TLR
Les récepteurs de type Toll (TLR) sont une classe de protéines qui jouent un rôle crucial dans le système immunitaire inné en reconnaissant les motifs moléculaires associés aux pathogènes (PAMP) et en initiant des réponses immunitaires. Les TLR sont impliqués dans la détection d'une large gamme de pathogènes, y compris les bactéries, les virus et les champignons, et sont essentiels pour l'activation des voies de signalisation inflammatoires. La dérégulation de la signalisation des TLR est associée à des maladies inflammatoires chroniques, des troubles auto-immuns et le cancer. Chez CymitQuimica, nous offrons une variété de modulateurs TLR de haute qualité pour soutenir vos recherches sur l'immunité innée, l'inflammation et les maladies infectieuses.
76 produits trouvés pour "TLR"
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BMS-905
CAS :BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.Formule :C23H29N3Degré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :347.5IAXO-102
CAS :IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.Formule :C35H71NO5Degré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :585.94CU-CPT22
CAS :CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).Formule :C19H22O7Degré de pureté :98.66% - 99.80%Couleur et forme :SolidMasse moléculaire :362.37Ref: TM-T15020
1mg52,00€2mg70,00€5mg99,00€10mg168,00€25mg313,00€50mg469,00€100mg682,00€200mg938,00€1mL*10mM (DMSO)114,00€TLR7/8 agonist 3
CAS :<p>TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.</p>Formule :C17H23N5ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :313.4CU-T12-9
CAS :CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).Formule :C17H13F3N4O2Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :362.31Ref: TM-T15017
1mg52,00€5mg111,00€10mg169,00€25mg283,00€50mg432,00€100mg615,00€1mL*10mM (DMSO)124,00€CU-CPT17e
CAS :CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).Formule :C27H24N2O8Degré de pureté :98.49%Couleur et forme :SolidMasse moléculaire :504.49Pam3CSK4-Biotin
CAS :Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.Formule :C103H192N14O17S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1962.85PVP-037.2
CAS :PVP-037.2 is a TLR7/8 agonist that acts as an adjuvant to enhance vaccine-induced TH1 immune responses and boost the production of antigen-specific antibodies IgG1 and IgG2c.Formule :C23H20F3N5OCouleur et forme :SoildMasse moléculaire :439.43RKH
PKH is a TLR4 antagonist, and it is a new tripeptide derived from Akkermansia muciniphila. PKH reduces inflammation-related cell activation and the overproduction of pro-inflammatory factors induced by sepsis.Formule :C18H33N9O4Masse moléculaire :439.26555TLR7 agonist 17
CAS :TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].Formule :C25H37N7O3Couleur et forme :SolidMasse moléculaire :483.61L07-2
CAS :L07-2 (Compound 6) is an active scaffold that includes a TLR7/8 agonist. It is suitable for the synthesis of immune-stimulating antibody conjugates (ISACs) used in cancer research.Formule :C56H83N15O14Couleur et forme :SolidMasse moléculaire :1190.35Tilsotolimod sodium
CAS :Tilsotolimod sodium, a synthetic Toll-like receptor 9 (TLR9) agonist, has shown antitumor activity in preclinical models.Formule :C223H262N74Na22O115P22S22Couleur et forme :SolidMasse moléculaire :7711.51MTvkPABC-P5 TFA
MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).Couleur et forme :Odour SolidPam2CSK4
CAS :TLR2/6 agonist; boosts TNF-α in human cells & mouse B cell growth/activation.Formule :C65H126N10O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1271.83TLR8 agonist 7
CAS :TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.Formule :C54H63N9O16Couleur et forme :SolidMasse moléculaire :1094.13CRX 527
CAS :CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.Formule :C81H151N2O19PCouleur et forme :SolidMasse moléculaire :1488.04Ezeprogind
CAS :Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can TrustFormule :C25H44N6Degré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :428.66TLR7/8 agonist 12
<p>TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.</p>Formule :C29H38N6O3Couleur et forme :SolidMasse moléculaire :518.65TLR8 agonist 8
CAS :TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.Formule :C53H63N11O10Couleur et forme :SolidMasse moléculaire :1014.14(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 serves as the E3 ubiquitin ligase ligand and linker for PROTAC(R)-NX-2127, utilized in cancer research.Formule :C29H33N5O4Couleur et forme :SolidMasse moléculaire :515.6
