>IκB kinase (IKK) inhibitor</p>Formule :C17H13Cl3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.67Anti-osteoporosis agent-8
<p>Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.</p>Formule :C18H19F3N2O2SeMasse moléculaire :432.05638LY2409881
CAS :<p>LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.</p>Formule :C24H29ClN6OSCouleur et forme :SolidMasse moléculaire :485.05Salicortin
CAS :<p>Salicortin, a phenolic glycoside from Populus and Salix, has anti-adipogenic, anti-amnesic, and immune effects.</p>Formule :C20H24O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :424.40TBK1/IKKε-IN-6
CAS :<p>TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.</p>Formule :C31H36F2N8O4Couleur et forme :SolidMasse moléculaire :622.678Siegesbeckialide I
<p>Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.</p>Formule :C20H28O6Couleur et forme :SolidMasse moléculaire :364.43Diprovocim-1
CAS :<p>Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.</p>Formule :C56H56N6O6Couleur et forme :SolidMasse moléculaire :909.1SN50 TFA
<p>SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.</p>Formule :C129H230N36O29S·XCF3COOHCouleur et forme :SolidMasse moléculaire :2781.5 (free base)Sootepin D
CAS :<p>Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.</p>Formule :C31H48O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.71Mesalamine impurity P
CAS :<p>Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.</p>Formule :C13H11NO6SCouleur et forme :SolidMasse moléculaire :309.30Licoagrochalcone C
CAS :<p>Licoagrochalcone C, a flavonoid, inhibits NF-κB and NO production effectively.</p>Formule :C21H22O5Couleur et forme :SolidMasse moléculaire :354.47-O-Methylaloeasinol
CAS :<p>7-O-Methylaloeasinol is a useful organic compound for research related to life sciences. The catalog number is T126468 and the CAS number is 105317-69-9.</p>Formule :C20H26O9Couleur et forme :SolidMasse moléculaire :410.419Anti-inflammatory agent 7
<p>Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.</p>Formule :C36H40N4O9Couleur et forme :SolidMasse moléculaire :672.72Nasunin
CAS :<p>Delphanin, also known as Nasunin, is an anthocyanin isolated as purple colored crystals from eggplant peels.</p>Formule :C42H47ClO23Couleur et forme :SolidMasse moléculaire :955.26COX-2-IN-48
<p>COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.</p>Couleur et forme :Odour SolidNLRP3-IN-51
<p>NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.</p>Couleur et forme :Odour SolidNF-κB-IN-9
<p>NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dual</p>Formule :C62H50N4O4SCouleur et forme :SolidMasse moléculaire :947.15Murrayafoline A
CAS :<p>Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.</p>Formule :C14H13NOCouleur et forme :SolidMasse moléculaire :211.264Ginger extract
CAS :<p>Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).</p>Couleur et forme :Solid12-Oxo phytodienoic acid
CAS :<p>12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.</p>Formule :C18H28O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.41MRT67307
CAS :<p>Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.</p>Formule :C26H36N6O2Degré de pureté :99.25% - 99.84%Couleur et forme :SolidMasse moléculaire :464.63-(2-Hydroxyethyl) thio withaferin A
<p>3-(2-Hydroxyethyl) thio withaferin A, a steroidal lactone, blocks NF-kB, targets vimentin, and inhibits EPCR shedding.</p>Formule :C30H44O7SCouleur et forme :SolidMasse moléculaire :548.73RIPK1-IN-25
<p>RIPK1-IN-25 (WL8) is a RIPK1 inhibitor with blood-brain barrier permeability, displaying an EC50 of 19.9 nM and a Kd of 25 nM. It is utilized in the research of neurodegenerative diseases.</p>Couleur et forme :Odour SolidPratensein
CAS :<p>Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.</p>Formule :C16H12O6Degré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :300.26Transcription Factor-Targeted Compound Library
<p>Well-chosen xnum compounds with unique structures targeting transcription factor;</p>Couleur et forme :Odour SolidMJ210
<p>MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.</p>Couleur et forme :Odour SolidIKKγ NBD Inhibitory Peptide
CAS :<p>A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF</p>Formule :C170H259N49O42S1Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3693.3R-HP210
<p>R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.</p>Formule :C22H19N3O2S2Couleur et forme :SolidMasse moléculaire :421.54CAY10512
CAS :<p>CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.</p>Formule :C15H13FOCouleur et forme :SolidMasse moléculaire :228.266NF-κB Signaling Compound Library
<p>A unique collection of xnum compounds targeting NF-κB signaling for high throughput screening and high content screening;</p>Couleur et forme :Odour Solid17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS :<p>DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).</p>Formule :C22H32O3Couleur et forme :SolidMasse moléculaire :344.495CAY10657
CAS :<p>CAY10657 has a wide range of applications in life science related research.</p>Formule :C17H20N4O3SCouleur et forme :SolidMasse moléculaire :360.43Lemnalol
CAS :<p>Lemnalol, from Lemnalia cervicorni, has anti-inflammatory and analgesic properties.</p>Formule :C15H24ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :220.35R1-ICR-5
CAS :<p>R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.</p>Formule :C54H70N8O7S2Couleur et forme :SolidMasse moléculaire :1007.31N-Acetyldopamine dimer-2
CAS :<p>Compound 2, an N-acetyldopamine dimer from Periostracum Cicadae, exhibits antioxidant and anti-inflammatory properties.</p>Formule :C20H20N2O6Couleur et forme :SolidMasse moléculaire :384.38
